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1. 发明申请

US20100261909A1 Regioselective copper catalyzed synthesis of benzimidazoles and azabenzimidazoles 有权
标题翻译：苯并咪唑和氮杂苯并咪唑的区域选择性铜催化合成
公开(公告)号：US20100261909A1
公开(公告)日：2010-10-14
申请号：US12644401
申请日：2009-12-22
申请人： Jorge ALONSO , Andreas LINDENSCHMIDT , Marc NAZARÉ , Matthias URMANN , Nis HALLAND , Omar RKYEK
发明人： Jorge ALONSO , Andreas LINDENSCHMIDT , Marc NAZARÉ , Matthias URMANN , Nis HALLAND , Omar RKYEK
IPC分类号： C07D471/04 , C07D235/08 , C07D401/04
CPC分类号： C07D235/08 , C07D235/16 , C07D235/18 , C07D401/04 , C07D471/04
摘要： The present invention relates to a process for the regioselective synthesis of compounds of the formula I, wherein R0; R1; R2; R3; R4; R5; A1; A2; A3; A4, Q and J have the meanings indicated in the claims. The present invention provides a direct copper catalyzed regioselective process to a wide variety of unsymmetrical, multifunctional N-substituted benzimidazoles or azabenzimidazoles of formula I starting from 2-halo-nitroarenes and N-substituted amides.
摘要翻译：本发明涉及一种用于区域选择性合成式I化合物的方法，其中R 0; R1; R2; R3; R4; R5; A1; A2; A3; A4，Q和J具有权利要求中所示的含义。本发明提供了从2-卤代 - 硝基芳烃和N-取代的酰胺开始的多种不同的式（I）的非对称，多官能的N-取代的苯并咪唑或氮杂苯并咪唑的直接铜催化的区域选择性方法。

2. 发明申请

US20100261900A1 Process for the palladium-catalyzed coupling of terminal alkynes with heteroaryl tosylates and heteroaryl benzenesulfonates 有权
标题翻译：末端炔烃与杂芳基甲苯磺酸酯和杂芳基苯磺酸盐的钯催化偶联的方法
公开(公告)号：US20100261900A1
公开(公告)日：2010-10-14
申请号：US12645508
申请日：2009-12-23
申请人： Omar RKYEK , Marc NAZARE , Andreas LINDENSCHMIDT , Jorge ALONSO , Matthias URMANN , Nis HALLAND
发明人： Omar RKYEK , Marc NAZARE , Andreas LINDENSCHMIDT , Jorge ALONSO , Matthias URMANN , Nis HALLAND
IPC分类号： C07D239/26 , C07D231/12 , C07D409/06 , C07D333/38 , C07D231/56 , C07D471/04 , C07D213/16 , C07D213/30 , C07D213/26 , C07D215/14
CPC分类号： C07D231/12 , C07D213/127 , C07D213/26 , C07D213/30 , C07D215/12 , C07D215/14 , C07D231/56 , C07D239/26 , C07D333/38 , C07D409/06 , C07D471/04
摘要： A process for the palladium-catalyzed coupling of terminal alkynes with heteroaryl tosylates and heteroaryl benzenesulfonatesThe present invention relates to a process for the regioselective synthesis of compounds of the formula (I), wherein D, J and W have the meanings indicated in the claims. The present invention provides an efficient and general palladium-catalyzed coupling process of heteroaryl tosylates with terminal alkynes to a wide variety of substituted, multifunctional heteroaryl-1-alkynes of the formula I.
摘要翻译：末端炔烃与杂芳基甲苯磺酸酯和杂芳基苯磺酸盐的钯催化偶合的方法本发明涉及式（I）化合物的区域选择性合成方法，其中D，J和W具有权利要求书中所示的含义。本发明提供了一种有效且一般的钯催化的杂芳基甲苯磺酸酯与末端炔烃与多种式I的取代的多官能杂芳基-1-炔烃的偶联方法。

3. 发明授权

US11125500B2 Method for efficient and effective drying 有权
公开(公告)号：US11125500B2
公开(公告)日：2021-09-21
申请号：US16626578
申请日：2018-06-12
申请人： Jorge Alonso Diaz
发明人： Jorge Alonso Diaz
IPC分类号： F26B19/00 , F26B11/04 , F26B9/06 , F26B21/10 , F26B23/00
摘要： Hot air drying is an intensive energy consuming process, 5000-8000 kJ per kg of water. More efficient processes produce low drying rates or cannot totally dry the product because they do not integrate the four drying phases, warm up, constant drying, falling drying and aeration and do not handle dripping. To reduce the energy consumption, the exhausted mix of air and vapor is used as working fluid to drive each phase, and the dripping is collected before it goes back to the product. This fluid is compressed inside of a heat-exchanger to heat the product; however, the mix proportion, vapor and air, changes on each phase. For warm up phase, the working fluid is either hot air or condensed water; in constant phase, it is mostly vapor; in falling phase, it changes from vapor to air; and for aeration, it is air. Inlet and outlet valves control these proportions.

4. 发明申请

US20140221354A1 IMIDAZO [1,2-a]PYRIDINE COMPOUNDS FOR USE IN THERAPY 审中-公开
标题翻译：咪达唑[1,2-a]吡啶化合物用于治疗
公开(公告)号：US20140221354A1
公开(公告)日：2014-08-07
申请号：US14007613
申请日：2011-03-31
申请人： Marcel Mulbaier , Jorge Alonso , Douglas Thomson , Bernd Janssen , Arantxa Encinas Lopez , Bernd Wendt , Christoph Schultes
发明人： Marcel Mulbaier , Jorge Alonso , Douglas Thomson , Bernd Janssen , Arantxa Encinas Lopez , Bernd Wendt , Christoph Schultes
IPC分类号： C07D471/04 , A61K31/496 , A61K45/06 , A61K31/551
CPC分类号： C07D471/04 , A61K31/496 , A61K31/551 , A61K45/06
摘要： The present invention provides novel imidazo[1,2-a]pyridine compounds that are useful in therapy of diseases and disorders. The novel compounds inhibit the activation of Hypoxia Inducible Factor (HIF)-mediated transcription and signaling under hypoxic conditions. In one aspect, the compounds of the present invention are useful for the preparation of a medicament for the treatment or prevention of a disease or disorder selected from the group consisting of an inflammatory disease, a hyperproliferative disease or disorder, a hypoxia-related pathology and a disease characterized by excessive vascularization. Also provided is a pharmaceutical composition, comprising a compound of the invention and a second therapeutic agent or radiation, useful for the treatment or prevention of the mentioned diseases or disorders, wherein X is CH2, CH2CH2 or C═O; R1 is phenyl or C-bound monocyclic 5- or 6-membered heteroaryl, wherein phenyl and monocyclic 5- or 6-membered heteroaryl are unsubstituted or carry 1, 2, 3, 4 or 5 radicals R1a which are identical or different; R2 is phenyl or C-bound monocyclic 5- or 6-membered heteroaryl, wherein phenyl and monocyclic 5- or 6-membered heteroaryl are unsubstituted or carry 1, 2, 3, 4 or 5 radicals R2a which are identical or different; R3 is hydrogen, C1-C6-alkyl, C1-C4-alkoxy-C1-C4-alkyl, fluorinated C1-C2-alkyl C(O)R4; where R1a, R2a and R4 are as defined in the claims and the specification.
摘要翻译：本发明提供可用于治疗疾病和病症的新的咪唑并[1,2-a]吡啶化合物。该新型化合物在低氧条件下抑制缺氧诱导因子（HIF）介导的转录和信号传导的活化。一方面，本发明的化合物可用于制备用于治疗或预防选自以下的疾病或病症的药物：炎性疾病，过度增殖性疾病或病症，缺氧相关病理学和一种以血管过度为特征的疾病。还提供了包含本发明化合物和第二治疗剂或辐射的药物组合物，其可用于治疗或预防所述疾病或病症，其中X为CH 2，CH 2 CH 2或C = O; R 1是苯基或C键的单环5或6元杂芳基，其中苯基和单环5或6元杂芳基是未取代的或带有相同或不同的1,2,3,4或5个基团R 1a; R 2是苯基或C结合的单环5或6元杂芳基，其中苯基和单环5或6元杂芳基是未取代的或带有相同或不同的1,2,3,4或5个基团R2a; R 3是氢，C 1 -C 6烷基，C 1 -C 4烷氧基-C 1 -C 4烷基，氟化C 1 -C 2烷基C（O）R 4; 其中R1a，R2a和R4如权利要求和说明书中所定义。

5. 发明授权

US08420812B2 Process for the palladium-catalyzed coupling of terminal alkynes with heteroaryl tosylates and heteroaryl benzenesulfonates 有权
标题翻译：末端炔烃与杂芳基甲苯磺酸酯和杂芳基苯磺酸盐的钯催化偶联的方法
公开(公告)号：US08420812B2
公开(公告)日：2013-04-16
申请号：US12645508
申请日：2009-12-23
申请人： Omar Rkyek , Marc Nazare , Andreas Lindenschmidt , Jorge Alonso , Matthias Urmann , Nis Halland
发明人： Omar Rkyek , Marc Nazare , Andreas Lindenschmidt , Jorge Alonso , Matthias Urmann , Nis Halland
IPC分类号： C07D213/127 , C07D213/26 , C07D215/12 , C07D239/26
CPC分类号： C07D231/12 , C07D213/127 , C07D213/26 , C07D213/30 , C07D215/12 , C07D215/14 , C07D231/56 , C07D239/26 , C07D333/38 , C07D409/06 , C07D471/04
摘要： A process for the palladium-catalyzed coupling of terminal alkynes with heteroaryl tosylates and heteroaryl benzenesulfonatesThe present invention relates to a process for the regioselective synthesis of compounds of the formula (I), wherein D, J and W have the meanings indicated in the claims. The present invention provides an efficient and general palladium-catalyzed coupling process of heteroaryl tosylates with terminal alkynes to a wide variety of substituted, multifunctional heteroaryl-1-alkynes of the formula I.
摘要翻译：末端炔烃与杂芳基甲苯磺酸酯和杂芳基苯磺酸盐的钯催化偶合的方法本发明涉及式（I）化合物的区域选择性合成方法，其中D，J和W具有权利要求书中所示的含义。本发明提供了一种有效且一般的钯催化的杂芳基甲苯磺酸酯与末端炔烃与多种式I的取代的多官能杂芳基-1-炔烃的偶联方法。

6. 发明申请

US20120121791A1 COFFEE EXTRACT HAVING RED FRUITS AND COFFEE AROMA 有权
标题翻译：咖啡提取物有红色水果和咖啡AROMA
公开(公告)号：US20120121791A1
公开(公告)日：2012-05-17
申请号：US13005523
申请日：2011-01-12
申请人： JORGE Alonso ECHEVERRY MUNETONES
发明人： JORGE Alonso ECHEVERRY MUNETONES
IPC分类号： A23L1/212
CPC分类号： A23F5/465 , A23F5/30
摘要： The present invention relates to the development and obtention of a liquid coffee extract bearing a combined natural coffee and red fruits aroma which modifies the aroma but keeps unaltered the coffee taste.
摘要翻译：本发明涉及一种具有混合天然咖啡和红色水果香气的液体咖啡提取物的开发和获取，其改变香气，但保持咖啡味道不变。

7. 发明申请

US20100261910A1 Process for the palladium-catalyzed coupling of terminal alkynes with aryl tosylates 有权
标题翻译：钯催化偶合末端炔烃与芳基甲苯磺酸酯的方法
公开(公告)号：US20100261910A1
公开(公告)日：2010-10-14
申请号：US12645509
申请日：2009-12-23
申请人： Omar RKYEK , Marc NAZARE , Andreas LINDENSCHMIDT , Matthias URMANN , Nis HALLAND , Jorge ALONSO
发明人： Omar RKYEK , Marc NAZARE , Andreas LINDENSCHMIDT , Matthias URMANN , Nis HALLAND , Jorge ALONSO
IPC分类号： C07D211/60 , C07C233/03 , C07D333/22 , C07C229/38 , C07C45/00
CPC分类号： C07C17/263 , C07B37/04 , C07C17/35 , C07C41/30 , C07C43/225 , C07C45/61 , C07C45/70 , C07C231/12 , C07C253/30 , C07C2601/16 , C07D295/00 , C07D333/20 , C07C25/24 , C07C49/84 , C07C47/548 , C07C233/07 , C07C233/43 , C07C233/54 , C07C255/33 , C07C255/50 , C07C255/51 , C07C255/53 , C07C255/54 , C07C255/58
摘要： The present invention relates to a process for the regioselective synthesis of compounds of the formula (I), wherein R1; R2; R3; R4; R5; J and W have the meanings indicated in the claims. The present invention provides an efficient and general palladium-catalyzed coupling process for aryl tosylates with terminal alkynes to a wide variety of substituted, multifunctional aryl-1-alkynes of the formula I.
摘要翻译：本发明涉及用于区域选择性合成式（I）化合物的方法，其中R1; R2; R3; R4; R5; J和W具有权利要求中所示的含义。本发明提供了对具有末端炔烃的芳基甲苯磺酸酯与式I的多种取代的多官能芳基-1-炔烃的有效且一般的钯催化偶联方法。

8. 发明申请

US20100168429A1 Transition metal catalyzed synthesis of N-aminoindoles 有权
标题翻译：过渡金属催化N-氨基吲哚的合成
公开(公告)号：US20100168429A1
公开(公告)日：2010-07-01
申请号：US12576339
申请日：2009-10-09
申请人： Nis HALLAND , Marc NAZARE , Andreas LINDENSCHMIDT , Omar AKYEK , Matthias URMANN , Jorge ALONSO
发明人： Nis HALLAND , Marc NAZARE , Andreas LINDENSCHMIDT , Omar AKYEK , Matthias URMANN , Jorge ALONSO
IPC分类号： C07D471/04 , C07D209/04 , C07D401/04
CPC分类号： C07D209/08
摘要： The present invention relates to a process for the regioselective synthesis of compounds of the formula I, wherein R0; R1; R2; R3; R4; R5; R6; A1; A2; A3; A4, Q, T and J have the meanings indicated in the claims. The present invention provides a direct transition metal catalyzed process to a wide variety of multifunctional N-aminoindole or N-amino-azaindoles of the formula I from 2-halo-phenylacetylenes or (2-sulfonato)phenyl-acetylenes and N,N-disubstituted hydrazines, useful for the production of pharmaceuticals, diagnostic agents, liquid crystals, polymers, herbicides, fungicidals, nematicidals, parasiticides, insecticides, acaricides and arthropodicides.
摘要翻译：本发明涉及一种用于区域选择性合成式I化合物的方法，其中R 0; R1; R2; R3; R4; R5; R6; A1; A2; A3; A4，Q，T和J具有权利要求中所示的含义。本发明提供了从2-卤代 - 苯基乙炔或（2-磺酸根合）苯基 - 乙炔和N，N-二取代的，由式I表示的多种多官能N-氨基吲哚或N-氨基 - 氮杂吲哚的直接过渡金属催化方法肼，可用于生产药物，诊断剂，液晶，聚合物，除草剂，杀真菌剂，杀线虫剂，杀寄生虫剂，杀虫剂，杀螨剂和节肢动物杀虫剂。

9. 发明授权

US06187574B1 Process for producing the enzyme D-amino acid oxidase of Rhodotorula gracilis in host cells 失效
标题翻译：在宿主细胞中生产细小红球菌的D-氨基酸氧化酶的方法
公开(公告)号：US06187574B1
公开(公告)日：2001-02-13
申请号：US08973914
申请日：1998-04-28
申请人： Jose Luis Garcia Lopez , Estrella Cortes Rubio , Jorge Alonso Palacios , Jose Luis Barredo Fuente , Bruno Diez Garcia , Miguel Angel Moreno Valle , Carmen Schleissner Sanchez , Alfonso Collados de la Vieja , Alejandro Vitaller Alba , Francisco Salto Maldonado
发明人： Jose Luis Garcia Lopez , Estrella Cortes Rubio , Jorge Alonso Palacios , Jose Luis Barredo Fuente , Bruno Diez Garcia , Miguel Angel Moreno Valle , Carmen Schleissner Sanchez , Alfonso Collados de la Vieja , Alejandro Vitaller Alba , Francisco Salto Maldonado
IPC分类号： C12N902
CPC分类号： C12N9/0024
摘要： Process for producing the enzyme D-amino acid oxydase of Rhodotorula gracilis in host cells. The process for the expression of the enzyme comprises isolating the complementary DNA corresponding to the messager RNA of the gene which codes for the D-amino acid oxydase of any strain of Rhodotorula gracillis producing said enzyme; fusing the fragment of DNA which codes for D-amino acid oxydase of Rhodotorula gracillis with a DNA sequence which contains a site of union to the ribosome and a high efficiency promoter sequence for the express of genes in host cells; inserting the DNA fragment into a plasmid appropriate for the host cell; cultivating the host cells transformed with said plasmid; and collecting the enzyme.
摘要翻译：在宿主细胞中生产细小红球菌的D-氨基酸氧化酶酶的方法。表达酶的过程包括分离与编码产生所述酶的任何红曲霉菌株的D-氨基酸氧化酶的基因的信使RNA相对应的互补DNA; 将编码红景天细菌的D-氨基酸氧化酶的DNA片段与包含与核糖体结合的位点的DNA序列和用于在宿主细胞中表达基因的高效启动子序列融合; 将DNA片段插入适合宿主细胞的质粒中; 培养用所述质粒转化的宿主细胞; 并收集酶。

10. 发明授权

US08603561B2 Coffee extract having red fruits and coffee aroma 有权
标题翻译：咖啡提取物具有红色水果和咖啡香气
公开(公告)号：US08603561B2
公开(公告)日：2013-12-10
申请号：US13005523
申请日：2011-01-12
申请人： Jorge Alonso Echeverry Munetones
发明人： Jorge Alonso Echeverry Munetones
IPC分类号： A23F5/00
CPC分类号： A23F5/465 , A23F5/30
摘要： The present invention relates to the development and obtention of a liquid coffee extract bearing a combined natural coffee and red fruits aroma which modifies the aroma but keeps unaltered the coffee taste.
摘要翻译：本发明涉及一种具有混合天然咖啡和红色水果香气的液体咖啡提取物的开发和获取，其改变香气，但保持咖啡味道不变。

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