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1. 发明申请

WO2012135500A1 ENGINEERED THIOREDOXIN-LIKE FOLD PROTEINS 审中-公开
标题翻译：工程化的硫氧还蛋白样蛋白
公开(公告)号：WO2012135500A1
公开(公告)日：2012-10-04
申请号：PCT/US2012/031212
申请日：2012-03-29
申请人： THE GENERAL HOSPITAL CORPORATION , WOLFE, Jia L. , CHO, Glen S. , SEED, Brian
发明人： WOLFE, Jia L. , CHO, Glen S. , SEED, Brian
IPC分类号： C12P21/00
CPC分类号： C07K14/001 , C07K2319/35 , C12N15/1044 , G01N33/53 , G01N33/68
摘要： The invention features compositions based on thioredoxin-like fold protein domains described as engineered thioredoxin-like fold proteins (ETRXs). These proteins include one or more artificially diversified thioredoxin-like fold protein domains; each domain may be originated from the same or different thioredoxin-like fold protein domains. Features of the invention also include methods for identifying and preparing an enriched composition of target binding, loop-diversified ETRXs with additional sequence variations to improve affinity, stability, selectivity, or solubility. The invention also features compositions of ETRXs substituted with prosthetic groups, polymers, proteins, nucleic acids, carbohydrates, metals, natural or synthetic small molecules and toxins.
摘要翻译：本发明的特征在于基于硫氧还蛋白样折叠蛋白质结构域的组合物，其描述为工程化硫氧还蛋白样折叠蛋白（ETRX）。这些蛋白质包括一个或多个人工多样化的硫氧还蛋白样折叠蛋白质结构域; 每个结构域可以源于相同或不同的硫氧还蛋白样折叠蛋白结构域。本发明的特征还包括用于鉴定和制备具有额外序列变异的靶结合，环多样化ETRX的富集组合物以提高亲和力，稳定性，选择性或溶解度的方法。本发明还特征在于用补体基团，聚合物，蛋白质，核酸，碳水化合物，金属，天然或合成的小分子和毒素取代的ETRX的组合物。

2. 发明申请

WO2009009139A3 RNA LIGASE POLYPEPTIDES AND METHODS OF SELECTION AND USE THEREOF 审中-公开
标题翻译： RNA连接酶多肽及其选择和使用方法
公开(公告)号：WO2009009139A3
公开(公告)日：2009-05-28
申请号：PCT/US2008008550
申请日：2008-07-11
申请人： GEN HOSPITAL CORP , SEELIG BURCHARD , SZOSTAK JACK W , KEEFE ANTHONY D , CHO GLEN S
发明人： SEELIG BURCHARD , SZOSTAK JACK W , KEEFE ANTHONY D , CHO GLEN S
IPC分类号： C07K14/00
CPC分类号： C12N9/93
摘要： The present invention features polypeptides capable of catalyzing a ligation reaction between a first RNA molecule comprising, e.g., a hydroxyl group at the 3' position and a second RNA molecule comprising, e.g., a triphosphate group at the 5' position. The invention further features methods of selecting, optimizing, and using such polypeptides.
摘要翻译：本发明的特征在于能够催化包含例如3'位羟基的第一RNA分子与包含例如5'位三磷酸基团的第二RNA分子之间的连接反应的多肽。本发明的特征还在于选择，优化和使用这些多肽的方法。

3. 发明申请

WO2008011157A3 METHODS, COMPOSITIONS, AND KITS FOR THE SELECTIVE ACTIVATION OF PROTOXINS THROUGH COMBINATORIAL TARGETING 审中-公开
公开(公告)号：WO2008011157A3
公开(公告)日：2008-01-24
申请号：PCT/US2007/016475
申请日：2007-07-20
申请人： THE GENERAL HOSPITAL CORPORATION , SEED, Brian , WOLFE, Jia, Liu , CHO, Glen, S. , TSAI, Chai-lun
发明人： SEED, Brian , WOLFE, Jia, Liu , CHO, Glen, S. , TSAI, Chai-lun
IPC分类号： A61K39/00
摘要： The present invention provides methods and compositions for treating various diseases through selective killipg of targeted cells μsing a combinatorial targeting approach. The invention features protoxin fusion proteins containing a cell targeting rηoiety and, a modifiable activation moiety which is activated by an activation moiety not riaturally operably found in, on, or in the vicinity of a target cell. These methods also include the combinatorial use of two or more therapeutic agents, at minimum comprising a protoxin and a protoxin activator, to target and destroy a specific cell population.

4. 发明申请

WO2008011157A2 METHODS, COMPOSITIONS, AND KITS FOR THE SELECTIVE ACTIVATION OF PROTOXINS THROUGH COMBINATORIAL TARGETING 审中-公开
标题翻译：组合靶向选择性激活原核蛋白的方法，组合物和试剂盒
公开(公告)号：WO2008011157A2
公开(公告)日：2008-01-24
申请号：PCT/US2007016475
申请日：2007-07-20
申请人： GEN HOSPITAL CORP , SEED BRIAN , WOLFE JIA LIU , CHO GLEN S , TSAI CHAI-LUN
发明人： SEED BRIAN , WOLFE JIA LIU , CHO GLEN S , TSAI CHAI-LUN
IPC分类号： A61K39/395
CPC分类号： C07K16/2803 , A61K38/00 , A61K47/6849 , A61K47/6889 , A61K47/6899 , B82Y5/00 , C07K14/195 , C07K14/28 , C07K14/34 , C07K2319/55 , C12N9/16
摘要： The present invention provides methods and compositions for treating various diseases through selective killipg of targeted cells µsing a combinatorial targeting approach. The invention features protoxin fusion proteins containing a cell targeting r?oiety and, a modifiable activation moiety which is activated by an activation moiety not riaturally operably found in, on, or in the vicinity of a target cell. These methods also include the combinatorial use of two or more therapeutic agents, at minimum comprising a protoxin and a protoxin activator, to target and destroy a specific cell population.
摘要翻译：本发明提供了通过组合靶向方法通过选择性杀死靶细胞来治疗各种疾病的方法和组合物。本发明的特征在于含有细胞靶向性突变的原毒素融合蛋白，以及可变活化部分，所述可修饰活化部分被在靶细胞内，靶标上或靶标细胞附近没有天然可操作发现的活化部分激活。这些方法还包括组合使用两种或更多种治疗剂，至少包含原毒素和原毒素激活剂，以靶向和破坏特定的细胞群。

5. 发明申请

WO2009009139A2 RNA LIGASE POLYPEPTIDES AND METHODS OF SELECTION AND USE THEREOF 审中-公开
公开(公告)号：WO2009009139A2
公开(公告)日：2009-01-15
申请号：PCT/US2008/008550
申请日：2008-07-11
申请人： THE GENERAL HOSPITAL CORPORATION , SEELIG, Burchard , SZOSTAK, Jack, W. , KEEFE, Anthony, D. , CHO, Glen, S.
发明人： SEELIG, Burchard , SZOSTAK, Jack, W. , KEEFE, Anthony, D. , CHO, Glen, S.
IPC分类号： C12Q1/68
CPC分类号： C12N9/93
摘要： The present invention features polypeptides capable of catalyzing a ligation reaction between a first RNA molecule comprising, e.g., a hydroxyl group at the 3' position and a second RNA molecule comprising, e.g., a triphosphate group at the 5' position. The invention further features methods of selecting, optimizing, and using such polypeptides.
摘要翻译：本发明的特征在于能够催化包含例如在3'位置的羟基的第一RNA分子与包含例如在5'位置的三磷酸基团的第二RNA分子之间的连接反应的多肽。本发明还涉及选择，优化和使用这些多肽的方法。

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