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1. 发明专利

JP2002132952A METHOD AND SYSTEM FOR MANAGING CHRONIC DISEASE AND WELLNESS ONLINE 失效
公开(公告)号：JP2002132952A
公开(公告)日：2002-05-10
申请号：JP2001134499
申请日：2001-05-01
申请人： CHAN BRYAN K , CHU LAWRENCE F
发明人： CHAN BRYAN K , CHU LAWRENCE F
IPC分类号： G06F19/00 , G06Q50/22 , G06F17/60
摘要： PROBLEM TO BE SOLVED: To provide a health management system for facilitating and improving the management of chronic disease and health maintenance and discriminating and preventing health deterioration. SOLUTION: These method and system for managing a multiple domain health program using a terminal device arranged remotely, a software agent and participant information that is related to a definable access level and accumulated remotely. The system called as an intelligent health management technology(IHMT) system provides assistance about the management of the chronic disease, together with the multi-domain health program. The system collects personal health information and medical treatment records, also analyzes the information and simulates medical treatment decision-making process, and the medical treatment decision-making process is based on specific logic in relation to a general medical treatment decision principles, a common-sense principles and a specific IHMT module. As a result, a specified advice is provided, and advice generated from a computer and an input from third party (namely, physicians, dieticians, pharmacists, etc.), are included.

2. 发明公开

EP1174816A2 Method and system for managing chronic disease and wellness online 审中-公开
标题翻译：方法及系统健康匍匐疾病和在线管理
公开(公告)号：EP1174816A2
公开(公告)日：2002-01-23
申请号：EP01303871.6
申请日：2001-04-27
申请人： Chan, Bryan K. , Chu, Lawrence F.
发明人： Chan, Bryan K. , Chu, Lawrence F.
IPC分类号： G06F19/00
CPC分类号： G06Q50/22 , G06F19/00 , G06F19/324 , G06F19/325 , G06F19/3418 , G06F19/3481 , G16H10/20 , G16H10/60 , G16H40/20 , G16H50/20
摘要： A method and system (100) for managing a multi-domain health and wellness program using remotely located terminal devices (108, 110, 124), software agents and remotely stored (146) participant information associated with definable access levels. The system referred to herein as Intelligent Health Management Technology (IHMT) system, provides assistance in regards to the management of chronic diseases in conjunction with multi-domain health and wellness programs. The system collects personal health information and medical record data and analyzes the information, and simulates medical decision-making process and is based on general medical decision making principles, common sense principles, and specific logic for a given IHMT module. As a result, customized recommendations are provided and may include computer generated recommendations and input from participating third parties (i.e., doctors, dieticians, pharmacists etc.).
摘要翻译：一种用于管理使用位于远程的终端设备（108,110，124），软件代理和具有可定义accesslevels相关联的远程存储的（146）的参与者信息的多域健康和保健计划的方法和系统（100）。转交的系统进入智能作为健康管理技术（IHMT）系统，在多领域的健康和保健方案一起关于慢性疾病的管理提供援助。该系统收集的个人健康信息，医疗记录数据和分析信息，并模拟医疗决策过程，是基于一般的医疗决策的原则，常识原则，对于一个给定IHMT模块的具体逻辑。其结果是，提供了定制的建议，并且可以包括从参与的第三方（即，医生，营养师，药剂师等）的计算机生成的建议和输入。

3. 发明专利

PH22019000843Y1 PORTABLE COOLER CONTAINER WITH REMOVABLE COMPARTMENT 未知
公开(公告)号：PH22019000843Y1
公开(公告)日：2019-08-05
申请号：PH22019000843
申请日：2019-07-04
申请人： CHAN BRYAN JEFFERSON
发明人： CHAN BRYAN JEFFERSON
IPC分类号： F25D3/02
摘要： The present utility model discloses a portable cooler container comprising: a container and a cover hinged to said container, said container consisting of an outer container member and an inner container member forming a cavity in between, said cavity provided with an insulation layer. The inner container member is provided with a peripheral shoulder proximate the top inner surface thereof. The portable cooler container further comprises at least one removable tray compartment fitted on the upper portion of the inner container member. The removable tray compartment includes a top flange adapted to be seated on the peripheral shoulder of the inner container member, and a perforated bottom portion. The container is adapted to be filled with ice and canned or bottled beverages and the removable tray compartment can contain food that needs to be chilled while separated from the ice so that the food will not get spoiled due to water from melted ice.

4. 发明专利

PH22019000843U1 PORTABLE COOLER CONTAINER WITH REMOVABLE COMPARTMENT 未知
公开(公告)号：PH22019000843U1
公开(公告)日：2019-08-05
申请号：PH22019000843
申请日：2019-07-04
申请人： CHAN BRYAN JEFFERSON
发明人： CHAN BRYAN JEFFERSON
IPC分类号： F25D3/02
摘要： The present utility model discloses a portable cooler container comprising: a container and a cover hinged to said container, said container consisting of an outer container member and an inner container member forming a cavity in between, said cavity provided with an insulation layer. The inner container member is provided with a peripheral shoulder proximate the top inner surface thereof. The portable cooler container further comprises at least one removable tray compartment fitted on the upper portion of the inner container member. The removable tray compartment includes a top flange adapted to be seated on the peripheral shoulder of the inner container member, and a perforated bottom portion. The container is adapted to be filled with ice and canned or bottled beverages and the removable tray compartment can contain food that needs to be chilled while separated from the ice so that the food will not get spoiled due to water from melted ice.

5. 发明申请

WO2010003133A2 CDK MODULATORS 审中-公开
标题翻译： CDK调制器
公开(公告)号：WO2010003133A2
公开(公告)日：2010-01-07
申请号：PCT/US2009/049637
申请日：2009-07-02
申请人： EXELIXIS INC. , BAHCECI, Suleyman , CHAN, Bryan , CHAN, Diva, Sze-ming , CHEN, Jeff , FORSYTH, Timothy, Patrick , FRANZINI, Maurizio , JAMMALAMADAKA, Vasu , JEONG, Joon, Won , JONES, Lisa, Renee , KELLEY, Ryan, Michael , KIM, Moon, Hwan , LEAHY, James, W. , MAC, Morrison, B. , NOGUCHI, Robin, Tammie , RAO, Pallavi , RIDGWAY, Brian, Hugh , XU, Wei , WANG, Yong
发明人： BAHCECI, Suleyman , CHAN, Bryan , CHAN, Diva, Sze-ming , CHEN, Jeff , FORSYTH, Timothy, Patrick , FRANZINI, Maurizio , JAMMALAMADAKA, Vasu , JEONG, Joon, Won , JONES, Lisa, Renee , KELLEY, Ryan, Michael , KIM, Moon, Hwan , LEAHY, James, W. , MAC, Morrison, B. , NOGUCHI, Robin, Tammie , RAO, Pallavi , RIDGWAY, Brian, Hugh , XU, Wei , WANG, Yong
IPC分类号： A61K31/437
CPC分类号： C07D487/04 , C07D471/04 , C07D519/00
摘要： A compound according to Formula I : or a pharmaceutically-acceptable salt thereof, wherein R1, R3, A, B and D are as defined in the specification; pharmaceutical compositions thereof, and methods of use thereof.
摘要翻译：根据式I的化合物或其药学上可接受的盐，其中R 1，R 3，A，B和D如说明书中所定义; 其药物组合物及其使用方法。

6. 发明申请

WO2012062783A1 PYRAZOLE AMINOPYRIMIDINE DERIVATIVES AS LRRK2 MODULATORS 审中-公开
标题翻译：作为LRRK2调节剂的吡咯氨基嘧啶衍生物
公开(公告)号：WO2012062783A1
公开(公告)日：2012-05-18
申请号：PCT/EP2011/069696
申请日：2011-11-09
申请人： F. HOFFMANN-LA ROCHE AG , BAKER-GLENN, Charles , BURDICK, Daniel Jon , CHAMBERS, Mark , CHEN, Huifen , ESTRADA, Anthony , SWEENEY, Zachary Kevin , CHAN, Bryan K.
发明人： BAKER-GLENN, Charles , BURDICK, Daniel Jon , CHAMBERS, Mark , CHEN, Huifen , ESTRADA, Anthony , SWEENEY, Zachary Kevin , CHAN, Bryan K.
IPC分类号： C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D413/14 , A61K31/506 , A61P25/16
CPC分类号： C07D403/14 , C07D401/14 , C07D403/12 , C07D405/14 , C07D413/14
摘要： Compounds of the formula (I), or pharmaceutically acceptable salts thereof, wherein X, R 1 , R 2 , R 3 , R 4 and R 5 are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of diseases associated with LRRK2 receptor, such as Parkinson's disease.
摘要翻译：式（I）化合物或其药学上可接受的盐，其中X，R 1，R 2，R 3，R 4和R 5如本文所定义。还公开了制备化合物和使用该化合物治疗与LRRK2受体（例如帕金森病）相关的疾病的方法。

7. 发明申请

WO2013079496A1 FLUORINE-18 AND CARBON-11 LABELED RADIOLIGANDS FOR POSITRON EMISSION TOMOGRAPHY (PET) IMAGING FOR LRRK2 审中-公开
标题翻译：氟烷-18和碳-11标记的放射性物质，用于LRRK2的立体排放成像（PET）成像
公开(公告)号：WO2013079496A1
公开(公告)日：2013-06-06
申请号：PCT/EP2012/073770
申请日：2012-11-28
申请人： F. HOFFMANN-LA ROCHE AG , CHAN, Bryan, K. , ESTRADA, Anthony , MARIK, Jan , SWEENEY, Zachary, Kevin
发明人： CHAN, Bryan, K. , ESTRADA, Anthony , MARIK, Jan , SWEENEY, Zachary, Kevin
IPC分类号： A61K51/04
CPC分类号： C07D403/12 , A61K51/0453 , A61K51/0455 , A61K51/0459 , C07D239/48
摘要： A method for positron emission tomography (PET) imaging of LRRK2 in the tissue of a subject, the method comprising: administering a compound of formula (I), formula (II) or formula (III), or a pharmaceutically acceptable salt thereof to the subject, wherein the compound includes at least one C 11 or F 18 label thereon; allowing the compound to penetrate into the tissue of the subject; and collecting a PET image of the CNS or brain tissue of the subject.
摘要翻译：一种用于受试者组织中LRRK2的正电子发射断层摄影（PET）成像的方法，所述方法包括：将式（I），式（II）或式（III）化合物或其药学上可接受的盐给予其中所述化合物在其上包含至少一个C11或F18标记; 允许化合物渗透到受试者的组织中; 并收集受试者的CNS或脑组织的PET图像。

8. 发明申请

WO2013079494A1 2-PHENYLAMINOPYRIMIDINE DERIVATIVES AS KINASE LRRK2 MODULATORS FOR THE TREATMENT OF PARKINSON'S DISEASE 审中-公开
标题翻译：作为激素治疗帕金森病的激素LRRK2调节剂的2-苯基亚氨基嘧啶衍生物
公开(公告)号：WO2013079494A1
公开(公告)日：2013-06-06
申请号：PCT/EP2012/073762
申请日：2012-11-28
申请人： F. HOFFMANN-LA ROCHE AG , BAKER-GLENN, Charles , BURDICK, Daniel Jon , CHAMBERS, Mark , CHAN, Bryan K. , CHEN, Huifen , ESTRADA, Anthony , GUNZNER-TOSTE, Janet , SHORE, Daniel , SWEENEY, Zachary , WANG, Shumei , ZHAO, Guiling
发明人： BAKER-GLENN, Charles , BURDICK, Daniel Jon , CHAMBERS, Mark , CHAN, Bryan K. , CHEN, Huifen , ESTRADA, Anthony , GUNZNER-TOSTE, Janet , SHORE, Daniel , SWEENEY, Zachary , WANG, Shumei , ZHAO, Guiling
IPC分类号： C07D239/47 , C07D239/48 , C07D401/12 , C07D403/12 , C07D405/12 , C07D405/14 , C07D413/12 , C07D487/04 , C07D498/08 , C07D491/107 , A61K31/505 , A61K31/506 , A61P25/16
CPC分类号： C07D498/18 , C07D239/47 , C07D239/48 , C07D401/12 , C07D403/12 , C07D405/12 , C07D405/14 , C07D413/12 , C07D487/04 , C07D491/107 , C07D498/08 , C07D498/10
摘要： Specific Compounds of formula (I): or pharmaceutically acceptable salts thereof, wherein m, X, R, R 2 , R 3 , R, R 6 and R 7 are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of diseases associated with LRRK2 receptor, such as Parkinson's disease.
摘要翻译：式（I）的具体化合物或其药学上可接受的盐，其中m，X，R，R 2，R 3，R 6，R 6和R 7如本文所定义。还公开了制备化合物和使用该化合物治疗与LRRK2受体（例如帕金森病）相关的疾病的方法。

9. 发明申请

WO2011151360A1 AMINOPYRIMIDINE DERIVATIVES AS LRRK2 MODULATORS 审中-公开
标题翻译：作为LRRK2调节剂的氨基嘧啶衍生物
公开(公告)号：WO2011151360A1
公开(公告)日：2011-12-08
申请号：PCT/EP2011/059009
申请日：2011-06-01
申请人： F. HOFFMANN-LA ROCHE AG , BAKER-GLENN, Charles , BURDICK, Daniel Jon , CHAMBERS, Mark , CHAN, Bryan K. , CHEN, Huifen , ESTRADA, Anthony , GUNZNER, Janet L. , SHORE, Daniel , SWEENEY, Zachary Kevin , WANG, Shumei , ZHAO, Guiling
发明人： BAKER-GLENN, Charles , BURDICK, Daniel Jon , CHAMBERS, Mark , CHAN, Bryan K. , CHEN, Huifen , ESTRADA, Anthony , GUNZNER, Janet L. , SHORE, Daniel , SWEENEY, Zachary Kevin , WANG, Shumei , ZHAO, Guiling
IPC分类号： C07D403/14 , C07D473/16 , A61K31/52
CPC分类号： C07D413/14 , C07D403/14 , C07D413/12 , C07D473/16 , C07D498/06 , C07D498/08
摘要： Compounds of the formula I: or pharmaceutically acceptable salts thereof, wherein m, n. X, R 1 , R 2 , R 3 , R 5 , R 6 and R 7 are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of diseases associated with LRRK2 receptor, such as Parkinson's disease.
摘要翻译：式I化合物或其药学上可接受的盐，其中m，n。 X，R 1，R 2，R 3，R 5，R 6和R 7如本文所定义。还公开了制备化合物和使用该化合物治疗与LRRK2受体（例如帕金森病）相关的疾病的方法。

10. 发明申请

WO2011101429A1 PYRIDO[3,2-D]PYRIMIDINE PI3K DELTA INHIBITOR COMPOUNDS AND METHODS OF USE 审中-公开
标题翻译：吡咯并[3,2-D]吡嗪PI3K DELTA抑制剂化合物及其使用方法
公开(公告)号：WO2011101429A1
公开(公告)日：2011-08-25
申请号：PCT/EP2011/052384
申请日：2011-02-18
申请人： F. HOFFMANN-LA ROCHE AG , CASTANEDO, Georgette , CHAN, Bryan , LUCAS, Matthew C. , SAFINA, Brian , SUTHERLIN, Daniel P. , SWEENEY, Zachary Kevin
发明人： CASTANEDO, Georgette , CHAN, Bryan , LUCAS, Matthew C. , SAFINA, Brian , SUTHERLIN, Daniel P. , SWEENEY, Zachary Kevin
IPC分类号： C07D471/04 , A61K31/519 , A61P35/00
CPC分类号： C07D471/04 , C07D491/107
摘要： Formula (I) compounds, including stereoisomers, geometric isomers, tautomers, metabolites and pharmaceutically acceptable salts thereof, are useful for inhibiting the delta isoform of PI3K, and for treating disorders mediated by lipid kinases such as inflammation, immunological disorders, and cancer. Methods of using compounds of Formula (I) for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.
摘要翻译：式（I）化合物，包括立体异构体，几何异构体，互变异构体，代谢物及其药学上可接受的盐，可用于抑制PI3K的δ同种型，以及用于治疗由脂质激酶如炎症，免疫学障碍和癌症介导的病症。公开了使用式（I）化合物在体外，原位和体内诊断，预防或治疗哺乳动物细胞或相关病理条件中的这种疾病的方法。

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