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1. 发明申请

US20230088872A1 ECO-FRIENDLY SMART PHOTOSENSITIZER AND PHOTO-STEM CELL THERAPY PRODUCT COMPRISING SAME 有权
公开(公告)号：US20230088872A1
公开(公告)日：2023-03-23
申请号：US17786980
申请日：2020-11-26
申请人： Jin Wang KIM , Jung Ok LEE , Hyun Ji KIM , Hyun Woo KIM
发明人： Jin Wang KIM , Jung Ok LEE , Hyun Ji KIM , Hyun Woo KIM
IPC分类号： A61K41/00 , A61K47/61 , A61K47/69 , A61P35/00
摘要： The present invention provides an eco-friendly smart photosensitizer comprising a conjugate of hydroxypropyl methylcellulose and porfimer sodium photosensitizer, and a photo-stem cell therapy product comprising the photosensitizer. The photosensitizer of the present invention can be advantageously used in various fields including anticancer therapy, stem cell therapy, and the like, without side effects.

2. 发明授权

US5824689A Quinoline compound extracted from scolopendra subspinipes, and derivatives thereof 失效
标题翻译：蛇舌草素提取的喹啉化合物及其衍生物
公开(公告)号：US5824689A
公开(公告)日：1998-10-20
申请号：US865126
申请日：1997-05-30
申请人： Ho-Seong Lee , Young-Jun Park , Min-Hwan Kim , Seok-Shik Moon , Nam-Sun Cho , Jong-Hyun Shin , Young-Whan Suh , Jung-Ok Lee
发明人： Ho-Seong Lee , Young-Jun Park , Min-Hwan Kim , Seok-Shik Moon , Nam-Sun Cho , Jong-Hyun Shin , Young-Whan Suh , Jung-Ok Lee
IPC分类号： C07D215/26 , A61K31/47 , C07D215/20 , C07D215/24
CPC分类号： C07D215/26
摘要： The jineol extracted from scolopendra subspinipes is represented as the following formula (I): ##STR1## The jineol is obtained from scolopendra subspinipes by extracting scolopendra subspinipes with a solvent, separating an activating portion from the extracted liquid with an organic solvent, and purifying an anticancerous activating portion from the activating portion by chromatography. The jineol derivatives prepared from the jineol extracted scolopendra subspinipes are represented as the following formula (II): ##STR2## wherein each R.sub.1 and R.sub.2, independently of each other, is a hydrogen; a lower alkyl group of C.sub.1 to C.sub.6 ; a cycloalkyl group of C.sub.5 to C.sub.7 having a substituting group; an alkyl group of C.sub.1 to C.sub.4 having a phenyl group with one to three substituting groups; a lower alkyl group of C.sub.1 to C.sub.6 having a hydroxy, an alkoxy having C.sub.1 to C.sub.5, or an aryloxy; a lower acyl group of C.sub.1 to C.sub.7 having a hydroxy, an alkoxy having C.sub.1 to C.sub.5, or an aryloxy; a cycloalkylcarbonyl group of C.sub.5 to C.sub.7 with one to three substituting groups; or an acyl group of C.sub.1 to C.sub.4 having a phenyl group with one to three substituting groups.
摘要翻译：从o藜提取的金枪鱼以下列公式（I）表示：ι（I）通过用溶剂提取槐叶子菜子，通过用有机溶剂从提取的液体中分离活化部分，从sc ra子菜子得到金银花，并通过色谱法从活化部分纯化抗癌活化部分。由金枪鱼提取的scolopendra subspinipes制备的jineol衍生物由下式（II）表示：其中每个R 1和R 2彼此独立地为氢; C1至C6的低级烷基; 具有取代基的C5〜C7的环烷基; 具有1-3个取代基的苯基的C1〜C4的烷基; 具有羟基的C1至C6的低级烷基，具有C1至C5的烷氧基或芳氧基; 具有羟基的C1至C7的低级酰基，具有C1至C5的烷氧基或芳氧基; 具有一至三个取代基的C5至C7的环烷基羰基; 或具有1-3个取代基的苯基的C1〜C4酰基。

3. 发明授权

US08575173B2 Piperazinyl 3-aminopyrrolidine derivatives as a CCR2 antagonists 有权
标题翻译：哌嗪基3-氨基吡咯烷衍生物作为CCR2拮抗剂
公开(公告)号：US08575173B2
公开(公告)日：2013-11-05
申请号：US13383104
申请日：2010-06-11
申请人： Jee Woong Lim , Jong-Hoon Kim , Min-Ho Oak , Yongho Na , Youna Oh , So-Hee Kang , Jung-Ok Lee , Jung-Duk Sohn , Seung-Woo Lee
发明人： Jee Woong Lim , Jong-Hoon Kim , Min-Ho Oak , Yongho Na , Youna Oh , So-Hee Kang , Jung-Ok Lee , Jung-Duk Sohn , Seung-Woo Lee
IPC分类号： A61K31/496 , C07D403/06
CPC分类号： C07D207/14
摘要： The present invention relates to compounds of chemical formula 1 and having CCR2 (chemokine receptor 2) antagonistic effects, and salts or isomers thereof. These compounds are very useful for treating, preventing, or relieving rheumatoid arthritis, arteriosclerosis, multiple sclerosis, asthma, and various diseases related to CCR2. wherein R1, R2, R3, R4, R5, R6, R7, R8 and R9 is the same as defined in the specification.
摘要翻译：本发明涉及化学式1化合物和具有CCR2（趋化因子受体2）拮抗作用的化合物及其盐或异构体。这些化合物对于治疗，预防或缓解类风湿性关节炎，动脉硬化，多发性硬化，哮喘和与CCR2有关的各种疾病非常有用。其中R1，R2，R3，R4，R5，R6，R7，R8和R9与说明书中定义相同。

4. 发明申请

US20110045111A1 COMPOSITION COMPRISING THE EXTRACTS OF LINDERA OBTUSILOBA FOR PREVENTION AND TREATMENT OF CARDIOVASCULAR DISEASES 有权
标题翻译：包含LINDERA OBTUSILOBA提取物用于预防和治疗心血管疾病的组合物
公开(公告)号：US20110045111A1
公开(公告)日：2011-02-24
申请号：US12863368
申请日：2008-12-17
申请人： Min-Ho Oak , Jung-Ok Lee , Woon-Sun Choi , Jung-Duk Sohn , Jong-Hoon Kim , Jee Woong Lim , Chung Keun Rhee
发明人： Min-Ho Oak , Jung-Ok Lee , Woon-Sun Choi , Jung-Duk Sohn , Jong-Hoon Kim , Jee Woong Lim , Chung Keun Rhee
IPC分类号： A61K36/54 , A61P9/00 , A61P3/06 , A61P9/10 , A61P3/00 , A61P9/12 , A61P9/06 , A61P9/02
CPC分类号： A61K36/54 , A23L33/105 , A23V2002/00 , A61K2300/00 , A23V2200/326 , A23V2250/21
摘要： The present invention relates to a composition for treatment and prevention of cardiovascular diseases, containing an extract of Lindera obtusiloba. More particularly, the extract of Lindera obtusiloba strongly inhibits NAD(P)H oxidases, which are the main cause of vascular diseases, and at the same time, regulates contraction and relaxation of vascular smooth muscles to manifest a potent vasorelaxant effect, thereby improving the blood pressure regulation and vascular endothelial dysfunction. Therefore, a composition containing this as an active ingredient can be usefully utilized as a pharmaceutical product or health functional food product for the prevention and treatment of cardiovascular diseases.
摘要翻译：本发明涉及一种用于治疗和预防心血管疾病的组合物，其含有石斛提取物。更具体地说，林德拉提取物强烈地抑制作为血管疾病的主要原因的NAD（P）H氧化酶，同时调节血管平滑肌的收缩和松弛，从而表现出有效的血管舒张作用，从而改善血压调节和血管内皮功能障碍。因此，含有该活性成分的组合物可有效地用作预防和治疗心血管疾病的药物产品或健康功能食品。

5. 外观设计

USD1047161S1 Biomodulation light therapy device for blood circulation enhancement comprising graduated scale 有权
公开(公告)号：USD1047161S1
公开(公告)日：2024-10-15
申请号：US35519951
申请日：2024-01-03
申请人： Jin Wang Kim , Jung Ok Lee , Hyun Ji Kim , Hyun Woo Kim
设计人： Jin Wang Kim , Jung Ok Lee , Hyun Ji Kim , Hyun Woo Kim
摘要： The file of this patent contains at least one drawing/photograph executed in color. Copies of this patent with color drawing(s)/photograph(s) will be provided by the Office upon request and payment of the necessary fee.
1. Bio-modulation light therapy device for blood circulation enhancement comprising graduated scale
1.1 : Perspective
1.2 : Front
1.3 : Back
1.4 : Left
1.5 : Right
1.6 : Top
1.7 : Bottom
1.8 : Exploded
The present design is used for irradiating light onto the blood after confirming the treated location using the graduated scale.

6. 发明公开

US20230390396A1 COMPOSITION CONTAINING 5-AMINOLEVULINIC ACID HYDROCHLORIDE 审中-公开
公开(公告)号：US20230390396A1
公开(公告)日：2023-12-07
申请号：US18034660
申请日：2021-10-25
申请人： Jin Wang KIM , Jung Ok LEE , Hyun Ji KIM , Hyun Woo KIM
发明人： Jin Wang KIM , Jung Ok LEE , Hyun Ji KIM , Hyun Woo KIM
IPC分类号： A61K41/00 , A61K45/06
CPC分类号： A61K41/0061 , A61K45/06
摘要： The present invention provides a composition containing acid hydrochloride, the composition comprising 5-aminolevulinic acid hydrochloride, fermented Codonopsis lanceolata extract, a Cordyceps militaris extract, krill oil, polydeoxyribonucleotide sodium, propylene glycol, hyaluronidase, L-carnitine, caffeine, Origanum vulgare leaf oil, ascorbic acid (vitamin C), allantoin, cetyl alcohol and mineral water.

7. 发明授权

US11654195B2 Eco-friendly smart photosensitizer and photo-stem cell therapy product comprising same 有权
公开(公告)号：US11654195B2
公开(公告)日：2023-05-23
申请号：US17786980
申请日：2020-11-26
申请人： Jin Wang Kim , Jung Ok Lee , Hyun Ji Kim , Hyun Woo Kim
发明人： Jin Wang Kim , Jung Ok Lee , Hyun Ji Kim , Hyun Woo Kim
IPC分类号： A61K47/00 , A61P35/00 , A61K41/00 , A61K47/69 , A61K47/61
CPC分类号： A61K41/0057 , A61K47/61 , A61K47/6939 , A61P35/00
摘要： The present invention provides an eco-friendly smart photosensitizer comprising a conjugate of hydroxypropyl methylcellulose and porfimer sodium photosensitizer, and a photo-stem cell therapy product comprising the photosensitizer. The photosensitizer of the present invention can be advantageously used in various fields including anticancer therapy, stem cell therapy, and the like, without side effects.

8. 发明授权

US08734866B2 Composition comprising the extracts of lindera obtusiloba for prevention and treatment of cardiovascular diseases 有权
标题翻译：组合物，其包含用于预防和治疗心血管疾病的扁桃体提取物
公开(公告)号：US08734866B2
公开(公告)日：2014-05-27
申请号：US12863368
申请日：2008-12-17
申请人： Min-Ho Oak , Jung-Ok Lee , Woon-Sun Choi , Jung-Duk Sohn , Jong-Hoon Kim , Jee Woong Lim , Chung Keun Rhee
发明人： Min-Ho Oak , Jung-Ok Lee , Woon-Sun Choi , Jung-Duk Sohn , Jong-Hoon Kim , Jee Woong Lim , Chung Keun Rhee
IPC分类号： A61K36/00
CPC分类号： A61K36/54 , A23L33/105 , A23V2002/00 , A61K2300/00 , A23V2200/326 , A23V2250/21
摘要： The present invention relates to a composition for treatment and prevention of cardiovascular diseases, containing an extract of Lindera obtusiloba. More particularly, the extract of Lindera obtusiloba strongly inhibits NAD(P)H oxidases, which are the main cause of vascular diseases, and at the same time, regulates contraction and relaxation of vascular smooth muscles to manifest a potent vasorelaxant effect, thereby improving the blood pressure regulation and vascular endothelial dysfunction. Therefore, a composition containing this as an active ingredient can be usefully utilized as a pharmaceutical product or health functional food product for the prevention and treatment of cardiovascular diseases.
摘要翻译：本发明涉及一种用于治疗和预防心血管疾病的组合物，其含有石斛提取物。更具体地说，林德拉提取物强烈地抑制作为血管疾病的主要原因的NAD（P）H氧化酶，同时调节血管平滑肌的收缩和松弛，从而表现出有效的血管舒张作用，从而改善血压调节和血管内皮功能障碍。因此，含有该活性成分的组合物可有效地用作预防和治疗心血管疾病的药物产品或健康功能食品。

9. 发明申请

US20120190689A1 PIPERAZINYL 3-AMINOPYRROLIDINE DERIVATIVES AS A CCR2 ANTAGONIST 有权
标题翻译：作为CCR2拮抗剂的哌嗪-3-氨基吡啶衍生物
公开(公告)号：US20120190689A1
公开(公告)日：2012-07-26
申请号：US13383104
申请日：2010-06-11
申请人： Jee Woong Lim , Jong-Hoon Kim , Min-Ho Oak , Yongho Na , Youna Oh , So-Hee Kang , Jung-Ok Lee , Jung-Duk Sohn , Seung-Woo Lee
发明人： Jee Woong Lim , Jong-Hoon Kim , Min-Ho Oak , Yongho Na , Youna Oh , So-Hee Kang , Jung-Ok Lee , Jung-Duk Sohn , Seung-Woo Lee
IPC分类号： A61K31/496 , A61P29/00 , A61P37/08 , A61P11/00 , A61P11/06 , A61P37/06 , A61P25/00 , A61P17/00 , A61P3/10 , A61P3/04 , A61P3/06 , A61P9/10 , C07D403/06 , A61P19/02
CPC分类号： C07D207/14
摘要： The present invention relates to compounds of chemical formula 1 and having CCR2 (chemokine receptor 2) antagonistic effects, and salts or isomers thereof. These compounds are very useful for treating, preventing, or relieving rheumatoid arthritis, arteriosclerosis, multiple sclerosis, asthma, and various diseases related to CCR2. wherein R1, R2, R3, R4, R5, R6, R7, R8 and R9 is the same as defined in the specification.
摘要翻译：本发明涉及化学式1化合物和具有CCR2（趋化因子受体2）拮抗作用的化合物及其盐或异构体。这些化合物对于治疗，预防或缓解类风湿性关节炎，动脉硬化，多发性硬化，哮喘和与CCR2有关的各种疾病非常有用。其中R1，R2，R3，R4，R5，R6，R7，R8和R9与说明书中定义相同。

10. 发明申请

US20120301562A1 COMPOSITION FOR IMPROVING BLOOD CIRCULATION, CONTAINING EXTRACT OF LINDERA OBTUSILOBA AS ACTIVE INGREDIENT 审中-公开
标题翻译：用于改善血液循环的组合物，含有作为活性成分的林德拉布提取物
公开(公告)号：US20120301562A1
公开(公告)日：2012-11-29
申请号：US13510767
申请日：2010-11-19
申请人： Min-Ho Oak , Jung-Ok Lee , So-Hee Kang , Jung-Duk Sohn , Jong-Hoon Kim , Jee Woong Lim , Yongho Na , Youna Oh , Seung-Woo Lee
发明人： Min-Ho Oak , Jung-Ok Lee , So-Hee Kang , Jung-Duk Sohn , Jong-Hoon Kim , Jee Woong Lim , Yongho Na , Youna Oh , Seung-Woo Lee
IPC分类号： A61K36/54 , A61P7/02
CPC分类号： A61K36/54 , A23L33/105 , A61K2236/333
摘要： Provided is a composition for improving blood circulation, comprising an extract of Lindera obtusiloba as an active ingredient, and more specifically, to a pharmaceutical composition and a health functional food for preventing and treating thrombotic disorders by improving blood circulation, comprising an extract of Lindera obtusiloba as an active ingredient. The extract of Lindera obtusiloba of the present invention and a crude purified product thereof can be obtained through extraction using various solvents such as water, ethanol, methanol, butanol, etc. Since the extract and the crude purified product have not only excellent inhibitory effect on platelet aggregation induced by various aggregation inductions in vitro, but also excellent inhibitory effect on rapid thrombus formation in vivo, they can be useful for preventing and treating diseases caused by blood circulation disorders such as thromboembolism, etc.
摘要翻译：提供一种用于改善血液循环的组合物，其包含作为活性成分的林德拉提取物，更具体地，涉及通过改善血液循环来预防和治疗血栓形成障碍的药物组合物和健康功能性食品，其包含石斛提取物作为活性成分。可以通过使用各种溶剂如水，乙醇，甲醇，丁醇等萃取来获得本发明的白芷提取物及其粗纯化产物。由于提取物和粗纯化产物不仅具有优异的抑制作用体外各种聚集诱导诱导的血小板聚集，对体内快速血栓形成的抑制作用也很好，可用于预防和治疗血栓栓塞等血液循环障碍等疾病。

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