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    • 1. 发明授权
    • Methods for the identification of inhibitors of an isoprenoid metabolic pathway
    • 用于鉴定类异戊二烯代谢途径抑制剂的方法
    • US07078169B2
    • 2006-07-18
    • US10205841
    • 2002-07-26
    • Matthew AshbyStewart SchererJohn W. PhillipsMichael ZimanNicholas Marini
    • Matthew AshbyStewart SchererJohn W. PhillipsMichael ZimanNicholas Marini
    • C12Q1/68C12Q1/02G01N33/53C12N15/63C07H21/02
    • G06F19/22G06F19/20
    • The present invention relates to methods of identifying genes whose expression is indicative of activation of a particular biochemical or metabolic pathway or a common set of biological reactions or functions in a cell (“regulon indicator genes”) The present invention provides an example of such an indicator gene. The present invention also relates to methods of partially characterizing a gene of unknown function by determining which biological pathways, reactions or functions its expression is associated with, thereby placing the gene within a functional genetic group or “regulon”. These partially characterized genes may be used to identify desirable therapeutic targets of biological pathways of interest (“regulon target genes”) The present invention provides examples of such target genes. Methods for identifying effectors (activators and inhibitors) of regulon target genes are provided. The present invention also provides examples of regulon target gene inhibitors.
    • 本发明涉及鉴定其表达指示特定生物化学或代谢途径的激活或细胞中的一组共同的生物反应或功能的基因的方法(“调节子指示基因”)。本发明提供了这样一种实例 指标基因。 本发明还涉及通过确定其表达与哪些生物学途径,反应或功能相关联来部分表征未知功能基因的方法,由此将基因置于功能性遗传组或“调节子”内。 这些部分表征的基因可用于鉴定感兴趣的生物学途径的所需治疗靶标(“调节基因靶基因”)本发明提供了这些靶基因的实例。 提供了用于鉴定调节子靶基因的作用剂(活化剂和抑制剂)的方法。 本发明还提供了调节基因靶基因抑制剂的实例。