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1. 发明申请

WO2010104314A3 METHOD FOR PREPARING NON-CRYSTALLINE (+)-LANSOPRAZOLE AND (+)-LANSOPRAZOLE ALCOHOLATE USED IN SAME 审中-公开
标题翻译：制备非晶型（+） - 兰吡唑和（+） - 使用于其中的兰索唑醇的方法
公开(公告)号：WO2010104314A3
公开(公告)日：2010-12-09
申请号：PCT/KR2010001461
申请日：2010-03-09
申请人： HANMI PHARM IND CO LTD , JANG SUN YOUNG , KIM TAI WON , KIM SUNGBUM , KIM BYUNG-KU , JEON JI YOUNG , CHO SEUNG HWAN , KO MYOUNG-SIL , SUH KWEE HYUN , LEE GWAN SUN
发明人： JANG SUN YOUNG , KIM TAI WON , KIM SUNGBUM , KIM BYUNG-KU , JEON JI YOUNG , CHO SEUNG HWAN , KO MYOUNG-SIL , SUH KWEE HYUN , LEE GWAN SUN
IPC分类号： C07D401/12 , C07D411/02
CPC分类号： C07D411/04
摘要： A method for preparing non-crystalline (+)-lansoprazole comprises crystallizing and yielding a (+)-lansoprazole alcoholate from a C1-C3 alcohol solution in which (+)-lansoprazole is dissolved, and drying the (+)-lansoprazole alcoholate at room temperature to a temperature of 50°C. The method prepares chemically, optically, and crystally pure and reproducible non-crystalline (+)-lansoprazole which is useful as a pharmaceutical preparation for treating and preventing diseases associated with gastric acid.
摘要翻译：制备非结晶（+） - 兰索拉唑的方法包括从（+） - 兰索拉唑溶解的C1-C3醇溶液中结晶并产生（+） - 兰索拉唑醇化物，并将（+） - 兰索拉唑醇化物室温至50℃。该方法制备化学，光学和结晶纯的可再现的非结晶（+） - 兰索拉唑，其可用作治疗和预防与胃酸相关的疾病的药物制剂。

2. 发明申请

WO2010068049A3 PROCESS FOR PREPARING (R)-(+)-LANSOPRAZOLE AND INTERMEDIATE USED THEREIN 审中-公开
公开(公告)号：WO2010068049A3
公开(公告)日：2010-06-17
申请号：PCT/KR2009/007389
申请日：2009-12-10
申请人： HANMI PHARM. CO., LTD. , JANG, Sun Young , KIM, Tai Won , KIM, Sungbum , KIM, Byung-ku , CHOI, Chang-Ju , KIM, Cheol Kyung , HA, Tae Hee , SUH, Kwee Hyun , LEE, Gwan Sun
发明人： JANG, Sun Young , KIM, Tai Won , KIM, Sungbum , KIM, Byung-ku , CHOI, Chang-Ju , KIM, Cheol Kyung , HA, Tae Hee , SUH, Kwee Hyun , LEE, Gwan Sun
IPC分类号： C07D403/12 , C07D403/02
摘要： A process for the preparation of (R)-(+)-lansoprazole having a high optical purity and a novel intermediates used therein are provided. The inventive process provides (R)-(+)-lansoprazole having a high optical purity through optical resolution of racemic lansoprazole.

3. 发明申请

WO2010056059A3 NOVEL CRYSTALLINE DEXLANSOPRAZOLE AND PHARMACEUTICAL COMPOSITION COMPRISING SAME 审中-公开
标题翻译：新型结晶异喹诺酮和包含其的药物组合物
公开(公告)号：WO2010056059A3
公开(公告)日：2010-07-29
申请号：PCT/KR2009006678
申请日：2009-11-13
申请人： HANMI PHARM IND CO LTD , JANG SUN YOUNG , KIM TAI WON , KIM SUNGBUM , KIM BYUNG-KU , CHO SOOHWA , HA TAE HEE , SUH KWEE HYUN , LEE GWAN SUN
发明人： JANG SUN YOUNG , KIM TAI WON , KIM SUNGBUM , KIM BYUNG-KU , CHO SOOHWA , HA TAE HEE , SUH KWEE HYUN , LEE GWAN SUN
IPC分类号： C07D401/12
CPC分类号： C07D401/12
摘要： A crystalline (+)-lansoprazole, whose X-ray diffraction spectrum comprises a major peak having a relative intensity of at least 20 % at an interplanar distance (d value) of 17.4 A, is homogeneous, non-hygroscopic, and stable, and a pharmaceutical composition comprising said crystal is effective for treating or preventing gastric acid-related diseases.
摘要翻译：结晶（+） - 兰索拉唑，其X射线衍射光谱包括在面间距离（d值）为17.4A的相对强度为至少20％的主峰，是均匀的，不吸湿的和稳定的，以及包含所述晶体的药物组合物对于治疗或预防胃酸相关疾病是有效的。

4. 发明申请

WO2011002184A2 PHOSPHORIC ACID ESTER OF BICALUTAMIDE FOR TREATING PROSTATE CANCER 审中-公开
标题翻译：用于治疗前列腺癌的贝伐菌胺的磷酸酯
公开(公告)号：WO2011002184A2
公开(公告)日：2011-01-06
申请号：PCT/KR2010004153
申请日：2010-06-25
申请人： HANMI PHARM IND CO LTD , JANG SUN YOUNG , KIM SUNG BUM , KIM BYUNG KU , HEO MIN HOE , KIM EUN YOUNG , SONG TAE HUN , KIM YOUNG HOON , SUH KWEE HYUN , LEE GWAN SUN
发明人： JANG SUN YOUNG , KIM SUNG BUM , KIM BYUNG KU , HEO MIN HOE , KIM EUN YOUNG , SONG TAE HUN , KIM YOUNG HOON , SUH KWEE HYUN , LEE GWAN SUN
IPC分类号： C07F9/09 , A61K31/661 , A61P13/08 , A61P35/00
CPC分类号： C07F9/091
摘要： Provided is a phosphoric acid ester of bicalutamide and a pharmaceutically acceptable salt thereof, and a pharmaceutical composition containing the same as an active ingredient for treating prostate cancer, with which a linear correlation between the systemic exposure to bicalutamide and the dosage level can be achievable, making it possible to increase the bioavailability of bicalutamide upon oral administration at a high dosage level.
摘要翻译：提供了比卡鲁胺及其药学上可接受的盐的磷酸酯以及含有该磷酸酯作为治疗前列腺癌的活性成分的药物组合物，可以实现全身暴露于比卡鲁胺与剂量水平之间的线性相关性，使得可以在高剂量水平下口服给药时提高比卡鲁胺的生物利用度。

5. 发明申请

WO2011002184A3 PHOSPHORIC ACID ESTER OF BICALUTAMIDE FOR TREATING PROSTATE CANCER 审中-公开
公开(公告)号：WO2011002184A3
公开(公告)日：2011-01-06
申请号：PCT/KR2010/004153
申请日：2010-06-25
申请人： HANMI PHARM. CO., LTD. , JANG, Sun Young , KIM, Sung Bum , KIM, Byung Ku , HEO, Min Hoe , KIM, Eun Young , SONG, Tae Hun , KIM, Young Hoon , SUH, Kwee Hyun , LEE, Gwan Sun
发明人： JANG, Sun Young , KIM, Sung Bum , KIM, Byung Ku , HEO, Min Hoe , KIM, Eun Young , SONG, Tae Hun , KIM, Young Hoon , SUH, Kwee Hyun , LEE, Gwan Sun
IPC分类号： C07F9/09 , A61K31/661 , A61P13/08 , A61P35/00
摘要： Provided is a phosphoric acid ester of bicalutamide and a pharmaceutically acceptable salt thereof, and a pharmaceutical composition containing the same as an active ingredient for treating prostate cancer, with which a linear correlation between the systemic exposure to bicalutamide and the dosage level can be achievable, making it possible to increase the bioavailability of bicalutamide upon oral administration at a high dosage level.

6. 发明申请

WO2010068049A2 PROCESS FOR PREPARING (R)-(+)-LANSOPRAZOLE AND INTERMEDIATE USED THEREIN 审中-公开
标题翻译：制备（R） - （+） - 兰索拉唑及其中间体的方法
公开(公告)号：WO2010068049A2
公开(公告)日：2010-06-17
申请号：PCT/KR2009007389
申请日：2009-12-10
申请人： HANMI PHARM IND CO LTD , JANG SUN YOUNG , KIM TAI WON , KIM SUNGBUM , KIM BYUNG-KU , CHOI CHANG-JU , KIM CHEOL KYUNG , HA TAE HEE , SUH KWEE HYUN , LEE GWAN SUN
发明人： JANG SUN YOUNG , KIM TAI WON , KIM SUNGBUM , KIM BYUNG-KU , CHOI CHANG-JU , KIM CHEOL KYUNG , HA TAE HEE , SUH KWEE HYUN , LEE GWAN SUN
IPC分类号： C07D403/12 , C07D403/02
CPC分类号： C07D401/12
摘要： A process for the preparation of (R)-(+)-lansoprazole having a high optical purity and a novel intermediates used therein are provided. The inventive process provides (R)-(+)-lansoprazole having a high optical purity through optical resolution of racemic lansoprazole.
摘要翻译：提供了制备具有高光学纯度的（R） - （+） - 兰索拉唑和其中使用的新型中间体的方法。本发明方法提供了通过旋光拆分外消旋兰索拉唑而具有高光学纯度的（R） - （+） - 兰索拉唑。

7. 发明申请

WO2010056059A2 NOVEL CRYSTALLINE DEXLANSOPRAZOLE AND PHARMACEUTICAL COMPOSITION COMPRISING SAME 审中-公开
标题翻译：新型结晶性地塞米松和包含它的药物组合物
公开(公告)号：WO2010056059A2
公开(公告)日：2010-05-20
申请号：PCT/KR2009/006678
申请日：2009-11-13
申请人： HANMI PHARM. CO., LTD. , JANG, Sun Young , KIM, Tai Won , KIM, Sungbum , KIM, Byung-Ku , CHO, Soohwa , HA, Tae Hee , SUH, Kwee Hyun , LEE, Gwan Sun
发明人： JANG, Sun Young , KIM, Tai Won , KIM, Sungbum , KIM, Byung-Ku , CHO, Soohwa , HA, Tae Hee , SUH, Kwee Hyun , LEE, Gwan Sun
IPC分类号： C07D401/12
CPC分类号： C07D401/12
摘要： A crystalline (+)-lansoprazole, whose X-ray diffraction spectrum comprises a major peak having a relative intensity of at least 20 % at an interplanar distance (d value) of 17.4 A, is homogeneous, non-hygroscopic, and stable, and a pharmaceutical composition comprising said crystal is effective for treating or preventing gastric acid-related diseases.
摘要翻译：结晶（+） - 兰索拉唑的X射线衍射光谱包括在17.4A的晶面间距离（d值）处具有至少20％的相对强度的主峰是均匀的，非吸湿性且稳定的，并且包含所述晶体的药物组合物对于治疗或预防胃酸相关疾病是有效的。

8. 发明公开

KR20100117182A Fruit protective packing vessel 审中-公开
标题翻译：水果保护包装船
公开(公告)号：KR20100117182A
公开(公告)日：2010-11-03
申请号：KR20090035793
申请日：2009-04-24
申请人： KIM BYUNG KU
发明人： KIM BYUNG KU
IPC分类号： B65D85/34 , B65D81/03 , B65D81/127 , B65D81/133
CPC分类号： B65D85/34 , B65D5/2033 , B65D81/03 , B65D81/133
摘要： PURPOSE: A fruit protection packing container is provided to enable a packed state to be very stable, thereby improving the value of the product with more graceful and perfect package. CONSTITUTION: A fruit protection packing container formed a semi circle shape fruit placing body(100) which upper side is opened and lower side is inserted to settled the fruit directly by using synthetic resin foam. A capture side(200) which covers the outer surface of the fruit and its center part is up-curved to protrude convexly and is extended to a plurality of number in petal shape is formed. The upward cured surface of the capture side extends the fruit placing body to the lower part of the inside surface. The extension part is comprised as a convex extension unit(210) which is popped up convexly to the inside more than inner surface of the fruit placing body.
摘要翻译：目的：提供水果保护包装容器，使包装状态非常稳定，从而以更优雅，完美的包装提高产品的价值。构成：水果保护包装容器形成半圆形水果放置体（100），其上侧开放，下侧插入以通过合成树脂泡沫直接使水果沉降。覆盖果实外表面的捕获侧（200）及其中心部分被上下弯曲成突出地突出并延伸至花瓣状的多个数。捕获侧的向上固化的表面将水果放置体延伸到内表面的下部。延伸部分包括作为凸出的延伸单元（210），该凸出的延伸单元比果实放置体的内表面凸出地突出到内部。

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