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1. 发明授权

US5496697A Methods and apparatus for detecting the effect of cell affecting agents on living cells 失效
标题翻译：用于检测细胞影响剂对活细胞的影响的方法和装置
公开(公告)号：US5496697A
公开(公告)日：1996-03-05
申请号：US118094
申请日：1993-09-08
申请人： John W. Parce , Harden M. McConnell , Gillian M. K. Humphries , Karen M. Kercso , John C. Owicki , Josef E. Kercso
发明人： John W. Parce , Harden M. McConnell , Gillian M. K. Humphries , Karen M. Kercso , John C. Owicki , Josef E. Kercso
IPC分类号： C12M1/34 , C12Q1/04 , G01N33/50 , C12Q1/02 , C12Q1/70
CPC分类号： G01N33/5008 , C12M23/12 , C12M35/08 , Y10S435/817
摘要： Methods and apparatus are disclosed for detecting the effects of cell affecting agents on living cells. The method steps include providing living cells that are retained in a micro flow chamber. The micro flow chamber is adapted for either continuous or intermittent flow of solutions or suspensions in intimate contact with the cells. The solutions or suspensions, which contain a cell affecting agent, are then flowed in intimate contact with the cells and the pit is measured.
摘要翻译：公开了用于检测细胞影响剂对活细胞的影响的方法和装置。方法步骤包括提供保留在微流动室中的活细胞。微流动室适于与细胞紧密接触的连续或间歇流动的溶液或悬浮液。然后将含有细胞影响剂的溶液或悬浮液与细胞紧密接触流动并测量凹坑。

2. 发明授权

US5278048A Methods for detecting the effect of cell affecting agents on living cells 失效
标题翻译：检测细胞影响剂对活细胞的影响的方法
公开(公告)号：US5278048A
公开(公告)日：1994-01-11
申请号：US708121
申请日：1991-05-29
申请人： John W. Parce , Harden M. McConnell , Gillian M. K. Humphries , Karen M. Kercso , John C. Owicki , Josef E. Kercso
发明人： John W. Parce , Harden M. McConnell , Gillian M. K. Humphries , Karen M. Kercso , John C. Owicki , Josef E. Kercso
IPC分类号： C12M1/34 , G01N33/50 , C12Q1/02
CPC分类号： C12M35/08 , G01N33/5008 , Y10S435/817 , Y10S436/806
摘要： Methods are disclosed for detecting the effects of cell affecting agents on living cells. The method steps include providing living cells that are retained in a micro flow chamber. The micro flow chamber is adapted for either continuous or intermittent flow of solutions or suspensions in intimate contact with the cells. The solutions or suspensions, which contain a cell affecting agent, are then flowed in intimate contact with the cells and at least one effect of the cell affecting agent on the cells is measured by an appropriate detecting means, which is operatively associated with the micro flow chamber.
摘要翻译：公开了用于检测细胞影响剂对活细胞的作用的方法。方法步骤包括提供保留在微流动室中的活细胞。微流动室适于与细胞紧密接触的连续或间歇流动的溶液或悬浮液。然后将含有细胞影响剂的溶液或悬浮液与细胞紧密接触流动，并通过合适的检测手段测量细胞影响剂对细胞的至少一种作用，该检测手段与微量流可操作地相关联房间。

3. 发明授权

US4105030A Implant apparatus 失效
标题翻译：植入装置
公开(公告)号：US4105030A
公开(公告)日：1978-08-08
申请号：US756450
申请日：1977-01-03
申请人： Josef E. Kercso
发明人： Josef E. Kercso
IPC分类号： A61D7/00 , A61M5/00 , A61M5/18
CPC分类号： A61M37/0069
摘要： Apparatus for subcutaneously implanting drug-containing pellets in animals. The apparatus comprises a handle; attached to the handle, a track along which a carriage moves; a carriage which moves along the track, the carriage having (i) a front part adapted to receive and retain a detachable needle having a passageway extending the length of the needle and (ii) a passageway extending the length of the carriage and corresponding to the needle passageway when retained in the carriage; a means to propel the carriage from the front to the rear of the track; means at the front and rear of the track to stop the carriage; a straight, retractable rod detachably attached to the rear stopping means so that the rod extends straight through the carriage passageway; a finger actuatable trigger attached to the handle to actuate the retraction of the carriage. A unique, flanged needle having a sharp metal end, an enlarged, flanged end, a passageway extending the length of the needle, and at least one pellet in the needle passageway is also described.
摘要翻译：用于在动物体内皮下植入含药颗粒的装置。该装置包括手柄; 连接到手柄上，一个滑架沿着轨道移动; 滑架沿着轨道移动，滑架具有（i）前部，其适于容纳和保持具有延伸针的长度的通道的可拆卸针，以及（ii）延伸滑架长度并对应于保留在托架中的针通道; 从轨道的前部到后面推动车厢的一种手段; 表示在轨道的前部和后部停止运输; 可拆卸地附接到后止动装置的直的可伸缩杆，使得杆直线延伸穿过托架通道; 附接到手柄的手指可触发的触发器来致动托架的收回。还描述了具有尖锐金属端，扩大的凸缘端，延伸针的长度的通道和针通道中的至少一个颗粒的独特的带凸缘的针。

4. 发明授权

US4038978A Intrauterine device 失效
标题翻译：宫内节育器
公开(公告)号：US4038978A
公开(公告)日：1977-08-02
申请号：US549584
申请日：1975-02-13
申请人： John McLean Morris , John P. Bennett , Josef E. Kercso
发明人： John McLean Morris , John P. Bennett , Josef E. Kercso
IPC分类号： A61F6/14 , A61F5/46
CPC分类号： A61F6/144 , A61F6/148
摘要： An intrauterine device providing a membrane to cover substantially the entire surface of the uterine cavity, said device having a Y- or V-shaped resilient member with two diverging arms, a membrane covering the entire area between the diverging arms and, in addition, extending above an imaginary line passing through the terminal ends of the arms, and a flexible tail or string connected to the intersection of the arms for aiding in the removal of the device from the uterus when desired. The ends of the diverging arms have enlarged end portions and the arms are of unequal length so that the arms may be resiliently collapsed and placed in a tubular inserter with the enlarged end portions longitudinally spaced in the inserter.
摘要翻译：一种子宫内装置，其提供膜以基本上覆盖子宫腔的整个表面，所述装置具有Y形或V形弹性构件，其具有两个发散臂，膜覆盖发散臂之间的整个区域，此外，延伸在穿过臂的终端的假想线上方，以及连接到臂的相交处的柔性尾部或弦，用于在需要时帮助从子宫移除装置。发散臂的端部具有扩大的端部并且臂具有不等长度，使得臂可以弹性地折叠并放置在管状插入器中，其中扩大的端部在插入器中纵向间隔开。

5. 发明授权

US3992630A Means for supporting an object during radiographic analysis 失效
标题翻译：用于在放射照相分析过程中支持物体的手段
公开(公告)号：US3992630A
公开(公告)日：1976-11-16
申请号：US622558
申请日：1975-10-15
申请人： Josef E. Kercso
发明人： Josef E. Kercso
IPC分类号： A61B6/00 , A61B6/04 , G01N21/34 , G01N21/00 , G01N23/00 , G01N23/04
CPC分类号： A61B6/0421 , A61B6/501 , A61B6/4423
摘要： Means for supporting an object, or a portion thereof, during radiographic analysis comprising a hollow reservoir adapted to receive and hold a constant volume of fluid material within the interior thereof, said reservoir having a pouch-like flexible member forming all or a portion of one wall thereof, said pouch-like flexible member being adapted to receive and support the object undergoing analysis during radiographic exposure thereof, a second flexible member forming all or a portion of a second wall thereof, and means operatively connected to said second flexible member for moving said second flexible member so as to cause a corresponding movement of said pouch-like flexible member. During use, the second flexible member is moved in such a manner as to cause an enlargement of the pouch-like deformation of the pouch-like flexible member. After the object to be examined is inserted in the enlarged deformation, the second flexible member is moved so as to cause the pouch-like flexible member to conform to the exterior surface of the object and thereby provide proper support therefor during the radiographic procedure.
摘要翻译：用于在射线照相分析期间支撑物体或其一部分的装置，包括适于在其内部容纳和保持恒定体积的流体材料的中空储存器，所述储存器具有形成一个或多个部分的袋状柔性构件所述袋状柔性构件适于在其放射照相曝光期间接收和支撑经历分析的物体，形成其第二壁的全部或一部分的第二柔性构件以及可操作地连接到所述第二柔性构件以移动的装置所述第二柔性构件，以引起所述袋状柔性构件的相应移动。在使用过程中，第二柔性构件以使袋状柔性构件的袋状变形扩大的方式移动。在被检查对象被插入扩大的变形中之后，移动第二柔性构件，使得袋状柔性构件与物体的外表面一致，从而在射线照相程序期间提供适当的支撑。

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