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1. 发明专利

IL246067D0 Prostate cancer classification 未知
公开(公告)号：IL246067D0
公开(公告)日：2016-07-31
申请号：IL24606716
申请日：2016-06-06
申请人： ALMAC DIAGNOSTICS LTD , LAURA HILL , PAUL HARKIN , RICHARD KENNEDY , STEVEN WALKER , ANDRENA MCCAVIGAN , TIMOTHY DAVISON
发明人： LAURA HILL , PAUL HARKIN , RICHARD KENNEDY , STEVEN WALKER , ANDRENA MCCAVIGAN , TIMOTHY DAVISON
IPC分类号： C12Q20060101
摘要： A method is provided for characterizing and/or prognosing prostate cancer in a subject comprising determining the expression level of at least one of CREM, ERRFI1, SRSF5, PDK4, HJURP, PDRG1, TRPM3, PDE4D, FI2, ADAMTS1, ADAMTS9, B3GNT5, CD38, CEBPD, CENPF, DKK1, EMP1, F3, IL1R1, IL8, JUNB, KLFIO, KLF4, LDLR, LGALS3, LPARI, MALAT1, MTUS1, MYBPC1, NFIL3, NR4A3, OAT, PI15, PTGS2, RHOBTB3, RIN2, RNFT2, SELE, SLC15A2, SOCS2, SOCS3, SSTR1, ST6GAL1, TSC22D1, XBP1 and ZFP36 in a sample from the subject. The method may be used to predict the likelihood of metastasis. Also disclosed are methods for diagnosing and selecting treatment for prostate cancer, together with corresponding methods of treatment. Systems, kits and computer programs for performing the methods are also provided.

2. 发明授权

US10260097B2 Method of using a gene expression profile to determine cancer responsiveness to an anti-angiogenic agent 有权
公开(公告)号：US10260097B2
公开(公告)日：2019-04-16
申请号：US14123406
申请日：2012-06-04
申请人： Denis Paul Harkin , Fionnuala Patterson , Claire Trinder , Eamonn J. O'Brien , Caroline Michie , Charlie Gourley , Laura A. Hill , Katherine E. Keating , Jude O'Donnell , Max Bylesjo , Steve Deharo , Vitali Proutski , Richard Kennedy , Timothy Davison , Andreas Winter , Andrena McCavigan
发明人： Denis Paul Harkin , Fionnuala Patterson , Claire Trinder , Eamonn J. O'Brien , Caroline Michie , Charlie Gourley , Laura A. Hill , Katherine E. Keating , Jude O'Donnell , Max Bylesjo , Steve Deharo , Vitali Proutski , Richard Kennedy , Timothy Davison , Andreas Winter , Andrena McCavigan
IPC分类号： C12Q1/6881 , C12Q1/6886 , G01N33/574
摘要： Methods and compositions are provided for the identification of a molecular diagnostic test for cancer. The test identifies cancer subtypes that are responsive to anti-angiogenesis therapeutics and enables classification of a patient within this subtype. The present invention can be used to determine whether patients with cancer are clinically responsive or non-responsive to a therapeutic regimen prior to administration of any anti-angiogenic agent. This test may be used in different cancer types and with different drugs that directly or indirectly affect angiogenesis or angiogenesis signalling. In addition, the present invention may be used as a prognostic indicator for certain cancer types. In particular, the present invention is directed to the use of certain combinations of predictive markers, wherein the expression of the predictive markers correlates with responsiveness or non-responsiveness to a therapeutic regimen.

3. 发明授权

US10196691B2 Colon cancer gene expression signatures and methods of use 有权
公开(公告)号：US10196691B2
公开(公告)日：2019-02-05
申请号：US13981601
申请日：2012-01-25
申请人： Denis Paul Harkin , Vitali Proutski , Julie Clarke , Peter Kerr , Richard Kennedy , Andreas Winter , Timothy Davison , Max Bylesjo , Vadim Farztdinov , Claire Trinder , Robert James Holt
发明人： Denis Paul Harkin , Vitali Proutski , Julie Clarke , Peter Kerr , Richard Kennedy , Andreas Winter , Timothy Davison , Max Bylesjo , Vadim Farztdinov , Claire Trinder , Robert James Holt
IPC分类号： C12Q1/6886
摘要： A gene expression signature of colon cancer, microarrays including them and methods of using the colon gene expression signature are provided. The gene expression signature is especially useful for determining the prognosis of a patient diagnosed with colon cancer, such as stage II colon cancer. The gene signature described herein is also useful for determining effectiveness of surgical resection with or without adjuvant chemotherapy, and determining possibility of cancer recurrence in patients with colon cancer.

4. 发明授权

US09670547B2 Molecular diagnostic test for cancer 有权
公开(公告)号：US09670547B2
公开(公告)日：2017-06-06
申请号：US13821404
申请日：2011-09-15
申请人： Jude O'Donnell , Max Bylesjo , Fionnuala Patterson , Steve Deharo , Laura A. Hill , Katherine E. Keating , Timothy Davison , Vitali Proutski , Denis Paul Harkin , Richard Kennedy , Nicolas Goffard
发明人： Jude O'Donnell , Max Bylesjo , Fionnuala Patterson , Steve Deharo , Laura A. Hill , Katherine E. Keating , Timothy Davison , Vitali Proutski , Denis Paul Harkin , Richard Kennedy , Nicolas Goffard
IPC分类号： C12Q1/68 , C40B30/04 , G06F19/20 , G06F19/24
CPC分类号： C12Q1/6886 , A61K33/24 , C12Q1/6876 , C12Q2600/106 , C12Q2600/112 , C12Q2600/158 , C40B30/04 , G06F19/00 , G06F19/20 , G06F19/24 , G16H50/30
摘要： Methods and compositions are provided for the identification of a molecular diagnostic test for cancer. The test defines a novel DNA damage repair deficient molecular subtype and enables classification of a patient within this subtype. The present invention can be used to determine whether patients with cancer are clinically responsive or non-responsive to a therapeutic regimen prior to administration of any chemotherapy. This test may be used in different cancer types and with different drugs that directly or indirectly affect DNA damage or repair, such as many of the standard cytotoxic chemotherapeutic drugs currently in use. In particular, the present invention is directed to the use of certain combinations of predictive markers, wherein the expression of the predictive markers correlates with responsiveness or non-responsiveness to a therapeutic regimen.

5. 发明申请

US20140094379A1 Colon Cancer Gene Expression Signatures and Methods of Use 审中-公开
标题翻译：结肠癌基因表达特征和使用方法
公开(公告)号：US20140094379A1
公开(公告)日：2014-04-03
申请号：US13981601
申请日：2012-01-25
申请人： Denis Paul Harkin , Vitali Proutski , Julie Black , Peter Kerr , Richard Kennedy , Andreas Winter , Timothy Davison , Max Bylesjo , Vadim Farztdinov , Claire Wilson , Robert James Holt
发明人： Denis Paul Harkin , Vitali Proutski , Julie Black , Peter Kerr , Richard Kennedy , Andreas Winter , Timothy Davison , Max Bylesjo , Vadim Farztdinov , Claire Wilson , Robert James Holt
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/112 , C12Q2600/118 , C12Q2600/158
摘要： A gene expression signature of colon cancer, microarrays including them and methods of using the colon gene expression signature are provided. The gene expression signature is especially useful for determining the prognosis of a patient diagnosed with colon cancer, such as stage II colon cancer. The gene signature described herein is also useful for determining effectiveness of surgical resection with or without adjuvant chemotherapy, and determining possibility of cancer recurrence in patients with colon cancer.
摘要翻译：提供了结肠癌的基因表达特征，包括它们的微阵列以及使用结肠基因表达特征的方法。基因表达特征对于确定诊断为结肠癌的患者如II期结肠癌的预后特别有用。本文描述的基因特征也可用于确定具有或不具有辅助化疗的手术切除的有效性，以及确定结肠癌患者的癌症复发的可能性。

6. 发明申请

US20140051591A1 MOLECULAR DIAGNOSTIC TEST FOR CANCER 有权
标题翻译：癌症分子诊断测试
公开(公告)号：US20140051591A1
公开(公告)日：2014-02-20
申请号：US13821404
申请日：2011-09-15
申请人： Jude O'Donnell , Max Bylesjo , Fionnuala Patterson , Steve Deharo , Laura A. Hills , Katherine E. Keating , Timothy Davison , Vitali Proutski , Dennis Paul Harkin , Richard Kennedy , Nicolas Goffard
发明人： Jude O'Donnell , Max Bylesjo , Fionnuala Patterson , Steve Deharo , Laura A. Hills , Katherine E. Keating , Timothy Davison , Vitali Proutski , Dennis Paul Harkin , Richard Kennedy , Nicolas Goffard
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , A61K33/24 , C12Q1/6876 , C12Q2600/106 , C12Q2600/112 , C12Q2600/158 , C40B30/04 , G06F19/00 , G06F19/20 , G06F19/24 , G16H50/30
摘要： Methods and compositions are provided for the identification of a molecular diagnostic test for cancer. The test defines a novel DNA damage repair deficient molecular subtype and enables classification of a patient within this subtype. The present invention can be used to determine whether patients with cancer are clinically responsive or non-responsive to a therapeutic regimen prior to administration of any chemotherapy. This test may be used in different cancer types and with different drugs that directly or indirectly affect DNA damage or repair, such as many of the standard cytotoxic chemotherapeutic drugs currently in use. In particular, the present invention is directed to the use of certain combinations of predictive markers, wherein the expression of the predictive markers correlates with responsiveness or non-responsiveness to a therapeutic regimen.
摘要翻译：提供了用于鉴定癌症分子诊断试验的方法和组合物。该测试定义了一种新的DNA损伤修复缺陷型分子亚型，并能够对该亚型中的患者进行分类。本发明可用于确定在施用任何化学疗法之前，癌症患者是否具有临床响应或对治疗方案无反应。该测试可以用于不同的癌症类型以及直接或间接影响DNA损伤或修复的不同药物，例如目前使用的许多标准的细胞毒性化学治疗药物。特别地，本发明涉及预测标记物的某些组合的用途，其中预测标记的表达与对治疗方案的反应性或非反应性相关。

7. 发明授权

US07543325B2 System for remotely controlling client recording and storage behavior 有权
标题翻译：用于远程控制客户端记录和存储行为的系统
公开(公告)号：US07543325B2
公开(公告)日：2009-06-02
申请号：US10339700
申请日：2003-01-08
申请人： Paul Westbrook , Howard Look , James Young , Stephen Lacy , Timothy Davison , James M. Barton
发明人： Paul Westbrook , Howard Look , James Young , Stephen Lacy , Timothy Davison , James M. Barton
IPC分类号： H04N7/173
CPC分类号： H04N21/6543 , H04N5/76 , H04N5/765 , H04N5/782 , H04N5/91 , H04N7/025 , H04N7/162 , H04N21/2181 , H04N21/2407 , H04N21/4147 , H04N21/4331 , H04N21/4334 , H04N21/4335 , H04N21/44222 , H04N21/4516 , H04N21/4532 , H04N21/458 , H04N21/4622 , H04N21/466 , H04N21/4667 , H04N21/47214 , H04N21/4755 , H04N21/8586
摘要： A system for remotely controlling client recording and storage behavior schedules the recording, storing, and deleting of multimedia content on a client system storage device. The invention accepts as input a prioritized list of program viewing preferences which is compared with a database of program guide objects that indicate when programs of interest are actually broadcast. A schedule of time versus available storage space is generated that is optimal for the viewer's explicit or derived preferred content. The viewer may request that certain content be captured, which results in the highest possible priority for those content. The invention provides objects called a capture requests that are sent by the service to client systems. Capture requests reflect local storage management decisions about how the client system storage is partitioned. Capture requests also allow the service to determine content to be recorded by the client system in the same manner that a viewer requests that certain content are recorded but are more powerful than what a viewer can request. Recording requests for a capture request can preempt viewer requests or be entered at the same or lower priority as a viewer request. Capture requests can adjust all aspects of a recording request and affect the capture request itself. Client system operational functionality are also manipulated by the service using capture requests.
摘要翻译：用于远程控制客户端记录和存储行为的系统在客户端系统存储设备上调度多媒体内容的记录，存储和删除。本发明接受作为输入的节目观看偏好的优先列表，其与指示感兴趣的节目实际上被广播的节目指南对象的数据库进行比较。生成时间与可用存储空间的时间表，对于观看者的显式或派生的优选内容是最佳的。观众可以请求捕获某些内容，这导致那些内容的最高可能的优先级。本发明提供了被称为由服务发送给客户端系统的捕获请求的对象。捕获请求反映了关于客户端系统存储分区的本地存储管理决策。捕获请求还允许服务以与观众请求某些内容被记录但是比观看者可以请求更强大的相同的方式确定由客户端系统记录的内容。拍摄请求的记录请求可以抢占查看器请求或以与查看器请求相同或较低的优先级输入。捕获请求可以调整记录请求的所有方面并影响捕获请求本身。客户端系统的操作功能也由服务使用捕获请求来操纵。

8. 发明申请

US20110047579A1 System for remotely controlling client recording and storage behavior 有权
标题翻译：用于远程控制客户端记录和存储行为的系统
公开(公告)号：US20110047579A1
公开(公告)日：2011-02-24
申请号：US12806661
申请日：2010-08-16
申请人： Paul Westbrook , Howard Look , James Young , Stephen Lacy , Timothy Davison , James M. Barton
发明人： Paul Westbrook , Howard Look , James Young , Stephen Lacy , Timothy Davison , James M. Barton
IPC分类号： H04N5/445
CPC分类号： H04N21/6543 , H04N5/76 , H04N5/765 , H04N5/782 , H04N5/91 , H04N7/025 , H04N7/162 , H04N21/2181 , H04N21/2407 , H04N21/4147 , H04N21/4331 , H04N21/4334 , H04N21/4335 , H04N21/44222 , H04N21/4516 , H04N21/4532 , H04N21/458 , H04N21/4622 , H04N21/466 , H04N21/4667 , H04N21/47214 , H04N21/4755 , H04N21/8586
摘要： A system for remotely controlling client recording and storage behavior schedules the recording, storing, and deleting of multimedia content on a client system storage device. The invention accepts as input a prioritized list of program viewing preferences which is compared with a database of program guide objects that indicate when programs of interest are actually broadcast. A schedule of time versus available storage space is generated that is optimal for the viewer's explicit or derived preferred content. The viewer may request that certain content be captured, which results in the highest possible priority for those content. The invention provides objects called a capture requests that are sent by the service to client systems. Capture requests reflect local storage management decisions about how the client system storage is partitioned. Capture requests also allow the service to determine content to be recorded by the client system in the same manner that a viewer requests that certain content are recorded but are more powerful than what a viewer can request. Recording requests for a capture request can preempt viewer requests or be entered at the same or lower priority as a viewer request. Capture requests can adjust all aspects of a recording request and affect the capture request itself. Client system operational functionality are also manipulated by the service using capture requests.
摘要翻译：用于远程控制客户端记录和存储行为的系统在客户端系统存储设备上调度多媒体内容的记录，存储和删除。本发明接受作为输入的节目观看偏好的优先列表，其与指示感兴趣的节目实际上被广播的节目指南对象的数据库进行比较。生成时间与可用存储空间的时间表，对于观看者的显式或派生的优选内容是最佳的。观众可以请求捕获某些内容，这导致那些内容的最高可能的优先级。本发明提供了被称为由服务发送给客户端系统的捕获请求的对象。捕获请求反映了关于客户端系统存储分区的本地存储管理决策。捕获请求还允许服务以与观众请求某些内容被记录但是比观看者可以请求更强大的相同的方式确定由客户端系统记录的内容。拍摄请求的记录请求可以抢占查看器请求或以与查看器请求相同或较低的优先级输入。捕获请求可以调整记录请求的所有方面并影响捕获请求本身。客户端系统的操作功能也由服务使用捕获请求来操纵。

9. 发明授权

US09144909B2 Defense related robotic systems 有权
标题翻译：国防相关的机器人系统
公开(公告)号：US09144909B2
公开(公告)日：2015-09-29
申请号：US12167735
申请日：2008-07-03
申请人： Mark DeLouis , Jorgen Pedersen , Jesse Easudes , Keith Gunnett , John Culbertson , Timothy Davison
发明人： Mark DeLouis , Jorgen Pedersen , Jesse Easudes , Keith Gunnett , John Culbertson , Timothy Davison
IPC分类号： B23B31/113 , B23B31/11 , B25J15/04 , F16B7/20 , F16B21/04 , H01R13/625 , B25J19/00
CPC分类号： B25J15/0408 , B23B31/11 , B23B31/113 , B25J13/08 , B25J15/04 , B25J15/045 , B25J15/0483 , B25J17/00 , B25J19/0029 , B25J19/04 , F16B7/20 , F16B21/04 , H01R13/625 , Y10S901/28 , Y10T74/20329 , Y10T403/18
摘要： A robot quick-release assembly has a first joint member and a robot component mounted thereon, the first joint member has a first coupler and a second joint member, a robot arm mounted thereon, has a second coupler, a clamp, and a locking collar. The first coupler can be coaxially aligned with the second coupler and pressed into the second joint member, and detachably connected to the second joint member. The first mechanical coupler is detachably connected to the second mechanical coupler for transferring power across the quick-release assembly. The robot component can receive an additional electrical connector, the additional electrical connector supplying power to the robot component. The quick-release assembly coupling assembly further exerts large forces with the application of a relatively small torque to the locking collar by applying a two stage wedge engagement and can further include a sequencing system.
摘要翻译：机器人快速释放组件具有安装在其上的第一关节构件和机器人部件，第一关节构件具有第一联接器和第二关节构件，安装在其上的机器人臂具有第二联接器，夹具和锁定环。第一联接器可以与第二联接器同轴对准并且被压入第二关节构件，并且可拆卸地连接到第二关节构件。第一机械耦合器可拆卸地连接到第二机械耦合器，用于将功率传递通过快速释放组件。机器人部件可以接收附加的电连接器，附加的电连接器向机器人部件供电。快速释放组件联接组件通过施加两级楔接合而进一步施加较大的力，通过施加相对小的转矩到锁定套环，并且还可包括排序系统。

10. 发明授权

US07933950B1 Secure control of features of a digital device 有权
标题翻译：安全控制数字设备的功能
公开(公告)号：US07933950B1
公开(公告)日：2011-04-26
申请号：US10958642
申请日：2004-10-04
申请人： Michael Barton , Richard Lee , J. Eric Townsend , Adam Feder , Timothy Davison , Paul Stevens , James Barton
发明人： Michael Barton , Richard Lee , J. Eric Townsend , Adam Feder , Timothy Davison , Paul Stevens , James Barton
IPC分类号： G06F15/16 , H04N7/173 , H04N7/167 , H04L9/32
CPC分类号： H04N21/485 , G06F17/30867 , G06F17/3087 , G11B27/005 , G11B27/105 , G11B27/34 , G11B2220/20 , H04N5/44513 , H04N5/44543 , H04N5/76 , H04N5/781 , H04N5/782 , H04N5/85 , H04N5/907 , H04N7/163 , H04N7/173 , H04N7/17318 , H04N7/17354 , H04N9/8042 , H04N21/252 , H04N21/25891 , H04N21/26606 , H04N21/4147 , H04N21/443 , H04N21/4532 , H04N21/454 , H04N21/4828 , H04N21/6334 , H04N21/6581 , H04N21/812 , H04N21/8453 , H04N2005/4441
摘要： A method providing secure control of features of a digital device. In one embodiment, the method comprises sending, from a digital device that participates in a service, to a service provider that provides the service, a request to participate in the service; receiving a digital message that identifies a service state for the digital device, wherein the digital message is encoded uniquely for the digital device, wherein the digital message is unusable at a different digital device; based on the digital message, determining a plurality of control values that collectively define the service state within the digital device; and providing the control values to one or more applications hosted by the digital device that deliver a service experience associated with the service, or a feature, to an end user of the digital device.
摘要翻译：一种提供数字设备特征的安全控制的方法。在一个实施例中，该方法包括从参与服务的数字设备向提供服务的服务提供商发送参与该服务的请求; 接收识别所述数字设备的服务状态的数字消息，其中所述数字消息对于所述数字设备唯一地进行编码，其中所述数字消息在不同的数字设备处不可用; 基于所述数字消息，确定在所述数字设备内共同定义所述服务状态的多个控制值; 以及将所述控制值提供给由所述数字设备托管的一个或多个应用，所述应用将与所述服务相关联的服务体验或特征提供给所述数字设备的终端用户。

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