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1. 发明申请

US20090035222A1 Techniques for Identifying Molecular Structures and Treating Cell Types Lining a Body Lumen Using Fluorescence 有权
标题翻译：识别分子结构和处理细胞类型的技术使用荧光衬里体液
公开(公告)号：US20090035222A1
公开(公告)日：2009-02-05
申请号：US12252436
申请日：2008-10-16
申请人： Igal Madar , John C. Murphy
发明人： Igal Madar , John C. Murphy
IPC分类号： A61K49/00
CPC分类号： A61B1/041 , A61B5/0071 , A61B5/073 , A61B2018/00982 , A61B2560/0468 , A61B2562/0233 , A61B2562/162 , A61K41/0057 , A61K41/0071 , A61K49/0013 , A61N1/327 , A61N5/062
摘要： Techniques for detecting fluorescence emitted by molecular constituents in a wall of a body lumen include introducing an autonomous solid support into the body lumen. Cells in a lumen wall of the body lumen are illuminated by a light source mounted to the solid support with a wavelength that excites a particular fluorescent signal. A detector mounted to the solid support detects whether illuminated cells emit the particular fluorescent signal. If the particular fluorescent signal is detected from the illuminated cells, then intensity or position in the lumen wall of the detected fluorescent signal, or both, is determined. These techniques allow the information collected by the capsule to support diagnosis and therapy of GI cancer and other intestinal pathologies and syndromes. For example, these techniques allow diagnostic imaging using endogenous and exogenous fluoroprobes, treating diseased sites by targeted release of drug with or without photoactivation, and determining therapeutic efficacy.
摘要翻译：用于检测体腔内的分子成分发出的荧光的技术包括将自主固体支持物引入体腔。体腔管腔壁中的细胞由安装在固体支持物上的光源照射，激发特定荧光信号的波长。安装到固体支架上的检测器检测照射的细胞是否发射特定的荧光信号。如果从照射的细胞检测到特定的荧光信号，则确定检测到的荧光信号或两者的管腔壁中的强度或位置。这些技术允许胶囊收集的信息支持GI癌症和其他肠道病理学和综合征的诊断和治疗。例如，这些技术允许使用内源和外源性荧光探针进行诊断成像，通过靶向释放具有或不具有光活化的药物来治疗患病部位，并确定治疗功效。

2. 发明授权

US08078262B2 Method for imaging and spectroscopy of tumors and determination of the efficacy of anti-tumor drug therapies 有权
标题翻译：肿瘤成像和光谱学方法以及抗肿瘤药物疗法疗效的测定
公开(公告)号：US08078262B2
公开(公告)日：2011-12-13
申请号：US10474977
申请日：2002-04-15
申请人： John C Murphy , Jerry R. Williams , Robert Osiander
发明人： John C Murphy , Jerry R. Williams , Robert Osiander
IPC分类号： A61B6/00
CPC分类号： A61B5/415 , A61B5/015 , A61B5/416 , A61B5/418
摘要： The present invention relates to methods of passive infrared imaging and dynamic infrared imaging of a tumor or lesion (“DIR”) where multiple images are taken before, during and after heating or cooling the tumor or lesion. Patterns of intensity of infrared emission in the infrared image(s) are related to the level of vascularity or metabolic activity of the tumor or lesion, and are used to identify size and shape of the tumor or lesion. The patterns can also be used to determine whether Kaposi's sarcoma lesions, skin cancer lesions and melanomas are active or inactive. Changes in the patterns of infrared emission determined by comparing images taken before, during and after the onset of drug or radiation therapy, are used to assess efficacy of the therapy. The methods can also be used to study tissue affected by angiogenic diseases.
摘要翻译：本发明涉及在加热或冷却肿瘤或病变之前，期间和之后摄取多个图像的肿瘤或病变（“DIR”）的被动红外成像和动态红外成像方法。红外图像中红外发射强度的模式与肿瘤或病变的血管分布或代谢活动水平有关，用于鉴定肿瘤或病变的大小和形状。这些模式也可用于确定卡波西肉瘤病变，皮肤癌病变和黑素瘤是否活跃或无活性。通过比较在药物或放射治疗之前，期间和之后拍摄的图像确定的红外发射模式的变化用于评估治疗的疗效。该方法也可用于研究受血管生成疾病影响的组织。

3. 发明授权

US5959452A Lorentz force magnetometer having a resonator 失效
标题翻译：洛伦兹力磁力计具有谐振器
公开(公告)号：US5959452A
公开(公告)日：1999-09-28
申请号：US943735
申请日：1997-10-03
申请人： Robert B. Givens , John C. Murphy , Dennis K. Wickenden , Robert Osiander , Thomas J. Kistenmacher
发明人： Robert B. Givens , John C. Murphy , Dennis K. Wickenden , Robert Osiander , Thomas J. Kistenmacher
IPC分类号： G01R33/028 , G01R33/02
CPC分类号： G01R33/028
摘要： The invention consists, in one embodiment, of a resonator such as a conductive bar supported by two wires placed at the nodal points of the fundamental resonance frequency. The wires also supply current of this frequency to the resonator. In the presence of a magnetic field, the Lorentz force causes the resonator to vibrate. The amplitude of this vibration is proportional to a vector component of the magnetic field. The motion of the resonator is detected using one of a number of possible methods including optical beam deflection. The invention has a sensitivity of at least 1 nT, comparable to that of a commercial fluxgate magnetometer, and a dynamic range exceeding 80 dB.
摘要翻译：本发明在一个实施例中包括诸如由放置在基本共振频率的节点处的两根电线支撑的导电棒的谐振器。电线还将该频率的电流提供给谐振器。在存在磁场的情况下，洛伦兹力使谐振器振动。该振动的振幅与磁场的矢量分量成比例。使用包括光束偏转的多种可能方法中的一种来检测谐振器的运动。本发明具有至少1nT的灵敏度，与商业磁通门磁强计相当，并且动态范围超过80dB。

4. 发明授权

US4184768A Self-calibrating photoacoustic apparatus for measuring light intensity and light absorption 失效
标题翻译：用于测量光强度和光吸收的自校准光声装置
公开(公告)号：US4184768A
公开(公告)日：1980-01-22
申请号：US848706
申请日：1977-11-04
申请人： John C. Murphy , Leonard C. Aamodt
发明人： John C. Murphy , Leonard C. Aamodt
IPC分类号： G01N21/17 , G01J3/42 , G01J1/56
CPC分类号： G01N21/1702
摘要： Pulsed light and readily measurable pulsed electrical energy are independently applied to a solid black, conductive sample in a gas-filled photoacoustic cell, each causing the black sample to heat. The heating of the black sample causes a pressure wave in the cell, which can be detected and measured. By adjusting the pulsed electrical energy, the pressure wave resulting from the pulsed electrical energy can be made to relate to the pressure wave resulting from the pulsed light in a predetermined manner. The pulsed light input intensity can then be measured in electrical units based on the measurable input of the electrical energy pulses. In this manner, the invention can be used as a radiometer. A second application for the present apparatus is in calibrating photoacoustic spectroscopy (PAS) cells. The PAS cell can be self-calibrated by discontinuing the light pulses and relating the pressure wave output to the electrical energy pulse input. The measurement then of light absorption in a test sample, which need be neither black nor conductive, can be made in absolute energy units based on the self-calibration relationship.
摘要翻译：脉冲光和容易测量的脉冲电能独立地施加到气体填充的光声单元中的固体黑色导电样品，每个导致黑色样品加热。黑色样品的加热导致电池中的压力波，这可以被检测和测量。通过调节脉冲电能，可以使由脉冲电能产生的压力波以与预定方式的脉冲光产生的压力波相关。然后可以基于电能脉冲的可测量输入以电单元测量脉冲光输入强度。以这种方式，本发明可以用作辐射计。本设备的第二个应用是校准光声光谱（PAS）单元。可以通过停止光脉冲并将压力波输出与电能脉冲输入相关联来对PAS单元进行自校准。基于自校准关系，可以以绝对能量单位进行测量样品中不需要黑色或不导电的测试样品的测量。

5. 发明授权

US4041722A Impact resistant tank for cryogenic fluids 失效
标题翻译：用于低温流体的耐冲击罐
公开(公告)号：US4041722A
公开(公告)日：1977-08-16
申请号：US617109
申请日：1975-09-26
申请人： John Terlesky , Hugh Emil Muller , John C. Murphy , Harold F. Honath
发明人： John Terlesky , Hugh Emil Muller , John C. Murphy , Harold F. Honath
IPC分类号： F17C3/02 , F17C3/06
CPC分类号： F17C3/022 , F17C2201/0109 , F17C2201/0119 , F17C2201/032 , F17C2201/052 , F17C2203/012 , F17C2203/0329 , F17C2203/0341 , F17C2203/0345 , F17C2203/0379 , F17C2203/0607 , F17C2203/0631 , F17C2203/0639 , F17C2203/0648 , F17C2203/0678 , F17C2205/0176 , F17C2205/0332 , F17C2209/228 , F17C2221/033 , F17C2223/0161 , F17C2223/033 , F17C2227/0135 , F17C2227/0178 , F17C2227/0304 , F17C2250/0413 , F17C2250/0439 , F17C2260/011 , F17C2260/036 , F17C2260/042 , F17C2270/0147 , F17C2270/016 , Y10S220/901
摘要： An impact resistant tank for storing cryogenic fluids, includes an inner metal tank having a metal side wall and a metal bottom and a concrete outer wall around the inner metal wall and having reinforcement therein to resist impact loads thereon, and to serve as a secondary containment for the cryogenic fluid.
摘要翻译：一种用于储存低温流体的抗冲击罐，包括内金属罐，其具有金属侧壁和金属底部以及围绕内金属壁的混凝土外壁，并且在其中具有加强件以抵抗其上的冲击载荷，并用作二级容纳物用于低温流体。

6. 发明授权

US07653429B2 Techniques for identifying molecular structures and treating cell types lining a body lumen using fluorescence 有权
标题翻译：用于识别分子结构和使用荧光处理衬里体腔的细胞类型的技术
公开(公告)号：US07653429B2
公开(公告)日：2010-01-26
申请号：US12252436
申请日：2008-10-16
申请人： Igal Madar , John C. Murphy
发明人： Igal Madar , John C. Murphy
IPC分类号： A61B6/00
CPC分类号： A61B1/041 , A61B5/0071 , A61B5/073 , A61B2018/00982 , A61B2560/0468 , A61B2562/0233 , A61B2562/162 , A61K41/0057 , A61K41/0071 , A61K49/0013 , A61N1/327 , A61N5/062
摘要： Techniques for detecting fluorescence emitted by molecular constituents in a wall of a body lumen include introducing an autonomous solid support into the body lumen. Cells in a lumen wall of the body lumen are illuminated by a light source mounted to the solid support with a wavelength that excites a particular fluorescent signal. A detector mounted to the solid support detects whether illuminated cells emit the particular fluorescent signal. If the particular fluorescent signal is detected from the illuminated cells, then intensity or position in the lumen wall of the detected fluorescent signal, or both, is determined. These techniques allow the information collected by the capsule to support diagnosis and therapy of GI cancer and other intestinal pathologies and syndromes. For example, these techniques allow diagnostic imaging using endogenous and exogenous fluoroprobes, treating diseased sites by targeted release of drug with or without photoactivation, and determining therapeutic efficacy.
摘要翻译：用于检测体腔内的分子成分发出的荧光的技术包括将自主固体支持物引入体腔。体腔管腔壁中的细胞由安装在固体支持物上的光源照射，激发特定荧光信号的波长。安装到固体支架上的检测器检测照射的细胞是否发射特定的荧光信号。如果从照射的细胞检测到特定的荧光信号，则确定检测到的荧光信号或两者的管腔壁中的强度或位置。这些技术允许胶囊收集的信息支持GI癌症和其他肠道病理学和综合征的诊断和治疗。例如，这些技术允许使用内源和外源性荧光探针进行诊断成像，通过靶向释放具有或不具有光活化的药物来治疗患病部位，并确定治疗功效。

7. 发明授权

US07515953B2 Techniques for identifying molecular structures and treating cell types lining a body lumen using fluorescence 有权
标题翻译：用于识别分子结构和使用荧光处理衬里体腔的细胞类型的技术
公开(公告)号：US07515953B2
公开(公告)日：2009-04-07
申请号：US10633446
申请日：2003-08-01
申请人： Igal Madar , John C. Murphy
发明人： Igal Madar , John C. Murphy
IPC分类号： A61B6/00
CPC分类号： A61B1/041 , A61B5/0071 , A61B5/073 , A61B2018/00982 , A61B2560/0468 , A61B2562/0233 , A61B2562/162 , A61K41/0057 , A61K41/0071 , A61K49/0013 , A61N1/327 , A61N5/062
摘要： Techniques for detecting fluorescence emitted by molecular constituents in a wall of a body lumen include introducing an autonomous solid support into the body lumen. Cells in a lumen wall of the body lumen are illuminated by a light source mounted to the solid support with a wavelength that excites a particular fluorescent signal. A detector mounted to the solid support detects whether illuminated cells emit the particular fluorescent signal. If the particular fluorescent signal is detected from the illuminated cells, then intensity or position in the lumen wall of the detected fluorescent signal, or both, is determined. These techniques allow the information collected by the capsule to support diagnosis and therapy of GI cancer and other intestinal pathologies and syndromes. For example, these techniques allow diagnostic imaging using endogenous and exogenous fluoroprobes, treating diseased sites by targeted release of drug with or without photoactivation, and determining therapeutic efficacy.
摘要翻译：用于检测体腔内的分子成分发出的荧光的技术包括将自主固体支持物引入体腔。体腔管腔壁中的细胞由安装在固体支持物上的光源照射，激发特定荧光信号的波长。安装到固体支架上的检测器检测照射的细胞是否发射特定的荧光信号。如果从照射的细胞检测到特定的荧光信号，则确定检测到的荧光信号或两者的管腔壁中的强度或位置。这些技术允许胶囊收集的信息支持GI癌症和其他肠道病理学和综合征的诊断和治疗。例如，这些技术允许使用内源和外源性荧光探针进行诊断成像，通过靶向释放具有或不具有光活化的药物来治疗患病部位，并确定治疗功效。

8. 发明授权

US06337627B1 System of providing medical treatment 有权
标题翻译：提供医疗的制度
公开(公告)号：US06337627B1
公开(公告)日：2002-01-08
申请号：US09699183
申请日：2000-10-27
申请人： Robert J. Von Gutfeld , James F. Ziegler , Scott J. McAllister , James H. Anderson , John C. Murphy , Matthias D. Ziegler
发明人： Robert J. Von Gutfeld , James F. Ziegler , Scott J. McAllister , James H. Anderson , John C. Murphy , Matthias D. Ziegler
IPC分类号： G08B1314
CPC分类号： A61B5/06 , A61B5/062 , G01V15/00
摘要： The invention describes methods for locating a treatment device disposed within a living body by means of magnetic fields that are produced by Barkhausen jumps, principally from amorphous tag wires with high permeability that exhibit reentrant flux reversal. When wires of this type are attached to concealed treatment devices such as catheters, interrogation or scanning of the tag wire by a low frequency ac magnetic field affords an accurate means for locating the treatment devices using a sensor coil to detect the magnetic field signal from the wire locating tag. The strength of the field detected by the position of a sensor coil with respect to the locator tag is used to determine the location of the tag. A favorable signal to noise detection ration is obtained as the signal emitted by the wire is at a very high frequency compared to that of the frequency of the interrogation field.
摘要翻译：本发明描述了通过由Barkhausen跳跃产生的磁场来定位设置在生物体内的治疗装置的方法，主要是来自呈现出可重入通量反转的高磁导率的非晶标签线。当这种类型的导线连接到诸如导管的隐蔽处理装置时，通过低频交流磁场对标签线的询问或扫描提供了使用传感器线圈来定位处理装置的精确装置，以检测来自电线定位标签。使用传感器线圈相对于定位器标签的位置检测的场强度来确定标签的位置。获得有利的信噪比检测比例，因为与线询问频率相比，由线发出的信号处于非常高的频率。

9. 发明授权

US06183126B2 Method for nondestructive/noncontact microwave detection of electrical and magnetic property discontinuities in materials 失效
标题翻译：非破坏性/非接触微波检测材料中电磁特性不连续性的方法
公开(公告)号：US06183126B2
公开(公告)日：2001-02-06
申请号：US08886236
申请日：1997-07-01
申请人： John C. Murphy , Robert Osiander , Jane W. Maclachlan Spicer
发明人： John C. Murphy , Robert Osiander , Jane W. Maclachlan Spicer
IPC分类号： G01N2572
CPC分类号： G01N22/00 , G01N25/72
摘要： Nondestructive/noncontact evaluation of a material for electrical and magnetic property discontinuities, e.g., a dielectric loss or the presence of a conducting contaminant, is accomplished by using microwaves to heat microwave-absorbing regions of the material caused by such discontinuities; monitoring the change in temperature of the material's surface due to the heating of the microwave-absorbing region as a function of time; and detecting the electrical and magnetic property discontinuities, e.g., the dielectric loss or the conducting contaminant, using the change in the material's surface temperature.
摘要翻译：通过使用微波来加热由这种不连续性引起的材料的微波吸收区域来实现用于电和磁性不连续性的材料（例如介电损耗或导电污染物的存在）的非破坏性/非接触式评估; 监测由于微波吸收区域的加热而导致的材料表面温度随时间的变化; 并使用材料表面温度的变化来检测电气和磁性不连续性，例如介电损耗或导电污染物。

10. 发明授权

US5998995A Microelectromechanical (MEMS)-based magnetostrictive magnetometer 失效
标题翻译：基于微机电（MEMS）的磁致伸缩磁力计
公开(公告)号：US5998995A
公开(公告)日：1999-12-07
申请号：US944625
申请日：1997-10-03
申请人： Robert Osiander , Scott A. Ecelberger , Robert B. Givens , Dennis K. Wickenden , John C. Murphy , Thomas J. Kistenmacher
发明人： Robert Osiander , Scott A. Ecelberger , Robert B. Givens , Dennis K. Wickenden , John C. Murphy , Thomas J. Kistenmacher
IPC分类号： G01R33/02
CPC分类号： G01R33/0286 , G01R33/02
摘要： A microelectromechanical-based magnetostrictive magnetometer that uses, as an active element, a commercial (001) silicon microcantilever coated with an amorphous thin film of the giant magnetostrictive alloy Terfenol-D and a compact optical beam deflection transduction scheme. A set of Helmholtz coils is used to create an ac magnetic excitation field for driving the mechanical resonance of the coated microcantilever. When the coated microcantilever is placed in a dc magnetic field, the dc field will change the amplitude at the mechanical resonance of the coated microcantilever thereby causing a deflection that can be measured. The magnetometer has been demonstrated with a sensitivity near 1 .mu.T.
摘要翻译：使用涂覆有巨磁致伸缩合金Terfenol-D的非晶薄膜的商业（001）硅微悬臂梁作为有源元件的微机电型磁致伸缩磁力计和紧凑的光束偏转换能方案。一组亥姆霍兹线圈用于产生用于驱动涂覆的微型悬臂梁的机械共振的交流磁激励场。当涂覆的微悬臂梁放置在直流磁场中时，直流场将改变涂覆的微型悬臂梁的机械谐振处的振幅，从而引起可测量的偏转。磁力计已被证明灵敏度接近1亩。

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