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1. 发明专利

SK277941B6 NICOTINE AGENT 未知
公开(公告)号：SK277941B6
公开(公告)日：1995-08-09
申请号：SK587488
申请日：1988-08-31
申请人： JAEGER HALVOR , HOFFMANN HANS-RAINER , MECONI REINHOLD , KLEIN ROBERT-PETER
发明人： JAEGER HALVOR , HOFFMANN HANS-RAINER , MECONI REINHOLD , KLEIN ROBERT-PETER
IPC分类号： A61K9/22 , A61K9/70 , A61K31/465 , A61L15/16 , A61M35/00 , A61L15/44 , A61L15/58 , A61M37/00 , A61P25/30 , G01N33/52
摘要： Nicotine agent contains reservoir (14) of nicotine for controlled release of nicotine in to skin (18), back layer (10), which is impermeable for nicotine and layer (12) of melting contact adhesive with elaborating temperature 40 to 80 degrees of Celsius.

2. 发明专利

SK279300B6 DEVICE FOR RELEASE SUBSTANCES MADE OF HOT-MELT ADHESIVES, PROCESS FOR ITS MANUFACTURE AND USE THEREOF 未知
公开(公告)号：SK279300B6
公开(公告)日：1998-09-09
申请号：SK587388
申请日：1988-08-31
申请人： JAEGER HALVOR , HOFFMANN HANS-RAINER , MECONI REINHOLD , KLEIN ROBERT-PETER
发明人： JAEGER HALVOR , HOFFMANN HANS-RAINER , MECONI REINHOLD , KLEIN ROBERT-PETER
IPC分类号： A61K9/22 , A61K9/70 , A61L15/16 , A61M35/00 , A61L15/44 , A61M37/00 , G01N33/48 , G01N33/52
摘要： The invention concerns a device for the release of substances made of hot-melt adhesives with uniform or non-uniform distribution of the substances wherein the hot-melt adhesive has a processing temperature between 40 and 80 degrees Celsius. Also described is a process for manufacturing the device in which the melted hot-melt adhesive containing the substances to be released is applied continuously or intermittently on a support or on a layer of protective material. The device can be used in both human and veterinary medicine, diagnostic or cosmetics, especially for release of substances which are thermo-sensitive or highly volatile.

3. 发明专利

SK279603B6 PROCESS FOR MANUFACTURING PHARMACEUTICAL PRESENTATION OR DOSAGE FORM OF DRUGS 未知
公开(公告)号：SK279603B6
公开(公告)日：1999-01-11
申请号：SK559088
申请日：1988-08-12
申请人： ANHAUSER DIETER , KLEIN ROBERT-PETER
发明人： ANHAEUSER DIETER , KLEIN ROBERT-PETER
IPC分类号： A61J3/00 , A61J3/10 , A61K9/44 , A61K9/70 , A61K31/465 , B41F17/00 , B41F17/34 , B41M1/40
摘要： A process for manufacturing pharmaceutical presentation or dosage form of drugs, which contain active substances, is based on a printing process wherein a semi-product of a presentation form is printed upon with pressure medium having an active ingredient by means of a printing pad. The semi-product is subsequently adjusted.

4. 发明专利

SK279514B6 METHOD OF OESTROGEN-CONTAINING DRESSING PRODUCTION 未知
公开(公告)号：SK279514B6
公开(公告)日：1998-12-02
申请号：SK485990
申请日：1990-10-05
申请人： HOFFMANN HANS-RAINER , KLEIN ROBERT-PETER , MECONI REINHOLD , CORDES GUNTER , WOLFF HANS M.
发明人： HOFFMANN HANS-RAINER , KLEIN ROBERT-PETER , MECONI REINHOLD , CORDES GUNTER , WOLFF HANS M
IPC分类号： A61K9/70 , A61K31/56 , A61K31/565 , A61L15/16 , A61M37/00 , A61L15/44 , A61L15/58 , C09J7/02
摘要： An adhesive based on homo- and/or copolymers is homogenised with at least one derivative of acrylic or methacrylic acid and is added, before or simultaneously, with an oestrogen or oestrogens and their pharmaceutically acceptable derivatives alone or in combination with gestagens. The adhesive is applied on a re-detachable protective layer or a re-detachable semi-layer and after evaporation of a diluent, it is covered with a backing layer retaining the active substance.

5. 发明专利

SK279297B6 DEVICE FOR CONTROLLED RELEASE OF NITROGLYCERINE AND METHOD OF ITS PRODUCTION 未知
公开(公告)号：SK279297B6
公开(公告)日：1998-09-09
申请号：SK587288
申请日：1988-08-31
申请人： JAEGER HALVOR , HOFFMANN HANS-RAINER , MECONI REINHOLD , KLEIN ROBERT-PETER
发明人： JAEGER HALVOR , HOFFMANN HANS-RAINER , MECONI REINHOLD , KLEIN ROBERT-PETER
IPC分类号： A61K9/22 , A61K9/70 , A61L15/16 , A61K31/21 , A61L15/44 , A61L15/58 , A61M37/00 , A61P9/08 , A61P9/10 , B01J4/00 , G01N33/52
摘要： A device is processed by applying a hot-melt adhesive, which contains nitroglycerine to be released, on a back layer, e.g. a polyester film, at temperatures from 40 to 80 degrees Celsius. The film is, on the side where the adhesive is meant to be applied, silicificated and aluminized and then a protective layer, e.g. an aluminized polyester film, is applied.

6. 发明专利

SK279911B6 TRANSDERMAL THERAPEUTIC SYSTEM FOR THE RELEASE OF 17-BETA- -ESTRADIOL AND PROCESS FOR ITS PRODUCTION 未知
公开(公告)号：SK279911B6
公开(公告)日：1999-05-07
申请号：SK58095
申请日：1993-10-27
申请人： HORSTMANN MICHAEL , HAHN SYLVIA , MECONI REINHOLD , KLEIN ROBERT-PETER
发明人： HORSTMANN MICHAEL , HAHN SYLVIA , MECONI REINHOLD , KLEIN ROBERT-PETER
IPC分类号： A61K20060101 , A61L15/00 , A61K9/70 , A61K31/565 , A61K47/34 , A61M37/00 , C07J1/00
摘要： The invention relates to a transdermal therapeutic system containing the active agent 17-beta-estradiol and possibly other active agents with a layered structure from a substantially moisture and active agent- impermeable substrate, one or more matrix layers and, if there are no adhesive matrix layers, an adhesive layer, in which the concentration of the dissolved estradiol in all the matrix layers and in the adhesive layer if it exists is between its saturation concentration in the dry state and that in the wet state, by "dry state" being meant that the basic material is in equilibrium with a gas phase with a relative humidity of under 10 percent and by "wet state" being meant that the basic material is in equilibrium with a gas phase with a relative humidity of over 90 percent.

7. 发明申请

WO1989001789A1 DEVICE FOR CONTROLLED RELEASE OF NICOTINE, PROCESS FOR MANUFACTURING IT, AND USE THEREOF 审中-公开
标题翻译：用于控制释放NICOTINE的装置，其制造方法及其使用
公开(公告)号：WO1989001789A1
公开(公告)日：1989-03-09
申请号：PCT/DE1988000479
申请日：1988-08-03
申请人： LTS LOHMANN THERAPIE-SYSTEME GMBH & CO. KG , JAEGER, Halvor , HOFFMANN, Hans-Rainer , MECONI, Reinhold , KLEIN, Robert-Peter
发明人： LTS LOHMANN THERAPIE-SYSTEME GMBH & CO. KG
IPC分类号： A61L15/03
CPC分类号： G01N33/521 , A61K9/7023 , A61K31/465
摘要： The device described has an adhesive nicotine reservoir with uniform or non-uniform distribution of the nicotine. The reservoir is manufactured using a hot-melt adhesive with a processing temperature of 40 to 80 degrees Celsius, preferably 40 to 60 degrees Celsius, and ideally between 40 and 55 degrees Celsius. Also described is a process for manufacturing the device with continuous or intermittent application of nicotine-containing molten hot-melt adhesive at an adhesive temperature between 40 and 80, preferably 40 and 60, and ideally 40 and 55 degrees Celsius, to a support and, if necessary, application of a layer of protective material.

8. 发明申请

WO1989001788A1 DEVICE FOR RELEASE OF NITROGLYCERINE ONTO THE SKIN, PROCESS FOR ITS MANUFACTURE AND USE THEREOF 审中-公开
标题翻译：用于将氮氧化物释放到皮肤上的装置，其制造方法及其用途
公开(公告)号：WO1989001788A1
公开(公告)日：1989-03-09
申请号：PCT/DE1988000478
申请日：1988-08-03
申请人： LTS LOHMANN THERAPIE-SYSTEME GMBH & CO. KG , JAEGER, Halvor , HOFFMANN, Hans-Rainer , MECONI, Reinhold , KLEIN, Robert-Peter
发明人： LTS LOHMANN THERAPIE-SYSTEME GMBH & CO. KG
IPC分类号： A61L15/03
CPC分类号： A61K9/7053 , G01N33/521
摘要： The invention concerns a device for the controlled release of nitrglycerine on to human or animal skin, preferably in plaster form, with a backing layer impermeable to nitroglycerine, an adhesive single- or multi-compartment reservoir containing nitroglycerine for uniform or non-uniform distribution of the nitroglycerine, and, if necessary, a detachable protective layer impermeable to nitroglycerine. The reservoir is manufactured using hot-melt adhesives with a processing temperature between 40 DEG and 80 DEG C, preferably 40 and 60 DEG C, and ideally 40 and 55 DEG C. Also described is a process for manufacturing the device in which the melted hot-melt adhesive containing the nitroglycerine to be released is applied continuously or intermittently to a support at a hot-melt adhesive temperature between 40 and 80 DEG C, preferably 40 and 60 DEG C, and ideally 45 and 55 DEG C, and in which, if necessary, a protective coating material is applied.
摘要翻译：本发明涉及一种用于将硝酸甘油控制释放到人或动物皮肤上，优选石膏形式的装置，其具有不可渗透到硝酸甘油的背衬层，含有硝化甘油的粘合剂单室或多室容器用于均匀或不均匀分布硝酸甘油，以及如果需要的话，硝酸甘油不可渗透的可拆卸保护层。储存器使用加热温度在40℃至80℃，优选40℃至60℃，理想地为40℃至55℃的热熔粘合剂制造。还描述了一种制造该熔融热的装置的方法包含要释放的硝酸甘油的粘合剂粘合剂在40至80℃，优选40至60℃，理想地为45至55℃的热熔粘合剂温度下连续或间歇地施加到载体上，如果需要，施加保护涂层材料。

9. 发明申请

WO1989001410A1 PRINTING PAD DEVICE FOR TRANSFERRING SPECIFIC QUANTITIES OF PRINTING MEDIUM PER UNIT AREA 审中-公开
标题翻译：用于传输每个印刷区域的特定数量的印刷装置
公开(公告)号：WO1989001410A1
公开(公告)日：1989-02-23
申请号：PCT/DE1988000364
申请日：1988-06-16
申请人： LTS LOHMANN THERAPIE-SYSTEME GMBH & CO. KG. , ANHÄUSER, Dieter , KLEIN, Robert-Peter
发明人： LTS LOHMANN THERAPIE-SYSTEME GMBH & CO. KG.
IPC分类号： B41F17/00
CPC分类号： B41F17/001
摘要： In the printing pad device described, the surface of the pad (20) is recessed while retaining essentially the same external form and volume. Also described is the use of the pad for at least partially coating a substrate (22) with a predetermined pattern. The substrate (22) is a printed circuit board for manufacturing integrated circuits, a component of a pharmaceutical presentation and/or dosage form, a label with raised characters, a prepolymer or similar.

10. 发明申请

WO2003077890A1 HORMONHALTIGES TRANSDERMALES THERAPEUTISCHES SYSTEM MIT EINEM WIRKSTOFFRESERVOIR AUF DER BASIS VON VINYLACETAT-VINYLPYRROLIDON-COPOLYMER MIT VERBESSERTER KOHÄSION. 审中-公开
标题翻译：含激素的透皮治疗系统具有基于乙酸乙烯酯 - 乙烯基吡咯烷酮共聚物的活性储层具有改进的内聚力。
公开(公告)号：WO2003077890A1
公开(公告)日：2003-09-25
申请号：PCT/EP2003/002521
申请日：2003-03-12
申请人： LTS LOHMANN THERAPIE-SYSTEME AG , MECONI, Reinhold , KLEIN, Robert-Peter , SEIBERTZ, Frank , BECKER, Franz-Josef , GÖTTE, Ursula
发明人： MECONI, Reinhold , KLEIN, Robert-Peter , SEIBERTZ, Frank , BECKER, Franz-Josef , GÖTTE, Ursula
IPC分类号： A61K9/70
CPC分类号： A61K9/7053 , A61K31/565 , A61K47/32
摘要： Ein transdermales therapeutisches System in Pflasterform zur kontrollierten Abgabe von Estrogenen und/oder Gestagenen an die menschliche oder tierische Haut weist eine Rückschicht, ein damit verbundenes, ein- oder mehrschichtiges wirkstoffhaltiges Reservoir und eine wiederablösbare Schutzschicht auf und ist dadurch gekennezeichnet, dass das wirkstoffhaltige Reservoir Vinylpyrrolidon-Vinylacetat-Copolymer und die Kohäsion verbessernde Stoffe enthält.
摘要翻译：在石膏形式的透皮治疗系统用于雌激素和/或孕激素，以人或动物皮肤的受控递送包括背层，相关联的，单层或多层含有活性物质的贮存器和一个可移除保护层，并且其特征在于gekennezeichnet，所述含有活性物质的贮存器乙烯基吡咯烷酮 -Vinylacetat含有共聚物和凝聚力增强物质。

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