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1. 发明申请

WO2011090552A1 OPTIMIZATION OF AV DELAY USING VENTRICULAR PRESSURE SIGNAL 审中-公开
标题翻译：使用心室压力信号优化AV延迟
公开(公告)号：WO2011090552A1
公开(公告)日：2011-07-28
申请号：PCT/US2010/058303
申请日：2010-11-30
申请人： MEDTRONIC, INC. , GREENHUT, Saul, E. , KARAMANOGLU, Mustafa
发明人： GREENHUT, Saul, E. , KARAMANOGLU, Mustafa
IPC分类号： A61N1/365 , A61N1/368
CPC分类号： A61N1/36564 , A61N1/3682
摘要： An implantable medical device system including an intraventricular pressure sensor controls an atrioventricular (AV) delay based on the intraventricular pressure signal. An atrial kick pressure waveform corresponding to active contraction of an atrial chamber is detected from the intraventricular pressure signal. In one embodiment, a time interval corresponding to the atrial kick pressure waveform is measured. An AV delay is set in response to the measured time interval..
摘要翻译：包括心室内压力传感器的可植入医疗装置系统基于心室内压力信号来控制房室（AV）延迟。从心室内压力信号检测与心房的主动收缩对应的心房踢压力波形。在一个实施例中，测量对应于心房踢压力波形的时间间隔。响应于测量的时间间隔设置AV延迟。

2. 发明申请

WO2011087581A3 METHOD AND APPARATUS FOR BLOOD PRESSURE WAVEFORM BASELINE ESTIMATION AND REMOVAL 审中-公开
标题翻译：血压波形基线估计和去除方法与装置
公开(公告)号：WO2011087581A3
公开(公告)日：2011-09-09
申请号：PCT/US2010057785
申请日：2010-11-23
申请人： MEDTRONIC INC , GREENHUT SAUL E , KARAMANOGLU MUSTAFA
发明人： GREENHUT SAUL E , KARAMANOGLU MUSTAFA
IPC分类号： A61B5/0215 , A61M25/00 , A61N1/36 , A61N1/362 , A61N1/365
CPC分类号： A61B5/0215 , A61B5/0402 , A61B5/686 , A61B5/7239 , A61B5/7246 , A61B5/7282 , A61N1/36564
摘要： An implantable medical device system including an implantable blood pressure sensor extracts a baseline signal from the sensed blood pressure signal and subtracts the extracted baseline signal from the sensed blood pressure signal to obtain a corrected pressure monitoring signal. The corrected pressure signal is monitored to detect a cardiac-related condition.
摘要翻译：包括可植入血压传感器的可植入医疗装置系统从感测的血压信号中提取基线信号，并从感测到的血压信号中减去提取的基线信号，以获得校正的压力监测信号。监视校正的压力信号以检测心脏相关状况。

3. 发明申请

WO2012015951A1 MEASUREMENT OF CARDIAC CYCLE LENGTH FROM PULMONARY ARTERIAL PRESSURE 审中-公开
标题翻译：从脉搏压力测量心脏循环长度
公开(公告)号：WO2012015951A1
公开(公告)日：2012-02-02
申请号：PCT/US2011/045575
申请日：2011-07-27
申请人： MEDTRONIC, INC. , GREENHUT, Saul, E. , TAEPKE, Robert, T. , BLOEM, David, R. , CHO, Yong, Kyun , SALMI, Donna, M.
发明人： GREENHUT, Saul, E. , TAEPKE, Robert, T. , BLOEM, David, R. , CHO, Yong, Kyun , SALMI, Donna, M.
IPC分类号： A61B5/0215 , A61B5/024
CPC分类号： A61N1/36564 , A61B5/0031 , A61B5/0215 , A61B5/024 , A61B5/0422 , A61B5/6847 , A61B5/686 , A61B5/6869 , A61B5/6876 , A61B5/7239 , A61M5/14276 , A61M5/1723 , A61M2205/054 , A61M2210/125 , A61N1/37247 , A61N1/3962 , A61N1/3987
摘要： Various techniques for measuring cardiac cycle length and pressure metrics based on pulmonary artery pressures are described. One example method described includes identifying a point (406) within the first derivative (404) of the pulmonary artery pressure signal that satifies a treshold (405), initiating a blanking period (414) from the identified point (406) in the derivative signal, and identifying a fiducial point (410 ) subsequent to the identified point that satifies the threshold, wherein the derivative signal is not compared to the threshold for indentification of a subsequent fiducial point during the blanking period.
摘要翻译：描述了基于肺动脉压力测量心脏周期长度和压力指标的各种技术。所描述的一个示例性方法包括识别饱和阈值（405）的肺动脉压力信号的一阶导数（404）内的点（406），从导数信号中的识别点（406）开始消隐期（414），并且识别在所述阈值饱和的所述标识点之后的基准点（410），其中所述导数信号不与所述消隐期间中随后的基准点的识别阈值进行比较。

4. 发明申请

WO2011053543A1 DETECTION OF WAVEFORM ARTIFACT 审中-公开
标题翻译：检测波浪文艺
公开(公告)号：WO2011053543A1
公开(公告)日：2011-05-05
申请号：PCT/US2010/053910
申请日：2010-10-25
申请人： MEDTRONIC, INC. , GREENHUT, Saul, E. , KARAMANOGLU, Mustafa , KLECKNER, Karin, J. , BENNETT, Tommy, D. , DAVIE, Scott, W.
发明人： GREENHUT, Saul, E. , KARAMANOGLU, Mustafa , KLECKNER, Karin, J. , BENNETT, Tommy, D. , DAVIE, Scott, W.
IPC分类号： A61N1/37
CPC分类号： A61N1/3702
摘要： An implantable medical device system including a physiological sensor detects signal artifact in a signal waveform acquired by the sensor. Features of individual waveforms in the sensor signal are extracted. Sample waveforms are classified by expert observation into at least two classes including an artifact class. A distribution range for each of the extracted features from the sample waveforms is determined for each of the classes. Waveform classification criteria are established in response to the determined distribution ranges.
摘要翻译：包括生理传感器的可植入医疗装置系统检测由传感器获取的信号波形中的信号伪影。提取传感器信号中各波形的特征。通过专家观察将样本波形分类为至少两个类，包括神器类。为每个类别确定来自采样波形的每个提取特征的分布范围。响应于确定的分布范围建立波形分类标准。

5. 发明申请

WO2010033400A1 FILTERING OF A PHYSIOLOGIC SIGNAL IN A MEDICAL DEVICE 审中-公开
标题翻译：医疗设备中生理信号的过滤
公开(公告)号：WO2010033400A1
公开(公告)日：2010-03-25
申请号：PCT/US2009/056184
申请日：2009-09-08
申请人： MEDTRONIC, INC. , CHO, Yong K. , BENNETT, Tommy D. , ERICKSON, Mark K. , SHRIVASTAV, Maneesh , KLECKNER, Karin J. , SPERLING, Charles P. , COREY, Robert A. , GREENHUT, Saul E.
发明人： CHO, Yong K. , BENNETT, Tommy D. , ERICKSON, Mark K. , SHRIVASTAV, Maneesh , KLECKNER, Karin J. , SPERLING, Charles P. , COREY, Robert A. , GREENHUT, Saul E.
IPC分类号： A61B5/08 , A61B5/0205 , A61B5/03 , H03H21/00 , A61N1/365 , A61N1/37 , A61N1/372
CPC分类号： A61B5/6846 , A61B5/0031 , A61B5/0205 , A61B5/0215 , A61B5/0816 , A61B5/4818 , A61N1/36514 , A61N1/3702 , A61N1/37258
摘要： A system and method for filtering a pressure signal in a medical device in which a sensor terminal senses the pressure signal, an electrode terminal receives cardiac electrical signals, a signal filtering system filters the sensed pressure signal in response to a determined heart rate to generate a heart-rate dependent frequency response, and a microprocessor derives a respiration signal in response to the heart rate dependent frequency response, and determines metrics of hemodynamic function in response to the derived respiration signal.
摘要翻译：一种用于过滤医疗装置中的压力信号的系统和方法，其中传感器端子感测压力信号，电极端子接收心脏电信号，信号滤波系统响应于确定的心率来过滤感测到的压力信号，以产生心率依赖频率响应，并且微处理器响应于心率依赖的频率响应导出呼吸信号，并且响应于所得到的呼吸信号确定血液动力学函数的度量。

6. 发明申请

WO2007117822A1 METHOD AND APPARATUS FOR DETECTING ARRHYTHMIAS IN A SUBCUTANEOUS MEDICAL DEVICE 审中-公开
标题翻译：用于检测亚急性医疗器械中的ARRHYTHMIAS的方法和装置
公开(公告)号：WO2007117822A1
公开(公告)日：2007-10-18
申请号：PCT/US2007/063784
申请日：2007-03-12
申请人： MEDTRONIC, INC. , STADLER, Robert W. , GHANEM, Raja N. , ZHANG, Xusheng , GREENHUT, Saul E.
发明人： STADLER, Robert W. , GHANEM, Raja N. , ZHANG, Xusheng , GREENHUT, Saul E.
IPC分类号： A61B5/046 , A61B5/0464 , A61N1/39
CPC分类号： A61N1/3956 , A61B5/046 , A61B5/0464 , A61B5/7239 , A61N1/3621
摘要： A method and apparatus for detecting a cardiac event in a medical device that includes sensing cardiac signals from a plurality of electrodes forming a first sensing vector and a second sensing vector, advancing from a first state to a second state in response to processing of an interval associated with a cardiac cycle of the sensed cardiac signals, and advancing from the second state in response to processing of a cardiac signal sensed during a predetermined sensing window.
摘要翻译：一种用于检测医疗装置中的心脏事件的方法和装置，包括：感测来自形成第一感测向量的多个电极的心脏信号和响应于间隔的处理从第一状态进入第二状态的第二感测向量与感测的心脏信号的心动周期相关联，并且响应于在预定感测窗口期间感测的心脏信号的处理而从第二状态前进。

7. 发明申请

WO2012148513A1 MEASUREMENT OF CARDIAC CYCLE LENGTH AND PRESSURE METRICS FROM PULMONARY ARTERIAL PRESSURE 审中-公开
标题翻译：心脏循环长度和压力测量从脉搏压力测量
公开(公告)号：WO2012148513A1
公开(公告)日：2012-11-01
申请号：PCT/US2012/022154
申请日：2012-01-23
申请人： MEDTRONIC, INC. , GREENHUT, Saul E.
发明人： GREENHUT, Saul E.
IPC分类号： A61B5/021 , A61B5/0215
CPC分类号： A61B5/0215 , A61B5/02108 , A61B5/4839 , A61B5/6869 , A61B5/7239 , A61B5/7246 , A61M5/1723 , A61N1/08 , A61N1/36564
摘要： A method and apparatus for monitoring a cardiovascular pressure signal in a medical device that includes determining whether the sensed pressure signal is greater than a first pressure threshold, determining a first metric of the pressure signal in response to the sensed pressure signal being greater than the first pressure threshold, determining whether the sensed pressure signal is greater than a second pressure threshold not equal to the first pressure threshold, determining a second metric of the pressure signal in response to the sensed pressure signal being greater than the first pressure threshold, and determining at least one of a systolic pressure or a diastolic pressure, wherein the at least one of a systolic pressure or a diastolic pressure is determined based on the first metric in response to the pressure signal not being greater than the second threshold, and based on the second metric in response to the pressure signal being greater than the second threshold.
摘要翻译：一种用于监测医疗装置中的心血管压力信号的方法和装置，包括确定感测到的压力信号是否大于第一压力阈值，响应于感测到的压力信号确定压力信号的第一度量大于第一压力信号压力阈值，确定所感测到的压力信号是否大于不等于第一压力阈值的第二压力阈值，响应于所感测的压力信号确定压力信号的第二度量大于第一压力阈值，并且在收缩压或舒张压中的至少一个，其中基于所述第一度量响应于所述压力信号不大于所述第二阈值来确定所述收缩压或舒张压中的至少一个，并且基于所述第二阈值响应于压力信号大于第二阈值的度量。

8. 发明申请

WO2012015948A1 MEASUREMENT OF CARDIAC CYCLE LENGTH AND PRESSURE METRICS FROM PULMONARY ARTERIAL PRESSURE 审中-公开
标题翻译：心脏循环长度和压力测量从脉搏压力测量
公开(公告)号：WO2012015948A1
公开(公告)日：2012-02-02
申请号：PCT/US2011/045571
申请日：2011-07-27
申请人： MEDTRONIC, INC. , GREENHUT, Saul, E. , TAEPKE, Robert, T. , BLOEM, David, R. , CHO, Yong, Kyun , SALMI, Donna, M.
发明人： GREENHUT, Saul, E. , TAEPKE, Robert, T. , BLOEM, David, R. , CHO, Yong, Kyun , SALMI, Donna, M.
IPC分类号： A61B5/0215
CPC分类号： A61N1/36564 , A61B5/0031 , A61B5/0215 , A61B5/024 , A61B5/0422 , A61B5/6847 , A61B5/686 , A61B5/6869 , A61B5/6876 , A61B5/7239 , A61M5/14276 , A61M5/1723 , A61M2205/054 , A61M2210/125 , A61N1/37247 , A61N1/3962 , A61N1/3987
摘要： Various techniques for measuring cardiac cycle length and pressure metrics based on pulmonary artery pressures are described. One example method described includes identifying a point (210) within the first derivative signal (208) of a pulmonary artery pressure signal (200) without reference to electrical activity of a heart and initiating a time window (212) from the identified point in the derivative signal. Peak- systolic pressure may then be determined by identifying a maximum (214) of the pulmonary artery signal within the time window. End- diastolic pressure may be determined by identifying a point of maximum second derivative within a time window extending backward in time.
摘要翻译：描述了基于肺动脉压力测量心脏周期长度和压力指标的各种技术。所描述的一个示例性方法包括在不参考心脏的电活动的情况下识别肺动脉压力信号（200）的一阶导数信号（208）内的点（210），并从心脏的识别点开始时间窗（212）衍生信号。然后可以通过在时间窗内识别肺动脉信号的最大值（214）来确定峰值收缩压。舒张末期压力可以通过在时间上向后延伸的时间窗中识别最大二阶导数来确定。

9. 发明申请

WO2011139686A1 METHOD AND APPARATUS FOR DETECTING AND DISCRIMINATING TACHYCARDIA 审中-公开
标题翻译：用于检测和鉴定TACHYCARDIA的方法和装置
公开(公告)号：WO2011139686A1
公开(公告)日：2011-11-10
申请号：PCT/US2011/033933
申请日：2011-04-26
申请人： MEDTRONIC, INC. , ZHANG, Xusheng , STADLER, Robert, W. , GREENHUT, Saul, E. , BROWN, Mark, L. , JACKSON, Troy, E. , WHITMAN, Teresa, A.
发明人： ZHANG, Xusheng , STADLER, Robert, W. , GREENHUT, Saul, E. , BROWN, Mark, L. , JACKSON, Troy, E. , WHITMAN, Teresa, A.
IPC分类号： A61B5/0452 , A61N1/39 , A61B5/046 , A61B5/0464 , A61B5/0472 , A61N1/362
CPC分类号： A61B5/0452 , A61B5/04525 , A61B5/046 , A61B5/0464 , A61B5/0472 , A61B5/7203 , A61N1/3621
摘要： A medical device and associated method obtaining cardiac event intervals corresponding to a tachycardia interval. Evidence of a rhythm breaking point is obtained in response to sensing a cardiac event having a morphology corresponding to a supraventricular beat. A non-treatable rhythm is detected in response to the plurality of cardiac event intervals and the evidence of the rhythm breaking point.
摘要翻译：获得对应于心动过速间隔的心脏事件间隔的医疗装置和相关方法。响应于感测具有对应于室上搏动的形态的心脏事件而获得节律断点的证据。响应于多个心脏事件间隔和节律断点的证据来检测不可治疗的节律。

10. 发明申请

WO2011087581A2 METHOD AND APPARATUS FOR BLOOD PRESSURE WAVEFORM BASELINE ESTIMATION AND REMOVAL 审中-公开
标题翻译：用于血压波形基线估计和去除的方法和装置
公开(公告)号：WO2011087581A2
公开(公告)日：2011-07-21
申请号：PCT/US2010/057785
申请日：2010-11-23
申请人： MEDTRONIC, INC. , GREENHUT, Saul, E. , KARAMANOGLU, Mustafa
发明人： GREENHUT, Saul, E. , KARAMANOGLU, Mustafa
IPC分类号： A61B5/0215 , A61N1/365 , A61N1/36 , A61M25/00 , A61N1/362
CPC分类号： A61B5/0215 , A61B5/0402 , A61B5/686 , A61B5/7239 , A61B5/7246 , A61B5/7282 , A61N1/36564
摘要： An implantable medical device system including an implantable blood pressure sensor extracts a baseline signal from the sensed blood pressure signal and subtracts the extracted baseline signal from the sensed blood pressure signal to obtain a corrected pressure monitoring signal. The corrected pressure signal is monitored to detect a cardiac-related condition.
摘要翻译：包括植入式血压传感器的可植入医疗设备系统从感测的血压信号中提取基线信号，并从感测的血压信号中减去提取的基线信号以获得校正的压力监测信号。监测校正的压力信号以检测心脏相关状况。

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