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1. 发明授权

US08602238B2 Drink bottle 有权
公开(公告)号：US08602238B2
公开(公告)日：2013-12-10
申请号：US13359178
申请日：2012-01-26
申请人： Sami El-Saden , Blair E. Miller , Daniel M. Wodka , John W. Phillips
发明人： Sami El-Saden , Blair E. Miller , Daniel M. Wodka , John W. Phillips
IPC分类号： B65D83/00
CPC分类号： B65D47/065 , A45F3/18 , A47G19/2266 , B65D47/066
摘要： A drink bottle may include a container and a lid connected to the container. The lid may include a spout and a spout cover. Each of the spout and the spout cover may be moved in opposite directions between a stowed configuration and a dispensing configuration.

2. 外观设计

USD682034S1 Drink bottle 有权
标题翻译：喝瓶子
公开(公告)号：USD682034S1
公开(公告)日：2013-05-14
申请号：US29411677
申请日：2012-01-25
申请人： Sami El-Saden , Blair E. Miller , Daniel M. Wodka , John W. Phillips
设计人： Sami El-Saden , Blair E. Miller , Daniel M. Wodka , John W. Phillips

3. 发明授权

US07078169B2 Methods for the identification of inhibitors of an isoprenoid metabolic pathway 失效
标题翻译：用于鉴定类异戊二烯代谢途径抑制剂的方法
公开(公告)号：US07078169B2
公开(公告)日：2006-07-18
申请号：US10205841
申请日：2002-07-26
申请人： Matthew Ashby , Stewart Scherer , John W. Phillips , Michael Ziman , Nicholas Marini
发明人： Matthew Ashby , Stewart Scherer , John W. Phillips , Michael Ziman , Nicholas Marini
IPC分类号： C12Q1/68 , C12Q1/02 , G01N33/53 , C12N15/63 , C07H21/02
CPC分类号： G06F19/22 , G06F19/20
摘要： The present invention relates to methods of identifying genes whose expression is indicative of activation of a particular biochemical or metabolic pathway or a common set of biological reactions or functions in a cell (“regulon indicator genes”) The present invention provides an example of such an indicator gene. The present invention also relates to methods of partially characterizing a gene of unknown function by determining which biological pathways, reactions or functions its expression is associated with, thereby placing the gene within a functional genetic group or “regulon”. These partially characterized genes may be used to identify desirable therapeutic targets of biological pathways of interest (“regulon target genes”) The present invention provides examples of such target genes. Methods for identifying effectors (activators and inhibitors) of regulon target genes are provided. The present invention also provides examples of regulon target gene inhibitors.
摘要翻译：本发明涉及鉴定其表达指示特定生物化学或代谢途径的激活或细胞中的一组共同的生物反应或功能的基因的方法（“调节子指示基因”）。本发明提供了这样一种实例指标基因。本发明还涉及通过确定其表达与哪些生物学途径，反应或功能相关联来部分表征未知功能基因的方法，由此将基因置于功能性遗传组或“调节子”内。这些部分表征的基因可用于鉴定感兴趣的生物学途径的所需治疗靶标（“调节基因靶基因”）本发明提供了这些靶基因的实例。提供了用于鉴定调节子靶基因的作用剂（活化剂和抑制剂）的方法。本发明还提供了调节基因靶基因抑制剂的实例。

4. 发明授权

US07022481B2 Methods of using glucan synthase pathway reporter genes to screen for antifungal compounds 失效
标题翻译：使用葡聚糖合酶通路报道基因筛选抗真菌化合物的方法
公开(公告)号：US07022481B2
公开(公告)日：2006-04-04
申请号：US10324035
申请日：2002-12-19
申请人： John W. Phillips
发明人： John W. Phillips
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6897 , C12Q1/6895 , C12Q2600/158
摘要： The present invention relates to methods of using nucleotide sequences from the promoter region of at least one of seven S. cerevisiae genes whose expression is an indicator of the inhibition or modulation of the glucan synthase pathway in S. cerevisiae. This invention envisions using at least one target polynucleotide sequence, each target polynucleotide sequence being operably linked to the promoter region of one of the seven glucan synthase pathway reporter genes, to screen chemical libraries and natural products for compounds which can be used as antifungal agents for use against a variety of fungal pathogens. This invention also envisions using the methods of the invention to assay the efficacy of and/or specificity of antifungal agents, and/or to monitor the activity of the glucan synthase pathway.
摘要翻译：本发明涉及使用七个酿酒酵母基因中至少一个的启动子区域的核苷酸序列的方法，其表达是酿酒酵母中葡聚糖合成酶途径的抑制或调节的指标。本发明设想使用至少一个靶多核苷酸序列，每个靶多核苷酸序列可操作地连接到七个葡聚糖合成酶途径报道基因之一的启动子区域，以筛选可用作抗真菌剂的化合物的化学文库和天然产物使用各种真菌病原体。本发明还设想使用本发明的方法来测定抗真菌剂的功效和/或特异性，和/或监测葡聚糖合成酶途径的活性。

5. 发明授权

US4153275A Checkbook cover 失效
标题翻译：支票簿封面
公开(公告)号：US4153275A
公开(公告)日：1979-05-08
申请号：US929303
申请日：1978-07-31
申请人： John W. Phillips
发明人： John W. Phillips
IPC分类号： B42D3/02 , B42D3/08
CPC分类号： B42D3/02 , B42D3/08 , Y10S428/904 , Y10T428/24033 , Y10T428/24504 , Y10T428/2462
摘要： A simulated leather checkbook cover includes an outer cover sheet and an inner pocket-forming sheet of vinyl sheet material. The peripheral edge of the outer sheet is turned inwardly over and around the peripheral edge of the inner sheet, and the layers of the edge portion are secured to each other by a radio-frequency dielectric heat sealed vinyl-to-vinyl bond and by a line of threaded stitching extending through all three layers close to the turned over edge. The cover sheet has a flow-molded design portion in its outer surface with a depth and pattern simulating a hand-tooled leather design. The design portion includes a depressed flat area within which any selected one of a plurality of originally separate and differently ornamental inserts is adhesively secured. Each insert has a shape and thickness substantially fitting the depressed flat area and a leather-like outer surface simulating an integral tooled leather-like portion of the cover sheet design with different individual identification symbols on some of the respective inserts. The simulated hand-tooled leather design is enhanced by a selective antique coating in depressed portions of the design.
摘要翻译：模拟皮革支票簿封面包括外覆盖片和乙烯基片材的内袋形成片。外片的周边边缘在内片的周边边缘上方转动，并且边缘部分的层通过射频电介质热密封的乙烯基 - 乙烯基键彼此固定，并且通过螺纹缝线延伸穿过接近翻转边缘的所有三层。覆盖片在其外表面具有流动模制的设计部分，其具有模拟手工设计的皮革设计的深度和图案。设计部分包括凹陷的平坦区域，粘合地固定多个原始分离和不同装饰的插入物中的任何选定的一个。每个插入物的形状和厚度基本上适合凹陷的平坦区域和皮革样的外表面，其模仿具有不同单独识别符号的盖片设计的整体工具皮革样部分，其中一些相应插入物上。模拟的手工制作的皮革设计通过选择性古董涂层在设计的凹陷部分得到增强。

6. 发明申请

US20140061255A1 DRINK BOTTLE 有权
标题翻译：饮料瓶
公开(公告)号：US20140061255A1
公开(公告)日：2014-03-06
申请号：US14072473
申请日：2013-11-05
申请人： Sami El-Saden , Blair E. Miller , Daniel M. Wodka , John W. Phillips
发明人： Sami El-Saden , Blair E. Miller , Daniel M. Wodka , John W. Phillips
IPC分类号： B65D47/06
CPC分类号： B65D47/065 , A45F3/18 , A47G19/2266 , B65D47/066
摘要： A drink bottle may include a container and a lid connected to the container. The lid may include a spout and a spout cover. Each of the spout and the spout cover may be moved in opposite directions between a stowed configuration and a dispensing configuration.
摘要翻译：饮料瓶可以包括容器和连接到容器的盖子。盖可以包括喷口和喷口盖。喷嘴和喷口盖中的每一个可以在收起的构型和分配构型之间沿相反的方向移动。

7. 发明申请

US20080050720A1 Methods for Using a Sterol Biosynthesis Pathway Reporter Gene to Screen for Antifungal or Lipid Lowering Compounds 审中-公开
标题翻译：使用甾醇生物合成途径报告基因筛选抗真菌或降脂化合物的方法
公开(公告)号：US20080050720A1
公开(公告)日：2008-02-28
申请号：US10566426
申请日：2004-07-26
申请人： John W. Phillips
发明人： John W. Phillips
IPC分类号： C12Q1/68
CPC分类号： C12N15/815 , C12N15/1086 , C12Q1/025 , C12Q1/6883 , C12Q1/6897
摘要： The present invention relates to methods of using nucleotide sequences from the promoter region of a S. cerevisiae gene YRM325W whose expression is an indicator of inhibition or modulation of the sterol biosynthesis pathway in S. cerevisiae. The invention envisions using a target polynucleotide sequence, wherein the target polynucleotide sequence is operably linked to the promoter region of the YMR325W gene, to screen chemical libraries and natural products for compounds which can be used either as antifungal agents for use against a variety of fungal pathogens, or as lipid lowering agents to treat hypercholesterolemia. The invention also envisions using the methods of the invention to assay the efficacy of and/or specificity of antifungal agents and lipid lowering agents, and/or to monitor the activity of the sterol biosynthesis pathway.
摘要翻译：本发明涉及使用来自酿酒酵母基因YRM325W的启动子区域的核苷酸序列的方法，其表达是酿酒酵母中甾醇生物合成途径的抑制或调节的指标。本发明设想使用靶多核苷酸序列，其中靶多核苷酸序列可操作地连接到YMR325W基因的启动子区域，以筛选化学文库和化合物的天然产物，其可用作抗真菌剂用于各种真菌病原体，或用作治疗高胆固醇血症的降脂剂。本发明还设想使用本发明的方法来测定抗真菌剂和降脂剂的功效和/或特异性，和/或监测甾醇生物合成途径的活性。

8. 发明授权

US635837A Level. 失效
标题翻译：水平。
公开(公告)号：US635837A
公开(公告)日：1899-10-31
申请号：US1898686368
申请日：1898-07-19
申请人： JOHN W PHILLIPS , ZIMMERMAN JOHN H
发明人： ZIMMERMAN JOHN H
CPC分类号： G01C9/24

9. 发明授权

US4714216A Fin erecting mechanisms 失效
标题翻译：翅片架设机构
公开(公告)号：US4714216A
公开(公告)日：1987-12-22
申请号：US843382
申请日：1986-03-24
申请人： Spencer D. Meston , John W. Phillips
发明人： Spencer D. Meston , John W. Phillips
IPC分类号： F42B10/14 , B64C5/12
CPC分类号： F42B10/14
摘要： A fin (1) suitable for stabilizing the flight of a projectile for example, is formed with an integral cantilever spring member (4). The fin (1) is rotatable about a pivot (3) from an initial stowed position (not shown) to a deployed position. The spring (4) is initially retained against the fin (1) but when it is released, the fin is forced outwards to its deployed position by the action of the spring (4), the free end of the spring moving into engagement with a surface (7) to retain the fin in the deployed position.
摘要翻译：适于稳定例如弹丸飞行的翼片（1）形成有一体的悬臂弹簧构件（4）。翅片（1）可绕枢轴（3）从初始收起位置（未示出）旋转到展开位置。弹簧（4）最初保持抵靠翅片（1），但是当其被释放时，翅片通过弹簧（4）的作用被迫向外移动到其展开位置，弹簧的自由端与表面（7）以将翅片保持在展开位置。

10. 外观设计

USD688056S1 Office chair 有权
公开(公告)号：USD688056S1
公开(公告)日：2013-08-20
申请号：US29424231
申请日：2012-06-08
申请人： John W. Phillips , Mitchell David Mulder , Matthew J. Gerules
设计人： John W. Phillips , Mitchell David Mulder , Matthew J. Gerules

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