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1. 发明申请

WO2007025669A2 WIRKSTOFFKOMBINATIONEN MIT INSEKTIZIDEN UND AKARIZIDEN EIGENSCHAFTEN 审中-公开
标题翻译： WITH杀虫剂和杀螨剂PROPERTIES有效组合
公开(公告)号：WO2007025669A2
公开(公告)日：2007-03-08
申请号：PCT/EP2006/008276
申请日：2006-08-23
申请人： BAYER CROPSCIENCE AG , THIELERT, Wolfgang , HUNGENBERG, Heike , MURATA, Tetsuya , KOICHI, Araki
发明人： THIELERT, Wolfgang , HUNGENBERG, Heike , MURATA, Tetsuya , KOICHI, Araki
IPC分类号： A01N51/00 , A01N43/40
CPC分类号： A01N43/82 , A01N43/40 , A01N47/12 , A01N47/34 , A01N47/40 , A01N51/00 , A01N2300/00
摘要： Erfindungsgemäß wurden Wirkstoffkombinationen aus Verbindungen der Formel (I), in der R 1 und A die in der Beschreibung angegebene Bedeutung haben, und Neonikotinylen gefunden, die sehr gute insektizide und akarizide Eigenschaften besitzen, sowie ihre Verwendung und Verfahren zu ihrer Herstellung.
摘要翻译：根据活性化合物的本发明，从式（I）的化合物制备，其中R ^{1 和A具有在说明书中给出的含义，并且Neonikotinylen发现具有很好的杀虫和杀螨性质，并且它们的使用和方法它们的制备方法。}

2. 发明申请

WO2007025669A3 ACTIVE SUBSTANCE COMBINATIONS WITH INSECTICIDAL AND ACARICIDAL PROPERTIES 审中-公开
标题翻译：杀虫剂和杀真菌活性化合物
公开(公告)号：WO2007025669A3
公开(公告)日：2007-07-26
申请号：PCT/EP2006008276
申请日：2006-08-23
申请人： BAYER CROPSCIENCE AG , THIELERT WOLFGANG , HUNGENBERG HEIKE , MURATA TETSUYA , KOICHI ARAKI
发明人： THIELERT WOLFGANG , HUNGENBERG HEIKE , MURATA TETSUYA , KOICHI ARAKI
IPC分类号： A01N51/00 , A01N43/40
CPC分类号： A01N43/82 , A01N43/40 , A01N47/12 , A01N47/34 , A01N47/40 , A01N51/00 , A01N2300/00
摘要： According to the invention, active substance combinations comprised of compounds of formula (I), in which R 1 and A have the meanings cited in the description, and of neonicotinyls have been discovered that have very good insecticidal and acaricidal properties, and to their use and method for the production thereof.
摘要翻译：根据活性化合物的本发明，从式（I）的化合物制备，其中R ^{1 和A具有在说明书中给出的含义，并且Neonikotinylen发现具有很好的杀虫和杀螨性质，并且它们的使用和方法为他们的生产。}

3. 发明专利

JP2006266440A Air purging implement for combustible gas piping 有权
标题翻译：可燃煤气管道的空气净化实施
公开(公告)号：JP2006266440A
公开(公告)日：2006-10-05
申请号：JP2005088212
申请日：2005-03-25
申请人： Koichi Araki , 紘一荒木
发明人： ARAKI KOICHI
IPC分类号： F16L55/07 , F17D3/10
摘要： PROBLEM TO BE SOLVED: To provide an air purging implement whereby air can be safely and surely replaced with a combustible gas without relying on perception and a knack, since when performing various construction works for a gas pipe to pass combustible gas, air remaining in the gas pipe is required to be replaced with the combustible gas after the construction works are finished.
SOLUTION: In order to structure this air purging implement for combustible gas piping, a tubular plug member 9 the outer diameter of which is reduced so as to form a reversely tapered shape is made to get engaged with the lower periphery of a cylindrical body 1 comprising a vertical part 2 and a bent part 3 and having an almost L-shape, in which a transparent portion is provided at least at the center of the vertical part 2, a level difference part 4 stretching inward is formed on the inner peripheral wall of a lower part slightly lower than the transparent portion, a determining sphere 5 having an outer diameter larger than the inner diameter of the level difference part 4 is disposed in the upper part of the level difference part 4 so that it can freely roll, and a shutter valve which can be freely opened and closed is mounted to the opening part 11 of the bent part 3.
COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：要解决的问题：提供一种空气净化装置，其中空气可以安全可靠地替换为可燃气体，而不依赖于感知和诀窍，因为当进行用于气体管道通过可燃气体的各种施工工作时，空气在施工作业结束后，留在气体管道中的气体需要更换为可燃气体。解决方案：为了构造用于可燃气体管道的空气净化装置，使其外径减小以形成倒锥形的管状塞构件9与圆筒形的下周边接合主体1包括垂直部分2和弯曲部分3，并且具有几乎为L形，其中透明部分至少设置在垂直部分2的中心处，向内延伸的水平差部分4形成在内部下部的周壁比透明部稍低，具有比水平差部4的内径大的外径的判定球5配置在水平差部4的上部，使其能够自由地滚动，并且可以自由地打开和关闭的快门阀被安装到弯曲部分3的开口部分11上。（C）2007，JPO＆INPIT

4. 发明申请

US20110129496A1 Use of mTOR Inhibitors to Enhance T Cell Immune Responses 有权
标题翻译：使用mTOR抑制剂增强T细胞免疫反应
公开(公告)号：US20110129496A1
公开(公告)日：2011-06-02
申请号：US13057057
申请日：2009-08-05
申请人： Rafi Ahmed , Christian P. Larsen , Koichi Araki
发明人： Rafi Ahmed , Christian P. Larsen , Koichi Araki
IPC分类号： A61K39/12 , A61K39/02 , A61K39/00 , A61P31/04 , A61P31/10 , A61P31/12 , A61P33/00 , A61P35/00
CPC分类号： A61K31/436 , A61K31/4745 , A61K39/0011 , A61K39/12 , A61K39/39 , A61K45/06 , A61K2039/5256 , A61K2039/5258 , A61K2039/53 , A61K2039/55516 , A61K2039/55561 , C07K14/005 , C12N2710/10343 , C12N2710/24122 , C12N2710/24143 , C12N2730/10134 , C12N2740/13023 , C12N2740/13043 , C12N2760/10034 , C12N2770/10022 , A61K2300/00
摘要： It is disclosed herein that treatment of a subject with an mTOR inhibitor enhances antigen-specific T cell immune responses. Thus, provided herein is a method of enhancing an antigen-specific T cell response in a subject by administering to the subject a therapeutically effective amount of an mTOR inhibitor. The antigen can be any antigen, such as an antigen from a pathogen or a vaccine, or a tumor antigen. In some embodiments, the method further comprises administering to the subject a vaccine, such as a virus vaccine or a cancer vaccine. The mTOR inhibitor can be administered either before or after vaccination to enhance the quantity and quality of the T cell immune response and immunological memory. In some examples, the mTOR inhibitor is rapamycin or a rapamycin analog.
摘要翻译：本文公开了用mTOR抑制剂治疗受试者增强抗原特异性T细胞免疫应答。因此，本文提供了通过向受试者施用治疗有效量的mTOR抑制剂来增强受试者中抗原特异性T细胞应答的方法。抗原可以是任何抗原，例如来自病原体或疫苗的抗原或肿瘤抗原。在一些实施方案中，该方法还包括向受试者施用疫苗，例如病毒疫苗或癌症疫苗。 mTOR抑制剂可以在接种之前或之后施用以增强T细胞免疫应答和免疫记忆的数量和质量。在一些实例中，mTOR抑制剂是雷帕霉素或雷帕霉素类似物。

5. 发明申请

US20100323896A1 USE OF SULFONANILIDES AS HERBICIDE 审中-公开
标题翻译：使用磺酰亚胺作为除草剂
公开(公告)号：US20100323896A1
公开(公告)日：2010-12-23
申请号：US12868032
申请日：2010-08-25
申请人： Koichi Araki , Yoshitaka Sato , Takuya Gomibuchi , Keiji Endo , Shinichi Shirakura , Shin Nakamura , Christopher Rosinger , Dieter Feucht
发明人： Koichi Araki , Yoshitaka Sato , Takuya Gomibuchi , Keiji Endo , Shinichi Shirakura , Shin Nakamura , Christopher Rosinger , Dieter Feucht
IPC分类号： A01N43/66 , C07D239/52 , C07D251/16 , A01N43/54 , A01P13/00
CPC分类号： C07D251/20 , A01N43/54 , A01N43/66 , C07D239/52
摘要： Herbicidal compositions comprising containing sulfonanilides of the formula (I) wherein R1 represents hydrogen, fluorine, chlorine, C1-4 alkyl, C1-4 alkoxy, C3-6 cycloalkyl-C1-4 alkyloxy or C1-4 haloalkoxy, R2 represents hydrogen, fluorine or chlorine, R3 represents hydrogen or fluorine, R4 represents hydrogen or C1-4 alkyl which may be optionally C1-4 alkoxy-substituted, C3-6 alkenyl or C3-6 alkynyl, R5 represents hydrogen, R6 represents hydroxy, fluorine or chlorine, or R5 and R6 may form, together with the carbon to which they are bonded, C═O, and X represents CH or N, provided that the following cases are excluded: (i) R1 represents hydrogen, fluorine or chlorine, R2 represents hydrogen, R3 represents hydrogen, R4 represents hydrogen, R5 represents hydrogen, and R6 represents hydroxy, (ii) R1 represents hydrogen, fluorine or chlorine, R2 represents hydrogen, R3 represents hydrogen, R4 represents hydrogen, and R5 and R6 form C═O together with the carbon to which they are bonded, (iii) R1 represents C1-4 alkyl, R2 represents hydrogen, R3 represents hydrogen, R4 represents hydrogen, R5 represents hydrogen, R6 represents hydroxy, and X represents CH, or (iv) R1 represents C1-4 alkyl, R2 represents hydrogen, R3 represents hydrogen, R4 represents hydrogen, R5 and R6 form C═O together with the carbon to which they are bonded, and X represents CH, and new compounds being embraced by the formula (I).
摘要翻译：包含含有式（I）的磺酰苯胺的除草组合物，其中R 1表示氢，氟，氯，C 1-4烷基，C 1-4烷氧基，C 3-6环烷基-C 1-4烷氧基或C 1-4卤代烷氧基，R 2表示氢，氟或氯，R 3表示氢或氟，R 4表示氢或可以任选被C 1-4烷氧基取代的C 1-4烷基，C 3-6烯基或C 3-6炔基，R 5表示氢，R 6表示羟基，氟或氯，或者R 5和R 6可以与它们所键合的碳一起形成C = O，X表示CH或N，条件是排除以下情况：（i）R 1表示氢，氟或氯，R 2表示氢，R3表示氢，R4表示氢，R5表示氢，R6表示羟基，（ii）R1表示氢，氟或氯，R2表示氢，R3表示氢，R4表示氢，R5和R6表示C = O 与它们结合的碳，（iii）R 1表示C 1-4烷基，R 2表示氢，R 3表示氢，R 4表示氢，R 5表示氢，R 6表示羟基，X表示CH，或（ⅳ）R 1表示C 1-4烷基， R3表示氢，R4表示氢，R5和R6与它们所键合的碳一起形成C = O，X表示CH，并且新化合物被式（I）所包围。

6. 发明授权

US07772395B2 Process for the preparation of phenyl 2-pyrimidinyl ketones and their novel intermediates 有权
标题翻译：苯基2-嘧啶基酮及其新型中间体的制备方法
公开(公告)号：US07772395B2
公开(公告)日：2010-08-10
申请号：US11666496
申请日：2005-10-28
申请人： Koichi Araki , Yoshitaka Sato , Mark James Ford
发明人： Koichi Araki , Yoshitaka Sato , Mark James Ford
IPC分类号： C07D239/52
CPC分类号： C07D239/52
摘要： A process for the preparation of the compounds of the formula (I), or salts thereof, wherein R represents a hydrogen atom or difluoromethanesulfonyl, characterized in that compounds of the formula (II), or salts thereof, wherein R has the same definition as aforementioned, and n represents 0 or 1, are reacted in the presence of hydrogen peroxide and acetic acid.
摘要翻译：制备式（I）化合物或其盐的方法，其中R表示氢原子或二氟甲磺酰基，其特征在于式（II）化合物或其盐，其中R的定义同并且n表示0或1，在过氧化氢和乙酸的存在下反应。

7. 发明申请

US20050227970A1 Pesticidal pyridinecarboxamide derivatives 失效
标题翻译：杀虫剂吡啶甲酰胺衍生物
公开(公告)号：US20050227970A1
公开(公告)日：2005-10-13
申请号：US10514430
申请日：2003-05-06
申请人： Koichi Araki , Tetsuya Murata , Koshi Gunjima , Norihiko Nakakura , Eiichi Shimojo , Dale Mitchell , Henricus Maria Bastiaans
发明人： Koichi Araki , Tetsuya Murata , Koshi Gunjima , Norihiko Nakakura , Eiichi Shimojo , Dale Mitchell , Henricus Maria Bastiaans
IPC分类号： A01N43/40 , A01N43/74 , A01N43/78 , A01N43/82 , A01N43/824 , A01N43/86 , A61K31/455 , A61K31/541 , A61P33/10 , A61P33/14 , C07D213/82 , C07D411/12 , C07D413/12 , C07D417/12 , C07D419/12 , C07D417/02 , A01N43/54 , C07D413/02 , C07D43/02
CPC分类号： C07D213/82 , A01N43/40 , C07D411/12 , C07D413/12 , C07D417/12 , C07D419/12
摘要： The invention relates to 3-pyridylcarboxamide derivatives of formula (I): wherein the various symbols are as defined in the description, compositions thereof, methods for controlling pests by applying same, and processes for their preparation.
摘要翻译：本发明涉及式（I）的3-吡啶基甲酰胺衍生物：其中各种符号如说明书中所定义，其组合，通过应用它们控制害虫的方法及其制备方法。

8. 发明授权

US5753538A Method of sealing electronic parts with molded resin and mold employed therefor 失效
标题翻译：用模塑树脂密封电子部件的方法和用于其的模具
公开(公告)号：US5753538A
公开(公告)日：1998-05-19
申请号：US399947
申请日：1995-03-06
申请人： Takaki Kuno , Yoshihisa Kawamoto , Makoto Matsuo , Koichi Araki , Satoshi Nihei
发明人： Takaki Kuno , Yoshihisa Kawamoto , Makoto Matsuo , Koichi Araki , Satoshi Nihei
IPC分类号： B29C45/26 , B29C45/02 , B29C45/14 , B29C45/34 , B29L31/34 , H01L21/56
CPC分类号： B29C45/14655 , B29C45/34 , H01L2224/48091 , H01L2924/19041
摘要： In a method of sealing electronic parts with molded resin, a hollow sealing member is arranged on a mold surface of an upper mold section of a mold comprising the upper mold section and a lower mold section, so that the hollow sealing member is pressurized and expanded to convexly project from the mold surface of the upper mold section. In this state, the lower mold section is upwardly moved to be brought into contact with the expanded hollow sealing member. Further, an internal space portion, including pots, cull portions, resin passages and cavities, which is enclosed with the expanded hollow sealing member is set in a state isolated from the exterior when the upper mold section and the lower mold section are closed, so that the internal space portion is forcibly evacuated in this state. Thus, air, moisture and gases are efficiently and reliably suction-discharged from the internal space portion, whereby the internal space portion is set at a prescribed degree of vacuum. Consequently, it is possible to avoid contamination of air, moisture and the like in melted resin materials, as well as to prevent formation of voids in resin-sealed compacts.
摘要翻译：在用模制树脂密封电子部件的方法中，中空密封件被布置在包括上模具部分和下模具部分的模具的上模具部分的模具表面上，使得中空密封件被加压膨胀从上模具部分的模具表面突出地突出。在这种状态下，下模部向上移动以与膨胀的中空密封构件接触。此外，当上部模具部分和下部模具部分闭合时，与膨胀的中空密封部件一起包围的包括罐，剔除部分，树脂通道和空腔的内部空间部分被设置成与外部隔离的状态，因此在该状态下内部空间部分被强制抽空。因此，空气，湿气和气体从内部空间部分被有效且可靠地抽吸排出，由此将内部空间部分设定在规定的真空度。因此，可以避免熔融树脂材料中的空气，水分等的污染，以及防止在树脂密封成形体中形成空隙。

9. 发明授权

US4659365A Herbicidal 2-chloro-2'-fluoroalkoxyacetanilides 失效
标题翻译：除草剂2-氯-2'-氟代烷氧基乙酰苯胺
公开(公告)号：US4659365A
公开(公告)日：1987-04-21
申请号：US769123
申请日：1985-08-26
申请人： Kazuhiko Konno , Koichi Araki , Kaoru Ikeda , Keiji Endo , Mitsuru Hikido
发明人： Kazuhiko Konno , Koichi Araki , Kaoru Ikeda , Keiji Endo , Mitsuru Hikido
IPC分类号： A01N37/24 , A01N37/26 , A01N43/56 , C07C233/88 , C07D231/12 , C07D521/00 , C07C103/375
CPC分类号： C07D231/12 , A01N37/24 , A01N37/26 , A01N43/56 , C07D233/56 , C07D249/08
摘要： An acetanilide derivative of the following formula (I) and a herbicide containing one or more of the acetanilide derivative as the active ingredient are described. ##STR1## In the formula, R.sup.1 is a lower alkyl group; R.sup.2 is a fluorine-substituted lower alkyl group; A is ##STR2## B is an optionally substituted pyrazolyl group, an optionally substituted alkoxy group or a hydrogen atom.The acetanilide derivative and the herbicide have a selective weed killing activity to gramiveous weeds.
摘要翻译：描述下式（I）的乙酰苯胺衍生物和含有一种或多种乙酰苯胺衍生物作为活性成分的除草剂。在该式中，R 1为低级烷基; R2是氟取代的低级烷基; A是B是任选取代的吡唑基，任选取代的烷氧基或氢原子。乙酰苯胺衍生物和除草剂对杂草杂草具有选择性除草活性。

10. 发明授权

US09944604B2 Aminobenzamide derivatives as useful agents for controlling animal parasites 有权
公开(公告)号：US09944604B2
公开(公告)日：2018-04-17
申请号：US13456880
申请日：2012-04-26
申请人： Ulrich Görgens , Akihiko Yanagi , Kazue Yanagi , Keisuke Yanagi , Kasumi Yanagi , Katsuaki Wada , Tetsuya Murata , Yukiyoshi Watanabe , Jun Mihara , Koichi Araki
发明人： Ulrich Görgens , Akihiko Yanagi , Katsuaki Wada , Tetsuya Murata , Yukiyoshi Watanabe , Jun Mihara , Koichi Araki
IPC分类号： A61K31/33 , C07D213/60 , A01N37/46 , A01N43/08 , A01N43/10 , A01N43/40 , A01N43/56 , A01N43/82 , A01N47/20 , C07C237/42 , C07C271/28 , C07C317/44 , C07C323/62
CPC分类号： C07D213/60 , A01N37/46 , A01N43/08 , A01N43/10 , A01N43/40 , A01N43/56 , A01N43/82 , A01N47/20 , C07C237/42 , C07C271/28 , C07C317/44 , C07C323/62 , C07C2601/10 , C07C2601/16
摘要： The invention relates to a composition comprising at least one aminobenzamide compound or a salt thereof for controlling animal parasites, veterinary pharmaceutical compositions comprising at least one aminobenzamide of formula (I) for preventing infection with diseases transmitted through parasites, its use for the preparation of a veterinary pharmaceutical for controlling animal parasites, and a method for preventing infection with diseases transmitted through parasites.

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