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1. 发明授权

US10260097B2 Method of using a gene expression profile to determine cancer responsiveness to an anti-angiogenic agent 有权
公开(公告)号：US10260097B2
公开(公告)日：2019-04-16
申请号：US14123406
申请日：2012-06-04
申请人： Denis Paul Harkin , Fionnuala Patterson , Claire Trinder , Eamonn J. O'Brien , Caroline Michie , Charlie Gourley , Laura A. Hill , Katherine E. Keating , Jude O'Donnell , Max Bylesjo , Steve Deharo , Vitali Proutski , Richard Kennedy , Timothy Davison , Andreas Winter , Andrena McCavigan
发明人： Denis Paul Harkin , Fionnuala Patterson , Claire Trinder , Eamonn J. O'Brien , Caroline Michie , Charlie Gourley , Laura A. Hill , Katherine E. Keating , Jude O'Donnell , Max Bylesjo , Steve Deharo , Vitali Proutski , Richard Kennedy , Timothy Davison , Andreas Winter , Andrena McCavigan
IPC分类号： C12Q1/6881 , C12Q1/6886 , G01N33/574
摘要： Methods and compositions are provided for the identification of a molecular diagnostic test for cancer. The test identifies cancer subtypes that are responsive to anti-angiogenesis therapeutics and enables classification of a patient within this subtype. The present invention can be used to determine whether patients with cancer are clinically responsive or non-responsive to a therapeutic regimen prior to administration of any anti-angiogenic agent. This test may be used in different cancer types and with different drugs that directly or indirectly affect angiogenesis or angiogenesis signalling. In addition, the present invention may be used as a prognostic indicator for certain cancer types. In particular, the present invention is directed to the use of certain combinations of predictive markers, wherein the expression of the predictive markers correlates with responsiveness or non-responsiveness to a therapeutic regimen.

2. 发明申请

US20130292793A1 LOCALIZED STRAIN RELIEF FOR AN INTEGRATED CIRCUIT 有权
标题翻译：集成电路的本地化应变消除
公开(公告)号：US20130292793A1
公开(公告)日：2013-11-07
申请号：US13740677
申请日：2013-01-14
申请人： Patrick F. M. POUCHER , Padraig L. FITZGERALD , John Jude O'DONNELL , Oliver J. KIERSE , Denis M. O'CONNOR
发明人： Patrick F. M. POUCHER , Padraig L. FITZGERALD , John Jude O'DONNELL , Oliver J. KIERSE , Denis M. O'CONNOR
IPC分类号： H01L29/06 , H01L21/764
CPC分类号： H01L29/0649 , H01L21/764 , H01L23/16 , H01L23/3135 , H01L23/3178 , H01L23/562 , H01L2924/0002 , H01L2924/00
摘要： An integrated circuit may include a semiconductor die having a trench formed in a surface of the semiconductor die. One or more circuit components may be formed on the surface of the semiconductor die. The trench can extend into the semiconductor die next to at least one circuit component. The trench may surround the circuit component partially or wholly. The trench may be filled with a material having a lower bulk modulus than the semiconductor die in which the trench is formed.
摘要翻译：集成电路可以包括具有形成在半导体管芯的表面中的沟槽的半导体管芯。可以在半导体管芯的表面上形成一个或多个电路部件。沟槽可以延伸到半导体管芯中，靠近至少一个电路部件。沟槽可以部分或全部地围绕电路部件。沟槽可以填充具有比其中形成沟槽的半导体管芯更低的体积模量的材料。

3. 发明授权

US08085177B2 Digital to analog converter system and method with multi-level scrambling 有权
标题翻译：数模转换器系统及方法具有多级扰频
公开(公告)号：US08085177B2
公开(公告)日：2011-12-27
申请号：US12624413
申请日：2009-11-24
申请人： John Jude O'Donnell , Frederick Carnegie Thompson
发明人： John Jude O'Donnell , Frederick Carnegie Thompson
IPC分类号： H03M1/66
CPC分类号： H03M1/067 , H03M1/74 , H03M3/502 , H04L25/03866
摘要： Tri-level scrambling in a digital to analog converter system is achieved by, in response to a tri-level binary code input, disabling a negative data directed scrambler circuit when the input code is in the positive cycle portion, disabling a positive data directed scrambler circuit when the input code is in the negative cycle portion and disabling both scrambler circuits upon a zero input code for reducing low level distortion due to a reversal of current during crossover between those cycles.
摘要翻译：数字到模拟转换器系统中的三电平扰频通过响应于三电平二进制码输入来实现，当输入码处于正周期部分时禁用负数据定向扰频电路，禁用正数据定向扰频器当输入代码处于负周期部分时，并且在零输入代码上禁用两个扰频器电路，以便在这些周期之间的交叉期间由于电流反转而导致的低电平失真。

4. 发明申请

US20100328124A1 CURRENT STEERING DIGITAL-TO-ANALOG CONVERTER 有权
标题翻译：电流转向数字到模拟转换器
公开(公告)号：US20100328124A1
公开(公告)日：2010-12-30
申请号：US12560602
申请日：2009-09-16
申请人： John Jude O'Donnell , Frederick Carnegie Thompson
发明人： John Jude O'Donnell , Frederick Carnegie Thompson
IPC分类号： H03M3/00 , H03M1/66
CPC分类号： H03M1/0836 , H03M1/66
摘要： A digital to analog converter (DAC) module receives an input digital signal having a first data rate and is associated with a first frequency, the DAC module also receiving a synchronization signal having a second frequency that is higher than the first frequency. The DAC module includes an up-sampling circuit to generate a first digital signal having bit values of the input digital signal alternating with zero values, the first digital signal having a data rate that is higher than the first data rate; a delay circuit to delay the first digital signal by a time period to generate a second digital signal; a first DAC cell to generate a first analog signal based on the first digital signal, the first DAC cell being synchronized by the synchronization signal; a second DAC cell to generate a second analog signal based on the second digital signal, the second DAC cell being synchronized by the synchronization signal; and an adder to sum the first and second analog signals and generate a third analog signal.
摘要翻译：数模转换器（DAC）模块接收具有第一数据速率并与第一频率相关联的输入数字信号，DAC模块还接收具有高于第一频率的第二频率的同步信号。 DAC模块包括上采样电路，用于产生具有与零值交替的输入数字信号的位值的第一数字信号，第一数字信号具有高于第一数据速率的数据速率; 延迟电路，用于将第一数字信号延迟一段时间以产生第二数字信号; 第一DAC单元，用于基于第一数字信号产生第一模拟信号，第一DAC单元由同步信号同步; 第二DAC单元，用于基于所述第二数字信号产生第二模拟信号，所述第二DAC单元由所述同步信号同步; 以及加法器，用于对第一和第二模拟信号求和并产生第三模拟信号。

5. 发明申请

US20200245915A1 Systems and Methods for Measuring Oxygen in a Patient's Bloodstream 审中-公开
公开(公告)号：US20200245915A1
公开(公告)日：2020-08-06
申请号：US16854657
申请日：2020-04-21
申请人： John Jude O'Donnell , Colin G. Lyden , Michael C.W. Coln
发明人： John Jude O'Donnell , Colin G. Lyden , Michael C.W. Coln
IPC分类号： A61B5/1455 , A61B5/00 , G01J1/46 , G01J1/08
摘要： A photometry device can include a first to emit light to a target in response to a first current through the first LED, a second LED to emit light to the target in response to a second current through the second LED, and an inductor, coupled to the first and second LEDs, to store energy associated with at least one of the first and second currents.

6. 发明申请

US20180190549A1 SEMICONDUCTOR WAFER WITH SCRIBE LINE CONDUCTOR AND ASSOCIATED METHOD 审中-公开
公开(公告)号：US20180190549A1
公开(公告)日：2018-07-05
申请号：US15395404
申请日：2016-12-30
申请人： John Jude O'Donnell , Colin G. Lyden , Shane Geary , Jonathan Ephraim David Hurwitz , Brian Beucler
发明人： John Jude O'Donnell , Colin G. Lyden , Shane Geary , Jonathan Ephraim David Hurwitz , Brian Beucler
IPC分类号： H01L21/66 , H01L23/544
CPC分类号： H01L22/32 , G01R31/2644 , G01R31/2818 , H01L22/14 , H01L23/544 , H01L2223/54493
摘要： A semiconductor wafer is provided that includes at least two integrated circuits (ICs); a scribe line extends adjacent to the at least two ICs; and a first conductor extends within the scribe line and is electrically coupled to the at least two ICs.

7. 发明申请

US20140342924A1 Molecular Diagnostic Test for Cancer 审中-公开
标题翻译：癌症分子诊断试验
公开(公告)号：US20140342924A1
公开(公告)日：2014-11-20
申请号：US14123406
申请日：2012-06-04
申请人： Dennis Paul Harkin , Fionnuala Patterson , Claire Trinder , Eamonn J. O'Brien , Caroline Michie , Charlie Gourley , Laura A. Hill , Katherine E. Keating , Jude O'Donnell , Max Bylesjo , Steve Deharo , Vitali Proutski , Richard Kennedy , Timothy Davison , Andreas Winter , Andrena McCavigan
发明人： Dennis Paul Harkin , Fionnuala Patterson , Claire Trinder , Eamonn J. O'Brien , Caroline Michie , Charlie Gourley , Laura A. Hill , Katherine E. Keating , Jude O'Donnell , Max Bylesjo , Steve Deharo , Vitali Proutski , Richard Kennedy , Timothy Davison , Andreas Winter , Andrena McCavigan
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6881 , C12Q1/6886 , C12Q2600/106 , C12Q2600/158 , G01N33/57407 , G01N33/57415 , G01N33/57449 , G01N33/57492 , G01N2800/50 , G01N2800/52 , G01N2800/7014
摘要： Methods and compositions are provided for the identification of a molecular diagnostic test for cancer. The test identifies cancer subtypes that are responsive to anti-angiogenesis therapeutics and enables classification of a patient within this subtype. The present invention can be used to determine whether patients with cancer are clinically responsive or non-responsive to a therapeutic regimen prior to administration of any anti-angiogenic agent. This test may be used in different cancer types and with different drugs that directly or indirectly affect angiogenesis or angiogenesis signalling. In addition, the present invention may be used as a prognostic indicator for certain cancer types. In particular, the present invention is directed to the use of certain combinations of predictive markers, wherein the expression of the predictive markers correlates with responsiveness or non-responsiveness to a therapeutic regimen.
摘要翻译：提供了用于鉴定癌症分子诊断试验的方法和组合物。该测试鉴定对抗血管生成治疗剂有反应的癌症亚型，并使得能够对该亚型内的患者进行分类。本发明可用于确定在施用任何抗血管生成剂之前，癌症患者是否具有临床响应性或对治疗方案无反应。该测试可以用于不同的癌症类型和不同的直接或间接影响血管生成或血管生成信号传导的药物。此外，本发明可以用作某些癌症类型的预后指标。特别地，本发明涉及预测标记物的某些组合的用途，其中预测标记的表达与对治疗方案的反应性或非反应性相关。

8. 发明授权

US07994957B2 Current steering digital-to-analog converter 有权
标题翻译：电流转向数模转换器
公开(公告)号：US07994957B2
公开(公告)日：2011-08-09
申请号：US12560602
申请日：2009-09-16
申请人： John Jude O'Donnell , Frederick Carnegie Thompson
发明人： John Jude O'Donnell , Frederick Carnegie Thompson
IPC分类号： H03M1/66
CPC分类号： H03M1/0836 , H03M1/66
摘要： A digital to analog converter (DAC) module receives an input digital signal having a first data rate and is associated with a first frequency, the DAC module also receiving a synchronization signal having a second frequency that is higher than the first frequency. The DAC module includes an up-sampling circuit to generate a first digital signal having bit values of the input digital signal alternating with zero values, the first digital signal having a data rate that is higher than the first data rate; a delay circuit to delay the first digital signal by a time period to generate a second digital signal; a first DAC cell to generate a first analog signal based on the first digital signal, the first DAC cell being synchronized by the synchronization signal; a second DAC cell to generate a second analog signal based on the second digital signal, the second DAC cell being synchronized by the synchronization signal; and an adder to sum the first and second analog signals and generate a third analog signal.
摘要翻译：数模转换器（DAC）模块接收具有第一数据速率并与第一频率相关联的输入数字信号，DAC模块还接收具有高于第一频率的第二频率的同步信号。 DAC模块包括上采样电路，用于产生具有与零值交替的输入数字信号的位值的第一数字信号，第一数字信号具有高于第一数据速率的数据速率; 延迟电路，用于将第一数字信号延迟一段时间以产生第二数字信号; 第一DAC单元，用于基于第一数字信号产生第一模拟信号，第一DAC单元由同步信号同步; 第二DAC单元，用于基于所述第二数字信号产生第二模拟信号，所述第二DAC单元由所述同步信号同步; 以及加法器，用于对第一和第二模拟信号求和并产生第三模拟信号。

9. 发明授权

US09670547B2 Molecular diagnostic test for cancer 有权
公开(公告)号：US09670547B2
公开(公告)日：2017-06-06
申请号：US13821404
申请日：2011-09-15
申请人： Jude O'Donnell , Max Bylesjo , Fionnuala Patterson , Steve Deharo , Laura A. Hill , Katherine E. Keating , Timothy Davison , Vitali Proutski , Denis Paul Harkin , Richard Kennedy , Nicolas Goffard
发明人： Jude O'Donnell , Max Bylesjo , Fionnuala Patterson , Steve Deharo , Laura A. Hill , Katherine E. Keating , Timothy Davison , Vitali Proutski , Denis Paul Harkin , Richard Kennedy , Nicolas Goffard
IPC分类号： C12Q1/68 , C40B30/04 , G06F19/20 , G06F19/24
CPC分类号： C12Q1/6886 , A61K33/24 , C12Q1/6876 , C12Q2600/106 , C12Q2600/112 , C12Q2600/158 , C40B30/04 , G06F19/00 , G06F19/20 , G06F19/24 , G16H50/30
摘要： Methods and compositions are provided for the identification of a molecular diagnostic test for cancer. The test defines a novel DNA damage repair deficient molecular subtype and enables classification of a patient within this subtype. The present invention can be used to determine whether patients with cancer are clinically responsive or non-responsive to a therapeutic regimen prior to administration of any chemotherapy. This test may be used in different cancer types and with different drugs that directly or indirectly affect DNA damage or repair, such as many of the standard cytotoxic chemotherapeutic drugs currently in use. In particular, the present invention is directed to the use of certain combinations of predictive markers, wherein the expression of the predictive markers correlates with responsiveness or non-responsiveness to a therapeutic regimen.

10. 发明申请

US20170102355A1 ELECTROCHEMICAL SENSOR, AND A METHOD OF FORMING AN ELECTROCHEMICAL SENSOR 审中-公开
公开(公告)号：US20170102355A1
公开(公告)日：2017-04-13
申请号：US14879738
申请日：2015-10-09
申请人： Patrick M. McGuinness , Seamus P. Whiston , William A. Lane , Thomas G. O'Dwyer , John Jude O'Donnell , Bernard Stenson , Shane Geary , Helen Berney , Raymond J. Speer
发明人： Patrick M. McGuinness , Seamus P. Whiston , William A. Lane , Thomas G. O'Dwyer , John Jude O'Donnell , Bernard Stenson , Shane Geary , Helen Berney , Raymond J. Speer
IPC分类号： G01N27/413 , H01G9/00 , H01G9/22
CPC分类号： G01N27/413 , G01N27/404 , H01G9/0029 , H01G9/22
摘要： It may be desirable to sense the concentration of a gas in another gas. This measurement may be important to warn of impending danger. Gas sensors may be made in batches by a manual process, leading to large variations in sensor performance between batches and indeed between sensors in a batch. This means the sensors often need individual calibration before use. The present approach to sensor design can make use of integrated circuit manufacturing techniques to give rise to sensors with well-matched and reproducible characteristics.

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