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1. 发明申请

WO2012122095A2 LED LUMINAIRE 审中-公开
公开(公告)号：WO2012122095A2
公开(公告)日：2012-09-13
申请号：PCT/US2012/027712
申请日：2012-03-05
申请人： LIGHTING SCIENCE GROUP CORPORATION , BOOMGAARDEN, Mark Penley , SULLIVAN, Shane , KELLEY, Ryan Chase , HENDERSON, David
发明人： BOOMGAARDEN, Mark Penley , SULLIVAN, Shane , KELLEY, Ryan Chase , HENDERSON, David
IPC分类号： F21V17/00 , F21V29/00 , F21V5/04
CPC分类号： F21V3/02 , F21K9/23 , F21K9/60 , F21V7/041 , F21V29/773 , F21V29/83 , F21Y2103/33 , F21Y2115/10
摘要： Disclosed is a luminaire including an electrical base, a driver circuit in electrical communication with the electrical base, a heat sink operably coupled to the electrical base, a lens coupled to the heat sink and having a first portion adjacent the heat sink and a second portion adjacent the first portion, the first portion having at least one aperture disposed therein or therethrough, the at least one aperture having a different optical transmission property from the first portion in which the at least one aperture is disposed, a reflective member between the second portion and the heat sink, and an LED light source between the reflective member and the heat sink, the LED having at least one LED member between the reflective member and the first portion to emit light towards the reflective member, each LED member being disposed in electrical communication with the driver circuit.
摘要翻译：公开了一种照明装置，其包括电气基座，与电气基座电气连通的驱动电路，可操作地耦合到电气基座的散热器，耦合到散热器的透镜，并具有与散热器相邻的第一部分和第二部分邻近第一部分，第一部分具有设置在其中或穿过其中的至少一个孔，所述至少一个孔具有与设置有至少一个孔的第一部分不同的光学透射性质;第二部分之间的反射构件和散热器，以及在反射构件和散热器之间的LED光源，LED在反射构件和第一部分之间具有至少一个LED构件，以朝向反射构件发射光，每个LED构件设置在电气与驱动电路通讯。

2. 发明申请

WO2006033004A1 QUINOLINE COMPOUNDS AS CETP INHIBITORS 审中-公开
标题翻译：喹啉化合物作为CETP抑制剂
公开(公告)号：WO2006033004A1
公开(公告)日：2006-03-30
申请号：PCT/IB2005/002890
申请日：2005-09-12
申请人： PFIZER PRODUCTS INC. , DIDIUK, Mary, Theresa , KELLEY, Ryan, Michael , PERRY, David, Austen , RUGGERI, Roger, Benjamin
发明人： DIDIUK, Mary, Theresa , KELLEY, Ryan, Michael , PERRY, David, Austen , RUGGERI, Roger, Benjamin
IPC分类号： C07D215/12 , A61K31/47 , A61P9/10
CPC分类号： C07D215/12
摘要： Quinoline compounds, pharmaceutical compositions containing such compounds and the use of such compounds to elevate certain plasma lipid levels, including high density lipoprotein-cholesterol and to lower certain other plasma lipid levels, such as LDL-cholesterol and triglycerides and accordingly to treat diseases which are exacerbated by low levels of HDL cholesterol and/or high levels of LDLcholesterol and triglycerides, such as atherosclerosis and cardiovascular diseases in some mammals, including humans.
摘要翻译：喹啉化合物，含有这些化合物的药物组合物以及使用这些化合物来提高某些血浆脂质水平，包括高密度脂蛋白胆固醇和降低某些其他血浆脂质水平，如低密度脂蛋白胆固醇和甘油三酸酯，从而治疗疾病，由于低水平的HDL胆固醇和/或高水平的LDL胆固醇和甘油三酸酯（例如一些哺乳动物，包括人类）的动脉粥样硬化和心血管疾病而加剧。

3. 发明申请

WO2018089199A1 OXAZOLE DERIVATIVES FOR USE AS IRAK INHIBITORS AND METHOD FOR THEIR PREPARATION 审中-公开
标题翻译：用作IRAK抑制剂的恶唑衍生物及其制备方法
公开(公告)号：WO2018089199A1
公开(公告)日：2018-05-17
申请号：PCT/US2017/058339
申请日：2017-10-25
申请人： RIGEL PHARMACEUTICALS, INC. , LI, Hui , HECKRODT, Thilo , CHEN, Yan , KELLEY, Ryan , MCMURTRIE, Darren , TSO, Kin , TAYLOR, Vanessa , SINGH, Rajinder , YEN, Rose , MAUNG, Jack
发明人： LI, Hui , HECKRODT, Thilo , CHEN, Yan , KELLEY, Ryan , MCMURTRIE, Darren , TSO, Kin , TAYLOR, Vanessa , SINGH, Rajinder , YEN, Rose , MAUNG, Jack
IPC分类号： C07D413/14 , A61P29/00 , A61K31/422
摘要： Disclosed embodiments concern interleukin receptor associated kinases (IRAK) inhibitors, which are oxazole compounds of formula 1, and compositions comprising such inhibitors. Also disclosed are methods of making and using the compounds and compositions. The disclosed compounds and/or compositions may be used to treat or prevent an IRAK-associated disease or condition.
摘要翻译：所公开的实施方案涉及作为式1的恶唑化合物的白细胞介素受体相关激酶（IRAK）抑制剂，以及包含这种抑制剂的组合物。还公开了制备和使用该化合物和组合物的方法。公开的化合物和/或组合物可以用于治疗或预防IRAK相关的疾病或病症。

4. 发明申请

WO2012122095A3 LED LUMINAIRE 审中-公开
公开(公告)号：WO2012122095A3
公开(公告)日：2012-11-29
申请号：PCT/US2012027712
申请日：2012-03-05
申请人： LIGHTING SCIENCE GROUP CORP , BOOMGAARDEN MARK PENLEY , SULLIVAN SHANE , KELLEY RYAN CHASE , HENDERSON DAVID
发明人： BOOMGAARDEN MARK PENLEY , SULLIVAN SHANE , KELLEY RYAN CHASE , HENDERSON DAVID
IPC分类号： F21V17/00 , F21V5/04 , F21V29/00
CPC分类号： F21V3/02 , F21K9/23 , F21K9/60 , F21V7/041 , F21V29/2212 , F21V29/773 , F21V29/83 , F21Y2103/33 , F21Y2115/10
摘要： Disclosed is a luminaire including an electrical base, a driver circuit in electrical communication with the electrical base, a heat sink operably coupled to the electrical base, a lens coupled to the heat sink and having a first portion adjacent the heat sink and a second portion adjacent the first portion, the first portion having at least one aperture disposed therein or therethrough, the at least one aperture having a different optical transmission property from the first portion in which the at least one aperture is disposed, a reflective member between the second portion and the heat sink, and an LED light source between the reflective member and the heat sink, the LED having at least one LED member between the reflective member and the first portion to emit light towards the reflective member, each LED member being disposed in electrical communication with the driver circuit.
摘要翻译：公开了一种照明器，其包括电基座，与电基座电连通的驱动器电路，可操作地耦合到电基座的散热器，耦合到散热器的透镜，并具有邻近散热器的第一部分和第二部分与所述第一部分相邻，所述第一部分具有设置在其中或穿过其中的至少一个孔，所述至少一个孔与所述至少一个孔设置于其中的所述第一部分具有不同的光传输特性，在所述第二部分和散热器，以及位于反射构件和散热器之间的LED光源，所述LED具有位于所述反射构件和所述第一部分之间的至少一个LED构件，以朝向所述反射构件发射光，每个LED构件被设置为电与驱动电路通信。

5. 发明申请

WO2010117409A1 REFLECTOR SYSTEM FOR LIGHTING DEVICE 审中-公开
标题翻译：照明装置的反射器系统
公开(公告)号：WO2010117409A1
公开(公告)日：2010-10-14
申请号：PCT/US2010/000817
申请日：2010-03-19
申请人： CREE LED LIGHTING SOLUTIONS, INC. , PICKARD, Paul, Kenneth , KELLEY, Ryan
发明人： PICKARD, Paul, Kenneth , KELLEY, Ryan
IPC分类号： F21V7/00 , F21K99/00
CPC分类号： F21V13/08 , F21K9/233 , F21K9/60 , F21V3/02 , F21V7/0033 , F21V9/08 , F21Y2113/13 , F21Y2115/10
摘要： A reflector system for a lighting device. The system uses two reflective surfaces to redirect the light before it is emitted. The light source/sources (102) are disposed at the base of a secondary reflector (106). The first reflective surface is provided by a primary reflector (104) which is arranged proximate to the source/sources. The primary reflector (104) initially redirects, and in some cases diffuses, light from the sources such that the different wavelengths of light are mixed as they are redirected toward the secondary reflector (106). The secondary reflector functions primarily to shape the light into a desired output beam. The primary and secondary reflectors may be specular or diffuse and may comprise faceted surfaces. The reflector arrangement allows the source to be placed at the base of the secondary reflector where it may be thermally coupled to a housing or another structure to provide an outlet for heat generated by the sources.
摘要翻译：一种用于照明装置的反射器系统。该系统使用两个反射表面来重新定向发光前的光。光源/源（102）设置在次级反射器（106）的基部。第一反射表面由靠近源/源设置的主反射器（104）提供。主反射器（104）最初重定向并且在某些情况下扩散来自光源的光，使得不同波长的光在被重定向到次级反射器（106）时被混合。次级反射器主要用于将光成形为期望的输出光束。初级和次级反射器可以是镜面的或漫射的，并且可以包括刻面。反射器布置允许源放置在次级反射器的基座处，其中它可以热耦合到壳体或另一结构以提供由源产生的热量的出口。

6. 发明申请

WO2010003133A2 CDK MODULATORS 审中-公开
标题翻译： CDK调制器
公开(公告)号：WO2010003133A2
公开(公告)日：2010-01-07
申请号：PCT/US2009/049637
申请日：2009-07-02
申请人： EXELIXIS INC. , BAHCECI, Suleyman , CHAN, Bryan , CHAN, Diva, Sze-ming , CHEN, Jeff , FORSYTH, Timothy, Patrick , FRANZINI, Maurizio , JAMMALAMADAKA, Vasu , JEONG, Joon, Won , JONES, Lisa, Renee , KELLEY, Ryan, Michael , KIM, Moon, Hwan , LEAHY, James, W. , MAC, Morrison, B. , NOGUCHI, Robin, Tammie , RAO, Pallavi , RIDGWAY, Brian, Hugh , XU, Wei , WANG, Yong
发明人： BAHCECI, Suleyman , CHAN, Bryan , CHAN, Diva, Sze-ming , CHEN, Jeff , FORSYTH, Timothy, Patrick , FRANZINI, Maurizio , JAMMALAMADAKA, Vasu , JEONG, Joon, Won , JONES, Lisa, Renee , KELLEY, Ryan, Michael , KIM, Moon, Hwan , LEAHY, James, W. , MAC, Morrison, B. , NOGUCHI, Robin, Tammie , RAO, Pallavi , RIDGWAY, Brian, Hugh , XU, Wei , WANG, Yong
IPC分类号： A61K31/437
CPC分类号： C07D487/04 , C07D471/04 , C07D519/00
摘要： A compound according to Formula I : or a pharmaceutically-acceptable salt thereof, wherein R1, R3, A, B and D are as defined in the specification; pharmaceutical compositions thereof, and methods of use thereof.
摘要翻译：根据式I的化合物或其药学上可接受的盐，其中R 1，R 3，A，B和D如说明书中所定义; 其药物组合物及其使用方法。

7. 发明申请

WO2004085401A8 1,2,4-SUBSTITUTED 1,2,3,4-TETRAHYDRO-AND 1,2 DIHYDRO-QUINOLINE AND 1,2,3,4-TETRAHYDRO-QUINOXALINE DERIVATIVES AS CETP INHIBITORS FOR THE TREATMENT OF ATHEROSCLEROSIS AND OBESITY 审中-公开
标题翻译： 1,2,4-取代的1,2,3,4-四氢-1,2,2-二氢喹啉和1,2,3,4-四氢喹啉衍生物作为CETP抑制剂治疗角膜内皮细胞病和肥胖症
公开(公告)号：WO2004085401A8
公开(公告)日：2005-12-01
申请号：PCT/IB2004000836
申请日：2004-03-15
申请人： PFIZER PROD INC , CHANG GEORGE , DIDIUK MARY THERESA , FINNEMAN JARI ILMARI , GARIGIPATI RAVI SHANKER , KELLEY RYAN MICHAEL , PERRY DAVID AUSTEN , RUGGERI ROGER BENJAMIN , BECHLE BRUCE MICHAEL , POLLASTRI MICHAEL P
发明人： CHANG GEORGE , DIDIUK MARY THERESA , FINNEMAN JARI ILMARI , GARIGIPATI RAVI SHANKER , KELLEY RYAN MICHAEL , PERRY DAVID AUSTEN , RUGGERI ROGER BENJAMIN , BECHLE BRUCE MICHAEL , POLLASTRI MICHAEL P
IPC分类号： C07D215/12 , C07D215/14 , C07D241/42 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/06 , C07D403/10 , C07D405/06 , C07D405/12 , C07D409/06 , C07D409/12 , C07D413/06 , C07D413/10 , C07D413/12 , C07D417/06 , C07D417/12 , C07D417/14 , C07D471/04 , C07D495/04 , C07D215/50
CPC分类号： C07D401/04 , C07D215/12 , C07D215/14 , C07D241/42 , C07D401/06 , C07D401/12 , C07D403/06 , C07D403/10 , C07D405/06 , C07D405/12 , C07D409/06 , C07D409/12 , C07D413/06 , C07D413/10 , C07D413/12 , C07D417/06 , C07D417/12 , C07D417/14 , C07D471/04 , C07D495/04
摘要： Quinoline and quinoxaline compounds of formula I and III wherein the subtituent are as defined in claims 1 and 15, pharmaceutical compositions containing such compounds and the use of such compounds to elevate certain plasma lipid levels, including high density lipoprotein-cholesterol and to lower certain other plasma lipid levels, such as LDL-cholesterol and triglycerides and accordingly to treat diseases which are exacerbated by low levels of HDL cholesterol and/or high levels of LDL-cholesterol and triglycerides, such as atherosclerosis and cardiovascular diseases in some mammals, including humans.
摘要翻译：式I和III的喹啉和喹喔啉化合物，其中取代基如权利要求1和15中所定义，含有这些化合物的药物组合物和使用这些化合物提高某些血浆脂质水平，包括高密度脂蛋白胆固醇和降低某些其他血浆脂质水平，如低密度脂蛋白胆固醇和甘油三酸酯，并因此治疗由低水平的HDL胆固醇和/或高水平的低密度脂蛋白胆固醇和甘油三酯加重的疾病，例如一些哺乳动物，包括人类的动脉粥样硬化和心血管疾病。

8. 发明申请

WO2010003133A3 CDK MODULATORS 审中-公开
标题翻译： CDK调制器
公开(公告)号：WO2010003133A3
公开(公告)日：2010-03-18
申请号：PCT/US2009049637
申请日：2009-07-02
申请人： EXELIXIS INC , BAHCECI SULEYMAN , CHAN BRYAN , CHAN DIVA SZE-MING , CHEN JEFF , FORSYTH TIMOTHY PATRICK , FRANZINI MAURIZIO , JAMMALAMADAKA VASU , JEONG JOON WON , JONES LISA RENEE , KELLEY RYAN MICHAEL , KIM MOON HWAN , LEAHY JAMES W , MAC MORRISON B , NOGUCHI ROBIN TAMMIE , RAO PALLAVI , RIDGWAY BRIAN HUGH , XU WEI , WANG YONG
发明人： BAHCECI SULEYMAN , CHAN BRYAN , CHAN DIVA SZE-MING , CHEN JEFF , FORSYTH TIMOTHY PATRICK , FRANZINI MAURIZIO , JAMMALAMADAKA VASU , JEONG JOON WON , JONES LISA RENEE , KELLEY RYAN MICHAEL , KIM MOON HWAN , LEAHY JAMES W , MAC MORRISON B , NOGUCHI ROBIN TAMMIE , RAO PALLAVI , RIDGWAY BRIAN HUGH , XU WEI , WANG YONG
IPC分类号： A61K31/437 , A61K31/506 , A61K31/519 , A61K31/5377 , A61K31/5383 , A61K31/55 , A61P35/00 , C07D471/04 , C07D487/04 , C07D487/10 , C07D491/107 , C07D498/04 , C07D498/14
CPC分类号： C07D487/04 , C07D471/04 , C07D519/00
摘要： A compound according to Formula I : or a pharmaceutically-acceptable salt thereof, wherein R1, R3, A, B and D are as defined in the specification; pharmaceutical compositions thereof, and methods of use thereof.
摘要翻译：根据式I的化合物或其药学上可接受的盐，其中R1，R3，A，B和D如说明书中所定义; 其药物组合物及其使用方法。

9. 发明申请

WO2004085401A1 1,2,4-SUBSTITUERTE 1,2,3,4-TETRAHYDRO-AND 1,2 DIHYDRO-QUINOLINE AND 1,2,3,4-TETRAHYDRO-QUINOXALINE DERIVATIVES AS CETP INHIBITORS FOR THE TREATMENT OF ATHEROSCLEROSIS AND OBESITY 审中-公开
标题翻译： 1,2,4代替1,2,3,4-四氢 - 1,2二氢喹啉和1,2,3,4-四氢喹啉衍生物作为CETP抑制剂治疗角膜内皮瘤和肥胖
公开(公告)号：WO2004085401A1
公开(公告)日：2004-10-07
申请号：PCT/IB2004/000836
申请日：2004-03-15
申请人： PFIZER PRODUCTS INC. , CHANG, George , DIDIUK, Mary, Theresa , FINNEMAN, Jari, Ilmari , GARIGIPATI, Ravi, Shanker , KELLEY, Ryan, Michael , PERRY, David, Austen , RUGGERI, Roger, Benjamin , BECHLE, Bruce, Michael
发明人： CHANG, George , DIDIUK, Mary, Theresa , FINNEMAN, Jari, Ilmari , GARIGIPATI, Ravi, Shanker , KELLEY, Ryan, Michael , PERRY, David, Austen , RUGGERI, Roger, Benjamin , BECHLE, Bruce, Michael
IPC分类号： C07D215/14
CPC分类号： C07D401/04 , C07D215/12 , C07D215/14 , C07D241/42 , C07D401/06 , C07D401/12 , C07D403/06 , C07D403/10 , C07D405/06 , C07D405/12 , C07D409/06 , C07D409/12 , C07D413/06 , C07D413/10 , C07D413/12 , C07D417/06 , C07D417/12 , C07D417/14 , C07D471/04 , C07D495/04
摘要： Quinoline and quinoxaline compounds of formula I and III wherein the subtituent are as defined in claims 1 and 15, pharmaceutical compositions containing such compounds and the use of such compounds to elevate certain plasma lipid levels, including high density lipoprotein-cholesterol and to lower certain other plasma lipid levels, such as LDL-cholesterol and triglycerides and accordingly to treat diseases which are exacerbated by low levels of HDL cholesterol and/or high levels of LDL-cholesterol and triglycerides, such as atherosclerosis and cardiovascular diseases in some mammals, including humans.
摘要翻译：式I和III的喹啉和喹喔啉化合物，其中取代基如权利要求1和15中所定义，含有这些化合物的药物组合物和使用这些化合物提高某些血浆脂质水平，包括高密度脂蛋白胆固醇和降低某些其他血浆脂质水平，如低密度脂蛋白胆固醇和甘油三酸酯，并因此治疗由低水平的HDL胆固醇和/或高水平的低密度脂蛋白胆固醇和甘油三酯加重的疾病，例如一些哺乳动物，包括人类的动脉粥样硬化和心血管疾病。

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