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1. 发明申请

US20050215628A1 Andrographolide and analogues as inhibitors of TNFalpha and IL-1beta expression 有权
标题翻译：穿心莲内酯和类似物作为TNFalpha和IL-1beta表达的抑制剂
公开(公告)号：US20050215628A1
公开(公告)日：2005-09-29
申请号：US11078198
申请日：2005-03-11
申请人： Xiaoqiang Yan , Tao Wang , Zhiming Ma , Ke Pan , Weihan Zhang , Jianrong Hong , Jeff Duan , Yu Cai
发明人： Xiaoqiang Yan , Tao Wang , Zhiming Ma , Ke Pan , Weihan Zhang , Jianrong Hong , Jeff Duan , Yu Cai
IPC分类号： A61K31/341 , A61K31/365
CPC分类号： A61K31/365
摘要： This invention relates to a method of inhibiting the expression of TNFα or IL-1β with a compound of the following formula: wherein R1 and R2 are defined herein. It also relates to is a method of treating inflammatory bowel disease with such a compound.
摘要翻译：本发明涉及用下式化合物抑制TNFα或IL-1β的表达的方法：其中R 1和R 2 2定义在本文中。它还涉及用这种化合物治疗炎症性肠病的方法。

2. 发明授权

US06892199B2 Saving burst data by using semi-merge sorting module 有权
标题翻译：使用半合并排序模块保存突发数据
公开(公告)号：US06892199B2
公开(公告)日：2005-05-10
申请号：US09896040
申请日：2001-06-29
申请人： Jianrong Hong , Lin Yu
发明人： Jianrong Hong , Lin Yu
IPC分类号： G06F17/30
CPC分类号： G06F17/30595 , Y10S707/99937
摘要： Systems, methods and computer program products for storing data from multiple clients in a database include a Multi-thread Shared Memory message Queue Buffer (MSMQB) that includes multiple First-In First-Out (FIFO) queues, a respective one of which is associated with a respective one of the clients. The MSMQB is configured to store sequential bursts of data records that are received from the clients in the associated FIFO queues. A Semi-Merge Sort Module (SMSM) is configured to sort the sequential bursts in the FIFO queues based on the primary key of at least one selected record but not every record, to produce a semi-sorted record stream for serially stored in the database.
摘要翻译：用于存储来自数据库中的多个客户端的数据的系统，方法和计算机程序产品包括：多线程共享存储器消息队列缓冲器（MSMQB），其包括多个先进先出（FIFO）队列，其中相应的一个相关联与相应的客户之一。 MSMQB被配置为存储在相关联的FIFO队列中从客户端接收的数据记录的连续突发。半合并分类模块（SMSM）被配置为基于至少一个所选记录的主键而不是每个记录对FIFO队列中的顺序突发进行排序，以产生串行存储在数据库中的半排序记录流。

3. 发明授权

US07625945B2 Andrographolide and analogues as inhibitors of TNFα and IL-1β expression 有权
标题翻译：穿心莲内酯和类似物作为TNFalpha和IL-1beta表达的抑制剂
公开(公告)号：US07625945B2
公开(公告)日：2009-12-01
申请号：US11078198
申请日：2005-03-11
申请人： Xiaoqiang Yan , Tao Wang , Zhiming Ma , Ke Pan , Weihan Zhang , Jianrong Hong , Jeff Duan , Yu Cai
发明人： Xiaoqiang Yan , Tao Wang , Zhiming Ma , Ke Pan , Weihan Zhang , Jianrong Hong , Jeff Duan , Yu Cai
IPC分类号： A61K31/341
CPC分类号： A61K31/365
摘要： This invention relates to a method of inhibiting the expression of TNFα or IL-1β with a compound of the following formula: wherein R1 and R2 are defined herein. It also relates to is a method of treating inflammatory bowel disease with such a compound.
摘要翻译：本发明涉及用下式化合物抑制TNFα或IL-1β的表达的方法：其中R1和R2如本文所定义。它还涉及用这种化合物治疗炎症性肠病的方法。

4. 发明申请

US20050226943A1 Extract of sophora flavescens flavonoids and uses thereof 审中-公开
标题翻译：槐花黄酮提取物及其用途
公开(公告)号：US20050226943A1
公开(公告)日：2005-10-13
申请号：US11095783
申请日：2005-03-30
申请人： Xiaoqiang Yan , Yumin Cui , Tao Wang , Zhiming Ma , Ke Pan , Weihan Zhang , Weihui Huang , Jianrong Hong , Jeff Duan , Yu Cai
发明人： Xiaoqiang Yan , Yumin Cui , Tao Wang , Zhiming Ma , Ke Pan , Weihan Zhang , Weihui Huang , Jianrong Hong , Jeff Duan , Yu Cai
IPC分类号： A61K31/353 , A61K31/7048 , A61K35/78
CPC分类号： A61K36/489 , A61K31/353 , A61K31/7048
摘要： Compositions containing a Sophora flavescens flavonoids extract or its active ingredients, Kurarinone, 2′-methoxy-Kurarinone, and Sophoraflavanone G are described. Also disclosed is a method of treating TNFα and IL-1β related diseases using such compositions.
摘要翻译：描述了含有苦参黄酮提取物或其活性成分的组合物，Kurarinone，2'-甲氧基 - Kurarinone和Sophoraflavanone G。还公开了使用这种组合物治疗TNFα和IL-1β相关疾病的方法。

5. 发明申请

US20050124684A1 5-(hydroxymethyl) furfural and derivatives as inhibitors of TNFalpha and IL-1beta production 审中-公开
标题翻译：糠醛和其衍生物作为TNFalpha和IL-1beta的抑制剂
公开(公告)号：US20050124684A1
公开(公告)日：2005-06-09
申请号：US10930887
申请日：2004-08-30
申请人： Ying Du , Kevin Pan , Weihan Zhang , Xiaoqiang Yan , Jianrong Hong
发明人： Ying Du , Kevin Pan , Weihan Zhang , Xiaoqiang Yan , Jianrong Hong
IPC分类号： A61K31/34 , A61K31/381
CPC分类号： A61K31/34
摘要： A method of inhibiting TNFα or IL-1β expression with 5-hydroxymethyl furfural and its derivatives. Also disclosed is a method of treating TNFα or IL-1β related disorders using these compounds.
摘要翻译：用5-羟甲基糠醛及其衍生物抑制TNFα或IL-1β表达的方法。还公开了使用这些化合物治疗TNFα或IL-1β相关病症的方法。

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