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1. 发明授权

US07056434B2 Method and system for identifying and quantifying chemical components of a mixture 失效
公开(公告)号：US07056434B2
公开(公告)日：2006-06-06
申请号：US10829680
申请日：2004-04-22
申请人： Jan van der Greef , Jacibus Thomas Wilhelmus Elisabeth Vogels , Florian Wulfert , Albert Tas
发明人： Jan van der Greef , Jacibus Thomas Wilhelmus Elisabeth Vogels , Florian Wulfert , Albert Tas
IPC分类号： B01D15/08
CPC分类号： G01N30/8665 , G01N30/8624 , G01N30/8641 , G01N30/8662 , G01N30/8686 , H01J49/0036
摘要： Method and system for processing and evaluating data from combination chromatographic and mass spectrometric data. The methods and system comprise data smoothing and determination of an quality factor for a chromatogram of a data set based on a determined entropy value. In one embodiment, the methods and system further comprise data baseline correction prior to entropy value determination. In a further embodiment, a correlation is determined between chromatograms processed according to the invention and one or more chromatograms of one or more data sets. Preferably, said correlation is performed using a multivariate analysis.

2. 发明申请

US20050283320A1 Method and system for profiling biological systems 审中-公开
标题翻译：生物系统分析方法和系统
公开(公告)号：US20050283320A1
公开(公告)日：2005-12-22
申请号：US11141253
申请日：2005-05-31
申请人： Noubar Afeyan , Jan van der Greef , Frederick Regnier , Aram Adourian , Eric Neumann , Matej Oresic , Elwin Verheij
发明人： Noubar Afeyan , Jan van der Greef , Frederick Regnier , Aram Adourian , Eric Neumann , Matej Oresic , Elwin Verheij
IPC分类号： G01N27/62 , B01J20/283 , C12Q1/02 , C12Q1/68 , G01N30/26 , G01N30/34 , G01N30/72 , G01N30/88 , G01N31/00 , G01N33/48 , G01N33/50 , G01N33/53 , G01R33/465 , G06F19/24
CPC分类号： G16B40/00 , Y10T436/24
摘要： The present invention provides methods and systems for developing profiles of a biological system based on the discernment of similarities, differences, and/or correlations between biomolecular components, of a single biomolecular component type, of a plurality of biological samples. Preferably, the method comprises utilizing hierarchical multivariate analysis of spectrometric data at one or more levels of correlation.
摘要翻译：本发明提供了用于基于多个生物样品的单个生物分子组分类型的生物分子组分之间的相似性，差异性和/或相关性来识别生物系统的图谱的方法和系统。优选地，该方法包括在一个或多个相关级别上利用光谱数据的分层多变量分析。

3. 发明申请

US20050273275A1 Method and system for profiling biological systems 审中-公开
公开(公告)号：US20050273275A1
公开(公告)日：2005-12-08
申请号：US11141258
申请日：2005-05-31
申请人： Noubar Afeyan , Jan van der Greef , Frederick Regnier , Aram Adourian , Eric Neumann , Matej Oresic , Elwin Verheij
发明人： Noubar Afeyan , Jan van der Greef , Frederick Regnier , Aram Adourian , Eric Neumann , Matej Oresic , Elwin Verheij
IPC分类号： G01N27/62 , B01J20/283 , C12Q1/02 , C12Q1/68 , G01N30/26 , G01N30/34 , G01N30/72 , G01N30/88 , G01N31/00 , G01N33/48 , G01N33/50 , G01N33/53 , G01R33/465 , G06F19/24
CPC分类号： G16B40/00 , Y10T436/24
摘要： The present invention provides methods and systems for developing profiles of a biological system based on the discernment of similarities, differences, and/or correlations between biomolecular components, of a single biomolecular component type, of a plurality of biological samples. Preferably, the method comprises utilizing hierarchical multivariate analysis of spectrometric data at one or more levels of correlation.

4. 发明申请

US20050170372A1 Methods and systems for profiling biological systems 审中-公开
标题翻译：生物系统分析方法和系统
公开(公告)号：US20050170372A1
公开(公告)日：2005-08-04
申请号：US10922820
申请日：2004-08-20
申请人： Noubar Afeyan , Jan van der Greef , Frederick Regnier , Aram Adourian , Eric Neumann , Matej Oresic , Elwin Verheij
发明人： Noubar Afeyan , Jan van der Greef , Frederick Regnier , Aram Adourian , Eric Neumann , Matej Oresic , Elwin Verheij
IPC分类号： C12Q1/68 , G01N33/00 , G01N33/48 , G01N33/50 , G06F19/12 , G06F19/24 , G06F19/00
CPC分类号： C12Q1/68 , G01N33/48 , G01N33/50 , G16B5/00 , G16B40/00
摘要： Methods and systems are disclosed for developing profiles of a state of a biological system based on the discernment of similarities, differences, and/or correlations between a plurality of data sets that are derived from one or more biomolecular component types, one or more biological sample types, and/or one or more types of measurements.
摘要翻译：公开了用于基于从一种或多种生物分子组分类型衍生的多个数据集之间的相似性，差异和/或相关性的辨别来发展生物系统的状态的方法和系统，一种或多种生物样品类型和/或一种或多种类型的测量。

5. 发明授权

US06743364B2 Method and system for identifying and quantifying chemical components of a mixture 失效
标题翻译：用于识别和定量混合物的化学成分的方法和系统
公开(公告)号：US06743364B2
公开(公告)日：2004-06-01
申请号：US09920993
申请日：2001-08-02
申请人： Jan van der Greef
发明人： Jan van der Greef
IPC分类号： B01D1508
CPC分类号： G01N30/8665 , G01N30/8624 , G01N30/8641 , G01N30/8662 , G01N30/8686 , H01J49/0036
摘要： Method and system for processing and evaluating data from combination chromatographic and mass spectrometric data. The methods and system comprise data smoothing and determination of an quality factor for a chromatogram of a data set based on a determined entropy value. In one embodiment, the methods and system further comprise data baseline correction prior to entropy value determination. In a further embodiment, a correlation is determined between chromatograms processed according to the invention and one or more chromatograms of one or more data sets. Preferably, said correlation is performed using a multivariate analysis.
摘要翻译：从组合色谱和质谱数据处理和评估数据的方法和系统。方法和系统包括基于确定的熵值的数据集的色谱图的数据平滑和质量因子的确定。在一个实施例中，方法和系统还包括在熵值确定之前的数据基线校正。在另一个实施方案中，在根据本发明处理的色谱图和一个或多个数据集的一个或多个色谱图之间确定相关性。优选地，所述相关性使用多变量分析进行。

6. 发明授权

US6080590A On-line coupling biochemical detection to continuous flow separation techniques 失效
标题翻译：在线耦合生物化学检测到连续流动分离技术
公开(公告)号：US6080590A
公开(公告)日：2000-06-27
申请号：US632540
申请日：1996-04-19
申请人： Jan Van Der Greef , Hubertus Irth , Aaike Johannes Oosterkamp , Eva Saskia Mareike Lutz
发明人： Jan Van Der Greef , Hubertus Irth , Aaike Johannes Oosterkamp , Eva Saskia Mareike Lutz
IPC分类号： G01N33/53 , G01N33/537 , G01N33/536 , C12Q1/70
CPC分类号： G01N33/537 , G01N33/53
摘要： The present invention relates to an on-line detection method comprising the on-line coupling of a fractionation and a biochemical detection technique, which method comprises the addition of a controlled amount of an affinity molecule to the effluent of the fractionation step to react with analytes in the effluent, the subsequent addition of a controlled amount of a detectable ligand capable of binding to the affinity molecule, and detection of the affinity molecule/detectable ligand complex. Further, the invention is directed to an on-line method for the screening of compounds on their binding capability to a known affinity molecule, which method comprises a fractionation step providing an effluent, the addition of a controlled amount of said affinity molecule to the effluent of the fractionation step and effecting a contact time sufficient to allow a reaction with or interaction between the compounds in the effluent, the subsequent addition of a controlled amount of a detectable ligand capable of binding to the affinity molecule, and detection of the affinity molecule/detectable ligand complex.
摘要翻译：本发明涉及一种在线检测方法，其包括分级分离的在线偶联和生物化学检测技术，该方法包括向分级步骤的流出物中添加受控量的亲和分子以与分析物反应在流出物中，随后添加受控量的能够结合亲和分子的可检测配体，以及检测亲和分子/可检测配体复合物。此外，本发明涉及用于筛选化合物对已知亲和分子的结合能力的在线方法，该方法包括提供流出物的分馏步骤，向流出物中加入受控量的所述亲和分子的分级步骤，并且实现足以允许流出物中化合物的反应或相互作用的接触时间，随后加入受控量的能够结合亲和分子的可检测配体，以及检测亲和分子/ 可检测的配体复合物。

7. 发明授权

US08068987B2 Method and system for profiling biological systems 有权
标题翻译：生物系统分析方法和系统
公开(公告)号：US08068987B2
公开(公告)日：2011-11-29
申请号：US10218880
申请日：2002-08-13
申请人： Noubar B. Afeyan , Jan van der Greef , Frederick E. Regnier , Aram S. Adourian , Eric K. Neumann , Matej Oresic , Elwin Robbert Verheij
发明人： Noubar B. Afeyan , Jan van der Greef , Frederick E. Regnier , Aram S. Adourian , Eric K. Neumann , Matej Oresic , Elwin Robbert Verheij
IPC分类号： G01N33/48 , G01N33/50
CPC分类号： G06F19/24 , Y10T436/24
摘要： The present invention provides methods and systems for developing profiles of a biological system based on the discernment of similarities, differences, and/or correlations between biomolecular components of a plurality of biological samples. Preferably, the method comprises utilizing hierarchical multivariate analysis of spectrometric data at one or more levels of correlation.
摘要翻译：本发明提供了基于对多个生物样品的生物分子组分之间的相似性，差异和/或相关性的鉴别来开发生物系统的分布的方法和系统。优选地，该方法包括在一个或多个相关级别上利用光谱数据的分层多变量分析。

8. 发明申请

US20070020180A1 Method for determining the impact of a multicomponent natural product mixture on the biological profile of a disease within a group of living systems and the developement and quality control of natural product based medicine 审中-公开
公开(公告)号：US20070020180A1
公开(公告)日：2007-01-25
申请号：US10570505
申请日：2004-09-03
申请人： Mei Wang , Renger Witkamp , Jan van Der Greef
发明人： Mei Wang , Renger Witkamp , Jan van Der Greef
IPC分类号： G06Q50/00 , C12Q1/00 , A61K49/00 , A61K36/18
CPC分类号： G01N33/6803 , G01N33/5023 , G01N33/5088 , G01N2550/00 , G06Q50/22 , G16B25/00
摘要： The present invention provides a method for determining the impact of a multicomponent natural product mixture on the biological profile of a disease comprising the steps of: (a) determining a biological profile of the disease by comparing the biological profile of a group of living systems with symptoms of the disease with the biological profile of a reference (or healthy) group of living systems, using a multivariate analysis; (b) determining the impact of a series of samples of the multicomponent mixture on the biological profile of the disease, in which samples the concentrations of one or more natural components or groups of natural components differ, using a multivariate analysis; (c) determining the composition of the samples of the multicomponent mixture that have shown in step (b) a desired impact on the biological profile of the disease, using a multivariate analysis; (d) identifying within the compositions as determined in step (c) the effective components or groups of components and their respective concentrations required for having the desired impact on the biological profile of the disease, using a multivariate analysis. The invention also provides a method for preparing a medicament, wherein the effective natural components or groups of components as identified in step (d) are combined in the respective concentrations required for having an impact on the biological profile of the disease. The invention further provides a method for designing and controlling the composition of a multicomponent mixture, wherein the concentration of at least one natural component of the mixture is adjusted to ensure that the at least one natural component of the mixture has an impact on a biological profile of the disease. The present invention also relates to the use of the present method as a tool for optimizing the breeding, cultivation or post harvesting processing of natural products for use in natural product-based medicines.

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