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1. 发明申请

WO2007003962A2 GPCR AGONISTS 审中-公开
标题翻译： GPCR激动剂
公开(公告)号：WO2007003962A2
公开(公告)日：2007-01-11
申请号：PCT/GB2006/050178
申请日：2006-06-29
申请人： PROSIDION LIMITED , BRADLEY, Stuart, Edward , FYFE, Matthew, Colin, Thor , BERTRAM, Lisa, Sarah , GATTRELL, William , JEEVARATNAM, Revathy, Perpetua , KEILY, John , PROCTER, Martin, James , RASAMISON, Chrystelle, Marie , RUSHWORTH, Philip, John , SAMBROOK-SMITH, Colin, Peter , STONEHOUSE, David, French , SWAIN, Simon, Andrew , WILLIAMS, Geoffrey, Martyn
发明人： BRADLEY, Stuart, Edward , FYFE, Matthew, Colin, Thor , BERTRAM, Lisa, Sarah , GATTRELL, William , JEEVARATNAM, Revathy, Perpetua , KEILY, John , PROCTER, Martin, James , RASAMISON, Chrystelle, Marie , RUSHWORTH, Philip, John , SAMBROOK-SMITH, Colin, Peter , STONEHOUSE, David, French , SWAIN, Simon, Andrew , WILLIAMS, Geoffrey, Martyn
IPC分类号： C07D211/08 , C07D211/36 , C07D401/04 , C07D401/06
CPC分类号： C07D401/14 , C07D211/20 , C07D211/22 , C07D211/24 , C07D211/26 , C07D211/28 , C07D211/34 , C07D211/48 , C07D401/04 , C07D401/10 , C07D401/12
摘要： Compounds of formula (I): or pharmaceutically acceptable salts thereof, are GPCR agonists and are useful as for the treatment of obesity and diabetes.
摘要翻译：式（I）的化合物：或其药学上可接受的盐是GPCR激动剂并且可用于治疗肥胖和糖尿病。

2. 发明申请

WO2006060381A2 N-SUBSTITUTED BENZIMIDAZOLYL C-KIT INHIBITORS AND COMBINATORIAL BENZIMIDAZOLE LIBRARY 审中-公开
标题翻译： N-取代苯并咪唑C-CIT抑制剂和联合苯并咪唑类化合物库
公开(公告)号：WO2006060381A2
公开(公告)日：2006-06-08
申请号：PCT/US2005/043114
申请日：2005-11-30
申请人： OSI PHARMACEUTICALS, INC. , CREW, Andrew, Philip , COX, Matthew , LAUFER, Radoslaw , SUN, Yingchuan , PEGG, Neil, Anthony , SAMBROOK SMITH, Colin, Peter , WILKES, Robin, David , WILLIAMS, Jonathan
发明人： CREW, Andrew, Philip , COX, Matthew , LAUFER, Radoslaw , SUN, Yingchuan , PEGG, Neil, Anthony , SAMBROOK SMITH, Colin, Peter , WILKES, Robin, David , WILLIAMS, Jonathan
IPC分类号： C07D235/06 , C07D409/14 , C07D403/14 , C07D401/12 , C07D417/14 , C07D409/10 , C07D403/10 , C07D405/10 , C07D413/10 , A61K31/4184 , A61P35/00 , C40B40/04 , C40B50/14
CPC分类号： C07D235/06 , C07B2200/11 , C07D401/12 , C07D403/10 , C07D403/14 , C07D405/10 , C07D409/10 , C07D409/14 , C07D413/10 , C07D417/14 , C40B40/00
摘要： Compounds represented by Formula (I) or a pharmaceutically acceptable salt or N-oxide thereof, are useful in the treatment of tumors. Combinatorial libraries composed of compounds represented by Formula (I) or benzimidazole compounds represented by Formula (II) are useful in providing compounds to assay for such therapeutically useful compounds.
摘要翻译：由式（I）表示的化合物或其药学上可接受的盐或N-氧化物可用于治疗肿瘤。由式（I）表示的化合物或由式（II）表示的苯并咪唑化合物组成的组合文库可用于提供化合物以测定这些治疗有用的化合物。

3. 发明申请

WO2005021537A1 N-SUBSTITUTED PYRAZOLYL-AMIDYL-BENZIMIDAZOLYL C-KIT INHIBITORS 审中-公开
标题翻译： N-取代的吡唑并咪唑基苯并咪唑C-CIT抑制剂
公开(公告)号：WO2005021537A1
公开(公告)日：2005-03-10
申请号：PCT/US2004/026481
申请日：2004-08-16
申请人： OSI PHARMACEUTICALS, INC. , BOLGER, Joshua , CASTELHANO, Arlindo, L. , CREW, Andrew, Phillip , LAUFER, Radoslaw , LI, An-Hu , SAMBROOK, SMITH, Colin, Peter , SUN, Yingchuan
发明人： BOLGER, Joshua , CASTELHANO, Arlindo, L. , CREW, Andrew, Phillip , LAUFER, Radoslaw , LI, An-Hu , SAMBROOK, SMITH, Colin, Peter , SUN, Yingchuan
IPC分类号： C07D403/12
CPC分类号： C07D403/12
摘要： Compounds represented by Formula (I): or a pharmaceutically acceptable salt or N-oxide thereof, are useful in the treatment of cancer.
摘要翻译：由式（I）表示的化合物或其药学上可接受的盐或N-氧化物可用于治疗癌症。

4. 发明申请

WO1991012139A1 IMAGING PROCESS 审中-公开
标题翻译：成像过程
公开(公告)号：WO1991012139A1
公开(公告)日：1991-08-22
申请号：PCT/GB1991000195
申请日：1991-02-07
申请人： COURTAULDS PLC , SAMBROOK-SMITH, Colin, Peter , HAWKINS, Michael
发明人： COURTAULDS PLC
IPC分类号： B41M03/14
CPC分类号： G03C5/56 , B41M3/142
摘要： A process for imaging a film containing a reversible organic photochromic compound comprises exposing the film to UV light in one or more selected areas followed by treating it with a chemical reagent which reacts irreversibly with only the relatively colourless form of the photochromic compound. An alternative process comprises exposing the film to UV light and the chemical reagent followed by exposing it to high-frequency light in one or more selected areas to cause irreversible reaction. Preferably the photochromic compound contains a cyclic carboxylic acid anhydride ring and the reagent is ammonia or an amine. The imaged films are useful as security markings.
摘要翻译：在含有可逆有机光致变色化合物的膜上形成图像的方法包括在一个或多个选定区域中将所述膜暴露于UV光，然后用调节只有相对无色的光致变色化合物才是不可逆的。另一种方法是将薄膜暴露在紫外光和化学试剂中，然后将其暴露于一个或多个选定区域的高频光线下，引起不可逆反应。光致变色化合物优选含有无水环状羧酸环，反应物是氨或胺。图像胶片可以有利地用作安全标记。

5. 发明申请

WO2009050523A1 AZETIDINYL G-PROTEIN COUPLED RECEPTOR AGONISTS 审中-公开
标题翻译： AZETIDINYL G蛋白偶联受体激动剂
公开(公告)号：WO2009050523A1
公开(公告)日：2009-04-23
申请号：PCT/GB2008/050971
申请日：2008-10-20
申请人： PROSIDION LIMITED , FYFE, Matthew, Colin, Thor , GATTRELL, William , SAMBROOK-SMITH, Colin, Peter
发明人： FYFE, Matthew, Colin, Thor , GATTRELL, William , SAMBROOK-SMITH, Colin, Peter
IPC分类号： C07D401/14 , C07D413/14 , C07D417/14 , A61K31/435 , A61P3/00
CPC分类号： C07D401/14 , C07D413/14 , C07D417/14
摘要： Compounds of formula (I) or pharmaceutically acceptable salts thereof, are agonists of GPR119 and are useful for the treatment of diabetes and as peripheral regulators of satiety, e.g. for the treatment of obesity and metabolic syndrome.
摘要翻译：式（I）化合物或其药学上可接受的盐是GPR119的激动剂，可用于治疗糖尿病和作为饱腹感的外周调节剂，例如，用于治疗肥胖和代谢综合征。

6. 发明申请

WO2009030962A1 BICYCLIC ARYL AND HETEROARYL RECEPTOR MODULATORS 审中-公开
标题翻译：双相ARYL和HETEROARYL受体调节剂
公开(公告)号：WO2009030962A1
公开(公告)日：2009-03-12
申请号：PCT/GB2008/050801
申请日：2008-09-08
申请人： PROSIDION LIMITED , BLOXHAM, Jason , BRADLEY, Stuart, Edward , KRULLE, Thomas, Martin , PROCTER, Martin, James , SAMBROOK-SMITH, Colin, Peter , SCHOFIELD, Karen, Lesley , SMYTH, Donald
发明人： BLOXHAM, Jason , BRADLEY, Stuart, Edward , KRULLE, Thomas, Martin , PROCTER, Martin, James , SAMBROOK-SMITH, Colin, Peter , SCHOFIELD, Karen, Lesley , SMYTH, Donald
IPC分类号： C07C237/30 , C07D213/56 , C07D333/20 , C07D333/58 , A61K31/166 , A61K31/381 , A61K31/451 , A61P3/04
CPC分类号： C07C237/30 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07C2602/42 , C07C2603/74 , C07D213/56 , C07D333/20 , C07D333/58
摘要： Compounds of formula (I) or pharmaceutically acceptable salts thereof, are opioid receptor modulators, e.g. mu-opioid receptor antagonists, neutral antagonists or inverse agonists, and are useful inter alia for the treatment of obesity.
摘要翻译：式（I）化合物或其药学上可接受的盐是阿片样物质受体调节剂，例如 μ-阿片受体拮抗剂，中性拮抗剂或反向激动剂，并且尤其用于治疗肥胖症。

7. 发明申请

WO2006060381A3 N-SUBSTITUTED BENZIMIDAZOLYL C-KIT INHIBITORS AND COMBINATORIAL BENZIMIDAZOLE LIBRARY 审中-公开
标题翻译： N-取代苯并咪唑C-CIT抑制剂和联合苯并咪唑类化合物库
公开(公告)号：WO2006060381A3
公开(公告)日：2006-12-28
申请号：PCT/US2005043114
申请日：2005-11-30
申请人： OSI PHARM INC , CREW ANDREW PHILIP , COX MATTHEW , LAUFER RADOSLAW , SUN YINGCHUAN , PEGG NEIL ANTHONY , SAMBROOK SMITH COLIN PETER , WILKES ROBIN DAVID , WILLIAMS JONATHAN
发明人： CREW ANDREW PHILIP , COX MATTHEW , LAUFER RADOSLAW , SUN YINGCHUAN , PEGG NEIL ANTHONY , SAMBROOK SMITH COLIN PETER , WILKES ROBIN DAVID , WILLIAMS JONATHAN
IPC分类号： C07D235/06 , A61K31/4184 , A61P35/00 , C07D401/12 , C07D403/10 , C07D403/14 , C07D405/10 , C07D409/10 , C07D409/14 , C07D413/10 , C07D417/14 , C40B40/04 , C40B50/14
CPC分类号： C07D235/06 , C07B2200/11 , C07D401/12 , C07D403/10 , C07D403/14 , C07D405/10 , C07D409/10 , C07D409/14 , C07D413/10 , C07D417/14 , C40B40/00
摘要： Compounds represented by Formula (I) or a pharmaceutically acceptable salt or N-oxide thereof act as c-kit inhibitors and are useful in the treatment of tumors. Combinatorial libraries composed of compounds represented by Formula (I) or benzimidazole compounds represented by Formula (II) are useful in providing compounds to assay for such therapeutically useful compounds.
摘要翻译：由式（I）表示的化合物或其药学上可接受的盐或N-氧化物作为c-kit抑制剂，可用于治疗肿瘤。由式（I）表示的化合物或由式（II）表示的苯并咪唑化合物组成的组合文库可用于提供化合物以测定这些治疗有用的化合物。

8. 发明申请

WO2006053342A3 INTEGRIN ANTAGONISTS USEFUL AS ANTICANCER AGENTS 审中-公开
标题翻译：整合拮抗剂有助于作为反应剂
公开(公告)号：WO2006053342A3
公开(公告)日：2006-09-28
申请号：PCT/US2005042048
申请日：2005-11-09
申请人： OSI PHARM INC , BLOXHAM JASON , BORZILLO GARY V , COLLINGTON ERIC WILLIAM , SADIQ SHAZIA , SAMBROOK SMITH COLIN PETER , WALLER CHRIS L , WYNNE GRAHAM M
发明人： BLOXHAM JASON , BORZILLO GARY V , COLLINGTON ERIC WILLIAM , SADIQ SHAZIA , SAMBROOK SMITH COLIN PETER , WALLER CHRIS L , WYNNE GRAHAM M
IPC分类号： C07D235/06 , A61K31/4184 , A61P35/00 , C07D401/04 , C07D401/06 , C07D401/14 , C07D403/12 , C07D405/12 , C07D413/12 , C07D417/12
CPC分类号： C07D235/06 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D417/14 , C07D487/04
摘要： The invention relates to compounds of the Formula (1) and to pharmaceutically acceptable salts and solvates thereof, wherein A, X 2 , X 4 , X 5 and X 1 are as defined herein. The invention also relates to methods of treating abnormal cell growth in mammals by administering the compounds of formula 1 and to pharmaceutical compositions for treating such disorders which contain the compounds of Formula (1). The compounds act as integrin antagonists.
摘要翻译：本发明涉及式（1）的化合物及其药学上可接受的盐和溶剂化物，其中A，X 2，X 4，X 5， SUP>和X 1'如本文所定义。本发明还涉及通过施用式1化合物和用于治疗含有式（1）化合物的这种病症的药物组合物来治疗哺乳动物异常细胞生长的方法。化合物作为整合素拮抗剂。

9. 发明申请

WO0220474A2 RESORCINOL DERIVATIVES 审中-公开
标题翻译：间苯二酚衍生物
公开(公告)号：WO0220474A2
公开(公告)日：2002-03-14
申请号：PCT/IB0101605
申请日：2001-08-31
申请人： PFIZER PROD INC , BRADLEY STUART EDWARD , COLLINGTON ERIC WILLIAM , FYFE MATTHEW COLIN THOR , PROCTER MARTIN JAMES , SAMBROOK SMITH COLIN PETER
发明人： BRADLEY STUART EDWARD , COLLINGTON ERIC WILLIAM , FYFE MATTHEW COLIN THOR , PROCTER MARTIN JAMES , SAMBROOK SMITH COLIN PETER
IPC分类号： A61K8/34 , A61K8/44 , A61K8/46 , A61K8/49 , A61K8/69 , A61K31/17 , A61K31/18 , A61K31/192 , A61K31/195 , A61K31/216 , A61K31/235 , A61K31/277 , A61K31/381 , A61K31/41 , A61K31/4164 , A61K31/422 , A61P17/00 , A61P17/16 , A61P43/00 , A61Q19/02 , C07C311/13 , C07C311/20 , C07C311/29 , C07C311/39 , C07C311/42 , C07C311/43 , C07C311/46 , C07C317/12 , C07C317/14 , C07D233/84 , C07D257/04 , C07D257/10 , C07D333/34 , C07D413/04 , C07C311/00
CPC分类号： C07C311/43 , A61K8/02 , A61K8/0216 , A61K8/347 , A61K8/44 , A61K8/466 , A61K8/49 , A61K8/4933 , A61K8/494 , A61K8/4946 , A61K8/4986 , A61K8/69 , A61K2800/92 , A61Q19/02 , C07C311/13 , C07C311/20 , C07C311/29 , C07C311/39 , C07C311/46 , C07C317/14 , C07C317/46 , C07C2601/14 , C07D233/84 , C07D257/04 , C07D333/34 , C07D413/04
摘要： The present invention relates to resorcinol derivatives of formula I, in which R is a (C3-C8)cycloalkyl ring or a (C5-C8)cycloalkenyl ring substituted by one of -N(R )SO2(CHR )nR and (C1-C6)alkyIN(R )SO2(CHR )nR , wherein R , R and n are as defined in the claims, and their use as skin lightening agents.
摘要翻译：本发明涉及式I的间苯二酚衍生物，其中R为被-N（R 1）SO 2（CHR 1）2 -NH 2（CH 3））nR 2和（C 1 -C 6）烷基（R 1）SO 2（CHR 1）n R 2，其中R 1，R 2和n如权利要求中所定义，且它们用作皮肤美白剂。

10. 发明申请

WO2011117254A1 PIPERIDINE AMIDES AS MODULATORS OF THE GHRELIN RECEPTOR 审中-公开
标题翻译：作为GHRELIN受体的调节剂的哌啶类药物
公开(公告)号：WO2011117254A1
公开(公告)日：2011-09-29
申请号：PCT/EP2011/054374
申请日：2011-03-22
申请人： PROSIDION LIMITED , BLOXHAM, Jason , BRADLEY, Stuart Edward , SAMBROOK-SMITH, Colin Peter , SMYTH, Donald , KEILY, John , DAWSON, Graham John , RASAMISON, Chrystelle Marie , BELL, James Charles
发明人： BLOXHAM, Jason , BRADLEY, Stuart Edward , SAMBROOK-SMITH, Colin Peter , SMYTH, Donald , KEILY, John , DAWSON, Graham John , RASAMISON, Chrystelle Marie , BELL, James Charles
IPC分类号： C07D211/26 , C07D265/30 , C07D401/04 , C07D401/12 , C07D401/14 , C07D407/14 , C07D413/12 , A61K31/4462 , A61K31/4545 , A61P3/10
CPC分类号： C07D401/12 , C07D211/26 , C07D265/30 , C07D401/04 , C07D401/14 , C07D407/14 , C07D413/12
摘要： Compounds of formula (I) or pharmaceutically acceptable salts thereof, are useful for the treatment of diabetes and obesity.
摘要翻译：式（I）化合物或其药学上可接受的盐可用于治疗糖尿病和肥胖症。

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