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1. 发明申请

US20070292923A1 Process For Production Of Enantiomer-Enriched Compounds 审中-公开
标题翻译：富含对映异构体的化合物的制备方法
公开(公告)号：US20070292923A1
公开(公告)日：2007-12-20
申请号：US11659473
申请日：2005-08-01
申请人： Akira Iwasaki , Motohisa Washida , Junzou Hasegawa
发明人： Akira Iwasaki , Motohisa Washida , Junzou Hasegawa
IPC分类号： C12P19/36 , C12N1/20 , C12N15/00 , C12N9/02 , C12N9/14
CPC分类号： C12P41/002 , C12P7/16 , C12P7/22 , Y02E50/10
摘要： The present invention relates to a production method of an enantiomer-enriched compound, which includes the following (1) and (2): (1) contacting an enantiomer mixture with a stereoselective dehydrogenase, for which NAD+ (nicotinamide adenine dinucleotide) is a coenzyme, thereby preferentially oxidizing one enantiomer and leaving the other enantiomer to form NADH, and (2) contacting the NADH formed by the oxidation reaction in (1) with a water-forming NADH oxidase stable under oxidative conditions to convert the NADH to NAD+. According to the present invention, in the production of an enantiomer-enriched compound from an enantiomer mixture, which uses a dehydrogenase, NAD+ can be regenerated even without addition of a stabilizer and an enantiomer-enriched compound can be obtained efficiently.
摘要翻译：本发明涉及富含对映异构体的化合物的制备方法，其包括以下（1）和（2）：（1）使对映异构体混合物与立体选择性脱氢酶接触，其中NAD +（烟酰胺腺嘌呤二核苷酸）是辅酶，从而优先氧化一种对映异构体并使另一种对映异构体形成NADH，和（2）使（1）中的氧化反应形成的NADH与在氧化条件下稳定的水形式的NADH氧化酶接触以将NADH转化为NAD +。根据本发明，在使用脱氢酶的对映异构体混合物的富含对映体的化合物的制造中，即使不添加稳定剂也能够再生NAD +，能够有效地获得富含对映体的化合物。

2. 发明申请

US20070026510A1 Process for biochemical production of glyoxylic acid 审中-公开
标题翻译：乙醛酸生化生产工艺
公开(公告)号：US20070026510A1
公开(公告)日：2007-02-01
申请号：US10544618
申请日：2004-02-13
申请人： Akira Iwasaki , Takehiro Matsumoto , Motohisa Washida , Hiroshi Watanabe , Junzou Hasegawa , Sakayu Shimizu
发明人： Akira Iwasaki , Takehiro Matsumoto , Motohisa Washida , Hiroshi Watanabe , Junzou Hasegawa , Sakayu Shimizu
IPC分类号： C12P7/50 , C12N1/20
CPC分类号： C12P7/40
摘要： The present invention provides an industrially advantageous process for biochemical production of glyoxylic acid from glyoxal. More specifically, the present invention provides a process for production of glyoxylic acid, which is characterized in that the process comprises allowing oxidoreductase that can convert glyoxal into glyoxylic acid, such as oxidase and dehydrogenase, to act on glyoxal, so as to convert glyoxal into glyoxylic acid.
摘要翻译：本发明提供了从乙二醛生物化生产乙醛酸的工业上有利的方法。更具体地说，本发明提供了一种生产乙醛酸的方法，其特征在于该方法包括允许将乙二醛转化为乙醛酸（如氧化酶和脱氢酶）的氧化还原酶作用于乙二醛，从而将乙二醛转化为乙醛酸。

3. 发明申请

US20080038803A1 Process for Producing Optically Active Secondary Alcohol 审中-公开
标题翻译：生产光活性二级醇的方法
公开(公告)号：US20080038803A1
公开(公告)日：2008-02-14
申请号：US11885056
申请日：2006-02-24
申请人： Akira Iwasaki , Motohisa Washida , Naoaki Taoka , Daisuke Moriyama , Junzou Hasegawa
发明人： Akira Iwasaki , Motohisa Washida , Naoaki Taoka , Daisuke Moriyama , Junzou Hasegawa
IPC分类号： C12P7/02 , C12N1/00
CPC分类号： C12P41/002 , C12N9/0008 , C12N9/0036 , C12P7/02 , C12P7/18
摘要： The present invention provides a method enabling convenient production of an optically active secondary alcohol useful as a pharmaceutical intermediate, particularly an optically active 1,2-diol and an optically active 2-alkanol, from an enantiomer mixture thereof. An oxidizing enzyme source having the capability of selectively oxidizing one enantiomer of secondary alcohol is allowed to act on an enantiomer mixture of secondary alcohol in the presence of a reducing enzyme source having the capability of reverse enantio-selectively reducing a ketone derivative, to convert the enantiomer mixture into a substantially single enantiomer at a theoretical percent recovery of 100%, whereby an optically active secondary alcohol is produced.
摘要翻译：本发明提供了一种能够方便地制备可用作药物中间体，特别是光学活性的1,2-二醇和光学活性2-链烷醇的光学活性仲醇的方法。在具有反向对映选择性还原酮衍生物的能力的还原酶源的存在下，使具有选择性氧化仲醇的对映异构体的氧化酶源作用于仲醇的对映体混合物，对映异构体混合物变成基本上单一的对映体，理论回收率为100％，由此产生光学活性的仲醇。

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