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    • 5. 发明申请
    • BATCH QUANTITY DIALYSATE CHEMICAL FORMULATIONS
    • 批量拨号化学制剂
    • WO1998010745A1
    • 1998-03-19
    • PCT/US1997014094
    • 1997-08-12
    • AKSYS, LTD.SHAH, Dilip, H.KENLEY, Rodney, S.
    • AKSYS, LTD.
    • A61K09/00
    • A61K33/14A61M1/1654A61M1/1666A61K2300/00
    • The present invention constitutes batch quantity dialysate formulations that are suitable for use in preparing a batch quantity of dialysate solution. The dialysate chemical formulations for one batch of dialysate comprise a liquid acid concentrate unit stored in a first vessel, and a dry bicarbonate unit stored in a second vessel. The contents of the first and second vessels are emptied into a dialysate preparation tank and mixed with water to form a batch quantity of dialysate solution. In a preferred embodiment, the liquid acid concentrate comprises (a) about 79.244-158.489 g/L of sodium chloride; (b) between about 0 and about 40.441 g/L of potassium chloride; (c) about 34.888 g/L of calcium chloride dihydrate; (d) between about 6.893 and about 20.680 g/L magnesium chloride hexahydrate; (e) about 339.00 g of dextrose; (f) about 36.643 g/L of acetic acid; and (g) water in sufficient amount to bring up to about 290-440 mL final volume. In a preferred embodiment, the dry bicarbonate unit contains between about 271.6 and about 358.4 g of sodium chloride; and between about 143.5-204.7 g of sodium bicarbonate.
    • 本发明构成适用于制备批量的透析液的批量透析液制剂。 用于一批透析液的透析液化学制剂包含存储在第一容器中的液体酸浓缩物单元和存储在第二容器中的干碳酸氢盐单元。 将第一和第二容器的内容物倒入透析液制备罐中并与水混合以形成一批量的透析液。 在优选的实施方案中,液体酸浓缩物包含(a)约79.244-158.489g / L氯化钠; (b)约0至约40.441g / L的氯化钾; (c)约34.888g / L的氯化钙二水合物; (d)约6.893至约20.680g / L氯化镁六水合物; (e)约339.00g葡萄糖; (f)约36.643g / L乙酸; 和(g)足够量的水以达到约290-440mL的最终体积。 在优选的实施方案中,干重碳酸氢盐单元含有约271.6-约358.4g氯化钠; 和约143.5-204.7g碳酸氢钠之间。