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1. 发明申请

WO2010115008A1 OCULAR SURFACE INTERFEROMETRY (OSI) DEVICES, SYSTEMS, AND METHODS FOR IMAGING, PROCESSING, AND/OR DISPLAYING AN OCULAR TEAR FILM AND/OR MEASURING OCULAR TEAR FILM LAYER THICKNESS (ES) 审中-公开
标题翻译：用于成像，处理和/或显示眼睛薄膜和/或测量眼部膜片厚度（ES）的OCULAR SURFACE INTERFEROMETRY（OSI）装置，系统和方法
公开(公告)号：WO2010115008A1
公开(公告)日：2010-10-07
申请号：PCT/US2010/029645
申请日：2010-04-01
申请人： TEARSCIENCE, INC. , KORB, Donald, R. , WEBER, William, L. , CHINNOCK, Randal, B. , GRAVELY, Benjamin, T. , GRENON, Steven, M.
发明人： KORB, Donald, R. , WEBER, William, L. , CHINNOCK, Randal, B. , GRAVELY, Benjamin, T. , GRENON, Steven, M.
IPC分类号： A01N57/26
CPC分类号： A61B3/101 , A61B3/0025 , A61B3/0041 , A61B3/1005 , A61B3/14 , G06T7/0012 , G06T2207/30041
摘要： Ocular surface interferometry (OSI) devices, systems, and methods are disclosed for measuring a tear film layer thickness (TFLT) of the ocular tear film, including lipid layer thickness (LLT) and/or aqueous layer thickness (ALT). The measured TFLT can be used to diagnosis dry eye syndrome (DES). In certain disclosed embodiments, a multi-wavelength light source can be controlled to illuminate the ocular tear film. Light emitted from the multi-wavelength light source undergoes optical wave interference interactions in the tear film. An imaging device can be focused on the lipid layer of the tear film to capture optical wave interference interactions of specularly reflected light from the tear film combined with a background signal(s) in a first image. The imaging device can also be focused on the lipid layer of the tear film to capture a second image containing the background signal(s) present in the first image.
摘要翻译：公开了用于测量眼泪膜的泪膜层厚度（TFLT），包括脂质层厚度（LLT）和/或水层厚度（ALT）的眼表干涉测量（OSI）装置，系统和方法。测量的TFLT可用于诊断干眼综合征（DES）。在某些公开的实施例中，可以控制多波长光源以照射眼泪膜。从多波长光源发射的光在泪膜中经历光波干涉相互作用。成像装置可以集中在泪膜的脂质层上，以捕获与第一图像中的背景信号结合的来自泪膜的镜面反射光的光波干涉相互作用。成像装置还可以聚焦在泪膜的脂质层上，以捕获包含存在于第一图像中的背景信号的第二图像。

2. 发明申请

WO2008024100A2 METHOD AND APPARATUS FOR TREATING GLAND DYSFUNCTION 审中-公开
标题翻译：治疗腺体功能障碍的方法和装置
公开(公告)号：WO2008024100A2
公开(公告)日：2008-02-28
申请号：PCT/US2006/032544
申请日：2006-08-21
申请人： KOLIS SCIENTIFIC, INC. , KORB, Donald, R. , WILLIS, Timothy, R. , GRAVELY, Benjamin, T. , GRENON, Stephen, M.
发明人： KORB, Donald, R. , WILLIS, Timothy, R. , GRAVELY, Benjamin, T. , GRENON, Stephen, M.
IPC分类号： A61F7/12
CPC分类号： A61F7/007 , A61F7/02 , A61F2007/0004 , A61N7/00
摘要： A method and apparatus for treating gland dysfunction caused by gland obstruction in order to restore the natural flow of secretion from the gland comprises the application of a combination of energy, suction, vibration, heat, aspiration, chemical agents and pharmacological agents to loosen and thereafter remove the obstructive material.
摘要翻译：用于治疗由腺体阻塞引起的腺体功能障碍以恢复从腺体分泌的天然流动的方法和装置包括施加能量，吸力，振动，热，吸入，化学药剂和药理学物质的组合以松动，此后清除阻塞物。

3. 发明申请

WO2006076308A1 DRY EYE TREATMENT 审中-公开
标题翻译：干眼剂治疗
公开(公告)号：WO2006076308A1
公开(公告)日：2006-07-20
申请号：PCT/US2006/000716
申请日：2006-01-10
申请人： OCULAR RESEARCH OF BOSTON, INC. , KORB, Donald R. , BRANCEWICZ, Chris J.
发明人： KORB, Donald R. , BRANCEWICZ, Chris J.
IPC分类号： A61K31/685
CPC分类号： A61K9/0048 , A61K9/107
摘要： This invention relates to an emulsion composition for the formation of an artificial tear film over the ocular surface of the eye capable of providing mechanical lubrication for the ocular surface while reducing evaporation of fluid therefrom. The emulsion is desirably in the form of a meta stable emulsion and is characterized by the use of a surfactant comprising a combination of a primary and secondary surfactant where the primary surfactant permits formation of the emulsion and the secondary surfactant permits autoclaving of the surfactant. The invention also includes a method for the formation of such an emulsion.
摘要翻译：本发明涉及一种用于在眼睛眼表面上形成人造泪膜的乳液组合物，其能够为眼表提供机械润滑，同时减少流体的蒸发。乳液理想地是间位稳定乳液的形式，其特征在于使用包含初级和次级表面活性剂的组合的表面活性剂，其中主表面活性剂允许形成乳液，第二表面活性剂允许表面活性剂的高压灭菌。本发明还包括形成这种乳液的方法。

4. 发明专利

CA2079658A1 DRY EYE TREATMENT PROCESS AND SOLUTION DRY EYE TREATMENT PROCESS AND SOLUTION 未知
公开(公告)号：CA2079658A1
公开(公告)日：1993-04-03
申请号：CA2079658
申请日：1992-10-01
申请人： KORB DONALD R , GLONEK THOMAS
发明人： KORB DONALD R , GLONEK THOMAS
IPC分类号： A61F9/007 , A61K9/00 , A61K9/107 , A61K31/23 , A61K35/06 , A61P27/02 , A61P43/00 , A61K47/44
摘要： A method and composition for reducing evaporation of an aqueous layer from the surface of the eye. The method comprises applying a gelled oil over the eye, preferably in the form of a meta-stable oil in water emulsion in a dosage not exceeding 100 microliters. The gelled oil is preferably formed by yelling a hydrocarbon oil with a wax.

5. 发明申请

WO2008085162A1 TREATMENT OF MEIBOMIAN GLANDS 审中-公开
标题翻译：治疗墨西哥湾
公开(公告)号：WO2008085162A1
公开(公告)日：2008-07-17
申请号：PCT/US2007/000525
申请日：2007-01-09
申请人： KOLIS SCIENTIFIC, INC. , KORB, Donald, R. , WILLIS, Timothy, R. , GRENON, Stephen, M.
发明人： KORB, Donald, R. , WILLIS, Timothy, R. , GRENON, Stephen, M.
IPC分类号： A61F7/00 , A61B19/00
CPC分类号： A61F7/02 , A61F2007/0004
摘要： In one embodiment consistent with the present invention a method of treating mammalian meibomian glands (10) involves clearing the glands by applying a regulated heat (104) to an eyelid containing the meibomian glands to a temperature adequate to melt obstructions in the meibomian glands to put the obstructions in a fluid or suspension (melted) state and maintaining the heat for a time period adequate to melt the obstructions. The glands can then be mechanically treated to express fluid from the glands (108), wherein the treating is carried out either during the time period or after the time period but while the obstruction remains in a fluid state. Subsequent pharmacological treatment of the glands by use a pharmacological agent (topical or systemic) (112) can then be used to assist in maintaining proper flow of lipids from the glands. This abstract is not to be considered limiting, since other embodiments may deviate from the features described in this abstract.
摘要翻译：在与本发明一致的一个实施方案中，治疗哺乳动物睑板腺的方法（10）涉及通过对含有睑板腺的眼睑施加调节热（104）至足以融化睑板腺中的阻塞物的温度来清除腺体在流体或悬浮（熔化）状态下的障碍物并将热量保持足以熔化障碍物的时间。然后可以对腺体进行机械处理以从腺体（108）表达流体，其中治疗在时间段期间或在时间段之后进行，但是阻塞物保持在流体状态。然后使用药物（局部或全身）（112）对腺体进行的后续药理学治疗可以用于帮助保持来自腺体的适当的脂质流动。该摘要不被认为是限制性的，因为其它实施例可能偏离本摘要中描述的特征。

6. 发明专利

CA2043366A1 DRY EYE TREATMENT SOLUTION AND PROCESS 未知
公开(公告)号：CA2043366A1
公开(公告)日：1991-11-30
申请号：CA2043366
申请日：1991-05-28
申请人： GLONEK THOMAS , GREINER JACK V , KORB DONALD R , BOSTON OCULAR RES
发明人： GLONEK THOMAS , GREINER JACK V , KORB DONALD R
IPC分类号： A61K9/107 , A61F9/00 , A61K9/00 , A61K31/685 , A61K47/24 , A61P27/02 , A61P27/04
摘要： A method and composition for reducing evaporation of an aqueous layer from the surface of the eye. The method comprises applying an admixture of a charged phospholipid and a non-polar oil over the eye, preferably in the form of a meta-stable oil in water emulsion in a dosage not exceeding 100 microliters.

7. 发明申请

WO2008024100A3 METHOD AND APPARATUS FOR TREATING GLAND DYSFUNCTION 审中-公开
标题翻译：治疗腺体功能障碍的方法和装置
公开(公告)号：WO2008024100A3
公开(公告)日：2009-04-30
申请号：PCT/US2006032544
申请日：2006-08-21
申请人： TEARSCIENCE INC , KORB DONALD R , WILLIS TIMOTHY R , GRAVELY BENJAMIN T , GRENON STEPHEN M
发明人： KORB DONALD R , WILLIS TIMOTHY R , GRAVELY BENJAMIN T , GRENON STEPHEN M
IPC分类号： A61F7/00
CPC分类号： A61F7/007 , A61F7/02 , A61F2007/0004 , A61N7/00
摘要： A method and apparatus for treating gland dysfunction caused by gland obstruction in order to restore the natural flow of secretion from the gland comprises the application of a combination of energy, suction, vibration, heat, aspiration, chemical agents and pharmacological agents to loosen and thereafter remove the obstructive material.
摘要翻译：用于治疗由腺体阻塞引起的腺体功能障碍以恢复从腺体分泌的天然流动的方法和装置包括施加能量，吸力，振动，热，吸入，化学药剂和药理学物质的组合以松动，此后清除阻塞物。

8. 发明申请

WO2008156883A2 TEAR FILM MEASUREMENT 审中-公开
标题翻译：眼膜测量
公开(公告)号：WO2008156883A2
公开(公告)日：2008-12-24
申请号：PCT/US2008057578
申请日：2008-03-20
申请人： KOLIS SCIENT INC , KORB DONALD R , GRAVELY BENJAMIN T
发明人： KORB DONALD R , GRAVELY BENJAMIN T
IPC分类号： G01B11/06
CPC分类号： G01B11/0675 , A61B3/101
摘要： The invention comprises an apparatus for measuring the relative thickness of the lipid layer component of the precorneal tear film on the surface of an eye after distribution of the lipid layer subsequent to blinking is disclosed. An illuminator directs light to the lipid layer of a patient's eye. The illuminator is a broad spectrum light source covering the visible region and is a lambertion light emitter such that the light source is specularly reflected from the lipid layer and undergoes constructive and destructive interference in the lipid layer. A collector collects and focuses the specularly reflected light such that the interference patterns on the tear film lipid layer are observable. The collector also produces an output signal representative of the specularly reflected light which is suitable for further analysis, such as projection on to a high resolution video monitor or analysis by or storage in a computer. In order to facilitate ease of measurement, the patient's head may be positioned on an observation platform when the illuminator directs light to the lipid layer of the patient's eye.
摘要翻译：本发明包括一种用于测量在眨眼之后脂质层分布之后眼前表面上的预角膜撕裂膜的脂质层组分的相对厚度的装置。照明器将光引导到患者眼睛的脂质层。照明器是覆盖可见光区域的广谱光源，是一个薄片光发射器，使得光源从脂质层镜面反射并在脂质层中发生建设性和破坏性干扰。收集器收集并聚焦镜面反射光，使得可以观察到泪膜脂质层上的干涉图案。收集器还产生代表镜面反射光的输出信号，其适用于进一步分析，例如投影到高分辨率视频监视器上，或由计算机分析或存储在计算机中。为了便于测量，当照明器将光引导到患者眼睛的脂质层时，患者的头部可以位于观察平台上。

9. 发明申请

WO2013003594A3 METHODS AND SYSTEMS FOR TREATING MEIBOMIAN GLAND DYSFUNCTION USING RADIO-FREQUENCY ENERGY 审中-公开
标题翻译：使用射频能量治疗睑缘腺功能障碍的方法和系统
公开(公告)号：WO2013003594A3
公开(公告)日：2013-02-28
申请号：PCT/US2012044650
申请日：2012-06-28
申请人： TEARSCIENCE INC , KORB DONALD R , GRENON STEPHEN M , WILLIS TIMOTHY R , GRAVELY BENJAMIN TYSON , BACICH STEVEN
发明人： KORB DONALD R , GRENON STEPHEN M , WILLIS TIMOTHY R , GRAVELY BENJAMIN TYSON , BACICH STEVEN
IPC分类号： A61M35/00
CPC分类号： G01N33/227 , A61B5/4836 , A61B18/12 , A61B2018/046 , A61B2018/048 , A61B2562/0247 , A61B2562/0271 , A61F9/007 , A61F9/00718 , A61F2007/0004 , A61F2007/0059 , A61H7/003 , A61H7/005 , A61H9/0057 , A61H9/0071 , A61H9/0078 , A61H23/0236 , A61H23/0245 , A61H23/0263 , A61H39/086 , A61H2015/0014 , A61H2201/0176 , A61H2201/0207 , A61H2201/0214 , A61H2201/5038 , A61H2201/5043 , A61H2205/024 , A61N1/403 , A61N7/00 , Y10T436/170769 , Y10T436/173076 , Y10T436/173845 , Y10T436/178459 , Y10T436/19 , Y10T436/206664
摘要： A method of treating meibomian gland dysfunction is disclosed. The method includes directing RF energy to an internal portion of a meibomian gland, selectively targeting an obstruction within a duct of the meibomian gland with the applied RF energy to melt, loosen, or soften the obstruction, and expressing the obstruction from the duct of the meibomian gland. An apparatus for treating meibomian gland dysfunction is also disclosed. The apparatus comprises at least one RF electrode configured to direct RF energy to an internal portion of a meibomian gland located in an eyelid of an eye, the at least one RF electrode further configured to selectively target an obstruction within a duct of the meibomian gland with the applied RF energy to melt, loosen, or soften the obstruction. The apparatus also comprises at least one expressor configured to express the obstruction from the duct of the meibomian gland.
摘要翻译：披露了一种治疗睑板腺功能障碍的方法。该方法包括将RF能量引导至睑板腺的内部部分，利用所施加的RF能量选择性地瞄准睑板腺的管道内的阻塞物以使阻塞物融化，松动或软化，并且将障碍物从睑板腺。还公开了治疗睑板腺功能障碍的装置。该设备包括至少一个RF电极，其被配置为将RF能量引导至位于眼睑中的睑板腺的内部部分，所述至少一个RF电极还被配置为选择性地将睑板腺的导管内的阻塞物靶向施加的RF能量融化，放松或软化阻塞。该设备还包括至少一个表达器，其被配置为表达来自睑板腺的管道的阻塞。

10. 发明申请

WO2013003594A2 METHODS AND SYSTEMS FOR TREATING MEIBOMIAN GLAND DYSFUNCTION USING RADIO-FREQUENCY ENERGY 审中-公开
标题翻译：使用无线电频率处理MEIBOMIAN GLAND DYSFUNCTION的方法和系统
公开(公告)号：WO2013003594A2
公开(公告)日：2013-01-03
申请号：PCT/US2012/044650
申请日：2012-06-28
申请人： TEARSCIENCE, INC. , KORB, Donald, R. , GRENON, Stephen, M. , WILLIS, Timothy, R. , GRAVELY, Benjamin, Tyson , BACICH, Steven
发明人： KORB, Donald, R. , GRENON, Stephen, M. , WILLIS, Timothy, R. , GRAVELY, Benjamin, Tyson , BACICH, Steven
IPC分类号： A61F7/00 , A61N1/39
CPC分类号： G01N33/227 , A61B5/4836 , A61B18/12 , A61B2018/046 , A61B2018/048 , A61B2562/0247 , A61B2562/0271 , A61F9/007 , A61F9/00718 , A61F2007/0004 , A61F2007/0059 , A61H7/003 , A61H7/005 , A61H9/0057 , A61H9/0071 , A61H9/0078 , A61H23/0236 , A61H23/0245 , A61H23/0263 , A61H39/086 , A61H2015/0014 , A61H2201/0176 , A61H2201/0207 , A61H2201/0214 , A61H2201/5038 , A61H2201/5043 , A61H2205/024 , A61N1/403 , A61N7/00 , Y10T436/170769 , Y10T436/173076 , Y10T436/173845 , Y10T436/178459 , Y10T436/19 , Y10T436/206664
摘要： A method of treating meibomian gland dysfunction is disclosed. The method includes directing RF energy to an internal portion of a meibomian gland, selectively targeting an obstruction within a duct of the meibomian gland with the applied RF energy to melt, loosen, or soften the obstruction, and expressing the obstruction from the duct of the meibomian gland. An apparatus for treating meibomian gland dysfunction is also disclosed. The apparatus comprises at least one RF electrode configured to direct RF energy to an internal portion of a meibomian gland located in an eyelid of an eye, the at least one RF electrode further configured to selectively target an obstruction within a duct of the meibomian gland with the applied RF energy to melt, loosen, or soften the obstruction. The apparatus also comprises at least one expressor configured to express the obstruction from the duct of the meibomian gland.
摘要翻译：公开了治疗睑板腺功能障碍的方法。该方法包括将RF能量引导到睑板腺的内部部分，以施加的RF能量选择性地靶向睑板腺导管内的阻塞物，以熔化，松开或软化阻塞物，并且将来自管道的阻塞物睑板腺还公开了一种治疗睑板腺功能障碍的装置。该装置包括至少一个RF电极，其被配置为将RF能量引导到位于眼睛的眼睑中的睑板腺的内部部分，所述至少一个RF电极还被配置为选择性地将睑板腺的管道内的阻塞物对准，应用的射频能量来融化，松动或软化障碍物。该装置还包括至少一个构造成从睑板腺的管道表达梗阻的表达器。

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