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1. 发明授权

US09168247B2 Beta carboline derivatives useful in the treatment of proliferative disorders 有权
标题翻译：可用于治疗增殖性疾病的β咔啉衍生物
公开(公告)号：US09168247B2
公开(公告)日：2015-10-27
申请号：US13704109
申请日：2011-06-24
申请人： Raphael Frederick , Bernard Masereel , Jeremy Reniers , Johan Wouters , Celine Bruyere , Robert Kiss , Céline Anne Marie Michelle Meinguet , Véronique Emmanuelle Julie Mathieu
发明人： Raphael Frederick , Bernard Masereel , Jeremy Reniers , Johan Wouters , Celine Bruyere , Robert Kiss , Céline Anne Marie Michelle Meinguet , Véronique Emmanuelle Julie Mathieu
IPC分类号： A61K31/437 , C07D471/04
CPC分类号： A61K31/437 , C07D471/04
摘要： The invention provides novel beta-carboline derivatives of formulae (Ia) and (Ib) useful in the treatment of proliferative disorders including cancer, intermediates used in their preparation, processes for preparing the same and uses thereof.
摘要翻译：本发明提供了可用于治疗包括癌症在内的增殖性疾病，其制备中使用的中间体，其制备方法及其应用的式（Ia）和（Ib）的新型β-咔啉衍生物。

2. 发明申请

US20050151726A1 Programmable remote control and method for programming a programmable remote control, a readable memory and a program 有权
标题翻译：可编程遥控器和可编程遥控器，可读存储器和程序的编程方法
公开(公告)号：US20050151726A1
公开(公告)日：2005-07-14
申请号：US10509238
申请日：2003-02-27
申请人： Johan Wouters
发明人： Johan Wouters
IPC分类号： H04N5/00 , G08C19/28 , H04Q9/00 , G09G5/00
CPC分类号： G08C19/28
摘要： A remote control comprises object keys and a selector for linking preset IR or RF code sets to the object keys. The remote control comprises:—a selector for the selection of an IR or RF preset code set by a user,—an activator for the activation of one or more links between an element of said preset IR or RF code set and an object key by the user after the selection,—a selector for the subsequent selection of a further preset code set by the user and—repeat means for repeating the steps a and b for the further preset code set until all object keys have been linked or the user terminates the process. This allows the user to combine more then one preset code set into a single code set.
摘要翻译：遥控器包括对象键和用于将预设的IR或RF代码集连接到对象键的选择器。遥控器包括： - 用于选择由用户设置的IR或RF预设代码的选择器， - 用于激活所述预设IR或RF代码组的元素与对象键之间的一个或多个链接的激活器，用户选择之后，选择器用于随后选择由用户设置的另外的预设代码和重复装置，用于重复步骤a和b用于另外的预设代码集，直到所有对象键已被链接或用户终止的过程。这允许用户将多于一个的预设代码集合在单个代码集中。

3. 发明授权

US5997201A Holder for a stick of a spreadable substance 失效
标题翻译：持有人的可扩散物质的棍子
公开(公告)号：US5997201A
公开(公告)日：1999-12-07
申请号：US556959
申请日：1996-03-12
申请人： Marie Claude Bossert , Joachim Franken , Johan Wouters , Johannes Hubertus Jozef Maria Kelders
发明人： Marie Claude Bossert , Joachim Franken , Johan Wouters , Johannes Hubertus Jozef Maria Kelders
IPC分类号： A45D40/02 , B65D83/00 , A45D40/04 , A45D40/16
CPC分类号： A45D40/02
摘要： A device for holding a stick or rod of spreadable material includes a sleeve or container open on one side, an element co-acting with the stick, and a hand-operated means for varying the distance between the edge of the open side of the sleeve and the stick element. The stick or rod of spreadable material can be an adhesive stick or a wax stick. The stick of spreadable material is packaged separately from the device in an envelope of thin material, and the container includes means for securely holding an envelope of thin material suitable for packaging the stick.
摘要翻译： PCT No.PCT / NL94 / 00137 Sec。 371日期：1996年3月12日 102（e）1996年3月12日PCT 1994年6月10日PCT公布。公开号WO94 / 28760 PCT 日期1994年12月22日用于保持可展开材料的棒或杆的装置包括在一侧开口的套筒或容器，与棒共同作用的元件，以及用于改变所述边缘的距离的手动装置袖子的开口侧和棒状元件。可伸展材料的棒或杆可以是粘合棒或蜡棒。可展开材料的棒与该装置分开地封装在薄材料的外壳中，并且容器包括用于牢固地保持适合于包装棒的薄材料的外壳的装置。

4. 发明申请

US20130116273A1 BETA CARBOLINE DERIVATIVES USEFUL IN THE TREATMENT OF PROLIFERATIVE DISORDERS 有权
标题翻译：用于治疗增生性疾病的β-碳醇衍生物
公开(公告)号：US20130116273A1
公开(公告)日：2013-05-09
申请号：US13704109
申请日：2011-06-24
申请人： Raphael Frederick , Bernard Masereel , Jeremy Reniers , Johan Wouters , Celine Bruyere , Robert Kiss
发明人： Raphael Frederick , Bernard Masereel , Jeremy Reniers , Johan Wouters , Celine Bruyere , Robert Kiss
IPC分类号： A61K31/437 , C07D471/04
CPC分类号： A61K31/437 , C07D471/04
摘要： The invention provides novel beta-carboline derivatives of formulae (Ia) and (Ib) useful in the treatment of proliferative disorders including cancer, intermediates used in their preparation, processes for preparing the same and uses thereof.
摘要翻译：本发明提供了可用于治疗包括癌症在内的增殖性疾病，其制备中使用的中间体，其制备方法及其应用的式（Ia）和（Ib）的新型β-咔啉衍生物。

5. 发明授权

US07979280B2 Text to speech synthesis 有权
标题翻译：文字到语音综合
公开(公告)号：US07979280B2
公开(公告)日：2011-07-12
申请号：US11709056
申请日：2007-02-22
申请人： Johan Wouters , Christof Traber , Marcel Riedi , Martin Reber , Jürgen Keller
发明人： Johan Wouters , Christof Traber , Marcel Riedi , Martin Reber , Jürgen Keller
IPC分类号： G10L13/06
CPC分类号： G10L13/033 , G10L13/07
摘要： An input linguistic description is converted into a speech waveform by deriving at least one target unit sequence corresponding to the linguistic description, selecting from a waveform unit database for the target unit sequences a plurality of alternative unit sequences approximating the target unit sequences, concatenating the alternative unit sequences to alternative speech waveforms and presenting the alternative speech waveforms to an operating person and enabling the choice of one of the presented alternative speech waveforms. There are no iterative cycles of manual modification and automatic selection, which enables a fast way of working. The operator does not need knowledge of units, targets, and costs, but chooses from a set of given alternatives. The fine-tuning of TTS prompts therefore becomes accessible to non-experts.
摘要翻译：输入语言描述通过导出与语言描述相对应的至少一个目标单元序列而被转换成语音波形，从波形单元数据库中选择目标单元序列多个替代单元序列近似目标单元序列，并置替代单元序列到替代语音波形，并向操作人员呈现替代语音波形，并且能够选择所呈现的替代语音波形之一。没有手动修改和自动选择的迭代循环，这使得快速的工作方式。运营商不需要知道单位，目标和成本，而是从一组给定的替代方案中选择。因此，TTS提示的微调可以非专业人员访问。

6. 发明申请

US20100001248A1 PHASE-CHANGE MEMORY CELL WITH A PATTERNED LAYER 有权
标题翻译：相变记忆细胞与图案层
公开(公告)号：US20100001248A1
公开(公告)日：2010-01-07
申请号：US11914638
申请日：2006-05-18
申请人： Dirk Johan Wouters , Ludovic Goux , Judith Lisoni , Thomas Gille
发明人： Dirk Johan Wouters , Ludovic Goux , Judith Lisoni , Thomas Gille
IPC分类号： H01L47/00 , H01L21/06
CPC分类号： H01L45/06 , G11C13/0004 , H01L45/1226 , H01L45/144 , H01L45/165 , H01L45/1675
摘要： A phase-change-material memory cell is provided. The cell comprises at least one patterned layer of a phase-change material, and is characterized in that this patterned layer comprises at least two regions having different resistivities. If the resistivity of the phase-change material is higher in a well-defined area with limited dimensions (“hot spot”) than outside this area, then, for a given current flow between the electrodes, advantageously more Joule heat will be generated within this area compared to the area of the phase-change material where the resistivity is lower.
摘要翻译：提供了相变材料存储单元。该电池包括至少一个相变材料的图案化层，其特征在于，该图案化层包括具有不同电阻率的至少两个区域。如果在具有有限尺寸（“热点”）的明确限定区域内的相变材料的电阻率高于该区域之外，则对于电极之间的给定电流，有利地将在内部产生更多的焦耳热该区域与电阻率较低的相变材料的面积相比。

7. 发明授权

US06374226B1 System and method for interfacing speech recognition grammars to individual components of a computer program 有权
标题翻译：将语音识别语法与计算机程序的各个组件进行接口的系统和方法
公开(公告)号：US06374226B1
公开(公告)日：2002-04-16
申请号：US09369577
申请日：1999-08-06
申请人： Andrew J. Hunt , William D. Walker , Johan Wouters
发明人： Andrew J. Hunt , William D. Walker , Johan Wouters
IPC分类号： G10L1528
CPC分类号： G10L15/26 , G10L15/18 , G10L15/193 , G10L2015/228
摘要： A system for incorporating speech recognition into a computer program, including a number of speech controller modules corresponding to program components within the computer program. Each speech controller module supports a speech recognition grammar having at least one rule, where the speech recognition grammar provides an interface to operations on the corresponding program component. The rules of the speech recognition grammar associate spoken commands with data stored in the corresponding program component. A rule may include a reference to another local rule, or to a rule in a different speech recognition grammar, in which case a “link” to the other rule is formed. In this way, the disclosed system allows rules from the same or different grammars to be combined together, in order to build complex grammars. Each speech controller module operates to dynamically enable one or more rules it contains within a speech recognizer, in response to detecting the occurrence of an associated enabling condition. The speech controller module receives a recognition result from the speech recognizer indicating that the speech recognizer has detected one or more tokens associated with an enabled rule. In response to receipt of the recognition result, a speech controller module operates to invoke a method on data within the corresponding program component, and passes the result on to other speech controller modules that are linked to the recognition rule corresponding to the result.
摘要翻译：一种用于将语音识别结合到计算机程序中的系统，包括与计算机程序内的程序组件对应的多个语音控制器模块。每个语音控制器模块支持具有至少一个规则的语音识别语法，其中语音识别语法提供对相应程序组件的操作的接口。语音识别语法的规则将口头命令与存储在相应程序组件中的数据相关联。规则可以包括对另一个本地规则的引用，或者指向不同语音识别语法中的规则，在这种情况下，形成与其他规则的“链接”。以这种方式，所公开的系统允许来自相同或不同语法的规则被组合在一起，以便构建复杂的语法。响应于检测到相关联的启用条件的发生，每个语音控制器模块操作以动态地使其在语音识别器内包含的一个或多个规则。语音控制器模块从语音识别器接收指示语音识别器已经检测到与启用的规则相关联的一个或多个令牌的识别结果。响应于识别结果的接收，语音控制器模块操作以调用相应程序组件内的数据的方法，并将结果传递给链接到对应于结果的识别规则的其他语音控制器模块。

8. 发明授权

US08301451B2 Speech synthesis with dynamic constraints 有权
标题翻译：语音合成与动态约束
公开(公告)号：US08301451B2
公开(公告)日：2012-10-30
申请号：US12457911
申请日：2009-06-25
申请人： Johan Wouters
发明人： Johan Wouters
IPC分类号： G10L13/00 , G10L13/08
CPC分类号： G10L13/07
摘要： A method is disclosed for providing speech parameters to be used for synthesis of a speech utterance. In at least one embodiment, the method includes receiving an input time series of first speech parameter vectors, preparing at least one input time series of second speech parameter vectors consisting of dynamic speech parameters, extracting from the input time series of first and second speech parameter vectors partial time series of first speech parameter vectors and corresponding partial time series of second speech parameter vectors, converting the corresponding partial time series of first and second speech parameter vectors into partial time series of third speech parameter vectors, wherein the conversion is done independently for each set of partial time series and can be started as soon as the vectors of the input time series of the first speech parameter vectors have been received. The speech parameter vectors of the partial time series of third speech parameter vectors are combined to form a time series of output speech parameter vectors to be used for synthesis of the speech utterance. At least one embodiment of the method allows a continuous providing of speech parameter vectors for synthesis of the speech utterance. The latency and the memory requirements for the synthesis of a speech utterance are reduced.
摘要翻译：公开了一种用于提供用于合成语音话语的语音参数的方法。在至少一个实施例中，该方法包括接收第一语音参数向量的输入时间序列，准备由动态语音参数组成的第二语音参数向量的至少一个输入时间序列，从输入时间序列中提取第一和第二语音参数矢量部分时间序列的第一语音参数矢量和第二语音参数矢量的相应部分时间序列，将第一和第二语音参数矢量的对应部分时间序列转换成第三语音参数向量的部分时间序列，其中独立地完成转换一组部分时间序列，一旦已经接收到第一语音参数矢量的输入时间序列的向量，就可以开始。组合第三语音参数矢量的部分时间序列的语音参数矢量以形成用于合成语音话语的输出语音参数向量的时间序列。该方法的至少一个实施例允许连续提供用于合成语音话语的语音参数矢量。降低了语音语音合成的延迟和内存需求。

9. 发明申请

US20090076819A1 Text to speech synthesis 有权
标题翻译：文字到语音综合
公开(公告)号：US20090076819A1
公开(公告)日：2009-03-19
申请号：US11709056
申请日：2007-02-22
申请人： Johan Wouters , Christof Traber , Marcel Riedi , Martin Reber , Jurgen Keller
发明人： Johan Wouters , Christof Traber , Marcel Riedi , Martin Reber , Jurgen Keller
IPC分类号： G10L13/00 , G10L13/08
CPC分类号： G10L13/033 , G10L13/07
摘要： An input linguistic description is converted into a speech waveform by deriving at least one target unit sequence corresponding to the linguistic description, selecting from a waveform unit database for the target unit sequences a plurality of alternative unit sequences approximating the target unit sequences, concatenating the alternative unit sequences to alternative speech waveforms and presenting the alternative speech waveforms to an operating person and enabling the choice of one of the presented alternative speech waveforms. There are no iterative cycles of manual modification and automatic selection, which enables a fast way of working. The operator does not need knowledge of units, targets, and costs, but chooses from a set of given alternatives. The fine-tuning of TTS prompts therefore becomes accessible to non-experts.
摘要翻译：输入语言描述通过导出与语言描述相对应的至少一个目标单元序列而被转换为语音波形，从波形单元数据库中选择目标单元序列多个替代单元序列近似目标单元序列，并置替代单元序列到替代语音波形，并向操作人员呈现替代语音波形，并且能够选择所呈现的替代语音波形之一。没有手动修改和自动选择的迭代循环，这使得快速的工作方式。运营商不需要知道单位，目标和成本，而是从一组给定的替代方案中选择。因此，TTS提示的微调可以非专业人员访问。

10. 发明授权

US07288247B2 Antibodies for use in targeted and temporary treatment of humans and animals 失效
标题翻译：用于靶向和临时治疗人类和动物的抗体
公开(公告)号：US07288247B2
公开(公告)日：2007-10-30
申请号：US09780205
申请日：2001-02-09
申请人： Stanislaus Laurens Johan Wouters , Heinz Helmut Renggli , Danielle Angelique Horbach
发明人： Stanislaus Laurens Johan Wouters , Heinz Helmut Renggli , Danielle Angelique Horbach
IPC分类号： A61K39/395 , A61K39/00 , C07K16/00
CPC分类号： A61Q11/00 , A61K8/64 , A61K47/6815
摘要： An antibody or an antibody fragment that binds to an epitope under specifically chosen conditions; the binding of which to the epitope is broken under specifically chosen different conditions. Also, an antibody or antibody fragment with which a diagnostically, therapeutically or cosmetically active substance is optionally conjugated, for targeted and temporary diagnostic, therapeutic, or cosmetic treatment of externally accessible parts of the human and animal body. Both the specifically chosen binding conditions and the conditions wherein the binding is broken lie within physiologically acceptable limits and involve pH and/or ionic strength. The antibody or antibody fragment can be used for targeted and temporary treatment of externally accessible parts of the human and animal body. Also, a composition including at least one antibody, or a fragment thereof, according to the invention such as a teeth cleaning agent, mouthwash, mouth spray, chewing tablet, cream or ointment.
摘要翻译：在特定选择的条件下结合表位的抗体或抗体片段; 在特定选择的不同条件下，其与表位的结合被破坏。此外，用于诊断，治疗或化妆活性物质任选缀合的抗体或抗体片段用于人和动物体外部可接近的部分的靶向和临时诊断，治疗或美容治疗。特异选择的结合条件和其中结合被破坏的条件都在生理学上可接受的限度内并且涉及pH和/或离子强度。抗体或抗体片段可用于靶向和临时治疗人体和动物体外部易接近部位。此外，还包含根据本发明的至少一种抗体或其片段的组合物，例如牙齿清洁剂，漱口剂，口腔喷雾剂，咀嚼片，霜剂或软膏剂。

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