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1. 发明申请

WO2011071279A3 BPB-BASED CARGO DELIVERY SYSTEM 审中-公开
标题翻译： BPB为基础的货物运输系统
公开(公告)号：WO2011071279A3
公开(公告)日：2011-11-10
申请号：PCT/KR2010008645
申请日：2010-12-03
申请人： KWANGJU INST SCI & TECH , JON SANG YONG , KIM SUNG HYUN , PARK SEHO , KIM DONGKYU , PARK JINHO , SAW PHEI ER
发明人： JON SANG YONG , KIM SUNG HYUN , PARK SEHO , KIM DONGKYU , PARK JINHO , SAW PHEI ER
IPC分类号： C07K19/00 , C07K7/08
CPC分类号： C07K19/00
摘要： The present invention relates to a BPB-based cargo delivery system, comprising: (a) bipodal peptide binder (BPB) including (i) a structure-stabilizing region that includes parallel, antiparallel, or parallel and antiparallel amino acid strands in which interstrand non-covalent bonds are formed, and (ii) a target-binding region I and a target-binding region II which are bonded to both terminals of the structure-stabilizing region and which include randomly selected n and m amino acids, respectively; and (b) a cargo bonded to the BPB. The BPB-based cargo delivery system of the present invention can deliver various substances onto or into cells by using the target-bonding and target-specific characteristics of the BPB. The BPB has a very low KD value (dissociation constant) (for example, nM level) and therefore exhibits a very high affinity toward a target. The BPB-based cargo delivery system of the present invention can be used in the fields of medicine, in vivo molecular imaging, in vitro cell imaging, and drug delivery targeting, and can be very useful as an escort molecule.
摘要翻译：本发明涉及一种基于BPB的货物递送系统，包括：（a）双齿肽结合物（BPB），其包括（i）结构稳定区域，其包括平行，反平行或平行和反平行的氨基酸链，（ii）与结构稳定化区域的两末端结合的目标结合区域I和目标结合区域II，其分别包括随机选择的n和m个氨基酸; 和（b）与BPB保税的货物。本发明的基于BPB的货物运送系统可以通过使用BPB的目标结合和目标特定特性将各种物质运送到细胞上或细胞内。 BPB具有非常低的KD值（解离常数）（例如，nM水平），因此对靶标表现出非常高的亲和力。本发明的基于BPB的货物递送系统可用于医学，体内分子成像，体外细胞成像和药物递送靶向领域，并且可作为护送分子非常有用。

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