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1. 发明申请

WO2011132939A8 CYTOKINE-BPB SPECIFICALLY BINDING TO CYTOKINE 审中-公开
标题翻译：细胞因子-BPB特异性结合细胞因子
公开(公告)号：WO2011132939A8
公开(公告)日：2012-08-09
申请号：PCT/KR2011002839
申请日：2011-04-20
申请人： KWANGJU INST SCI & TECH , JON SANG YONG , KIM SUNG HYUN , PARK SE HO , KIM DAE JIN , LEE SANG HEON
发明人： JON SANG YONG , KIM SUNG HYUN , PARK SE HO , KIM DAE JIN , LEE SANG HEON
IPC分类号： C07K1/107 , C12N15/63 , C40B30/04 , C40B40/10
CPC分类号： C07K14/47 , G01N2333/705
摘要： The present invention relates to a Cytokine-bipodal peptide binder specifically binding to Cytokine, comprising: (a) a structure stabilizing region comprising parallel, antiparallel, or parallel and antiparallel, amino acid strands in which interstrand non-covalent bonds are formed; and (b) a KCytokine-target binding region I and a Cytokine-target binding region I which bond to both terminals of the structure stabilizing region and which comprise n and m amino acids randomly selected, respectively. The Cytokine-bipodal peptide binder of the present invention exhibits a very low (for example, nM levels) KD value (dissociation constant) relative to Cytokine and therefore exhibits a very high affinity toward a Cytokine target. The Cytokine-bipodal peptide binder of the present invention may have a use as a pharmaceutical, for in vivo molecular imaging and drug delivery targeting, and be useful as an escort molecule.
摘要翻译：本发明涉及特异性结合细胞因子的细胞因子 - 双足肽结合蛋白，其包含：（a）包含平行，反向平行或平行和反向平行的氨基酸链的结构稳定区，其中形成链间非共价键; 和（b）分别结合到结构稳定区的两个末端并且分别包含n和m个氨基酸的随机选择的K细胞因子 - 靶结合区I和细胞因子 - 靶结合区I。本发明的细胞因子 - 双足肽粘合剂相对于细胞因子显示非常低（例如，nM水平）KD值（解离常数），因此对细胞因子靶标表现出非常高的亲和力。本发明的细胞因子 - 双齿肽结合物可以用作药物，用于体内分子成像和药物递送靶向，并且可用作护送分子。

2. 发明申请

WO2011132938A3 GPCR-BPB SPECIFICALLY BINDING TO GPCR 审中-公开
标题翻译： GPCR-BPB特异性绑定到GPCR
公开(公告)号：WO2011132938A3
公开(公告)日：2012-05-10
申请号：PCT/KR2011002838
申请日：2011-04-20
申请人： KWANGJU INST SCI & TECH , JON SANG YONG , KIM SUNG HYUN , PARK SE HO , KIM DAE JIN , LEE SANG HEON
发明人： JON SANG YONG , KIM SUNG HYUN , PARK SE HO , KIM DAE JIN , LEE SANG HEON
IPC分类号： C07K1/107 , C12N15/63 , C40B30/04 , C40B40/10
CPC分类号： C07K14/705 , A61K47/64 , A61K49/0002 , A61K49/0056 , G01N2333/726
摘要： The present invention relates to a GPCR-bipodal peptide binder specifically binding to GPCR, comprising: (a) a structure stabilizing region comprising parallel, antiparallel, or parallel and antiparallel amino acid strands in which an interstrand noncovalent bond is formed; and (b) a GPCR-target binding region I and a GPCR-target binding region II which bind respectively to both ends of the structure stabilizing region and comprise randomly selected n and m amino acids, respectively. The GPCR-bipodal peptide binder of the present invention shows a very low level (for example, nM level) of KD value (dissociation constant) to GPCR, thereby showing very high affinity to a GPCR target. The GPCR-bipodal peptide binder of the present invention has medical use, can be used for in vivo molecular imaging, in vitro cell imaging and targeting for drug delivery, and also can be very usefully used as an escort molecule.
摘要翻译：本发明涉及与GPCR特异性结合的GPCR-双足肽结合物，其包含：（a）包含平行，反向平行或平行和反平行的氨基酸链的结构稳定区，其中形成链间非共价键; 和（b）分别结合结构稳定区两端的GPCR靶结合区I和GPCR-靶结合区II，分别包含随机选择的n和m个氨基酸。本发明的GPCR-双足肽粘合剂对GPCR显示非常低的KD值（解离常数）的水平（例如，nM水平），从而对GPCR靶表现出非常高的亲和力。本发明的GPCR-双足肽粘合剂具有医学应用，可用于体内分子成像，体外细胞成像和药物递送靶向，也可非常有效地用作护送分子。

3. 发明申请

WO2011071279A3 BPB-BASED CARGO DELIVERY SYSTEM 审中-公开
标题翻译： BPB为基础的货物运输系统
公开(公告)号：WO2011071279A3
公开(公告)日：2011-11-10
申请号：PCT/KR2010008645
申请日：2010-12-03
申请人： KWANGJU INST SCI & TECH , JON SANG YONG , KIM SUNG HYUN , PARK SEHO , KIM DONGKYU , PARK JINHO , SAW PHEI ER
发明人： JON SANG YONG , KIM SUNG HYUN , PARK SEHO , KIM DONGKYU , PARK JINHO , SAW PHEI ER
IPC分类号： C07K19/00 , C07K7/08
CPC分类号： C07K19/00
摘要： The present invention relates to a BPB-based cargo delivery system, comprising: (a) bipodal peptide binder (BPB) including (i) a structure-stabilizing region that includes parallel, antiparallel, or parallel and antiparallel amino acid strands in which interstrand non-covalent bonds are formed, and (ii) a target-binding region I and a target-binding region II which are bonded to both terminals of the structure-stabilizing region and which include randomly selected n and m amino acids, respectively; and (b) a cargo bonded to the BPB. The BPB-based cargo delivery system of the present invention can deliver various substances onto or into cells by using the target-bonding and target-specific characteristics of the BPB. The BPB has a very low KD value (dissociation constant) (for example, nM level) and therefore exhibits a very high affinity toward a target. The BPB-based cargo delivery system of the present invention can be used in the fields of medicine, in vivo molecular imaging, in vitro cell imaging, and drug delivery targeting, and can be very useful as an escort molecule.
摘要翻译：本发明涉及一种基于BPB的货物递送系统，包括：（a）双齿肽结合物（BPB），其包括（i）结构稳定区域，其包括平行，反平行或平行和反平行的氨基酸链，（ii）与结构稳定化区域的两末端结合的目标结合区域I和目标结合区域II，其分别包括随机选择的n和m个氨基酸; 和（b）与BPB保税的货物。本发明的基于BPB的货物运送系统可以通过使用BPB的目标结合和目标特定特性将各种物质运送到细胞上或细胞内。 BPB具有非常低的KD值（解离常数）（例如，nM水平），因此对靶标表现出非常高的亲和力。本发明的基于BPB的货物递送系统可用于医学，体内分子成像，体外细胞成像和药物递送靶向领域，并且可作为护送分子非常有用。

4. 发明申请

WO2009031804A3 MULTI-FUNCTIONAL POLYMERIC LAYERS AND ITS USES 审中-公开
标题翻译：多功能聚合物层及其用途
公开(公告)号：WO2009031804A3
公开(公告)日：2009-04-30
申请号：PCT/KR2008005170
申请日：2008-09-03
申请人： KWANGJU INST SCI & TECH , JON SANG YONG , PARK SANGJIN , SUNG DAE KYUNG , YANG HAESIK
发明人： JON SANG YONG , PARK SANGJIN , SUNG DAE KYUNG , YANG HAESIK
IPC分类号： G01N33/68
CPC分类号： G01N33/54393 , B01J19/0046 , B01J2219/00315 , B01J2219/00382 , B01J2219/00576 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00626 , B01J2219/0063 , B01J2219/00637 , B01J2219/00659 , B01J2219/00677 , B01J2219/00702 , B01J2219/00725
摘要： The present invention relates to a process of preparing a polymer-coated anti-biofouling solid substrate comprising a covalently-bondable functional group, comprising (a) preparing a polymer comprising a surface- anchoring part, a protein-repellent part and a reactive part by reacting (i) a first monomer comprising a surface-anchoring part that can be bound onto the surface of the solid substrate, (ii) a second monomer comprising an anti- biofouling polymer, and (iii) a third monomer comprising a covalently- bondable functional group; and (b) coating the polymer onto the surface of the solid substrate.
摘要翻译：本发明涉及一种制备包含共价键合官能团的聚合物涂覆的抗生物污损固体基质的方法，其包括（a）通过以下步骤制备包含表面锚定部分，蛋白质驱避部分和反应性部分的聚合物：使（i）包含可结合到固体基材表面上的表面锚定部分的第一单体，（ii）包含抗生物污损聚合物的第二单体，和（iii）包含可共价键合的第三单体功能组和（b）将聚合物涂覆在固体基材的表面上。

5. 发明申请

WO2005103125A1 ULTRATHIN POLYMER FILM USING CUCURBITURIL DERIVATIVE AND METHOD OF FORMING THE SAME 审中-公开
标题翻译：超级聚合物薄膜使用CURGBITURIL衍生物及其形成方法
公开(公告)号：WO2005103125A1
公开(公告)日：2005-11-03
申请号：PCT/KR2005/001141
申请日：2005-04-21
申请人： POSTECH ACADEMY-INDUSTRY FOUNDATION , KIM, Ki-Moon , JEON, Woo-Sung , KIM, Dong-Woo , OH, Dong-Hyun , JON, Sang-Yong
发明人： KIM, Ki-Moon , JEON, Woo-Sung , KIM, Dong-Woo , OH, Dong-Hyun , JON, Sang-Yong
IPC分类号： C08J5/22
CPC分类号： C08J5/18 , B82Y30/00 , C08J2329/02 , Y10S977/882 , Y10S977/883 , Y10S977/897 , Y10T428/31504 , Y10T428/31678
摘要： Provided are an ultrathin polymer film formed by homopolymerization or copolymerization of a cucurbituril derivative with an organic monomer and a method of forming the same. The ultrathin polymer film has a thickness of 10 nm or less, and can retain its film shape even after being separated from a substrate.
摘要翻译：提供了通过葫芦巴衍生物与有机单体的均聚或共聚形成的超薄聚合物膜及其形成方法。超薄聚合物膜的厚度为10nm以下，即使在与基板分离后也能够保持其膜形状。

6. 发明申请

WO2009031859A3 MULTI-FUNCTIONAL COMPLEX FOR IMAGING AND DRUG DELIVERY 审中-公开
标题翻译：用于成像和药物递送的多功能复合体
公开(公告)号：WO2009031859A3
公开(公告)日：2009-05-14
申请号：PCT/KR2008005268
申请日：2008-09-05
申请人： ANYGEN CO LTD , JON SANG YONG , YU MIKYUNG
发明人： JON SANG YONG , YU MIKYUNG
IPC分类号： A61K9/51
CPC分类号： A61K49/1854 , A61K47/6923 , A61K49/1848 , A61K49/1857 , A61K49/186 , A61K49/1866 , B82Y5/00
摘要： The present invention relates to a multi-functional complex for imaging and drug delivery comprising a plurality of nanoparticles, wherein the nanoparticles comprise: (a) a signal generating core; and a water soluble polymeric outer shell coated on the signal generating core, comprising a surface-anchoring site containing silyl-, hydroxysilyl- or alkoxysilyl-functionalized groups and a drug-binding site.
摘要翻译：本发明涉及包含多个纳米颗粒的用于成像和药物递送的多功能复合物，其中纳米颗粒包括：（a）信号产生芯; 以及涂覆在信号产生芯上的水溶性聚合物外壳，其包含含有甲硅烷基，羟基甲硅烷基或烷氧基甲硅烷基官能化基团的表面锚定位点和药物结合位点。

7. 发明申请

WO2009031804A2 MULTI-FUNCTIONAL POLYMERIC LAYERS AND ITS USES 审中-公开
标题翻译：多功能聚合物层及其用途
公开(公告)号：WO2009031804A2
公开(公告)日：2009-03-12
申请号：PCT/KR2008/005170
申请日：2008-09-03
申请人： GWANGJU INSTITUTE OF SCIENCE AND TECHNOLOGY , JON, Sang Yong , PARK, Sangjin , SUNG, Dae Kyung , YANG, Haesik
发明人： JON, Sang Yong , PARK, Sangjin , SUNG, Dae Kyung , YANG, Haesik
IPC分类号： G01N33/68
CPC分类号： G01N33/54393 , B01J19/0046 , B01J2219/00315 , B01J2219/00382 , B01J2219/00576 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00626 , B01J2219/0063 , B01J2219/00637 , B01J2219/00659 , B01J2219/00677 , B01J2219/00702 , B01J2219/00725
摘要： The present invention relates to a process of preparing a polymer-coated anti-biofouling solid substrate comprising a covalently-bondable functional group, comprising (a) preparing a polymer comprising a surface- anchoring part, a protein-repellent part and a reactive part by reacting (i) a first monomer comprising a surface-anchoring part that can be bound onto the surface of the solid substrate, (ii) a second monomer comprising an anti- biofouling polymer, and (iii) a third monomer comprising a covalently- bondable functional group; and (b) coating the polymer onto the surface of the solid substrate.
摘要翻译：本发明涉及一种制备包含共价键性官能团的聚合物包衣的抗生物附着固体基质的方法，其包括（a）制备包含表面锚定部分，蛋白质（i）包含可结合到所述固体基质表面上的表面锚定部分的第一单体，（ii）包含抗生物污垢聚合物的第二单体，和（iii）包含抗生物附着聚合物的第二单体，包含共价键合官能团的第三单体; 和（b）将聚合物涂覆到固体基材的表面上。

8. 发明申请

WO2003055888A1 HYDROXYCUCURBITURIL DERIVATIVES, THEIR PREPARATION METHODS AND USES 审中-公开
标题翻译：羟脯氨酸衍生物，其制备方法和用途
公开(公告)号：WO2003055888A1
公开(公告)日：2003-07-10
申请号：PCT/KR2002/002213
申请日：2002-11-26
申请人： POSTECH FOUNDATION , KIM, Ki-Moon , JON, Sang-Yong , SELVAPALAM, NARAYANAN , OH, Dong-Hyun
发明人： KIM, Ki-Moon , JON, Sang-Yong , SELVAPALAM, NARAYANAN , OH, Dong-Hyun
IPC分类号： C07D487/22
CPC分类号： C07D487/22 , Y02C10/08
摘要： Provided are hydroxycucurbituril derivatives, their preparation methods and uses. The hydroxycucurbituril derivative is easy to further functionalize with enhanced solubility in common solvents, thereby providing wider applications.
摘要翻译：提供羟ucurituril衍生物，其制备方法和用途。羟基葫芦脲衍生物易于进一步官能化，在普通溶剂中的溶解度增加，从而提供更广泛的应用。

9. 发明申请

WO2012157945A3 METHOD FOR EXPRESSING A TARGET PROTEIN AT THE SURFACE OF A VACUOLE, AND DRUG DELIVERY CARRIER 审中-公开
标题翻译：用于在真空表面表达目标蛋白的方法和药物递送载体
公开(公告)号：WO2012157945A3
公开(公告)日：2013-01-17
申请号：PCT/KR2012003811
申请日：2012-05-15
申请人： KWANGJU INST SCI & TECH , JON SANG YONG , JUN YOUNG SOO , LEE SANG EUN , LEE MIRIAM , KIM SUNG HYUN
发明人： JON SANG YONG , JUN YOUNG SOO , LEE SANG EUN , LEE MIRIAM , KIM SUNG HYUN
IPC分类号： C12N15/62 , C07K19/00 , C12N1/19 , C12N15/74
CPC分类号： C12N15/1037 , C07K16/32 , C07K2318/20 , C07K2319/03 , C07K2319/06
摘要： The present invention relates to a method for expressing a target protein at the surface of a vacuole of a microorganism, and to a drug delivery carrier. More particularly, the present invention relates to a method comprising the steps of: (a) creating a vector including a nucleotide sequence encoding a fusion protein containing a target protein and a vacuole-targeting transmembrane protein; (b) transforming a microorganism containing a vacuole using said vector; and (c) expressing the fusion protein from the transformed microorganism. According to the present invention, the expressed fusion protein targets the vacuole and the target protein of the fusion protein is expressed at the surface of the vacuole. The present invention relates to a method for preparing a drug delivery carrier which is safe and easily applied in a clinical setting by fusion expressing the target protein and vacuole targeting transmembrane protein on the surface of a vacuole of a yeast. Further, the present invention relates to a method for preparing a drug delivery carrier which is cost-efficient when the method of the present invention is industrialized, using yeast having more economically advantageous culturing conditions.
摘要翻译：本发明涉及在微生物的液泡表面和药物递送载体上表达靶蛋白的方法。更具体地，本发明涉及一种方法，其包括以下步骤：（a）产生包含编码含有靶蛋白和液泡靶向跨膜蛋白的融合蛋白的核苷酸序列的载体; （b）使用所述载体转化含有液泡的微生物; 和（c）从转化的微生物表达融合蛋白。根据本发明，表达的融合蛋白靶向液泡，融合蛋白的靶蛋白在液泡的表面表达。本发明涉及一种制备药物递送载体的方法，其通过在酵母的液泡表面上融合表达靶蛋白和液泡靶向跨膜蛋白而在临床环境中安全和容易地应用。此外，本发明涉及一种制备药物递送载体的方法，当使用具有更经济有利的培养条件的酵母将本发明的方法工业化时，其成本效益高。

10. 发明申请

WO2011132940A3 RTK-BPB SPECIFICALLY BINDING TO RTK 审中-公开
标题翻译： RTK-BPB特异性绑定到RTK
公开(公告)号：WO2011132940A3
公开(公告)日：2012-04-05
申请号：PCT/KR2011002840
申请日：2011-04-20
申请人： KWANGJU INST SCI & TECH , JON SANG YONG , KIM SUNG HYUN , PARK SE HO , KIM DAE JIN , LEE SANG HEON
发明人： JON SANG YONG , KIM SUNG HYUN , PARK SE HO , KIM DAE JIN , LEE SANG HEON
IPC分类号： C07K1/107 , C12N15/63 , C40B30/04 , C40B40/10
CPC分类号： C07K14/47 , G01N2333/715
摘要： The present invention relates to a cytokine-bipodal peptide binder specifically binding to cytokine, comprising (a) a structure stabilizing region comprising parallel, antiparallel, or parallel and antiparallel amino acid strands in which an interstrand noncovalent bond is formed; and (b) a cytokine-target binding region I and a cytokine-target binding region II which bind to both ends of the structure stabilizing region and comprise n and m amino acids randomly selected, respectively. The cytokine-bipodal peptide binder of the present invention shows a very low level (for example, nM level) of KD value (dissociation constant) to cytokine, thereby showing very high affinity to a cytokine target. The cytokine-bipodal peptide binder of the present invention has medical use, can be used for in vivo molecular imaging and targeting for drug delivery, and is very useful as an escort molecule.
摘要翻译：本发明涉及特异性结合细胞因子的细胞因子 - 双足肽结合蛋白，其包含（a）包含平行，反向平行或平行和反向平行的氨基酸链的结构稳定区，其中形成链间非共价键; 和（b）分别结合结构稳定区的两端并且分别包含n和m个氨基酸的随机选择的细胞因子 - 靶结合区I和细胞因子 - 靶结合区II。本发明的细胞因子 - 双足肽粘合剂对细胞因子显示非常低的KD值（例如，nM水平）的KD值（解离常数），从而对细胞因子靶标显示非常高的亲和力。本发明的细胞因子 - 双足肽粘合剂具有医学应用，可用于体内分子成像和靶向用于药物递送，并且作为护送分子非常有用。

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