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1. 发明申请

WO2006093801A1 THIADIAZINE DERIVATIVES USEFUL AS ANTI-INFECTIVE AGENTS 审中-公开
标题翻译：三氮唑衍生物有效用作抗感染剂
公开(公告)号：WO2006093801A1
公开(公告)日：2006-09-08
申请号：PCT/US2006/006452
申请日：2006-02-24
申请人： ABBOTT LABORATORIES , KLEIN, Larry , HUANG, Peggy-Pei-Yu , RANDOLPH, John, T. , HUTCHINSON, Douglas, K. , YEUNG, Ming, C. , FLENTGE, Charles, A.
发明人： KLEIN, Larry , HUANG, Peggy-Pei-Yu , RANDOLPH, John, T. , HUTCHINSON, Douglas, K. , YEUNG, Ming, C. , FLENTGE, Charles, A.
IPC分类号： C07D417/12 , C07D285/30 , C07D471/04 , A61K31/549 , A61P31/00
CPC分类号： C07D471/04 , C07D285/24 , C07D285/30 , C07D417/12
摘要： Compounds having the formula (I) are hepatitis C (HCV) polymerase inhibitors. Also disclosed are compositions and methods for inhibiting hepatitis C (HCV) polymerase, processes for making the compounds, and synthetic intermediates employed in the processes.
摘要翻译：具有式（I）的化合物是丙型肝炎（HCV）聚合酶抑制剂。还公开了用于抑制丙型肝炎（HCV）聚合酶，制备化合物的方法和在该方法中使用的合成中间体的组合物和方法。

2. 发明申请

WO2005058841A2 HIV PROTEASE INHIBITING COMPOUNDS 审中-公开
标题翻译：艾滋病病毒蛋白抑制化合物
公开(公告)号：WO2005058841A2
公开(公告)日：2005-06-30
申请号：PCT/US2004/041658
申请日：2004-12-09
申请人： ABBOTT LABORATORIES , DEGOEY, David, A. , FLENTGE, Charles, A. , FLOSI, William, J. , GRAMPOVNIK, David, J. , KEMPF, Dale, J. , KLEIN, Larry, L. , YEUNG, Ming, C. , RANDOLPH, John, T. , WANG, Xiu, C. , YU, Su
发明人： DEGOEY, David, A. , FLENTGE, Charles, A. , FLOSI, William, J. , GRAMPOVNIK, David, J. , KEMPF, Dale, J. , KLEIN, Larry, L. , YEUNG, Ming, C. , RANDOLPH, John, T. , WANG, Xiu, C. , YU, Su
IPC分类号： C07D233/00
CPC分类号： C07D401/06 , C07D213/30 , C07D213/40 , C07D401/12 , C07D401/14 , C07D417/06 , C07D417/14 , C07D471/04 , C07D493/04
摘要： A compound of the formula (I) is disclosed as an HIV protease inhibitor. Methods and compositions for inhibiting an HIV infection are also disclosed.
摘要翻译：公开了式（I）化合物作为HIV蛋白酶抑制剂。还公开了用于抑制HIV感染的方法和组合物。

3. 发明申请

WO2008100970A3 METHOD FOR CHARGING A BATTERY USING A CONSTANT CURRENT ADAPTED TO PROVIDE A CONSTANT RATE OF CHANGE OF OPEN CIRCUIT BATTERY VOLTAGE 审中-公开
标题翻译：使用适应于恒定电流的电池充电以提供持续的开路电流变化率的方法电池电压
公开(公告)号：WO2008100970A3
公开(公告)日：2009-01-22
申请号：PCT/US2008053768
申请日：2008-02-12
申请人： EXAR CORP , KERNAHAN KENT , RIBEIRO MILTON D , ZHOU DONGSHENG , KLEIN LARRY A
发明人： KERNAHAN KENT , RIBEIRO MILTON D , ZHOU DONGSHENG , KLEIN LARRY A
IPC分类号： H02J7/16
CPC分类号： H02J7/045 , H01M10/44 , H01M10/48 , H02J7/0077
摘要： A constant battery charging current is periodically adjusted as needed such that the change in battery voltage increases approximately linearly during the charging period. Charging may be performed in three phases. A first phase charges with a low current until the battery voltages rises to a certain minimum. During a second phase a constant current is provided and periodically increased if the rate of change of battery voltage is less than a predetermined value. A third phase begins when the battery voltage attains a predetermined value, wherein a constant voltage is applied to the battery while the battery current draw is periodically monitored. Charging is stopped when the battery current draw falls to a predetermined value or when the charging current drops to a value that is a certain percentage of the charging current at the termination of phase two.
摘要翻译：根据需要周期性地调节恒定的电池充电电流，使得电池电压的变化在充电期间近似线性地增加。充电可以分三个阶段进行。第一阶段以低电流充电直到电池电压上升到一定的最小值。在第二阶段期间，如果电池电压的变化率小于预定值，则提供恒定电流并且周期性地增加。当电池电压达到预定值时，第三阶段开始，其中在电池电流消耗被周期性地监视的同时向电池施加恒定电压。当电池电流消耗下降到预定值时或当充电电流下降到在阶段2结束时充电电流的一定百分比的值时，停止充电。

4. 发明申请

WO2008100970A2 METHOD FOR CHARGING A BATTERY USING A CONSTANT CURRENT ADAPTED TO PROVIDE A CONSTANT RATE OF CHANGE OF OPEN CIRCUIT BATTERY VOLTAGE 审中-公开
标题翻译：使用适应于恒定电流的电池充电以提供持续的开路电流变化率的方法电池电压
公开(公告)号：WO2008100970A2
公开(公告)日：2008-08-21
申请号：PCT/US2008/053768
申请日：2008-02-12
申请人： EXAR CORPORATION , KERNAHAN, Kent , RIBEIRO, Milton, D. , ZHOU, Dongsheng , KLEIN, Larry, A.
发明人： KERNAHAN, Kent , RIBEIRO, Milton, D. , ZHOU, Dongsheng , KLEIN, Larry, A.
IPC分类号： H02J7/00 , H02J7/04
CPC分类号： H02J7/045 , H01M10/44 , H01M10/48 , H02J7/0077
摘要： A method for charging a battery is disclosed, wherein a constant current charging current is periodically adjusted as needed such that the change in battery voltage increases approximately linearly during the charging period. In some embodiments the charging is in three phases. An optional first phase charges with a low current until the battery voltages rises to a certain minimum. During a second phase a constant current is provided while the battery voltage is monitored. The second phase constant current is periodically increased if the rate of change of battery voltage is less than a predetermined value and is decreased if the rate of change of battery voltage is more than the predetermined value. When the battery voltage attains a predetermined value, a third phase begins wherein a constant voltage is applied to the battery while the battery current draw is periodically monitored. Charging is stopped when the battery current draw falls to a predetermined value or, in some embodiments, when the charging current drops to a value that is a certain percentage of the charging current at the termination of phase two. In one embodiment the battery voltage is monitored to determine a possible battery failure, for example in the case of the battery voltage decreasing during the constant current charging of phase two. In some embodiments the battery is shorted out in response to detection of a possible failure.
摘要翻译：公开了一种用于对电池充电的方法，其中根据需要周期性地调节恒定电流充电电流，使得电池电压的变化在充电期间近似线性地增加。在一些实施例中，充电分三个阶段。可选的第一阶段以低电流充电直到电池电压上升到一定的最小值。在第二阶段期间，在监视电池电压的同时提供恒定电流。如果电池电压的变化率小于预定值，则第二相恒定电流周期性地增加，并且如果电池电压的变化率大于预定值，则第二相恒定电流会降低。当电池电压达到预定值时，开始第三阶段，其中在电池电流消耗被周期性地监测的同时向电池施加恒定电压。当电池电流下降到预定值时，或者在一些实施例中当充电电流下降到在阶段2结束时充电电流的一定百分比的值时，停止充电。在一个实施例中，监视电池电压以确定可能的电池故障，例如在阶段2的恒定电流充电期间电池电压降低的情况下。在一些实施例中，响应于可能的故障的检测，电池被短路。

5. 发明申请

WO2008027932A2 CYTOCHROME P450 OXIDASE INHIBITORS AND USES THEREOF 审中-公开
标题翻译： CYTOCHROME P450氧化酶抑制剂及其用途
公开(公告)号：WO2008027932A2
公开(公告)日：2008-03-06
申请号：PCT/US2007/077046
申请日：2007-08-29
申请人： ABBOTT LABORATORIES , KLEIN, Larry, L. , CHEN, Hui-Ju , YEUNG, Ming, C. , FLENTGE, Charles, A. , RANDOLPH, John, T. , HUANG, Peggy, P. , HUTCHINSON, Douglas, K. , KEMPF, Dale, J.
发明人： KLEIN, Larry, L. , CHEN, Hui-Ju , YEUNG, Ming, C. , FLENTGE, Charles, A. , RANDOLPH, John, T. , HUANG, Peggy, P. , HUTCHINSON, Douglas, K. , KEMPF, Dale, J.
IPC分类号： C07D277/24 , C07D417/12 , A61K31/427 , A61K31/426 , A61P43/00
CPC分类号： A61K31/5377 , A61K31/4164 , A61K31/4178 , A61K31/4439 , A61K31/4525 , A61K31/496 , A61K31/506 , A61K45/06 , C07D213/79 , C07D277/24 , C07D277/30 , C07D277/593 , C07D417/12
摘要： The present invention features compounds of formula I or pharmaceutically acceptable salts, solvates or prodrugs thereof, and methods of using the same to inhibit the metabolizing activities of CYP enzymes. The present invention also features methods of using these compounds, salts, solvates or prodrugs to improve the pharmacokinetics of drugs that are metabolized by CYP enzymes.
摘要翻译：本发明的特征在于式I化合物或其药学上可接受的盐，溶剂合物或前药，以及使用该化合物抑制CYP酶代谢活性的方法。本发明还涉及使用这些化合物，盐，溶剂合物或前药来改善由CYP酶代谢的药物的药代动力学的方法。

6. 发明申请

WO2007103670A2 NOVEL COMPOUNDS THAT ARE USEFUL FOR IMPROVING PHARMACOKINETICS 审中-公开
标题翻译：新型化合物可用于改善药代动力学
公开(公告)号：WO2007103670A2
公开(公告)日：2007-09-13
申请号：PCT/US2007/062906
申请日：2007-02-27
申请人： ABBOTT LABORATORIES , KEMPF, Dale J. , FLENTGE, Charles A. , RANDOLPH, John T. , HUANG, Peggy , KLEIN, Larry L.
发明人： KEMPF, Dale J. , FLENTGE, Charles A. , RANDOLPH, John T. , HUANG, Peggy , KLEIN, Larry L.
IPC分类号： A61K31/427 , A61K31/426 , C07D417/02 , C07D277/38
CPC分类号： C07D277/30 , A61K31/426 , A61K31/427 , A61K45/06 , C07C53/18 , C07D213/30 , C07D231/12 , C07D233/64 , C07D263/32 , C07D277/24 , C07D277/38 , C07D277/587 , C07D333/16 , C07D417/04
摘要： Novel compounds of formula I, or a pharmaceutically acceptable salt thereof inhibit cytochrome P450 monooxygenase.
摘要翻译：式I的新化合物或其药学上可接受的盐抑制细胞色素P450单加氧酶。

7. 发明申请

WO2006014282A2 PRODRUGS OF HIV PROTEASE INHIBITORS 审中-公开
标题翻译： HIV蛋白酶抑制剂的前体
公开(公告)号：WO2006014282A2
公开(公告)日：2006-02-09
申请号：PCT/US2005023047
申请日：2005-06-29
申请人： ABBOTT LAB , DEGOEY DAVID A , FLOSI WILLIAM J , GRAMPOVNIK DAVID J , KLEIN LARRY L , KEMPF DALE J , WANG XIU C
发明人： DEGOEY DAVID A , FLOSI WILLIAM J , GRAMPOVNIK DAVID J , KLEIN LARRY L , KEMPF DALE J , WANG XIU C
IPC分类号： C07F9/00
CPC分类号： A61K45/06 , A61K31/661 , A61K2300/00
摘要： A compound of the formula , or is disclosed as a prodrug of an HIV protease inhibitor. Methods and compositions or inhibiting HIV protease activity and treating HIV infection are also disclosed.
摘要翻译：下式的化合物，或者公开为HIV蛋白酶抑制剂的前药。还公开了方法和组合物或抑制HIV蛋白酶活性和治疗HIV感染。

8. 发明申请

WO2005061450A3 HIV PROTEASE INHIBITING SULFONAMIDES 审中-公开
标题翻译：艾滋病病毒蛋白抑制磺脲
公开(公告)号：WO2005061450A3
公开(公告)日：2005-10-20
申请号：PCT/US2004037745
申请日：2004-11-10
申请人： ABBOTT LAB , FLENTGE CHARLES A , CHEN HUI-JU , DEGOEY DAVID A , FLOSI WILLIAM J , GRAMPOVNIK DAVID J , HUANG PEGGY P , KEMPF DALE J , KLEIN LARRY L , KRUEGER ALLAN C , MADIGAN DAROLD L , RANDOLPH JOHN T , SUN MINGHUA , YEUNG MING C , ZHAO CHEN
发明人： FLENTGE CHARLES A , CHEN HUI-JU , DEGOEY DAVID A , FLOSI WILLIAM J , GRAMPOVNIK DAVID J , HUANG PEGGY P , KEMPF DALE J , KLEIN LARRY L , KRUEGER ALLAN C , MADIGAN DAROLD L , RANDOLPH JOHN T , SUN MINGHUA , YEUNG MING C , ZHAO CHEN
IPC分类号： A61K31/175 , A61K31/18 , A61K31/195 , A61K31/277 , A61K31/4168 , A61K31/65 , A61K45/06 , C07C311/17 , C07D213/30 , C07D213/40 , C07D213/78 , C07D233/32 , C07D233/72 , C07D277/28 , C07D277/46 , C07D277/48 , C07D307/20 , C07D307/42 , C07D401/06 , C07D403/06 , C07D403/10 , C07D405/06 , C07D405/10 , C07D409/06 , C07D417/06 , C07D417/14 , C07D471/04 , C07D493/04
CPC分类号： C07D471/04 , A61K31/175 , A61K31/18 , A61K31/195 , A61K31/277 , A61K31/4168 , A61K31/65 , A61K45/06 , C07D213/30 , C07D213/40 , C07D213/78 , C07D233/32 , C07D233/72 , C07D277/28 , C07D277/46 , C07D277/48 , C07D307/20 , C07D307/42 , C07D401/06 , C07D403/06 , C07D403/10 , C07D405/06 , C07D405/10 , C07D409/06 , C07D417/06 , C07D417/14 , C07D493/04 , A61K2300/00
摘要： A compound of the formula (I) is disclosed as an HIV protease inhibitor. Methods and compositions for inhibiting an HIV infection are also disclosed.
摘要翻译：公开了式（I）化合物作为HIV蛋白酶抑制剂。还公开了用于抑制HIV感染的方法和组合物。

9. 发明申请

WO2005061487A1 HIV PROTEASE INHIBITING COMPOUNDS 审中-公开
公开(公告)号：WO2005061487A1
公开(公告)日：2005-07-07
申请号：PCT/US2004/037711
申请日：2004-11-10
申请人： ABBOTT LABORATORIES , RANDOLPH, John, T. , CHEN, Hui-Ju , DEGOEY, David, A. , FLENTGE, Charles, A. , FLOSI, William, J. , GRAMPOVNIK, David, J. , HUANG, Peggy, P. , HUTCHINSON, Douglas, K. , KEMPF, Dale, J. , KLEIN, Larry, L. , YEUNG, Ming, C.
发明人： RANDOLPH, John, T. , CHEN, Hui-Ju , DEGOEY, David, A. , FLENTGE, Charles, A. , FLOSI, William, J. , GRAMPOVNIK, David, J. , HUANG, Peggy, P. , HUTCHINSON, Douglas, K. , KEMPF, Dale, J. , KLEIN, Larry, L. , YEUNG, Ming, C.
IPC分类号： C07D401/14
CPC分类号： C07C271/22 , C07D401/06 , C07D401/14 , C07D403/06 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/06 , C07D417/14
摘要： A compound of the formula (I) is disclosed as an HIV protease inhibitor. Methods and compositions for inhibiting an HIV infection are also disclosed.

10. 发明申请

WO2005019191A2 ANTI-INFECTIVE AGENTS 审中-公开
标题翻译：抗感染药物
公开(公告)号：WO2005019191A2
公开(公告)日：2005-03-03
申请号：PCT/US2004/027000
申请日：2004-08-19
申请人： ABBOTT LABORATORIES , HUTCHINSON, Douglas, K. , BELLETTINI, John, R. , BETEBENNER, David, A. , BISHOP, Richard, D. , BORCHARDT, Thomas, B. , BOSSE, Todd, D. , CINK, Russell, D. , FLENTGE, Charles, A. , GATES, Bradley, D. , GREEN, Brian, E. , HINMAN, Mira, M. , HUANG, Peggy, P. , KLEIN, Larry, L. , KRUEGER, Allan, C. , LARSON, Daniel, P. , LEANNA, M., Robert , LIU, Dachun , MADIGAN, Darold, L. , MCDANIEL, Keith, F. , RANDOLPH, John, T. , ROCKWAY, Todd, W. , ROSENBERG, Teresa, A. , STEWART, Kent, D. , STOLL, Vincent, S. , WAGNER, Rolf , YEUNG, Ming, C.
发明人： HUTCHINSON, Douglas, K. , BELLETTINI, John, R. , BETEBENNER, David, A. , BISHOP, Richard, D. , BORCHARDT, Thomas, B. , BOSSE, Todd, D. , CINK, Russell, D. , FLENTGE, Charles, A. , GATES, Bradley, D. , GREEN, Brian, E. , HINMAN, Mira, M. , HUANG, Peggy, P. , KLEIN, Larry, L. , KRUEGER, Allan, C. , LARSON, Daniel, P. , LEANNA, M., Robert , LIU, Dachun , MADIGAN, Darold, L. , MCDANIEL, Keith, F. , RANDOLPH, John, T. , ROCKWAY, Todd, W. , ROSENBERG, Teresa, A. , STEWART, Kent, D. , STOLL, Vincent, S. , WAGNER, Rolf , YEUNG, Ming, C.
IPC分类号： C07D285/00
CPC分类号： C07D417/12 , C07D285/24 , C07D285/30 , C07D513/04
摘要： Compounds having the formula (I) are hepatitis C (HCV) polymerase inhibitors. Also disclosed are a composition and method for inhibiting hepatitis C (HCV) polymerase, processes for making the compounds, and synthetic intermediates employed in the processes.
摘要翻译：具有式（I）的化合物是丙型肝炎（HCV）聚合酶抑制剂。还公开了用于抑制丙型肝炎（HCV）聚合酶的组合物和方法，用于制备化合物的方法和在该方法中使用的合成中间体。

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