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1. 发明授权

US07303922B2 Reagentless analysis of biological samples by applying mathematical algorithms to smoothed spectra 有权
标题翻译：通过应用数学算法平滑光谱对生物样品进行无谓分析
公开(公告)号：US07303922B2
公开(公告)日：2007-12-04
申请号：US10829777
申请日：2004-04-22
申请人： Tzyy-Wen Jeng , Larry L. McDowell , Joseph Larry Pezzaniti , Gary M. Oosta , Eric B. Shain
发明人： Tzyy-Wen Jeng , Larry L. McDowell , Joseph Larry Pezzaniti , Gary M. Oosta , Eric B. Shain
IPC分类号： G01N21/00
CPC分类号： G01N21/4133 , G01N21/05 , G01N21/274 , Y10T436/144444 , Y10T436/146666 , Y10T436/147777 , Y10T436/171538 , Y10T436/200833
摘要： Apparatus and method for determining at least one parameter, e. g., concentration, of at least one analyte, e. g., urea, of a biological sample, e. g., urine. A biological sample particularly suitable for the apparatus and method of this invention is urine. In general, spectroscopic measurements can be used to quantify the concentrations of one or more analytes in a biological sample. In order to obtain concentration values of certain analytes, such as hemoglobin and bilirubin, visible light absorption spectroscopy can be used. In order to obtain concentration values of other analytes, such as urea, creatinine, glucose, ketones, and protein, infrared light absorption spectroscopy can be used. The apparatus and method of this invention utilize one or more mathematical techniques to improve the accuracy of measurement of parameters of analytes in a biological sample. The invention also provides an apparatus and method for measuring the refractive index of a sample of biological fluid while making spectroscopic measurements substantially simultaneously.
摘要翻译：用于确定至少一个参数的装置和方法，至少一种分析物的浓度，例如，例如生物样品的尿素，例如，例如尿。特别适用于本发明的装置和方法的生物样品是尿液。通常，光谱测量可用于量化生物样品中一种或多种分析物的浓度。为了获得某些分析物（如血红蛋白和胆红素）的浓度值，可以使用可见光吸收光谱。为了获得尿素，肌酐，葡萄糖，酮和蛋白质等其他分析物的浓度值，可以使用红外光吸收光谱。本发明的装置和方法利用一种或多种数学技术来提高生物样品中分析物参数的测量精度。本发明还提供了一种用于在基本上同时进行光谱测量的同时测量生物流体样品的折射率的装置和方法。

2. 发明授权

US6087182A Reagentless analysis of biological samples 有权
标题翻译：对生物样品进行无谓分析
公开(公告)号：US6087182A
公开(公告)日：2000-07-11
申请号：US141483
申请日：1998-08-27
申请人： Tzyy-Wen Jeng , Larry L. McDowell , Joseph Larry Pezzaniti , Gary M. Oosta , Eric B. Shain
发明人： Tzyy-Wen Jeng , Larry L. McDowell , Joseph Larry Pezzaniti , Gary M. Oosta , Eric B. Shain
IPC分类号： G01N21/64 , G01N21/05 , G01N21/27 , G01N21/33 , G01N21/35 , G01N21/41 , G01N21/65 , G01N33/483 , G01N33/493 , G01N21/25
CPC分类号： G01N21/4133 , G01N21/05 , G01N21/274 , Y10T436/144444 , Y10T436/146666 , Y10T436/147777 , Y10T436/171538 , Y10T436/200833
摘要： Apparatus and method for determining at least one parameter, e. g., concentration, of at least one analyte, e. g., urea, of a biological sample, e.g, urine. A biological sample particularly suitable for the apparatus and method of this invention is urine. In general, spectroscopic measurements can be used to quantify the concentrations of one or more analytes in a biological sample. In order to obtain concentration values of certain analytes, such as hemoglobin and bilirubin, visible light absorption spectroscopy can be used. In order to obtain concentration values of other analytes, such as urea, creatinine, glucose, ketones, and protein, infrared light absorption spectroscopy can be used. The apparatus and method of this invention utilize one or more mathematical techniques to improve the accuracy of measurement of parameters of analytes in a biological sample. The invention also provides an apparatus and method for measuring the refractive index of a sample of biological fluid while making spectroscopic measurements substantially simultaneously.
摘要翻译：用于确定至少一个参数的装置和方法，至少一种分析物的浓度，例如，例如尿素，例如尿液。特别适用于本发明的装置和方法的生物样品是尿液。通常，光谱测量可用于量化生物样品中一种或多种分析物的浓度。为了获得某些分析物（如血红蛋白和胆红素）的浓度值，可以使用可见光吸收光谱。为了获得尿素，肌酐，葡萄糖，酮和蛋白质等其他分析物的浓度值，可以使用红外光吸收光谱。本发明的装置和方法利用一种或多种数学技术来提高生物样品中分析物参数的测量精度。本发明还提供了一种用于在基本上同时进行光谱测量的同时测量生物流体样品的折射率的装置和方法。

3. 发明授权

US07070278B2 Autostereoscopic 3-D display 有权
标题翻译：自动立体三维显示
公开(公告)号：US07070278B2
公开(公告)日：2006-07-04
申请号：US10787973
申请日：2004-02-27
申请人： Joseph Larry Pezzaniti
发明人： Joseph Larry Pezzaniti
IPC分类号： G03B21/14 , G02B27/22
CPC分类号： G02B27/2214 , G02B3/0006 , G02B3/0031 , G02B3/0043 , G02B3/005 , G02B3/0068 , H04N13/305
摘要： A lenslet array having variously shaped and sized lenslets, where the lenslets are rotated and/or tilted, reducing gap images in an image formed by pixels/subpixels, where the pixel/subpixels have gaps between each other forming the gap images.
摘要翻译：具有各种形状和尺寸的小透镜的小透镜阵列，其中小透镜被旋转和/或倾斜，减少由像素/子像素形成的图像中的间隙图像，其中像素/子像素在彼此之间形成间隙图像。

4. 发明授权

US06365109B1 Reagentless analysis of biological samples 有权
标题翻译：对生物样品进行无谓分析
公开(公告)号：US06365109B1
公开(公告)日：2002-04-02
申请号：US09407397
申请日：1999-09-28
申请人： Tzyy-Wen Jeng , Larry L. McDowell , Joseph Larry Pezzaniti , Gary M. Oosta , Eric B. Shain
发明人： Tzyy-Wen Jeng , Larry L. McDowell , Joseph Larry Pezzaniti , Gary M. Oosta , Eric B. Shain
IPC分类号： G01N110
CPC分类号： G01N21/4133 , G01N21/05 , G01N21/274 , Y10T436/144444 , Y10T436/146666 , Y10T436/147777 , Y10T436/171538 , Y10T436/200833
摘要： Apparatus and method for determining at least one parameter, e.g., concentration, of at least one analyte, e.g., urea, of a biological sample, e.g., urine. A biological sample particularly suitable for the apparatus and method of this invention is urine. In general, spectroscopic measurements can be used to quantify the concentrations of one or more analytes in a biological sample. In order to obtain concentration values of certain analytes, such as hemoglobin and bilirubin, visible light absorption spectroscopy can be used. In order to obtain concentration values of other analytes, such as urea, creatinine, glucose, ketones, and protein, infrared light absorption spectroscopy can be used. The apparatus and method of this invention utilize one or more mathematical techniques to improve the accuracy of measurement of parameters of analytes in a biological sample. The invention also provides an apparatus and method for measuring the refractive index of a sample of biological fluid while making spectroscopic measurements substantially simultaneously.
摘要翻译：用于确定生物样品例如尿液的至少一种分析物（例如尿素）的至少一个参数例如浓度的装置和方法。特别适用于本发明的装置和方法的生物样品是尿液。通常，光谱测量可用于量化生物样品中一种或多种分析物的浓度。为了获得某些分析物（如血红蛋白和胆红素）的浓度值，可以使用可见光吸收光谱。为了获得其他分析物（如尿素，肌酐，葡萄糖，酮和蛋白质）的浓度值，可以使用红外光吸收光谱。本发明的装置和方法利用一种或多种数学技术来提高生物样品中分析物参数的测量精度。本发明还提供了一种用于在基本上同时进行光谱测量的同时测量生物流体样品的折射率的装置和方法。

5. 发明授权

US06825985B2 Autostereoscopic display with rotated microlens and method of displaying multidimensional images, especially color images 有权
标题翻译：具有旋转微透镜的自动立体显示和显示多维图像的方法，特别是彩色图像
公开(公告)号：US06825985B2
公开(公告)日：2004-11-30
申请号：US10194276
申请日：2002-07-15
申请人： Daniel M. Brown , Peter Scott Erbach , Joseph Larry Pezzaniti , Takahisa Minamitani
发明人： Daniel M. Brown , Peter Scott Erbach , Joseph Larry Pezzaniti , Takahisa Minamitani
IPC分类号： B02B2710
CPC分类号： G02B27/225 , G02B27/2214 , H04N13/305 , H04N13/307 , H04N13/324 , H04N13/349
摘要： A display and method of displaying multidimensional images on an autostereoscopic display includes establishing a lenslet array to include a plurality of lens elements. There is an interlacing of a plurality of multiple images on the display with a fanning of the multiple images out into an angular array. The method establishes a plurality of views in a vertical and horizontal direction. A mapping of a plurality of views onto a plurality of pixels makes up the display and a three dimensional image is generated from the fanned out multiple images.
摘要翻译：在自动立体显示器上显示多维图像的显示和方法包括建立一个小透镜阵列以包括多个透镜元件。在显示器上存在多个图像的多个图像的交织，其中多个图像的扇形变成角阵列。该方法在垂直和水平方向上建立多个视图。将多个视图映射到多个像素上构成显示，并且从扇出的多个图像生成三维图像。

6. 发明授权

US06773922B2 Reagentless analysis of biological samples 有权
标题翻译：对生物样品进行无谓分析
公开(公告)号：US06773922B2
公开(公告)日：2004-08-10
申请号：US10191148
申请日：2002-07-09
申请人： Tzyy-Wen Jeng , Larry L. McDowell , Joseph Larry Pezzaniti , Gary M. Oosta , Eric B. Shain
发明人： Tzyy-Wen Jeng , Larry L. McDowell , Joseph Larry Pezzaniti , Gary M. Oosta , Eric B. Shain
IPC分类号： G01N2141
CPC分类号： G01N21/4133 , G01N21/05 , G01N21/274 , Y10T436/144444 , Y10T436/146666 , Y10T436/147777 , Y10T436/171538 , Y10T436/200833
摘要： Apparatus and method for determining at least one parameter, e.g., concentration, of at least one analyte, e.g., urea, of a biological sample, e.g., urine. A biological sample particularly suitable for the apparatus and method of this invention is urine. In general, spectroscopic measurements can be used to quantify the concentrations of one or more analytes in a biological sample. In order to obtain concentration values of certain analytes, such as hemoglobin and bilirubin, visible light absorption spectroscopy can be used. In order to obtain concentration values of other analytes, such as urea, creatinine, glucose, ketones, and protein, infrared light absorption spectroscopy can be used. The apparatus and method of this invention utilize one or more mathematical techniques to improve the accuracy of measurement of parameters of analytes in a biological sample. The invention also provides an apparatus and method for measuring the refractive index of a sample of biological fluid while making spectroscopic measurements substantially simultaneously.
摘要翻译：用于确定生物样品例如尿液的至少一种分析物（例如尿素）的至少一个参数例如浓度的装置和方法。特别适用于本发明的装置和方法的生物样品是尿液。通常，光谱测量可用于量化生物样品中一种或多种分析物的浓度。为了获得某些分析物（如血红蛋白和胆红素）的浓度值，可以使用可见光吸收光谱。为了获得其他分析物（如尿素，肌酐，葡萄糖，酮和蛋白质）的浓度值，可以使用红外光吸收光谱。本发明的装置和方法利用一种或多种数学技术来提高生物样品中分析物参数的测量精度。本发明还提供了一种用于在基本上同时进行光谱测量的同时测量生物流体样品的折射率的装置和方法。

7. 发明授权

US09194858B2 System for measuring the concentration of an additive in a mixture 有权
标题翻译：用于测量混合物中添加剂浓度的系统
公开(公告)号：US09194858B2
公开(公告)日：2015-11-24
申请号：US13469995
申请日：2012-05-11
申请人： Joseph Larry Pezzaniti
发明人： Joseph Larry Pezzaniti
IPC分类号： G01N33/28 , G01J3/42 , G01J3/28 , G01N21/00 , G01N21/31 , G01N21/3577 , G01N21/17
CPC分类号： G01N33/2835 , G01J3/28 , G01J3/42 , G01N21/17 , G01N21/314 , G01N21/3577
摘要： An apparatus and method for determining a concentration of an additive in a mixture is provided. The apparatus for determining the concentration of an additive in a mixture comprises a distillation system, a filtration system, a detection system and a fluid transportation system. An alternative apparatus is a portable apparatus comprising a distillation system, a filtration system, a detection system and a fluid transportation system removably coupled to a portable container. A method for determining the concentration of the additive in the mixture includes concentrating the additive in the mixture, removing the additive from a fraction of the mixture and measuring a spectral signature of both the non-additive fraction of the mixture and the mixture. A spectral signature value of the non-additive fraction of the mixture to the mixture is determined and then compared to spectral signatures of a plurality of reference mixtures containing known concentrations of the additive.
摘要翻译：提供了一种用于确定混合物中添加剂浓度的装置和方法。用于测定混合物中添加剂浓度的装置包括蒸馏系统，过滤系统，检测系统和流体输送系统。替代装置是一种便携式装置，其包括蒸馏系统，过滤系统，检测系统和可移除地联接到便携式容器的流体输送系统。用于确定混合物中添加剂浓度的方法包括将添加剂浓缩在混合物中，从混合物的一部分中除去添加剂并测量混合物的非添加部分和混合物的光谱特征。确定混合物与混合物的非添加级分的光谱特征值，然后与含有已知浓度的添加剂的多种参考混合物的光谱特征进行比较。

8. 发明申请

US20140009751A1 System for Measuring the Concentration of an Additive in a Mixture 有权
标题翻译：用于测量混合物中添加剂浓度的系统
公开(公告)号：US20140009751A1
公开(公告)日：2014-01-09
申请号：US13469995
申请日：2012-05-11
申请人： Joseph Larry Pezzaniti
发明人： Joseph Larry Pezzaniti
IPC分类号： G01J3/42
CPC分类号： G01N33/2835 , G01J3/28 , G01J3/42 , G01N21/17 , G01N21/314 , G01N21/3577
摘要： An apparatus and method for determining a concentration of an additive in a mixture is provided. The apparatus for determining the concentration of an additive in a mixture comprises a distillation system, a filtration system, a detection system and a fluid transportation system. An alternative apparatus is a portable apparatus comprising a distillation system, a filtration system, a detection system and a fluid transportation system removably coupled to a portable container. A method for determining the concentration of the additive in the mixture includes concentrating the additive in the mixture, removing the additive from a fraction of the mixture and measuring a spectral signature of both the non-additive fraction of the mixture and the mixture. A spectral signature value of the non-additive fraction of the mixture to the mixture is determined and then compared to spectral signatures of a plurality of reference mixtures containing known concentrations of the additive.
摘要翻译：提供了一种用于确定混合物中添加剂浓度的装置和方法。用于测定混合物中添加剂浓度的装置包括蒸馏系统，过滤系统，检测系统和流体输送系统。替代装置是一种便携式装置，其包括蒸馏系统，过滤系统，检测系统和可移除地联接到便携式容器的流体输送系统。用于确定混合物中添加剂浓度的方法包括将添加剂浓缩在混合物中，从混合物的一部分中除去添加剂并测量混合物的非添加部分和混合物的光谱特征。确定混合物与混合物的非添加级分的光谱特征值，然后与含有已知浓度的添加剂的多种参考混合物的光谱特征进行比较。

9. 发明授权

US06974216B2 Autostereoscopic 3-D display 失效
标题翻译：自动立体三维显示
公开(公告)号：US06974216B2
公开(公告)日：2005-12-13
申请号：US10766240
申请日：2004-01-29
申请人： Joseph Larry Pezzaniti
发明人： Joseph Larry Pezzaniti
IPC分类号： G02B27/22 , H04N13/00 , G03B21/14
CPC分类号： G02B27/2214 , H04N13/305
摘要： A lenslet array having lenslets where the lenslets are variously shaped, and/or rotated and/or tilted, reducing gap images in an image formed by pixels/subpixels, where the pixel/subpixels have gaps between each other forming the gap images.
摘要翻译：具有小透镜的小透镜阵列，其中小透镜被各种形状和/或旋转和/或倾斜，减小由像素/子像素形成的图像中的间隙图像，其中像素/子像素在彼此之间形成间隙图像。

10. 发明授权

US6067463A Method and apparatus for non-invasively measuring the amount of glucose in blood 有权
标题翻译：用于非侵入性测量血液中葡萄糖量的方法和装置
公开(公告)号：US6067463A
公开(公告)日：2000-05-23
申请号：US225430
申请日：1999-01-05
申请人： Tzyy-Wen Jeng , Shu-Jen Yeh , John M. Lindberg , Joseph Larry Pezzaniti , Omar S. Khalil , Gary M. Oosta , Charles F. Hanna , Arnold F. Stalder , Ete Z. Szuts
发明人： Tzyy-Wen Jeng , Shu-Jen Yeh , John M. Lindberg , Joseph Larry Pezzaniti , Omar S. Khalil , Gary M. Oosta , Charles F. Hanna , Arnold F. Stalder , Ete Z. Szuts
IPC分类号： G01N21/35 , A61B5/00 , A61B5/145 , A61B5/1455
CPC分类号： A61B5/1455 , A61B5/14532
摘要： A method and apparatus for measuring the concentration of an analyte of interest, e.g. glucose, in blood non-invasively, i.e., without penetrating the skin or obtaining a biological sample from the body of a patient. The method and apparatus uses a plurality of measurement channels with appropriate wavelengths of interest to control variations of signal and to separate the contribution of the analyte of interest from those of interfering compounds. The method and apparatus of this invention can also be adapted to allow a portion of a body part to be engorged with blood to bring about greater accuracy in optical measurements. In the method of this invention, at least two similar, but not identical, measurements are made concurrently. For example, at least two measurements can be made with similar, but not identical, wavelengths of electromagnetic radiation. The two wavelengths should not be overlapping to allow maximum non-identity. By making measurements concurrently, each measurement channel in the system experiences variations as they occur substantially simultaneously in all channels. By selecting one of the channels as a reference channel and by normalizing the optical measurements of the other channels to this reference channel, the variations common to all channels are eliminated. Removing these common variations from the optical measurements by normalization, such as by calculating ratios of the measurement of each of the measuring channels to that of the reference channel, will allow the actual changes of the signal for a specific analyte of interest to be measured.
摘要翻译：用于测量所关注的分析物的浓度的方法和装置，例如，葡萄糖在血液中非侵入性地，即不渗透皮肤或从患者的身体获得生物样品。该方法和装置使用具有适当的感兴趣波长的多个测量通道来控制信号的变化并分离感兴趣分析物对干扰化合物的贡献。本发明的方法和装置还可以适于允许身体部分的一部分被血液吸收以在光学测量中带来更高的精度。在本发明的方法中，同时进行至少两个相似但不相同的测量。例如，可以用类似但不相同的电磁辐射波长进行至少两次测量。两个波长不应重叠，以允许最大的非身份。通过同时进行测量，系统中的每个测量通道在所有通道中基本上同时发生变化。通过选择一个通道作为参考通道，并将其他通道的光学测量标准化到该参考通道，可以消除所有通道共用的变化。通过归一化从光学测量中去除这些常见的变化，例如通过计算每个测量通道的测量与参考通道的测量的比率，将允许测量特定分析物的信号的实际变化。

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