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1. 发明专利

JP2013520258A Intra-articular supplementation method to treat joint disease and joint damage 有权
公开(公告)号：JP2013520258A
公开(公告)日：2013-06-06
申请号：JP2012554283
申请日：2011-02-11
申请人：ユニベルシテ・ド・リエージュUniversite De Liege , キットザイム・ソシエテ・アノニムKitozyme S.A.
发明人：ヘンロティン、イヴス , サンチェス、クリステル , オプレニーズク、フレデリク , ドリオン、ピエール
IPC分类号： A61L27/00
CPC分类号： A61K9/06 , A61K9/14 , A61K31/722 , A61K31/734 , A61K45/06 , A61L27/20 , A61L27/26 , A61L27/3817 , A61L27/52 , A61L2430/06 , C08L5/04 , C08L5/08
摘要： The present invention relates to a method of producing a hydrogel matrix comprising cartilage-forming cells wherein alginate, chitosan and cartilage-forming cells are mixed and subsequently polymerised into beads.

3. 发明专利

JP2005529191A Cell wall derivatives and their preparation from biomass 审中-公开
公开(公告)号：JP2005529191A
公开(公告)日：2005-09-29
申请号：JP2003567950
申请日：2003-02-12
申请人：キトツィーム・エス・アーKitozyme S.A.
发明人：ヴェルサリ，マリー−フランス , クレリス，ファビエンヌ , ゴーティエ，サンドリーヌ , ブリュイエール，ジャン−ミッシェル
IPC分类号： A23L1/308 , C08B37/08 , C12P19/26
CPC分类号： A61Q19/00 , A61K8/9706 , C08B37/003
摘要：第１の態様において、本発明は、真菌又は酵母のバイオマスから細胞壁誘導体を単離する方法に関する。この方法により、キチンポリマー又はキチン−グルカンコポリマーを得ることができる。別の態様において、本発明は、キチンからキトサンを調製する方法に関する。本発明は更に、本発明の方法により得ることができる、キチンポリマー、キチン−グルカンポリマー及びキトサンポリマーに関する。更には、本発明は、医療、医薬、農業、栄養補助食品、食品、テキスタイル、化粧品、工業及び／又は環境応用における、本発明の方法により得ることができる、キチンポリマー、キチン−グルカンコポリマー又はキトサンポリマーの使用に関する。

4. 发明申请

US20150072013A1 INTRA-ARTICULARLY SUPPLEMENTATION METHOD FOR TREATING JOINT DISEASES AND INJURIES 有权
标题翻译：用于治疗关节疾病和创伤的内在补充方法
公开(公告)号：US20150072013A1
公开(公告)日：2015-03-12
申请号：US14541540
申请日：2014-11-14
申请人： UNIVERSITE DE LIEGE , KITOZYME S.A.
发明人： Yves Henrotin , Christelle Sanchez , Frederic Oprenyeszk , Pierre Drion
IPC分类号： A61K9/06 , A61K45/06 , A61K9/14 , A61K31/734 , A61K31/722
CPC分类号： A61K9/06 , A61K9/14 , A61K31/722 , A61K31/734 , A61K45/06 , A61L27/20 , A61L27/26 , A61L27/3817 , A61L27/52 , A61L2430/06 , C08L5/04 , C08L5/08
摘要： A hydrogel bead for intra-articular supplement made by:providing a solution of alginate,providing a solution with chitosan having a Mw between lower than 60 kD,mixing the solution of alginate and the solution of chitosan, wherein the mixed solution comprises between 0.5 and 0.7% (w/v) of chitosan and between 1 and 1.4% alginate (w/v),introducing droplets of the mixed solution into a solution with Ca2+ or Sr2+ cations andisolating polymerised beads from the solution with cations.
摘要翻译：一种用于关节内补充剂的水凝胶珠，其通过：提供藻酸盐溶液，提供具有低于60kD的Mw的壳聚糖的溶液，混合藻酸盐溶液和壳聚糖溶液，其中所述混合溶液包含0.5至 0.7％（w / v）的壳聚糖和1至1.4％的藻酸盐（w / v），将混合溶液的液滴引入具有Ca 2+或Sr 2+阳离子的溶液中，并用阳离子从溶液中分离聚合珠。

5. 发明授权

US09561180B2 Intra-articularly supplementation method for treating joint diseases and injuries 有权
标题翻译：治疗关节疾病和损伤的关节内补充方法
公开(公告)号：US09561180B2
公开(公告)日：2017-02-07
申请号：US14541540
申请日：2014-11-14
申请人： UNIVERSITE DE LIEGE , KITOZYME S.A.
发明人： Yves Henrotin , Christelle Sanchez , Frederic Oprenyeszk , Pierre Drion
IPC分类号： A61K9/00 , A61K31/722 , A61K31/734 , A61K9/06 , A61L27/20 , A61L27/26 , A61L27/38 , A61L27/52 , A61K9/14 , A61K45/06
CPC分类号： A61K9/06 , A61K9/14 , A61K31/722 , A61K31/734 , A61K45/06 , A61L27/20 , A61L27/26 , A61L27/3817 , A61L27/52 , A61L2430/06 , C08L5/04 , C08L5/08
摘要： A hydrogel bead for intra-articular supplement made by: providing a solution of alginate, providing a solution with chitosan having a Mw between lower than 60 kD, mixing the solution of alginate and the solution of chitosan, wherein the mixed solution comprises between 0.5 and 0.7% (w/v) of chitosan and between 1 and 1.4% alginate (w/v), introducing droplets of the mixed solution into a solution with Ca2+ or Sr2+ cations and isolating polymerised beads from the solution with cations.
摘要翻译：本发明涉及一种生产包含软骨形成细胞的水凝胶基质的方法，其中藻酸盐，壳聚糖和软骨形成细胞混合并随后聚合成珠。

6. 发明申请

WO2011104133A1 AN INTRA-ARTICULAR SUPPLEMENTATION METHOD FOR TREATING JOINT DISEASES AND INJURIES 审中-公开
标题翻译：治疗关节疾病和创伤的临床辅助补充方法
公开(公告)号：WO2011104133A1
公开(公告)日：2011-09-01
申请号：PCT/EP2011/052020
申请日：2011-02-11
申请人： UNIVERSITE DE LIEGE , HENROTIN, Yves , SANCHEZ, Christelle , OPRENYESZK, Frédéric , DRION, Pierre , KITOZYME S.A.
发明人： HENROTIN, Yves , SANCHEZ, Christelle , OPRENYESZK, Frédéric , DRION, Pierre
IPC分类号： A61L27/20 , A61L27/52
CPC分类号： A61K9/06 , A61K9/14 , A61K31/722 , A61K31/734 , A61K45/06 , A61L27/20 , A61L27/26 , A61L27/3817 , A61L27/52 , A61L2430/06 , C08L5/04 , C08L5/08
摘要： A method of producing a hydrogel for intra-articular supplement comprising the steps of: - providing a solution of alginate, - providing a solution with chitosan having a Mw between lower than 60 kD, - mixing the solution of alginate and the solution of chitosan, wherein the mixed solution comprises between 0.5 and 0.7 % (w/v) of chitosan and between 1 and 1.4 % alginate (w/v), - introducing droplets of the mixed solution into a solution with Ca 2+ or Sr 2+ cations and - isolating polymerised beads from the solution with cations
摘要翻译：一种生产关节内补充水凝胶的方法，包括以下步骤： - 提供藻酸盐溶液， - 提供具有小于60kD的Mw的壳聚糖的溶液; - 将藻酸盐溶液与壳聚糖溶液混合，其中所述混合溶液包含0.5至0.7％（w / v）的壳聚糖和1至1.4％的藻酸盐（w / v）， - 将所述混合溶液的液滴引入具有Ca 2+或Sr 2+阳离子的溶液中，并且 - 分离聚合珠粒从阳离子溶液中

7. 发明申请

WO2003068824A1 CELL WALL DERIVATIVES FROM BIOMASS AND PREPARATION THEREOF 审中-公开
标题翻译：细胞壁衍生物从生物量和其制备
公开(公告)号：WO2003068824A1
公开(公告)日：2003-08-21
申请号：PCT/EP2003/001375
申请日：2003-02-12
申请人： KITOZYME S.A. , VERSALI, Marie-France , CLERISSE, Fabienne , BRUYERE, Jean-Michel , GAUTIER, Sandrine
发明人： VERSALI, Marie-France , CLERISSE, Fabienne , BRUYERE, Jean-Michel , GAUTIER, Sandrine
IPC分类号： C08B37/08
CPC分类号： A61Q19/00 , A61K8/9706 , C08B37/003
摘要： In a first aspect, the present invention relates to a method for isolating cell wall derivatives from fungal or yeast biomass. According to this method, chitin polymers or chitin-glucan copolymers can be obtained. In another aspect, the invention relates to a method for preparing chitosan from chitin. The invention further relates to chitin polymers, chitin-glucan polymers and chitosan polymers obtainable by the methods according to the invention. Moreover, the invention relates to the use of chitin polymers, chitin-glucan copolymers or chitosan polymers obtainable by the method according to the present invention in medical, pharmaceutical, agricultural, nutraceutical, food, textile, cosmetic, industrial and/or environmental applications.
摘要翻译：在第一方面，本发明涉及从真菌或酵母生物质中分离细胞壁衍生物的方法。根据该方法，可以得到几丁质聚合物或几丁质 - 葡聚糖共聚物。另一方面，本发明涉及从壳多糖制备壳聚糖的方法。本发明还涉及可通过本发明方法获得的几丁质聚合物，几丁质 - 葡聚糖聚合物和壳聚糖聚合物。此外，本发明涉及通过根据本发明的方法可获得的壳多糖聚合物，几丁质 - 葡聚糖共聚物或壳聚糖聚合物在医学，制药，农业，营养食品，食品，纺织品，化妆品，工业和/或环境应用中的用途。

8. 发明申请

WO2010142507A3 ADHESIVE COMPOSITION 审中-公开
公开(公告)号：WO2010142507A3
公开(公告)日：2010-12-16
申请号：PCT/EP2010/056574
申请日：2010-05-12
申请人： KITOZYME S.A. , PRAVATA, Laurent
发明人： PRAVATA, Laurent
IPC分类号： A61L15/58 , A61L15/28
摘要： The invention relates to a new biocompatible, biodegradable removable and repositionable adhesive composition, its preparation method and various uses thereof, including its use as surgical aid. The invention also discloses a matrix comprising such composition, such as e.g. a solid support covered, impregnated or saturated by said adhesive composition. Adhesive compositions according to the invention comprise at least one chitin and/or chitosan containing material. In a particular embodiment said adhesive composition further comprises at least one adhesive-enhancing agent whereby said agent is provided in a granular form, and preferably is a chitin and/or chitosan containing material as defined herein. The present adhesive composition and matrix comprising such composition can be used as gluing composition, in particular in wound-healing and/or surgical applications.

9. 发明申请

WO2004072280A1 METHOD FOR THE PRODUCTION OF CHITIN DEACETYLASE 审中-公开
标题翻译：生产脱乙酰壳多糖的方法
公开(公告)号：WO2004072280A1
公开(公告)日：2004-08-26
申请号：PCT/EP2004/001313
申请日：2004-02-12
申请人： KITOZYME S.A. , UNIVERSITE DE LIEGE , VERSALI, Marie-France , CLERISSE, Fabienne , GAUTHIER, Carole , DUMONT, Françoise , DOMMES, Jacques
发明人： VERSALI, Marie-France , CLERISSE, Fabienne , GAUTHIER, Carole , DUMONT, Françoise , DOMMES, Jacques
IPC分类号： C12N9/80
CPC分类号： C12N1/16 , C07K2319/21 , C12N9/80 , C12Y305/01041
摘要： In a first aspect, the present invention relates to a recombinant fungal strain, capable of expressing chitin deacetylase, comprising an expression vector that contains a nucleic acid molecule encoding chitin deacetylase, a suitable promoter and a transcription terminator. In particular, the present invention provides a recombinant Aspergillus oryzae strain capable of expressing chitin deacetylase obtained from Mucor rouxii. The present invention also relates to a method for producing chitin deacetylase by a recombinant fungal strain. In a second aspect, the present invention relates to a recombinant yeast strain, capable of expressing chitin deacetylase, comprising an expression vector that contains a nucleic acid molecule encoding chitin deacetylase, a suitable promoter and a transcription terminator. In particular, the present invention provides a recombinant Pichia pastoris strain capable of expressing chitin deacetylase obtained from Mucor rouxii. The present invention also relates to a method for producing chitin deacetylase by a recombinant yeast strain. The present invention further relates to purified recombinant chitin deacetylase enzyme.
摘要翻译：在第一方面，本发明涉及能够表达几丁质脱乙酰酶的重组真菌菌株，其包含含有编码甲壳素脱乙酰酶的核酸分子，合适的启动子和转录终止子的表达载体。特别地，本发明提供了能够表达从毛霉（Mucor rouxii）获得的几丁质脱乙酰酶的重组米曲霉菌株。本发明还涉及通过重组真菌菌株生产壳多糖脱乙酰酶的方法。在第二方面，本发明涉及能够表达几丁质脱乙酰酶的重组酵母菌株，其包含含有编码甲壳素脱乙酰酶的核酸分子，合适的启动子和转录终止子的表达载体。特别地，本发明提供能够表达从毛霉（Mucor rouxii）获得的几丁质脱乙酰酶的重组毕赤酵母菌株。本发明还涉及通过重组酵母菌株生产壳多糖脱乙酰酶的方法。本发明还涉及纯化的重组壳多糖脱乙酰酶。

10. 发明公开

EP2010200A2 UTILISATION DE POLYSACCHARIDES D'ORIGINE FONGIQUE COMME COMPOSITION PHARMACEUTIQUE OU COMPLEMENTS ALIMENTAIRES 有权
标题翻译：多糖的真菌AS药物组合物或作为食品补充剂应用
公开(公告)号：EP2010200A2
公开(公告)日：2009-01-07
申请号：EP07728332.3
申请日：2007-04-20
申请人： Kitozyme S.A.
发明人： TEISSEDRE, Pierre-Louis , BORNET, Aurélie , GAUTIER, Sandrine , BRUYERE, Jean-Michel , ROUANET, Jean-Max
IPC分类号： A61K38/00
CPC分类号： C12P19/26
摘要： The invention concerns the use of at least one fungal polysaccharide comprising for the major part a chitin-glucan copolymer, for making an orally administered composition. In particular, the invention concerns a pharmaceutical composition or food complements for preventing, treating or controlling in particular dyslipidemia, hypercholesterolemia, atherosclerosis, and for stimulating antioxidant activities of the organism to stimulate the immune system, perform a hypoglycemic action beneficial in the case of diabetes, and promoting satiety to minimise the metabolic syndrome.
摘要翻译：本发明涉及使用至少一种真菌多糖，包括用于所述主要部分的几丁质 - 葡聚糖共聚物，用于制备口服给药的组合物。特别地，本发明涉及药物组合物或食品补充用于预防，治疗或特别是异常脂肪血症，高胆固醇血症，动脉粥样硬化的控制，以及用于刺激生物刺激免疫系统的抗氧化活性，进行血糖降低作用在糖尿病的情况下，有利和宣传婷饱腹感，以最大限度地减少代谢综合征。

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