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1. 发明申请

WO2004056874A3 NEUROPILIN-1 INHIBITORS 审中-公开
标题翻译：神经保护素-1抑制剂
公开(公告)号：WO2004056874A3
公开(公告)日：2004-12-09
申请号：PCT/EP0314756
申请日：2003-12-22
申请人： XERION PHARMACEUTICALS AG , UNIV TUFTS , UNGER CHRISTINE MARGARETE , BESTE GERALD , ZEHETMEIER CAROLIN , LAIN BLANCA , TORELLA CLAUDIA , NIEWOEHNER JENS , JAY DANIEL G , EUSTACE BRENDA K , KNAUER ROLAND , JENSEN KRISTIAN HOBOLD
发明人： UNGER CHRISTINE MARGARETE , BESTE GERALD , ZEHETMEIER CAROLIN , LAIN BLANCA , TORELLA CLAUDIA , NIEWOEHNER JENS , JAY DANIEL G , EUSTACE BRENDA K , KNAUER ROLAND , JENSEN KRISTIAN HOBOLD
IPC分类号： A61K39/395 , A61P35/00 , C07K16/28 , C07K16/30 , C12N15/113 , C12N15/13
CPC分类号： G01N33/57492 , A61K38/00 , A61K2039/505 , C07K16/28 , C07K16/2863 , C07K16/30 , C07K2317/21 , C07K2317/565 , C07K2317/622 , C07K2317/76 , C12N15/1138 , C12N2310/14 , G01N2333/515 , G01N2500/00
摘要： The present invention relates to molecules interfering with the function of neuropilin-1 in the context of angiogenesis and the treatment of cancer. Molecules, polypeptides, antibodies, compositions and methods are provided that are useful for reducing, inhibiting or treating angiogenesis, the invasion of blood vessels into tumors, and/or the invasion or the metastatic potential of specific tumor cells. Additionally, a method is provided that allows identifying molecules, which interfere with the functionality of neuropilin-1. Furthermore, a method is provided that allows determining whether a naturally occuring tumor cell depends on functional neuropilin-1 for its invasiveness and/or metastatic potential.
摘要翻译：本发明涉及在血管发生和癌症治疗的情况下干扰神经纤维蛋白-1的功能的分子。提供了分子，多肽，抗体，组合物和方法，其可用于减少，抑制或治疗血管生成，血管侵入肿瘤，和/或特异性肿瘤细胞的侵袭或转移潜力。另外，提供了允许鉴定干扰神经纤维蛋白-1的功能的分子的方法。此外，提供了一种方法，其允许确定天然存在的肿瘤细胞是否依赖于功能性神经蛋白-1对其侵袭性和/或转移潜力。

2. 发明申请

WO2004056874A2 NEUROPILIN-1 INHIBITORS 审中-公开
标题翻译：神经营养因子-1抑制剂
公开(公告)号：WO2004056874A2
公开(公告)日：2004-07-08
申请号：PCT/EP2003/014756
申请日：2003-12-22
申请人： XERION PHARMACEUTICALS AG , TUFTS UNIVERSITY , UNGER, Christine, Margarete , BESTE, Gerald , ZEHETMEIER, Carolin , LAIN, Blanca , TORELLA, Claudia , NIEWÖHNER, Jens , JAY, Daniel, G. , EUSTACE, Brenda, K. , KNAUER, Roland , JENSEN, Kristian, Hobold
发明人： UNGER, Christine, Margarete , BESTE, Gerald , ZEHETMEIER, Carolin , LAIN, Blanca , TORELLA, Claudia , NIEWÖHNER, Jens , JAY, Daniel, G. , EUSTACE, Brenda, K. , KNAUER, Roland , JENSEN, Kristian, Hobold
IPC分类号： C07K16/28
CPC分类号： G01N33/57492 , A61K38/00 , A61K2039/505 , C07K16/28 , C07K16/2863 , C07K16/30 , C07K2317/21 , C07K2317/565 , C07K2317/622 , C07K2317/76 , C12N15/1138 , C12N2310/14 , G01N2333/515 , G01N2500/00
摘要： The present invention relates to molecules interfering with the function of neuropilin-1 in the context of angiogenesis and the treatment of cancer. Molecules, polypeptides, antibodies, compositions and methods are provided that are useful for reducing, inhibiting or treating angiogenesis, the invasion of blood vessels into tumors, and/or the invasion or the metastatic potential of specific tumor cells. Additionally, a method is provided that allows identifying molecules, which interfere with the functionality of neuropilin-1. Furthermore, a method is provided that allows determining whether a naturally occuring tumor cell depends on functional neuropilin-1 for its invasiveness and/or metastatic potential.
摘要翻译：本发明涉及在血管生成和癌症治疗中干扰神经毡蛋白-1功能的分子。提供了用于减少，抑制或治疗血管生成，血管侵入肿瘤和/或特定肿瘤细胞的侵袭或转移潜能的分子，多肽，抗体，组合物和方法。此外，提供了一种方法，可以识别干扰神经毡蛋白-1功能的分子。此外，提供了一种方法，其允许确定自然发生的肿瘤细胞是否依赖于功能性神经毡蛋白-1的功能，因为它的侵袭性和/或转移潜能。

3. 发明申请

WO2005051771A2 SPENDERPUMPE 审中-公开
标题翻译：供体PUMP
公开(公告)号：WO2005051771A2
公开(公告)日：2005-06-09
申请号：PCT/EP2003/012267
申请日：2003-11-04
申请人： RPC WIKO GMBH & CO. KG , KNAUER, Roland , RAUCH, Frank , PORZELT, Stephan , AHRENS, Hans-Joachim , KÖBKE, Barbara , HEUKAMP, Wolfgang
发明人： KNAUER, Roland , RAUCH, Frank , PORZELT, Stephan , AHRENS, Hans-Joachim , KÖBKE, Barbara , HEUKAMP, Wolfgang
IPC分类号： B65D
CPC分类号： B05B11/3064 , B05B11/3032
摘要： Die Erfindung betrifft eine Spenderpumpe (1) zum tropfenfreien dosierten Spenden von flüssigen bis pastösen Produkten aus Behältern wie beispielsweise Flaschen, Kanistern oder Tuben, bestehend aus einem mit einer Ansaugöffnung (4) versehenen Pumpenunterteil (6) und einem Pumpenoberteil (8) mit einer beweglichen Haube (10) zum Ansaugen des Produkts durch die Ansaugöffnung (4) des Pumpenunterteils (6) in eine Ansaugkammer (14) und zum Spenden des Produkts über einen Spendekanal (3) mit Applikationsöffnung (24) aus dieser Ansaugkammer (14). Zur konstruktiven Vereinfachung wird gemäss der Erfindung vorgeschlagen, das untere Ende der unterhalb der Haube (10) angeordneten Ansaugkammer (14) durch eine „schwimmende" elastische Ventilscheibe (7) auszubilden, die wechselweise bei axialer Verschiebung der Haube (10) durch Verwölbung ihres Mittelteils die mittig angeordnete untere Öffnung (2) des Spendekanalteils (3') öffnet und schliesst und gleichzeitig umgekehrt durch Verformung ihres äusseren Randbereichs (25) die Ansaugöffnung (4) des Pumpenunterteils (6) schliesst und öffnet.
摘要翻译：本发明涉及一种分配泵（1）用于液体无滴漏计量分配到膏状产品从容器如瓶子，罐或管，泵下部从一个设置有一个吸入口选自（4）（6）和一泵上部（8）的可动罩（10），用于通过吸入口泵下部部分（6）的（4）划分成吸入室（14）吸入的产物，并用于经由分配通道（3）与吸入室（14）的应用开口（24）分配产品。建设性简化，的发动机罩（10）下的下端部设置吸入室（14）根据本发明提出了通过“浮动”弹性阀盘来形成（7），交替地在其中心部的拱形罩（10）的轴向位移打开分配信道部分（3“）和关闭，并同时通过泵下部（6）关闭和打开的（4）的吸入口的外边缘区域（25）的变形反转的居中布置的下部开口（2）。

4. 发明申请

WO2004007717A1 PROTEOMIC SCREEN TO IDENTIFY DISEASE-RELATED BIOLOGICAL MOLECULES AND INHIBITORS THERETO 审中-公开
标题翻译：鉴定疾病相关生物分子和抑制剂的PROTEMIC筛选
公开(公告)号：WO2004007717A1
公开(公告)日：2004-01-22
申请号：PCT/EP2003/007660
申请日：2003-07-15
申请人： XERION PHARMACEUTICALS AG , UNGER, Christine, Margarete , BESTE, Gerald , JENSEN, Kristian, H. , ZEHETMEIER, Carolin , KNAUER, Roland , GUELBENZU, Blanca, Lain , TORELLA, Claudia , ILAG, L., Leodevico
发明人： UNGER, Christine, Margarete , BESTE, Gerald , JENSEN, Kristian, H. , ZEHETMEIER, Carolin , KNAUER, Roland , GUELBENZU, Blanca, Lain , TORELLA, Claudia , ILAG, L., Leodevico
IPC分类号： C12N15/10
CPC分类号： C07K16/30 , A61K2039/505 , C07K14/70503 , C07K16/2896 , C07K2317/622 , C12N15/1037 , C40B40/02
摘要： The invention provides a new paradigm for a screening method by combining the biochemical approach of specific binding between a ligand and a target, e.g. an antibody and an antigen, with the genetic principle of a functional screen. The present invention demonstrates its utility for identifying novel disease-relevant proteins and inhibitory ligands, e.g. antibodies or antibody fragments, that may serve as therapeutic leads for a wide variety of diseases, whether the cause of the disease is derivable from a virus, a bacterium, a lower eukaryote or from a misregulation of the cells of the subject to be treated.
摘要翻译：本发明通过结合配体和靶标之间的特异性结合的生物化学方法，例如，提供了一种筛选方法的新范例。抗体和抗原，具有功能筛选的遗传学原理。本发明证明其用于鉴定新的疾病相关蛋白和抑制性配体，例如，抗体或抗体片段，其可以用作各种疾病的治疗引导，无论疾病的病因是源自病毒，细菌，低等真核生物还是来自待治疗对象的细胞的错配。

5. 发明申请

WO1995026306A1 CLOSURE 审中-公开
标题翻译：闭幕
公开(公告)号：WO1995026306A1
公开(公告)日：1995-10-05
申请号：PCT/EP1995001104
申请日：1995-03-23
申请人： S DESIGN UDO SUFFA GMBH , SUFFA, Udo , KNAUER, Roland
发明人： S DESIGN UDO SUFFA GMBH
IPC分类号： B65D47/20
CPC分类号： B65D47/2081
摘要： The invention concerns a closure with a cap (1) and a lid (21). Fitted in the cap (1) is a readily flexible seal (2) which, at least in the flexed state, forms a pour aperture and which is held underneath by a support element (17) forming part of the closure cap (1) and on top by a flange (13, 14) against which radially outer zone of the seal (2) presses from below. The seal (2) can be pressed outwards out of the closed position into the pouring position, against the curvature of the seal, by lifting the support element (17). In order to improve the pour characteristics, the invention proposes that the seal (2) has a permanently open central pour aperture (23) which is sealed off in the closed position merely by being pressed against the support element (17).
摘要翻译：本发明涉及一种具有封闭盖（1）和一个封闭盖（21），其中，在所述封闭帽（1）加入到容易变形的，至少在分配开口形成密封元件（2）的变形状态下，其一方面下来（由支撑元件的闭合 17）所述封闭帽（1）和上在由支撑凸缘（13顶部的另一方面，14）（以从下方在径向外部接触区域施加密封元件2），被安装，其特征在于，进一步在密封元件（2）从关闭位置在分配位置至其弯曲形状通过剥离从支承构件（17）是被压到外部。对于改进的分配问题，本发明提出的是，密封元件（2）具有一个常开，仅通过搁置在闭合位置捐赠中心开口（23）密封所述支撑构件（17）上。

6. 发明申请

WO2005051771A3 DISPENSER PUMP 审中-公开
标题翻译：供体PUMP
公开(公告)号：WO2005051771A3
公开(公告)日：2006-07-27
申请号：PCT/EP0312267
申请日：2003-11-04
申请人： RPC WIKO GMBH & CO KG , KNAUER ROLAND , RAUCH FRANK , PORZELT STEPHAN , AHRENS HANS-JOACHIM , KOEBKE BARBARA , HEUKAMP WOLFGANG
发明人： KNAUER ROLAND , RAUCH FRANK , PORZELT STEPHAN , AHRENS HANS-JOACHIM , KOEBKE BARBARA , HEUKAMP WOLFGANG
IPC分类号： B05B11/00 , B65D83/00
CPC分类号： B05B11/3064 , B05B11/3032
摘要： The invention relates to a dispenser pump (1), for the non-dropping, dosed dispensing of liquid to pasty products from containers, for example, from bottles, canisters, or tubes, comprising a pump lower section (6) with a suction opening (4) and a pump upper section (8) with a moving lid (10), for sucking up the product through the suction opening (4) of the pump lower section (6) into a suction chamber (14) and to dispense the product from said suction chamber (14), through a dispensing channel (3) with an application opening (24). According to the invention, a constructive simplification may be achieved, whereby the lower end of the suction chamber (14), arranged beneath the lid (10), is embodied by a floating elastic disc valve (7) which, on alternate axial displacement of the lid (10), opens and closes the lower opening (2) of the dispensing channel section (3'), due to arching of the mid-section thereof and conversely, by deformation of the outer boundary region (25) thereof, opens and closes the suction opening (4) of the pump lower section (6).
摘要翻译：本发明涉及一种分配泵（1）用于液体无滴漏计量分配到膏状产品从容器如瓶子，罐或管，泵下部从一个设置有一个吸入口选自（4）（6）和一泵上部（8）的可动罩（10），用于通过吸入口泵下部部分（6）的（4）划分成吸入室（14）吸入的产物，并用于经由分配通道（3）与吸入室（14）的应用开口（24）分配产品。建设性简化，的发动机罩（10）下的下端部设置吸入室（14）根据本发明提出了通过“浮动”弹性阀盘来形成（7），交替地在其中心部的拱形罩（10）的轴向位移打开分配信道部分（3“）和关闭，并同时通过泵下部（6）关闭和打开的（4）的吸入口的外边缘区域（25）的变形反转的居中布置的下部开口（2）。

7. 发明申请

WO2004007717A8 PROTEOMIC SCREEN TO IDENTIFY DISEASE-RELATED BIOLOGICAL MOLECULES AND INHIBITORS THERETO 审中-公开
标题翻译：鉴定疾病相关生物分子和抑制剂的PROTEMIC筛选
公开(公告)号：WO2004007717A8
公开(公告)日：2005-05-12
申请号：PCT/EP0307660
申请日：2003-07-15
申请人： XERION PHARMACEUTICALS AG , UNGER CHRISTINE MARGARETE , BESTE GERALD , JENSEN KRISTIAN H , ZEHETMEIER CAROLIN , KNAUER ROLAND , GUELBENZU BLANCA LAIN , TORELLA CLAUDIA , ILAG L LEODEVICO
发明人： UNGER CHRISTINE MARGARETE , BESTE GERALD , JENSEN KRISTIAN H , ZEHETMEIER CAROLIN , KNAUER ROLAND , GUELBENZU BLANCA LAIN , TORELLA CLAUDIA , ILAG L LEODEVICO
IPC分类号： A61K39/395 , A61K48/00 , A61P35/00 , C07K14/705 , C07K16/28 , C07K16/30 , C12N15/10 , C12N15/12 , C40B40/02 , G01N33/53
CPC分类号： C07K16/30 , A61K2039/505 , C07K14/70503 , C07K16/2896 , C07K2317/622 , C12N15/1037 , C40B40/02
摘要： The invention provides a new paradigm for a screening method by combining the biochemical approach of specific binding between a ligand and a target, e.g. an antibody and an antigen, with the genetic principle of a functional screen. The present invention demonstrates its utility for identifying novel disease-relevant proteins and inhibitory ligands, e.g. antibodies or antibody fragments, that may serve as therapeutic leads for a wide variety of diseases, whether the cause of the disease is derivable from a virus, a bacterium, a lower eukaryote or from a misregulation of the cells of the subject to be treated.
摘要翻译：本发明通过结合配体和靶标之间的特异性结合的生物化学方法，例如，提供了一种筛选方法的新范例。抗体和抗原，具有功能筛选的遗传学原理。本发明证明其用于鉴定新的疾病相关蛋白和抑制性配体，例如，抗体或抗体片段，其可以用作各种疾病的治疗引导，无论疾病的病因是源自病毒，细菌，低等真核生物还是来自待治疗对象的细胞的错配。

8. 发明专利

DE10225087A1 Spray gun for cleaning fluids and foams for windows, tiles, stoves, etc. is screwed onto bottle and ha closed/open fork holding turnable control shaft with turning knob, to vary spray direction 未知
公开(公告)号：DE10225087A1
公开(公告)日：2003-11-13
申请号：DE10225087
申请日：2002-06-05
申请人： AHRENS HANS-JOACHIM , AHRENS GEB REULEKE , AHRENS STEPHAN , KNAUER ROLAND
发明人： AHRENS HANS-JOACHIM , AHRENS GEB REULEKE , AHRENS STEPHAN , KNAUER ROLAND
IPC分类号： B05B7/00 , B05B11/00 , B05B15/06 , B05B15/652 , B05B1/26
摘要： The spray gun is screwed onto a bottle and has a feed tube projecting into the bottle. The gun housing (1) has a closed or open fork (2) fastened to or formed with, its front face (15). A turnable and sealed control shaft (3) with side turning knob (6) extends through the fork. The knob is aligned with a bore (4) extending through the shaft, and has a tip extending in spray direction (17). The fork has an aperture (14), which extends from the horizontal (24) to the top face (16). The knob engages on an end stop when in 'closed' position.

9. 发明专利

DE3718835A1 Clock 未知
公开(公告)号：DE3718835A1
公开(公告)日：1988-12-15
申请号：DE3718835
申请日：1987-06-05
申请人： KNAUER ROLAND DIPL ING
发明人： KNAUER ROLAND DIPL ING
IPC分类号： G04B19/00 , G04B45/00 , G04C17/00
摘要： A clock (1) with a scale mount (2) for the time markings (3) of the time scale has a numbered track instead of a dial, the scale mount being formed by a freely ending or annularly closed scale-bearing track (4). Controlling or transporting means for the indicator (10) are provided inside the scale-bearing track (4), which is in the form of a hollow profile, so that a central hand bearing can be omitted. The scale-bearing track (4) can be designed to be articulated or flexible.

10. 发明专利

DE1810749U 未知
公开(公告)号：DE1810749U
公开(公告)日：1960-05-05
申请号：DEK0034626
申请日：1960-03-14
申请人： KNAUER ROLAND
发明人： KNAUER ROLAND

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