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1. 发明授权

US07585278B2 Analyte monitor 有权
公开(公告)号：US07585278B2
公开(公告)日：2009-09-08
申请号：US10722074
申请日：2003-11-24
申请人： John Gregory Aceti , Zvi Gerald Lowey , Richard Morgan Moroney , Christopher Carter Gregory , Peter John Zanzucchi
发明人： John Gregory Aceti , Zvi Gerald Lowey , Richard Morgan Moroney , Christopher Carter Gregory , Peter John Zanzucchi
IPC分类号： A61B5/00
CPC分类号： A61B5/157 , A61B5/14532 , A61B5/1455 , A61B5/1486 , A61B5/150022 , A61B5/150229 , A61B5/150389 , A61B5/150473 , A61B5/150511 , A61B5/150755 , A61B5/15117 , A61B5/15123 , A61B5/15146 , A61B5/15153 , A61B5/15163 , G06F19/00
摘要： Provided is an analyte monitoring device having a housing, the device comprising: a plurality of needles, each having a tip, a retracted position, a position wherein the tip is extended from the housing a distance adapted to pierce skin; an electrically or spring powered needle pushing apparatus movable to separately engage each of the needles to move each from the retracted position to the extended position; an energy source located within the housing; a plurality of analysis sites comprising an analysis preparation, each adapted to receive liquid from the needles to wet the analysis preparation; one or more light sources adapted to direct light at the analysis sites; one or more light detectors adapted to receive light from the analysis sites; and a processor.

2. 发明授权

US07119838B2 Method and imager for detecting the location of objects 失效
标题翻译：用于检测物体位置的方法和成像器
公开(公告)号：US07119838B2
公开(公告)日：2006-10-10
申请号：US10921294
申请日：2004-08-19
申请人： Peter John Zanzucchi , Richard Morgan Moroney, III , John Gregory Aceti , Timothy Allen Pletcher , Herschel Clement Burstyn
发明人： Peter John Zanzucchi , Richard Morgan Moroney, III , John Gregory Aceti , Timothy Allen Pletcher , Herschel Clement Burstyn
IPC分类号： H04N5/235 , H04N5/228
CPC分类号： G06T7/20
摘要： A device detects the location of objects in an environment by receiving an optical image and converting the optical image of the lost object into a color digital image. The device employs software to perform an analysis of the color digital image to detect the location of the one or more objects in the environment by using color and shape characteristics of the one or more objects. The software uses a range of the visible portion of the color space uniquely identified for the type of object in that environment and identifies those pixels in the color digital image that may be possible targets. Intensity of background and object size are used to exclude pixels as possible target objects.
摘要翻译：设备通过接收光学图像并将丢失的对象的光学图像转换成彩色数字图像来检测环境中对象的位置。该设备使用软件来执行彩色数字图像的分析，以通过使用一个或多个对象的颜色和形状特征来检测环境中的一个或多个对象的位置。该软件使用针对该环境中的对象类型唯一标识的颜色空间的可见部分的范围，并且识别可能是目标的彩色数字图像中的那些像素。背景和对象大小的强度用于将像素排除为可能的目标对象。

3. 发明授权

US07004928B2 Autonomous, ambulatory analyte monitor or drug delivery device 有权
公开(公告)号：US07004928B2
公开(公告)日：2006-02-28
申请号：US10131268
申请日：2002-04-23
申请人： John Gregory Aceti , Sterling Eduard McBride , Richard Morgan Moroney, III , Christopher Carter Gregory , Peter John Zanzucchi
发明人： John Gregory Aceti , Sterling Eduard McBride , Richard Morgan Moroney, III , Christopher Carter Gregory , Peter John Zanzucchi
IPC分类号： A61M5/00 , A61M5/315 , A61B5/00 , B65D81/00
CPC分类号： A61B5/150984 , A61B5/1411 , A61B5/14514 , A61B5/14532 , A61B5/14546 , A61B5/1455 , A61B5/150022 , A61B5/150076 , A61B5/150213 , A61B5/150389 , A61B5/150503 , A61B5/150526 , A61B5/150755 , A61B5/15087 , A61B5/150969 , A61B5/15109 , A61B5/15119 , A61B5/15123 , A61B5/15146 , A61B5/15153 , A61B5/15163 , A61B5/155 , A61B5/157 , A61B5/681 , A61B5/6833 , A61B2560/0412 , A61B2560/0443 , A61M37/0015 , A61M2037/0023 , A61M2037/0038 , A61M2209/088 , A61M2230/201 , G01N33/491
摘要： The invention relates to analyte monitoring/drug (pharmaceutical agent) delivery device. The invention is suited for monitoring various blood constituents such as glucose. The device has a housing that at least partially encloses a plurality of microneedles disposed on a carrier and an electronics portion. Each microneedle is in fluid communication with a corresponding microchannel. Each microneedle is individually addressable. That is, each microneedle can be extended and retracted individually via an actuator. The electronics portion includes a processor and associated circuitry (e.g., memory, supporting electronics and the like), a motor or the like, a sensor, a power supply (e.g., battery) and optionally an interface. In general, the processor controls the operation of the device and is data communication with the actuator, motor, sensor and interface. The invention provides for autonomous operation, that is, without intervention of the user. The invention can optionally provide for calibration without intervention of the user. The invention can also provide for semi-continuous monitoring for day and night time. The invention can provide for up to four, or more, weeks of operation. The invention can provide for a device that is relative small in size, and therefore unobtrusive. The invention can also provide for device with remote control and interactive electronics. The invention may be also used for the delivery of various pharmaceutical agents including high potency drugs to minimize patient intervention and minimize discomfort.

4. 发明授权

US06253871B1 Disposable in-the-ear monitoring instrument using a flexible earmold and casing, and method of manufacture 有权
标题翻译：一次性耳内监测仪器使用灵活的耳罩和套管，以及制造方法
公开(公告)号：US06253871B1
公开(公告)日：2001-07-03
申请号：US09264656
申请日：1999-03-08
申请人： John Gregory Aceti
发明人： John Gregory Aceti
IPC分类号： A61B702
CPC分类号： A61B5/6817 , A61B5/0002 , H04R25/453 , H04R25/456 , H04R25/60 , H04R25/604 , H04R25/608 , H04R25/652 , H04R25/656 , H04R25/658 , H04R2225/023
摘要： A disposable in-the-ear monitoring instrument includes a monitoring assembly for monitoring one or more vital health signs of a user, a transmitter assembly for transmitting the monitored vital health signs to a remote receiving unit, and a battery which is sealed within the monitoring instrument for energizing the assemblies. The assemblies and battery are mounted on a flexible printed circuit which is disposed in a flexible, cylindrical casing. And the casing itself is mounted in an earmold made of soft and compliant material, with conical fins extending from an outer surface of the earmold so that the earmold and monitoring circuitry may be easily deformed to comfortably fit a user. The disposable in-the-ear monitoring instrument is of a design having minimal components, and thus is easy to assemble on an automated basis. The automated assembly of the in-the-ear monitoring instrument and its minimal design reduces cost and allows for the disposability of the monitoring instrument.
摘要翻译：一次性耳内监测仪器包括用于监测用户的一个或多个重要健康标志的监测组件，用于将监测到的重要健康标志传送到远程接收单元的发射器组件和密封在监测器内的电池用于激励组件的仪器。组件和电池安装在设置在柔性圆柱形壳体中的柔性印刷电路上。并且套管本身安装在由柔软且顺从的材料制成的电动工具中，其具有从电动工具的外表面延伸的锥形翅片，使得电动工具和监控电路可以容易地变形以舒适地适合使用者。一次性耳内监测仪器具有最小部件的设计，因此易于在自动化基础上组装。耳内监测仪器的自动组装及其最小设计降低了成本，并允许监测仪器的可处理性。

5. 发明授权

US08303518B2 Autonomous, ambulatory analyte monitor or drug delivery device 有权
标题翻译：自主，动态分析物监测或药物输送装置
公开(公告)号：US08303518B2
公开(公告)日：2012-11-06
申请号：US11311667
申请日：2005-12-20
申请人： John Gregory Aceti , Sterling Eduard Mcbride , Richard Morgan Moroney , Christopher Carter Gregory , Peter John Zanzucchi
发明人： John Gregory Aceti , Sterling Eduard Mcbride , Richard Morgan Moroney , Christopher Carter Gregory , Peter John Zanzucchi
IPC分类号： A61B5/00
CPC分类号： A61B5/150984 , A61B5/1411 , A61B5/14514 , A61B5/14532 , A61B5/14546 , A61B5/1455 , A61B5/150022 , A61B5/150076 , A61B5/150213 , A61B5/150389 , A61B5/150503 , A61B5/150526 , A61B5/150755 , A61B5/15087 , A61B5/150969 , A61B5/15109 , A61B5/15119 , A61B5/15123 , A61B5/15146 , A61B5/15153 , A61B5/15163 , A61B5/155 , A61B5/157 , A61B5/681 , A61B5/6833 , A61B2560/0412 , A61B2560/0443 , A61M37/0015 , A61M2037/0023 , A61M2037/0038 , A61M2209/088 , A61M2230/201 , G01N33/491
摘要： The invention relates to analyte monitoring/drug (pharmaceutical agent) delivery device. The invention is suited for monitoring various blood constituents such as glucose. The device has a housing that at least partially encloses a plurality of microneedles disposed on a carrier and an electronics portion. Each microneedle is in fluid communication with a corresponding microchannel. Each microneedle is individually addressable. That is, each microneedle can be extended and retracted individually via an actuator. The electronics portion includes a processor and associated circuitry (e.g., memory, supporting electronics and the like), a motor or the like, a sensor, a power supply (e.g., battery) and optionally an interface. In general, the processor controls the operation of the device and is data communication with the actuator, motor, sensor and interface. The invention provides for autonomous operation, that is, without intervention of the user. The invention can optionally provide for calibration without intervention of the user. The invention can also provide for semi-continuous monitoring for day and night time. The invention can provide for up to four, or more, weeks of operation. The invention can provide for a device that is relative small in size, and therefore unobtrusive. The invention can also provide for device with remote control and interactive electronics. The invention may be also used for the delivery of various pharmaceutical agents including high potency drugs to minimize patient intervention and minimize discomfort.
摘要翻译：本发明涉及分析物监测/药物（药剂）递送装置。本发明适用于监测各种血液成分如葡萄糖。该装置具有至少部分地包围设置在载体和电子部分上的多个微针的壳体。每个微针与相应的微通道流体连通。每个微针都可单独寻址。也就是说，每个微针可以通过致动器单独地延伸和缩回。电子部分包括处理器和相关联的电路（例如，存储器，支持电子设备等），电动机等，传感器，电源（例如电池）和可选的接口。通常，处理器控制设备的操作，并且与致动器，电动机，传感器和接口进行数据通信。本发明提供自主操作，即不用户干预。本发明可以任选地提供校准而不需要用户的干预。本发明还可以提供昼夜半连续监测。本发明可以提供多达四个或更多周的操作。本发明可以提供尺寸相对较小并因此不显眼的装置。本发明还可以为具有远程控制和交互式电子设备的设备提供。本发明还可以用于递送包括高效药物在内的各种药剂，以最小化患者干预并使不适程度最小化。

6. 发明授权

US07295121B2 Methods and apparatus for aurally presenting notification message in an auditory canal 失效
标题翻译：在听觉通道中听觉地呈现通知信息的方法和装置
公开(公告)号：US07295121B2
公开(公告)日：2007-11-13
申请号：US10927852
申请日：2004-08-27
申请人： John Gregory Aceti
发明人： John Gregory Aceti
IPC分类号： G08B23/00
CPC分类号： G08B21/24 , H04R1/1016 , H04R2420/07
摘要： Methods and apparatus for aurally presenting predefined notification messages within an auditory canal of a user are disclosed. Aural notification is provided by positioning a device at least partially within the auditory canal, processing a digitized notification signal at the device, and aurally presenting a predefined notification message from the device responsive to the processed digitized notification signal.
摘要翻译：公开了在用户的耳道内听觉地呈现预定义的通知消息的方法和装置。通过将设备至少部分地定位在听道内，在设备处理数字化的通知信号，以及响应于处理的数字化通知信号从设备中听觉地呈现预定义的通知消息来提供听觉通知。

7. 发明授权

US06540675B2 Analyte monitor 有权
公开(公告)号：US06540675B2
公开(公告)日：2003-04-01
申请号：US09741755
申请日：2000-12-20
申请人： John Gregory Aceti , Zvi Gerald Loewy , Richard Morgan Moroney, III , Christopher Carter Gregory , Peter John Zanzucchi
发明人： John Gregory Aceti , Zvi Gerald Loewy , Richard Morgan Moroney, III , Christopher Carter Gregory , Peter John Zanzucchi
IPC分类号： A61B500
CPC分类号： A61B5/157 , A61B5/14532 , A61B5/1455 , A61B5/1486 , A61B5/150022 , A61B5/150229 , A61B5/150389 , A61B5/150473 , A61B5/150511 , A61B5/150755 , A61B5/15117 , A61B5/15123 , A61B5/15146 , A61B5/15153 , A61B5/15163 , G06F19/00
摘要： Provided is an analyte monitoring device having a housing, the device comprising: a plurality of needles, each having a tip, a retracted position, a position wherein the tip is extended from the housing a distance adapted to pierce skin; an electrically or spring powered needle pushing apparatus movable to separately engage each of the needles to move each from the retracted position to the extended position; an energy source located within the housing; a plurality of analysis sites comprising an analysis preparation, each adapted to receive liquid from the needles to wet the analysis preparation; one or more light sources adapted to direct light at the analysis sites; one or more light detectors adapted to receive light from the analysis sites; and a processor.

8. 发明授权

US07107088B2 Pulse oximetry methods and apparatus for use within an auditory canal 失效
标题翻译：用于耳道内的脉搏血氧测定方法和装置
公开(公告)号：US07107088B2
公开(公告)日：2006-09-12
申请号：US10847678
申请日：2004-05-17
申请人： John Gregory Aceti
发明人： John Gregory Aceti
IPC分类号： A61B5/00 , A61B5/02
CPC分类号： A61B5/14552 , A61B5/6817 , A61B7/003
摘要： Methods and apparatus for detecting oxygen saturation levels in blood from within an auditory canal of a living being proximal to a tympanic membrane are disclosed. The auditory canal is lined with tissue and includes a proximal bend and a distal bend located between the proximal bend and the tympanic membrane. Oxygen levels are detected by emitting one or more wavelengths of light into a first position on the tissue of the auditory canal in a first region defined by the distal bend and the tympanic membrane. The wavelengths of light are then sensed at a second position on the tissue of the auditory canal in the first region. A blood oxygen saturation level and/or pulse rate is then calculated responsive to intensity information corresponding to the wavelengths of light detected at the second position.
摘要翻译：公开了一种用于检测血液中邻近鼓膜内的生物体内的血液中氧饱和度水平的方法和装置。耳道内衬有组织，包括近端弯曲部和位于近端弯曲部和鼓膜之间的远端弯曲部。通过在由远端弯曲部和鼓膜限定的第一区域中将一个或多个波长的光发射到耳道组织上的第一位置来检测氧水平。然后在第一区域的听觉管的组织上的第二位置处感测光的波长。然后响应于对应于在第二位置处检测到的光的波长的强度信息来计算血氧饱和度和/或脉搏率。

9. 发明授权

US06923764B2 Analyte monitor 有权
标题翻译：分析物监测仪
公开(公告)号：US06923764B2
公开(公告)日：2005-08-02
申请号：US10347620
申请日：2003-01-22
申请人： John Gregory Aceti , Zvi Gerald Loewy , Richard Morgan Moroney, III , Christopher Carter Gregory , Peter John Zanzucchi
发明人： John Gregory Aceti , Zvi Gerald Loewy , Richard Morgan Moroney, III , Christopher Carter Gregory , Peter John Zanzucchi
IPC分类号： A61B5/145 , A61B5/00 , A61B5/1459 , A61B5/15 , A61B5/151 , A61B5/157
CPC分类号： A61B5/157 , A61B5/14532 , A61B5/1455 , A61B5/1486 , A61B5/150022 , A61B5/150229 , A61B5/150389 , A61B5/150473 , A61B5/150511 , A61B5/150755 , A61B5/15117 , A61B5/15123 , A61B5/15146 , A61B5/15153 , A61B5/15163 , G06F19/00
摘要： Provided is an analyte monitoring device having a housing, the device comprising: a plurality of needles, each having a tip, a retracted position, a position wherein the tip is extended from the housing a distance adapted to pierce skin; an electrically or spring powered needle pushing apparatus movable to separately engage each of the needles to move each from the retracted position to the extended position; an energy source located within the housing; a plurality of analysis sites comprising an analysis preparation, each adapted to receive liquid from the needles to wet the analysis preparation; one or more light sources adapted to direct light at the analysis sites; one or more light detectors adapted to receive light from the analysis sites; and a processor.
摘要翻译：提供了一种具有壳体的分析物监测装置，该装置包括：多个针，每个针具有尖端，缩回位置，其中尖端从壳体延伸适合于刺穿皮肤的距离; 电动或弹簧动力的推针装置，其可移动以分别接合每个针，以使其从缩回位置移动到延伸位置; 位于壳体内的能源; 多个分析位点，包括分析制剂，每个分析制剂适于从针头接收液体以润湿分析制剂; 适于在分析场所引导光的一个或多个光源; 一个或多个适于从分析位置接收光的光检测器; 和处理器。

10. 发明授权

US06473511B1 Disposable hearing aid with integral power source 有权
标题翻译：一体式电源助听器
公开(公告)号：US06473511B1
公开(公告)日：2002-10-29
申请号：US09263593
申请日：1999-03-05
申请人： John Gregory Aceti , Walter Paul Sjursen , Marvin Allan Leedom , Derek Mahoney , Fredrick Fritz
发明人： John Gregory Aceti , Walter Paul Sjursen , Marvin Allan Leedom , Derek Mahoney , Fredrick Fritz
IPC分类号： H04R2500
CPC分类号： H04R25/608 , A61B5/6817 , H04R25/453 , H04R25/456 , H04R25/602 , H04R25/65 , H04R25/656 , H04R25/658 , H04R2225/31 , H04R2225/61 , H04R2460/03 , H04R2460/17
摘要： A hearing aid includes a microphone, signal processing circuitry, receiver and integral battery all mounted in a casing. The battery may be a metal-air device. The battery may be activated by removing a tape which blocks air holes on the battery or, if the battery is sealed into the hearing aid, air-vent holes on the hearing aid. The hearing aid may also include an air-blocking mechanism which is activated when the hearing aid is inserted in the user's ear and deactivated when the hearing aid is removed. The assembled hearing aid may also be packaged in non-permeable packaging material to extinguish battery activity. The hearing aid may also include an electronic switch which monitors the battery potential to disconnect the battery from the hearing aid electronics when the battery is deprived of oxygen and which connects the battery to the electronics when oxygen is provided to the battery. In one embodiment of the invention, the integral battery is a rechargeable battery which is recharged via external contacts. In another embodiment, the battery is recharged using an induced alternating current potential which is rectified before being applied to the battery.
摘要翻译：助听器包括麦克风，信号处理电路，接收器和全部安装在壳体中的整体电池。电池可以是金属空气装置。可以通过去除阻挡电池上的空气孔的磁带来激活电池，或者如果电池被密封到助听器中，则助听器上的通气孔。助听器还可以包括空气阻塞机构，当助听器插入使用者的耳朵时被激活，并且当助听器被移除时停用。组装的助听器也可以包装在不可渗透的包装材料中以扑灭电池活动。助听器还可以包括电子开关，其在电池被剥夺氧气时监测电池电位以将电池与助听器电子设备断开，并且当向电池提供氧气时，该开关将电池连接到电子设备。在本发明的一个实施例中，整体电池是通过外部触点再充电的可再充电电池。在另一个实施例中，使用在施加到电池之前被整流的感应交流电位对电池进行再充电。

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