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1. 发明专利

CA237968A TREATMENT OF TIMBER 未知
公开(公告)号：CA237968A
公开(公告)日：1924-02-26
申请号：CA237968D
申请人： LEFEBURE VICTOR , KITCHIN JOHN WILLIAM
发明人： LEFEBURE VICTOR , KITCHIN JOHN WILLIAM

2. 发明申请

WO2006017443A2 ARYL-AMINO SUBSTITUTED PYRROLOPYRIMIDINE MULTI-KINASE INHIBITING COMPOUNDS 审中-公开
标题翻译： ARYL-AMINO取代的吡咯并咪唑多激酶抑制化合物
公开(公告)号：WO2006017443A2
公开(公告)日：2006-02-16
申请号：PCT/US2005/027274
申请日：2005-08-01
申请人： OSI PHARMACEUTICALS, INC. , AHMED, Saleh , BARBA, Oscar , BLOXHAM, Jason , DAWSON, Graham , GATTRELL, William , KITCHIN, John , PEGG, Neil, Anthony , SABA, Imaad , SHADIQ, Shazia , SMITH, Colin, Peter, Sambrook , SMYTH, Don , STEINIG, Arno, G. , WILKES, Robin , FOREMAN, Kenneth , WENG, Qinghua, Felix , STOLZ, Kathryn , TAVARES, Paula , PANICKER, Bijoy , LI, An-Hu , DONG, Hanqing , MA, Lifu , COX, Matthew
发明人： AHMED, Saleh , BARBA, Oscar , BLOXHAM, Jason , DAWSON, Graham , GATTRELL, William , KITCHIN, John , PEGG, Neil, Anthony , SABA, Imaad , SHADIQ, Shazia , SMITH, Colin, Peter, Sambrook , SMYTH, Don , STEINIG, Arno, G. , WILKES, Robin , FOREMAN, Kenneth , WENG, Qinghua, Felix , STOLZ, Kathryn , TAVARES, Paula , PANICKER, Bijoy , LI, An-Hu , DONG, Hanqing , MA, Lifu , COX, Matthew
IPC分类号： A61K31/519 , C07D487/02
CPC分类号： C07D471/02 , C07D487/02 , C07D487/04
摘要： Compounds represented by Formula (I): or stereoisomers or pharmaceutically acceptable salts thereof, are inhibitors of least two of the Abl, Aurora-A, Blk, c-Raf, cSRC, Src, PRK2, FGFR3, Flt3, Lck, Mekl, PDK-1, GSK3ß, EGFR, p70S6K, BMX, SGK, CaMKII, Tie-2, IGF-lR, Ron, Ret, and KDR kinases in animals, including humans, for the treatment and/or prevention of various diseases and conditions such as cancer.
摘要翻译：由式（I）表示的化合物或其立体异构体或其药学上可接受的盐是Abl，Aurora-A，Blk，c-Raf，cSRC，Src，PRK2，FGFR3，Flt3，Lck，Mekl，PDK中的至少两种的抑制剂 -1，GSK3β，EGFR，p70S6K，BMX，SGK，CaMKII，Tie-2，IGF-1R，Ron，Ret和KDR激酶，用于治疗和/或预防各种疾病和病症，癌症。

3. 发明申请

WO1993001174A1 THIAZOLIDINE DERIVATIVES AND THEIR USE AS ANTI-VIRAL COMPOUNDS 审中-公开
标题翻译：噻唑烷衍生物及其作为抗病毒化合物的用途
公开(公告)号：WO1993001174A1
公开(公告)日：1993-01-21
申请号：PCT/EP1992001494
申请日：1992-07-03
申请人： GLAXO GROUP LIMITED , KITCHIN, John , HOLMES, Duncan, Stuart , HUMBER, David, Cedric , STORER, Richard , DOLAN, Simon, Charles , HANN, Michael, Menteith , MCMEEKIN, Peter , MURRAY-RUST, Peter , PATEL, Binakumari , WEINGARTEN, Gordon, Gad
发明人： GLAXO GROUP LIMITED
IPC分类号： C07D217/06
CPC分类号： C07D417/12 , C07D277/06 , C07D417/14
摘要： The present invention provides compounds of formula (I), wherein R is hydrogen, alkyl or CH2alkyl where the alkyl portion is substituted by OH; A represents either a group CHR CHR OH or a group (II), where R is hydrogen, alkyl, cycloalkylalkyl or Aralkyl, R is hydrogen, alkyl, cycloalkylalkyl, aralkyl, CHR CONR R (where R is hydrogen, alkyl, cycloalkylalkyl or Aralkyl, R is hydrogen or methyl and R is hydrogen, alkyl optionnally substituted by one or two hydroxyl groups, aryl, heteroaryl, cycloalkylalkyl, Aralkyl wherein the alkyl portion is optionnally substituted by hydroxymethyl, or Hetalkyl) or CHR NHCOR (where R is alkyl, cycloalkylalkyl or an aralkyl), R is alkoxy or NR R (where R is hydrogen or methyl and R is hydrogen, alkyl, aryl, aralkyl or cycloalkylalkyl); X is a group -CHR (CHR )r(CHR )sCHR -, where R and R are hydrogen, r is 1, s is zero and R is hydroxyl or hydroxymethyl, or R and R are hydrogen, r and s are 1 and R and R are each hydrogen or hydroxyl provided that at least one of R and R is hydroxyl, or one of R and R is hydrogen and the other is hydroxymethyl and r and s are zero; useful in chemotherapy, particularly of viral infections.
摘要翻译：本发明提供式（I）化合物，其中R 1是氢，烷基或C 2烷基，其中烷基部分被OH取代; A代表基团CHR 21 CHR 22 OH或基团（II），其中R 21是氢，烷基，环烷基烷基或芳烷基，R 22是氢，烷基，环烷基烷基，芳烷基，CHR 24 R CONR 25 R 26（其中R 24是氢，烷基，环烷基烷基或芳烷基，R 25是氢或甲基，R 26是氢，烷基选择性地被一个或两个羟基取代，芳基，杂芳基，环烷基烷基，芳烷基，其中烷基部分选择性地被羟甲基或Hetalkyl取代）或CHR 24 NHCOR 27（其中R 27是烷基，环烷基烷基或芳烷基），R 23是烷氧基或NR 28 R 29（其中R 28是氢或甲基，R 29是氢，烷基，芳基，芳烷基或环烷基烷基）; X是基团-CHR 30（CHR 31）r（CHR 32）s CHR 33，其中R 30和R 33是氢，r是1，s是0，R 31是羟基或羟甲基，或R 30和R 33是氢，r和s是1，R 31和R 32各自是氢或羟基，条件是R 31中至少有一个且R 32为羟基，R 30和R 33之一为氢，另一个为羟甲基，r和s为0; 可用于化疗，特别是病毒感染。

4. 发明申请

WO1992020665A1 THIAZOLIDINE DERIVATIVES AND THEIR USE IN THERAPY 审中-公开
标题翻译：噻唑啶衍生物及其在治疗中的应用
公开(公告)号：WO1992020665A1
公开(公告)日：1992-11-26
申请号：PCT/GB1992000840
申请日：1992-05-08
申请人： GLAXO GROUP LIMITED , HUMBER, Dai, Cedric , WEINGARTEN, Gordon, Gad , STORER, Richard , KITCHIN, John , HANN, Michael, Menteith
发明人： GLAXO GROUP LIMITED
IPC分类号： C07D277/06
CPC分类号： C07D417/14 , C07D277/06 , C07D499/00
摘要： The present invention provides compounds of formula (I), wherein x is zero, 1 or 2; R and R are each independently hydrogen, C1-4alkyl or CH2C1-3alkyl where the C1-3alkyl portion is substituted by OH; R , R , R and R are each independently hydrogen, methyl, ethyl, CH2OH,CH2NH2 or COOH when x is zero, or R , R , R and R are each independently hydrogen, methyl or CH2OH when x is 1 or 2; R and R are each independently hydrogen, C1-10alkyl, C3-8cycloalkyl, ArC1-4alkyl, HetC1-4alkyl, COAr, COHet, COCH2R , COCH(OH)Ar, COCH(OH)Het, COCH=CHPh, COR , CO2CH2Ar, CO2CH2Het, SO2Ar, SO2Het,SO2CH2R , SO2CH=CHPh or SO2R [where R and R each independently represent hydrogen, C1-6alkyl, aryl, heteroaryl, ArC1-4alkyl, HetC1-4alkyl, aryloxy, heteroaryloxy, C3-8cycloalkyl, C3-8cycloalkylC1-4alkyl, (CH2)nCO2R (where n is zero or 1 and R is hydrogen or C1-6alkyl), (CH2)mNR R (where m is zero, 1, 2, 3, 4 or 5 and R are each independently hydrogen or C1-4alkyl or together with the nitrogen atom to which they are attached form a saturated heterocyclic amino group), and R and R each independently represent C3-8cycloalkyl substituted by phenyl]; R and R are each independently hydrogen, C1-6alkyl, COOR (where R is hydrogen, C1-6alkyl or ArC1-4alkyl) or CONR R [where R is hydrogen or C1-4alkyl and R is hydrogen, OH, aryl, heteroaryl, ArC1-4alkyl (wherein the C1-4alkyl portion is optionally substituted by hydroxymethyl), HetC1-4alkyl, C3-8cycloalkyl, C3-8cycloalkylC1-4alkyl, (CH2pR (where p is zero or 1 and R is CF3 or CO2R where R is hydrogen or C1-6alkyl), (CH2)qNR R (where q is zero, 1, 2, 3, 4, or 5 and R and R are each independently hydrogen, C1-4alkyl or aryl or together with the nitrogen atom to which they are attached form a saturated heterocyclic amino group), CHArCO2R , CHHet CO2R (where R and R are each independently hydrogen or C1-6alkyl) or C1-6alkyl optionally substituted by OH, or R and R together with the nitrogen atom to which they are attached form a saturated heterocyclic amino group]; R and R are each independently hydrogen, hydroxy or acetoxy; and physiologically acceptable salts and solvates thereof. Also described are the use of the compounds as antiviral agents, pharmaceutical compositions containing them and methods for their preparation.
摘要翻译：本发明提供式（I）化合物，其中x为0,1或2; R 1和R 6各自独立地为氢，C 1-4烷基或C 2 -C 1-3烷基，其中C 1-3烷基部分被OH取代; 当x为零时，R 2，R 3，R 4和R 5各自独立地为氢，甲基，乙基，CH 2 OH，CH 2 NH 2或COOH，或R 2，R 3，R 当x为1或2时，R 4和R 5各自独立地为氢，甲基或CH 2 OH; R 7和R 9各自独立地为氢，C 1-10烷基，C 3-8环烷基，Ar C 1-4烷基，Het C 1-4烷基，COAr，COHet，COCH 2 R 13，COCH（OH）Ar，COCH（OH）Het ，COCH = CHPh，COR 14，CO 2 CH 2 Ar，CO 2 CH 2 Het，SO 2 Ar，SO 2 Het，SO 2 CH 2 R 15，SO 2 CH = CHPh或SO 2 R 16 [其中R 13和R 15各自独立地表示氢，C 1-6烷基，芳基，杂芳基，ArC 1-4烷基，HetC 1-4烷基，芳氧基，杂芳氧基，C 3-8环烷基，C 3-8环烷基C 1-4烷基，（CH 2）n CO 2 R 17（其中n为0或1，R 17为氢或C 1 烷基），（CH 2）m NR R 18 R（其中m为0,1,2,3,4或5，R 19各自独立地为氢或C 1-4烷基或与氮原子一起它们连接形成饱和杂环氨基），R 14和R 16各自独立地表示被苯基取代的C 3-8环烷基; R 8和R 10各自独立地为氢，C 1-6烷基，COOR 20（其中R 20为氢，C 1-6烷基或ArC 1-4烷基）或CONR 21 R 22 [其中 R 21是氢或C 1-4烷基，R 22是氢，OH，芳基，杂芳基，ArC 1-4烷基（其中C 1-4烷基部分任选被羟甲基取代），HetC 1-4烷基，C 3-8环烷基，C 3 -8环烷基C 1-4烷基，（CH 2 p R 23）（其中p为0或1，R 23为CF 3或CO 2 R 24，其中R 24为氢或C 1-6烷基），（CH 2）q NR R R <26>（其中q为零，1,2,3,4或5，R 25和R 26各自独立地为氢，C 1-4烷基或芳基，或与它们相连的氮原子一起形成饱和杂环氨基），CHArCO 2 R 27，CHHet CO 2 R 28（其中R 27和R 28各自独立地为氢或C 1-6烷基）或任选被OH取代的C 1-6烷基， 21>和R 22与它们所连接的氮原子一起形成饱和杂环氨基]; R 11和R 12各自独立地为氢羟基或乙酰氧基; 及其生理上可接受的盐和溶剂合物。还描述了化合物作为抗病毒剂的用途，含有它们的药物组合物及其制备方法。

5. 发明申请

WO2006017443A3 ARYL-AMINO SUBSTITUTED PYRROLOPYRIMIDINE MULTI-KINASE INHIBITING COMPOUNDS 审中-公开
标题翻译： ARYL-AMINO取代的吡咯烷酮多激酶抑制化合物
公开(公告)号：WO2006017443A3
公开(公告)日：2007-01-18
申请号：PCT/US2005027274
申请日：2005-08-01
申请人： OSI PHARM INC , AHMED SALEH , BARBA OSCAR , BLOXHAM JASON , DAWSON GRAHAM , GATTRELL WILLIAM , KITCHIN JOHN , PEGG NEIL ANTHONY , SABA IMAAD , SADIQ SHAZIA , SAMBROOK SMITH COLIN PETER , SMYTH DON , STEINIG ARNO G , WILKES ROBIN , FOREMAN KENNETH , WENG QINGHUA FELIX , STOLZ KATHRYN , TAVARES PAULA , PANICKER BIJOY , LI AN-HU , DONG HANQING , MA LIFU , COX MATTHEW
发明人： AHMED SALEH , BARBA OSCAR , BLOXHAM JASON , DAWSON GRAHAM , GATTRELL WILLIAM , KITCHIN JOHN , PEGG NEIL ANTHONY , SABA IMAAD , SADIQ SHAZIA , SAMBROOK SMITH COLIN PETER , SMYTH DON , STEINIG ARNO G , WILKES ROBIN , FOREMAN KENNETH , WENG QINGHUA FELIX , STOLZ KATHRYN , TAVARES PAULA , PANICKER BIJOY , LI AN-HU , DONG HANQING , MA LIFU , COX MATTHEW
IPC分类号： C07D295/185 , A61K31/437 , A61K31/519 , A61K31/5355 , A61K31/541 , A61K31/55 , A61K31/5513 , C07D223/04 , C07D295/02 , C07D471/04 , C07D487/04
CPC分类号： C07D471/02 , C07D487/02 , C07D487/04
摘要： Compounds represented by Formula (I): or stereoisomers or pharmaceutically acceptable salts thereof, are inhibitors of least two of the Abl, Aurora-A, Blk, c-Raf, cSRC, Src, PRK2, FGFR3, Flt3, Lck, Mekl, PDK-1, GSK3ß, EGFR, p70S6K, BMX, SGK, CaMKII, Tie-2, IGF-lR, Ron, Ret, and KDR kinases in animals, including humans, for the treatment and/or prevention of various diseases and conditions such as cancer.
摘要翻译：由式（I）表示的化合物或其立体异构体或其药学上可接受的盐是Abl，Aurora-A，Blk，c-Raf，cSRC，Src，PRK2，FGFR3，Flt3，Lck，Mekl，PDK中的至少两种的抑制剂 -1，GSK3β，EGFR，p70S6K，BMX，SGK，CaMKII，Tie-2，IGF-1R，Ron，Ret和KDR激酶，用于治疗和/或预防各种疾病和病症，癌症。

6. 发明授权

US1653710A Antirodent preparation 失效
标题翻译：防腐制剂
公开(公告)号：US1653710A
公开(公告)日：1927-12-27
申请号：US6524425
申请日：1925-10-27
申请人： COLBY KITCHIN JOHN
发明人： COLBY KITCHIN JOHN
IPC分类号： A01N25/00
CPC分类号： A01N25/00 , A01N31/08 , A01N65/00 , A01N65/08 , A01N25/34 , A01N59/26 , A01N65/18

7. 发明授权

US1544013A Treatment of timber 失效
标题翻译：木材处理
公开(公告)号：US1544013A
公开(公告)日：1925-06-30
申请号：US61280323
申请日：1923-01-15
申请人： KITCHIN JOHN W , VICTOR LEFEBURE
发明人： KITCHIN JOHN W , VICTOR LEFEBURE
IPC分类号： B27K3/52
CPC分类号： B27K3/52 , B27K3/0278 , B27K3/20 , B27K3/30 , B27K3/42 , B27K5/04

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