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1. 发明申请

US20040134248A1 Hydratable form of keratin for use as a soil amendment 审中-公开
标题翻译：角质的可水合形式用作土壤修复
公开(公告)号：US20040134248A1
公开(公告)日：2004-07-15
申请号：US10715337
申请日：2003-11-17
申请人： Southwest Research Institute , Keraplast Technologies, Ltd.
发明人： Robert Allen Smith , Scott F. Timmons , Mark E. Van Dyke , Cheryl R. Blanchard , Arlene J. Siller-Jackson
IPC分类号： C05F001/00
CPC分类号： C09K17/32 , C05F1/005 , C05F1/007 , C05F11/08 , Y02A40/201 , Y02A40/203 , Y02E50/343 , Y02P20/145 , Y02W30/47 , Y10S106/90 , Y10S530/842
摘要： A hydratable oxidized keratin composition comprising one or more metal ion species capable of absorbing water to form a hydrogel. The keratin material is useful as a soil amendment providing organic and inorganic nutrients. The keratin material is also useful as a nutrient source in the bioremediation of toxic contaminants soils and liquids.
摘要翻译：一种可水合的氧化角蛋白组合物，其包含一种或多种能够吸收水以形成水凝胶的金属离子种类。角蛋白材料可用作提供有机和无机营养物质的土壤修复。角蛋白材料也可用作生物修复有毒污染物土壤和液体的营养源。

2. 发明申请

US20040076599A1 Keratin-based powders and hydrogel for pharmaceutical applications 审中-公开
标题翻译：用于制药应用的角蛋白基粉末和水凝胶
公开(公告)号：US20040076599A1
公开(公告)日：2004-04-22
申请号：US10409018
申请日：2003-04-08
申请人： Southwest Research Institute , Keraplast Technologies, Ltd.
发明人： Arlene J. Siller-Jackson , Mark E. Van Dyke , Scott F. Timmons , Cheryl R. Blanchard , Robert A. Smith
IPC分类号： A61K007/06 , A61K007/11 , C07K014/78
CPC分类号： A61K8/042 , A61F2013/530481 , A61F2013/530613 , A61K8/65 , A61K9/0024 , A61K9/06 , A61K9/146 , A61K9/2063 , A61K9/7007 , A61K38/015 , A61K38/17 , A61K47/42 , A61K47/6953 , A61L15/32 , A61L15/60 , A61L27/227 , A61L27/52 , A61Q19/00
摘要： A hydratable, highly absorbent keratin solid fiber or powder capable of absorbing a large weight excess of water may be produced by partially oxidizing hair keratin disulfide bonds to sulfonic acid residues and reacting the sulfonic acid residues with a cation. The neutralized suspension can be filtered, washed, and dried, leaving keratin solid which can be shredded into fibers and further ground into powder. Addition of water to the solid produces a hydrogel. The powder or hydrogel may be useful as an absorbent material, as a therapeutic for skin, or as an excipient. The keratin materials can be incorporated into nonwoven films. The hydrogel can be used as a biocompatible viscoelastic filler for implant applications. Another use for the absorbent keratin and keratin hydrogel is as an excipient in pharmaceutical and cosmetic applications.
摘要翻译：可以通过将头发角蛋白二硫键部分氧化成磺酸残基并使磺酸残基与阳离子反应来制备能够吸收大量过量水分的可水合的高吸收性角蛋白固体纤维或粉末。中和的悬浮液可以过滤，洗涤和干燥，留下角蛋白固体，将其切成纤维并进一步研磨成粉末。向固体中加入水产生水凝胶。粉末或水凝胶可用作吸收材料，作为皮肤的治疗剂或赋形剂。角蛋白材料可以并入无纺膜中。水凝胶可用作植入物应用的生物相容性粘弹性填料。吸收性角蛋白和角蛋白水凝胶的另一用途是作为药物和化妆品应用中的赋形剂。

3. 发明申请

US20040082717A1 Keratin-silicone copolymers and interpenetrating networks (IPN's), methods of production and methods of use thereof 审中-公开
标题翻译：角蛋白 - 硅氧烷共聚物和互穿网络（IPN），生产方法及其使用方法
公开(公告)号：US20040082717A1
公开(公告)日：2004-04-29
申请号：US10606279
申请日：2003-06-24
申请人： Southwest Research Institute , Keraplast Technologies, Ltd.
发明人： Mark E. Van Dyke , Cheryl R. Blanchard , Robert A. Smith
IPC分类号： C08H001/00
CPC分类号： C08G77/42 , C07K14/4741 , C07K2319/00 , C08H1/04 , G02B1/043 , C08L83/10
摘要： Materials comprising proteinaceous prepolymers comprising at least one first reactive group reacted with one or more reactive groups on synthetic prepolymers, and methods of making and using same.
摘要翻译：包含至少一种与合成预聚物上的一个或多个反应性基团反应的第一反应性基团的蛋白质预聚物的材料，及其制备和使用方法。

4. 发明申请

US20010032019A1 Implantable prosthetic or tissue expanding device 有权
标题翻译：植入假体或组织扩张装置
公开(公告)号：US20010032019A1
公开(公告)日：2001-10-18
申请号：US09802113
申请日：2001-03-08
申请人： Southwest Research Institute and Keraplast technol
发明人： Mark E. Van Dyke , Cheryl R. Blanchard , Scott F. Timmons , Arlene J. Siller-Jackson , Robert A. Smith
IPC分类号： A61F002/44
CPC分类号： A61L27/52 , A61F2/0059 , A61F2/12 , A61F2/441 , A61F2002/30971 , A61L27/227 , A61L27/306 , A61L27/34 , A61L2430/04 , A61L2430/38 , A61L27/38 , C08L83/04
摘要： A keratin hydrogel-filled implantable prosthetic device. One device is a breast implant for augmenting or reconstructing a human breast including an envelope containing a keratin hydrogel. One keratin hydrogel is formed from a solid precursor which forms a keratin hydrogel upon addition of water. One source of keratin is human hair. In one method, an envelope suitable for implantation and a solid keratin hydrogel precursor are provided. The solid can be in fibrous or powder form. The solid precursor can be inserted into the envelope interior. A small incision near the breast can be made and the envelope inserted into the incision. After insertion, water can be injected into the envelope interior, preferably through the incision and through a self-sealing port in the envelope. In one method, the implant is provided as a kit, with the envelope and keratin hydrogel provided. The hydrogel can be injected into the envelope either before or after insertion into the breast area. One kit has a powdered, keratin hydrogel precursor disposed within the envelope interior, awaiting the addition of water, preferably after insertion of the implant into the body.
摘要翻译：角蛋白水凝胶填充的可植入假体装置。一种装置是用于增强或重建人乳房的乳房植入物，其包括含有角蛋白水凝胶的包膜。一种角蛋白水凝胶由固体前体形成，其在加入水时形成角蛋白水凝胶。角蛋白的一个来源是人的头发。在一种方法中，提供适于植入的包膜和固体角蛋白水凝胶前体。固体可以是纤维或粉末形式。固体前体可以插入信封内部。乳房附近有一个小切口，信封插入切口。插入后，水可以注入信封内部，优选通过切口并通过信封中的自密封端口注入。在一种方法中，植入物作为试剂盒提供，其中提供了包膜和角蛋白水凝胶。在插入乳房区域之前或之后，可以将水凝胶注入到信封中。一个试剂盒具有设置在信封内部的粉末状角蛋白水凝胶前体，等待加入水，优选在将植入物插入体内之后。

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