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1. 发明专利

FR394266A 未知
公开(公告)号：FR394266A
公开(公告)日：1909-01-19
申请号：FR394266D
申请日：1908-09-14
申请人： JOSEPH DIAZ
发明人： DIAZ JOSEPH
IPC分类号： G10D1/06

2. 发明授权

US4581168A Synthesis of hpGRF (Somatocrinin) in liquid phase and intermediate peptides 失效
标题翻译：液相中的hpGRF（somatocrinin）和中间体肽的合成
公开(公告)号：US4581168A
公开(公告)日：1986-04-08
申请号：US580287
申请日：1984-02-17
申请人： Joseph Diaz , Henri Demarne , Romeo Roncucci , Paul-Henry Schmelck
发明人： Joseph Diaz , Henri Demarne , Romeo Roncucci , Paul-Henry Schmelck
IPC分类号： A61K38/00 , C07K5/062 , C07K5/068 , C07K5/072 , C07K5/083 , C07K5/107 , C07K5/113 , C07K7/06 , C07K14/60 , C07C103/52
CPC分类号： C07K7/06 , C07K14/60 , C07K5/06043 , C07K5/06069 , C07K5/06086 , C07K5/06095 , C07K5/06104 , C07K5/06113 , C07K5/0804 , C07K5/1016 , C07K5/1021 , A61K38/00 , Y10S930/12
摘要： The invention relates to synthesis of hpGRF (Somatocrinin) in liquid phase and to intermediate peptides, comprising:--coupling, one after the other and in the order of the sequence of the GRF, the fragments in which: (a) the side acid functions of the aspartic and glutamic acids and the side amine function of the lysine are protected by protector groups stable in the conditions of deprotection of the group Boc, (b) the guanidine function of the arginine is protected by protonation, and (c) the N-terminal amino acid is protected on the amine by the Boc group;--selectively eliminating the group Boc from the N-terminal amine of the peptide in phase of elongation by hydrolysis with trifluoroacetic acid, said coupling being effected in an aprotic polar solvent and--eliminating, at the end of sequence, all the protector groups by hydrolysis with the aid of a 0.1 to 1M solution of methanesulfonic or trifluoromethanesulfonic acid in trifluoroacetic acid.
摘要翻译：本发明涉及液相和中间肽中hpGRF（somatocrinin）的合成，其包括： - 一个接一个接合并按照GRF序列的顺序，其中：（a）侧酸功能的天冬氨酸和谷氨酸以及赖氨酸的侧胺官能团由Boc组脱保护条件下稳定的保护基团保护，（b）精氨酸的胍功能受到质子化保护，（c）N - 末端氨基酸被Boc基团保护在胺上; - 通过用三氟乙酸水解选择性地在延伸期通过肽从N末端胺除去基团Boc，所述偶联在非质子极性溶剂中进行，在序列结束时，通过在0.1至1M甲磺酸或三氟甲磺酸三氟乙酸溶液中水解除去所有的保护基团。

3. 发明授权

US4797469A Synthesis of hGRF (Somatocrinin) in liquid phase and intermediate peptides 失效
标题翻译：在液相和中间肽中合成hGRF（somatocrinin）
公开(公告)号：US4797469A
公开(公告)日：1989-01-10
申请号：US87892
申请日：1987-08-21
申请人： Joseph Diaz , Henri Demarne , Romeo Roncucci , Paul-Henry Schmelck
发明人： Joseph Diaz , Henri Demarne , Romeo Roncucci , Paul-Henry Schmelck
IPC分类号： C07K5/04 , A61K38/00 , A61K38/04 , A61K38/22 , C07K7/06 , C07K7/08 , C07K14/00 , C07K14/575 , C07K14/60 , C07K7/10 , C07K5/10
CPC分类号： C07K14/60 , A61K38/00 , Y10S930/12
摘要： A process for the synthesis, in liquid phase and by fragments, of hGRF 1-44 and hGRF 1-40. This process consists in coupling, one after the other and in the order of the sequence of the GRF,(1) on the one hand, the following fragments:__________________________________________________________________________H--Ala--Arg--Ala--Arg--Leu--NH.sub.2 called Fragment A hGRF (40-44) or alaninamide (40) H--Gln--Glu--Arg--Gly--OH called Fragment B'.sub.1 hGRF (36-39) H--Glu--Ser--Asn--OH called Fragment B'.sub.2 hGRF (33-35) H--Ser--Arg--Gln--Gln--Gly--OH called Fragment C hGRF (28-32) H--Leu--Gln--Asp--Ile--Met--OH called Fragment D' hGRF (23-27) H--Arg--Lys--Leu--OH called Fragment E'.sub.1 hGRF (20-22) __________________________________________________________________________to obtain the peptide K.sub.1 [(hGRF (20-44)] on the corresponding peptide having the sequence (20-40) and(2) on the other hand, the following fragments:__________________________________________________________________________H--Gln--Leu--Ser--Ala called Fragment F.sub.1 hGRF (16-19) H--Tyr--Arg--Lys--Val--Leu--Gly OH called Fragment G.sub.1 hGRF (10-15) H--Ile--Phe--Thr--Asn--Ser--OH called Fragment H.sub.1 hGRF (5-9) __________________________________________________________________________to obtain the peptide J [hGRF (5-19)] and thereafter to couple together the peptides J and K.sub.1 in order to form the peptide having the sequence hGRF (5-44) or hGRF (5-40) and finally to couple the resulting peptide with the peptide H-Tyr-Ala-Asp-Ala-OH, called fragment I hGRF (1-4).
摘要翻译：用于合成hGRF 1-44和hGRF 1-40的液相和碎片的方法。该方法一个接一个地并且按照GRF的序列顺序偶联，（1）一方面是以下片段：称为片段A的-H-Ala-Arg-Ala-Arg-Leu-NH2 称为片段B'1 hGRF（36-39）-H-Glu-Ser-Asn-OH的片段B'2（40-44）或 - 丙氨酰胺（40）-H-Gln-Glu-Arg-Gly-OH 称为片段C hGRF（28-32）-H-Leu-Gln-Asp-Ile-Met-OH的称为片段D'hGRF（23-35）的hGRF（33-35）-H-Ser-Arg-Gln-Gln-Gly-OH -27）-H-Arg-Lys-Leu-OH称为片段E'1 hGRF（20-22） - 获得具有序列（20-40）的相应肽上的肽K1 [（hGRF（20-44）] ）和（2）另一方面，以下片段：称为片段F1的h-Gln-Leu-Ser-Ala hGRF（16-19）-H-Tyr-Arg-Lys-Val-Leu-Gly OH称为片段称为片段H1 hGRF（5-9）的G1 hGRF（10-15）-H-Ile-Phe-Thr-Asn-Ser-OH，以获得肽J [hGRF（5-19）]，然后将肽J和K1以形成具有序列hGRF（5-44）或hGRF（5-40）的肽和最终的将所得肽与肽H-Tyr-Ala-Asp-Ala-OH（称为片段I hGRF（1-4））偶联。

4. 发明授权

US4707541A Synthesis of hGRF (somatocrinin) in liquid phase and intermediate peptides 失效
标题翻译：在液相和中间体肽中合成hGRF（somatocrinin）
公开(公告)号：US4707541A
公开(公告)日：1987-11-17
申请号：US752799
申请日：1985-07-08
申请人： Joseph Diaz , Henri Demarne , Romeo Roncucci , Paul-Henry Schmelck
发明人： Joseph Diaz , Henri Demarne , Romeo Roncucci , Paul-Henry Schmelck
IPC分类号： C07K5/04 , A61K38/00 , A61K38/04 , A61K38/22 , C07K7/06 , C07K7/08 , C07K14/00 , C07K14/575 , C07K14/60 , C07K7/10
CPC分类号： C07K14/60 , A61K38/00 , Y10S930/12
摘要： A process for the synthesis, in liquid phase and by fragments, of hGRF 1-44 and hGRF 1-40. This process consists in coupling, one after the other and in the order of the sequence of the GRF,(1) on the one hand, the following fragments:______________________________________ H--Ala--Arg--Ala--Arg--Leu--NH.sub.2 called hGRF Frag- (40-44) or ment A alaninamide (40) H--Gln--Glu--Arg--Gly--OH called hGRF Frag- (36-39) ment B'.sub.1 H--Glu--Ser--Asn--OH called hGRF Frag- (33-35) ment B'.sub.2 H--Ser--Arg--Gln--Gln--Gly--OH called hGRF Frag- (28-32) ment C H--Leu--Gln--Asp--Ile--Met--OH called hGRF Frag- (23-27) ment D' H--Arg--Lys--Leu--OH called hGRF Frag- (20-22) ment E'.sub.1 ______________________________________ to obtain the peptide K.sub.1 [(hGRF (20-44)] on the corresponding peptide having the sequence (20-40) and(2) on the other hand, the following fragments:______________________________________ H--Gln--Leu--Ser--Ala called hGRF Frag- (16-19) ment F.sub.1 H--Tyr--Arg--Lys--Val--Leu--Gly OH called hGRF Frag- (10-15) ment G.sub.1 H--Ile--Phe--Thr--Asn--Ser--OH called hGRF Frag- (5-9) ment H.sub.1 ______________________________________ to obtain the peptide J [hGRF (5-19)] and thereafter to couple together the peptides J and K.sub.1 in order to form the peptide having the sequence hGRF (5-44) or hGRF (5-40) and finally to couple the resulting peptide with the peptide H-Tyr-Ala-Asp-Ala-H, called fragment I hGRF (1-4).
摘要翻译：用于合成hGRF 1-44和hGRF 1-40的液相和碎片的方法。该方法一个接一个地并且按照GRF序列的顺序偶联，（1）一方面是以下片段：称为hGRF的-H-Ala-Arg-Ala-Arg-Leu-NH2 - Frag-（40-44）或称为丙氨酰胺 - （40）-H-Gln-Glu-Arg-Gly-OH称为hGRF-Frag-（36-39）B'1-Glu-Ser- Asn-OH称为hGRF - Frag-（33-35） - 称为hGRF-Frag-（28-32）C -H-Leu-的B'2 -H-Ser-Arg-Gln-Gln-Gly-OH 称为hGRF-Frag-（23-27）的Gln-Asp-Ile-Met-OH称为hGRF-Frag-（20-22）E'1至D'-H-Arg-Lys-Leu-OH 另一方面，获得具有序列（20-40）和（2）的相应肽上的肽K1 [（hGRF（20-44）]，以下片段：称为hGRF的-H-Gln-Leu-Ser-Ala 被称为hGRF-Frag-（10-15）的G1-Ile-Phe-Thr-Asn-的Frag-（16-19）F1 -H-Tyr-Arg-Lys-Val-Leu-Gly OH Ser-OH称为hGRF-Frag-（5-9） - H1以获得肽J [hGRF（5-19）]，然后将肽J和K1偶联以形成肽ha v序列hGRF（5-44）或hGRF（5-40），最后将所得肽与肽H-Tyr-Ala-Asp-Ala-H（称为片段I hGRF（1-4））偶联。

5. 发明申请

US20130278492A1 DISTRIBUTED, PREDICTIVE, DICHOTOMOUS DECISION ENGINE FOR AN ELECTRONIC PERSONAL ASSISTANT 有权
标题翻译：用于电子个人助理的分布式，预测性，双重决策发动机
公开(公告)号：US20130278492A1
公开(公告)日：2013-10-24
申请号：US13358004
申请日：2012-01-25
申请人： Damien Phelan Stolarz , David Joseph Diaz , James Rossfeld , Scott Raven , Chris O'Malley
发明人： Damien Phelan Stolarz , David Joseph Diaz , James Rossfeld , Scott Raven , Chris O'Malley
IPC分类号： G06F3/01
CPC分类号： G06N7/005 , G06F3/01 , G06F3/012 , G06F3/0482 , G06F3/14 , G06F17/30389 , G06F2203/011 , G06N5/04
摘要： A system, method and user interface are described for providing a personal assistant functionality using a predictive, adaptive, dichotomous (two choices) decision engine that proactively prompts the user for decisions on matters deemed relevant by the decision engine based on past user decisions and activities.
摘要翻译：描述了一种系统，方法和用户界面，用于使用预测性，自适应的二分法（两个选择）决策引擎来提供个人助理功能，所述决策引擎基于过去的用户决策和活动来主动地提示用户对由决策引擎认为相关的事件做出决定。

6. 发明授权

US4337194A Process for the preparation of somatostatin 失效
标题翻译：制备生长抑素的方法
公开(公告)号：US4337194A
公开(公告)日：1982-06-29
申请号：US126993
申请日：1980-03-03
申请人： Joseph Diaz , Remy Guegan
发明人： Joseph Diaz , Remy Guegan
IPC分类号： A61K38/00 , C07C231/00 , C07K1/113 , C07K14/575 , C07K14/655 , C07C103/52
CPC分类号： C07K14/655 , A61K38/00 , Y10S930/16
摘要： The present invention relates to a new process for the stepwise preparation of somatostatin enabling a product of high purity to be obtained, with high yields, from cysteine in 14 position whose acid function is protected by the phenylazobenzylsulfonylethyloxy group and thiol function is protected by the acetamidomethyl group, all the peptide coupling reactions being effected in liquid phase in the dimethylformamide, the intermediate peptides being precipitated by addition of a second solvent and purified in solid phase by washing with the aid of suitable solvents dissolving the impurities.
摘要翻译：本发明涉及一种用于逐步制备生长抑素的新方法，其能够从14位的半胱氨酸以高产率获得高纯度产物，其酸功能受苯基偶氮苄基磺酰基乙氧基和硫醇官能团的保护作用受到乙酰氨基甲基组，所有肽偶联反应在液相中在二甲基甲酰胺中进行，中间体肽通过加入第二溶剂沉淀并通过在溶解有杂质的合适溶剂的溶剂中洗涤而固相纯化。

7. 发明申请

US20090006219A1 METHOD FOR DISTRIBUTION OF AN AQUARIUM KIT 审中-公开
标题翻译：用于分配水袋的方法
公开(公告)号：US20090006219A1
公开(公告)日：2009-01-01
申请号：US12164051
申请日：2008-06-28
申请人： Alan Blake , Joseph Diaz
发明人： Alan Blake , Joseph Diaz
IPC分类号： G06Q30/00
CPC分类号： G06Q30/00 , G06Q20/105 , G06Q20/348 , G06Q20/367 , G06Q30/0641 , G07F7/02
摘要： A method for distributing an aquarium kit through use of a Gift Card or Redemption Card. The Redemption Card is similar to a gift card and will entitle consumers to redeem an aquarium kit, via phone or internet, for direct shipment to any desired location. The Redemption Card will eliminate the hassle of purchasing an aquarium and fish, which often requires multiple transactions, and will free them from dedicating up to several hours in the process. Instead, the aquarium kit will conveniently arrive at the desired location ready for immediate setup.
摘要翻译：通过使用礼品卡或赎回卡分发水族箱套件的方法。兑换卡类似于礼品卡，并有权利消费者通过电话或互联网兑换水族箱，直接运送到任何所需位置。赎回卡将消除购买水族箱和鱼类的麻烦，这往往需要多次交易，并将在过程中将其免除多达几个小时的时间。相反，水族箱套件将方便地到达所需的位置，以便立即进行设置。

8. 发明授权

US06244844B1 Fluid displacement apparatus with improved helical rotor structure 有权
标题翻译：具有改进的螺旋转子结构的流体位移装置
公开(公告)号：US06244844B1
公开(公告)日：2001-06-12
申请号：US09283118
申请日：1999-03-31
申请人： Daniel Joseph Diaz
发明人： Daniel Joseph Diaz
IPC分类号： F03C200
CPC分类号： F01C1/084
摘要： A fluid displacement apparatus includes a housing defining a chamber therein having a first port and a second port. First and second helical rotors with opposing pitches are meshed within the chamber, in fluid communication with the first and second ports. A respective one of the first and second helical rotors includes a cylindrical body portion having a helical groove therein and a helical tooth portion extending radially from the cylindrical body portion adjacent the helical groove. The first and second helical rotors are arranged such that respective longitudinal axes of the first and second helical rotors are parallel to one another and a helical tooth portion of one of the first and second helical rotors engages a helical groove of another of the first and second helical rotors, such that the first and second helical rotors are operative to rotate within the chamber and provide fluid transport between the first and second ports parallel to the longitudinal axes. A respective one of the first and second helical rotors has a first tooth surface lying within the helical groove and extending onto the helical tooth portion and a second tooth surface extending from the cylindrical body portion onto the helical tooth portion opposite the first tooth surface. The first tooth surface preferably includes an epitrochoid-derived surface, i.e., a surface defining an epitrochoid curve in radial cross section. The second tooth surface preferably includes an epicycloid-derived surface, i.e., a surface defining an epicycloid curve in radial cross section.
摘要翻译：流体位移设备包括在其中限定其中具有第一端口和第二端口的壳体的壳体。具有相对间距的第一和第二螺旋转子在室内啮合，与第一和第二端口流体连通。第一和第二螺旋转子中的相应一个包括在其中具有螺旋槽的圆柱形主体部分和从邻近螺旋槽的圆柱形主体部分径向延伸的螺旋齿部分。第一和第二螺旋转子被布置成使得第一和第二螺旋转子的相应纵向轴线彼此平行，并且第一和第二螺旋转子之一的螺旋齿部分接合第一和第二螺旋转子中的另一个的螺旋槽螺旋转子，使得第一和第二螺旋转子可操作以在腔室内旋转并且在平行于纵向轴线的第一和第二端口之间提供流体输送。第一和第二螺旋转子中的相应一个具有位于螺旋槽内并延伸到螺旋齿部分上的第一齿面和从圆柱体部分延伸到与第一齿面相对的螺旋齿部分上的第二齿面。第一齿表面优选地包括表皮生物衍生表面，即在径向横截面中限定外旋体曲线的表面。第二牙齿表面优选地包括来自外周血源的表面，即在径向横截面中限定外周血曲线的表面。

9. 发明授权

US4704450A Synthesis of hpGRF(Somatocrinin) in liquid phase and intermediate peptides 失效
标题翻译：液相中的hpGRF（somatocrinin）和中间体肽的合成
公开(公告)号：US4704450A
公开(公告)日：1987-11-03
申请号：US807691
申请日：1985-12-11
申请人： Joseph Diaz , Henri Demarne , Romeo Roncucci , Paul-Henry Schmelck
发明人： Joseph Diaz , Henri Demarne , Romeo Roncucci , Paul-Henry Schmelck
IPC分类号： A61K38/00 , C07K5/062 , C07K5/068 , C07K5/072 , C07K5/083 , C07K5/107 , C07K5/113 , C07K7/06 , C07K14/60 , C07K7/10 , C07K5/08 , C07K5/10
CPC分类号： C07K7/06 , C07K14/60 , C07K5/06043 , C07K5/06069 , C07K5/06104 , C07K5/06113 , C07K5/0804 , C07K5/1016 , C07K5/1021 , A61K38/00 , Y10S930/12
摘要： The invention relates to synthesis of hpGRF (Somatocrinin) in liquid phase and to intermediate peptides, comprising: coupling, one after the other and in the order of the sequence of the GRF, the fragments in which: (a) the side acid functions of the aspartic and glutamic acids and the side amine function of the lysine are protected by protector groups stable in the conditions of deprotection of the group Boc, (b) the guanidine function of the arginine is protected by protonation, and (c) the N-terminal amino acid is protected on the amine by the Boc group; selectively eliminating the group Boc from the N-terminal amine of the peptide in phase of elongation by hydrolysis with trifluoroacetic acid, said coupling being effected in an aprotic polar solvent and eliminating, at the end of sequence, all the protector groups by hydrolysis with the aid of a 0.1 to 1M solution of methanesulfonic or trifluoromethanesulfonic acid in trifluoroacetic acid.
摘要翻译：本发明涉及在液相和中间肽中合成hpGRF（somatocrinin），其包括：一个接一个地并按照GRF序列顺序偶联其中：（a）侧酸功能的赖氨酸的天冬氨酸和谷氨酸和侧胺的功能受到Boc组脱保护条件稳定的保护基保护，（b）精氨酸的胍官能团被质子化保护，（c）N- 末端氨基酸被Boc保护在胺上; 通过用三氟乙酸水解，选择性地从氨基末端胺中除去基团Boc的延伸相，所述偶联在非质子极性溶剂中进行，并且在序列结束时通过水解将所有保护基团除去帮助0.1至1M甲磺酸或三氟甲磺酸在三氟乙酸中的溶液。

10. 发明授权

US09842299B2 Distributed, predictive, dichotomous decision engine for an electronic personal assistant 有权
公开(公告)号：US09842299B2
公开(公告)日：2017-12-12
申请号：US13358004
申请日：2012-01-25
申请人： Damien Phelan Stolarz , David Joseph Diaz , James Rossfeld , Scott Raven , Chris O'Malley , Christopher Kurpinski
发明人： Damien Phelan Stolarz , David Joseph Diaz , James Rossfeld , Scott Raven , Chris O'Malley , Christopher Kurpinski
IPC分类号： G09G5/00 , G06N7/00 , G06F3/01 , G06F3/0482 , G06F3/14 , G06F17/30 , G06N5/04
CPC分类号： G06N7/005 , G06F3/01 , G06F3/012 , G06F3/0482 , G06F3/14 , G06F17/30389 , G06F2203/011 , G06N5/04
摘要： A system, method and user interface are described for providing a personal assistant functionality using a predictive, adaptive, dichotomous (two choices) decision engine that proactively prompts the user for decisions on matters deemed relevant by the decision engine based on past user decisions and activities.

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