会员体验
专利管家(专利管理)
工作空间(专利管理)
风险监控(情报监控)
数据分析(专利分析)
侵权分析(诉讼无效)
联系我们
交流群
官方交流:
QQ群: 891211   
微信请扫码    >>>
现在联系顾问~
热词
    • 5. 发明申请
    • POLYHYDROXYLATED DIBENZ (C,E) AZEPINES AS PROTEIN KINASE C INHIBITORS
    • 作为蛋白激酶C抑制剂的聚甲氧基二苯胺(C,E)
    • WO1993020695A1
    • 1993-10-28
    • PCT/US1993000193
    • 1993-01-11
    • SPHINX PHARMACEUTICALS CORPORATIONJIANG, Jack, B.HUGHES, Philip, F.
    • SPHINX PHARMACEUTICALS CORPORATION
    • A01N43/46
    • C07D223/18
    • The invention provides compounds having formula (I) wherein: R1, R2, R3, R4, R5 and R6, independently, are H, halo, methoxy or hydroxyl, provided that at least one of R1, R2, R3, R4, R5 and R6 is hydroxyl, R7 and R8 are H or taken together form a carbonyl; R12 and R13 are H or taken together form a carbonyl; A is H or CR9R10R11; R9 and R10 are H or taken together form a carbonyl; R11 is H, C1 - C17 alkyl, C1 - C17 alkenyl, C1 - C17 alkynyl, or aryl; and, R14 and R15, independently are H, halo, methoxy or hydroxyl when at least 5 of R1 - R6 are hydroxyl, and H when less than 5 of R1 - R6 are hydroxyl. The compounds are useful for inhibiting protein kinase C, and treating conditions affected by protein kinase C activity, particularly cancer tumors, inflammatory disease, reperfusion injury and cardiac dysfunctions related to reperfusion injury.
    • 本发明提供具有式(I)的化合物,其中:R 1,R 2,R 3,R 4,R 5和R 6独立地是H,卤素,甲氧基或羟基,条件是R 1,R 2,R 3,R 4,R 5和 R6是羟基,R7和R8是H或一起形成羰基; R 12和R 13是H或一起形成羰基; A为H或CR9R10R11; R9和R10是H或一起形成羰基; R 11是H,C 1 -C 17烷基,C 1 -C 17烯基,C 1 -C 17炔基或芳基; 当R 1至R 5中的至少5个为羟基时,R 14和R 15独立地为H,卤素,甲氧基或羟基,当小于5的R 1 -R 6为羟基时,R 14和R 15独立地为H。 这些化合物可用于抑制蛋白激酶C,以及治疗受蛋白激酶C活性,特别是癌症肿瘤,炎性疾病,再灌注损伤和与再灌注损伤相关的心脏功能障碍的影响。
    • 7. 发明申请
    • LED RETROFIT DRIVER CIRCUIT AND METHOD OF OPERATING THE SAME
    • LED转换驱动电路及其操作方法
    • WO2012156891A3
    • 2013-01-10
    • PCT/IB2012052384
    • 2012-05-14
    • KONINKL PHILIPS ELECTRONICS NVTOUSAIN ROBERTUS LEONARDUSEDDEANE REDOUANECLAESSENS DENNIS JOHANNES ANTONIUSVAEL PHILIP LOUIS ZULMAJIANG JACK
    • TOUSAIN ROBERTUS LEONARDUSEDDEANE REDOUANECLAESSENS DENNIS JOHANNES ANTONIUSVAEL PHILIP LOUIS ZULMAJIANG JACK
    • H05B33/08
    • H05B33/0845F21K9/23H05B39/044
    • A LED retrofit driver circuit (3) is provided, comprising at least an input (6) for receiving an operating voltage from a power supply (2), an output (8) for connection to one or more LED units (5), a power converter (7) connected with said input (6) and said output (8) and configured to provide a lamp current (50) at said output (8) during operation in at least a first and a second operating state. To provide a versatile circuit (3), allowing operation with a variety of power supplies and under various load conditions, in said first operating state, the power converter (7) is adapted to switch between a high current generating mode (40), in which the power converter (7) is configured to draw current pulses from said power supply (2) to provide a first average input current (33a), and an OFF mode (42) in which no current is drawn from said power supply (2). In said second operating state, said power converter (7) is adapted at least to operate in a low current generating mode (41), in which the power converter (7) is configured to draw a current from said power supply (2) to provide a second average input current (33b)which is lower than said first average input current (33a).
    • 提供了一种LED改装驱动器电路(3),至少包括用于从电源(2)接收工作电压的输入端(6),用于连接到一个或多个LED单元(5)的输出端(8) 功率转换器(7),其与所述输入端(6)和所述输出端(8)连接并被配置为在至少第一和第二操作状态下在所述输出端(8)处提供灯电流(50)。 为了提供通用电路(3),允许在所述第一操作状态下使用各种电源和在各种负载条件下操作,功率转换器(7)适于在高电流产生模式(40)之间切换, 功率转换器(7)被配置为从所述电源(2)提取电流脉冲以提供第一平均输入电流(33a),以及不从所述电源(2)吸取电流的OFF模式(42) )。 在所述第二操作状态下,所述功率转换器(7)至少适于在低电流产生模式(41)中工作,其中功率转换器(7)被配置为将来自所述电源(2)的电流吸入 提供低于所述第一平均输入电流(33a)的第二平均输入电流(33b)。
    • 10. 发明申请
    • BIS-(HYDROXYALKYLAMINO)-ANTHRAQUINONE INHIBITORS OF PROTEIN KINASE C
    • 蛋白激酶C(BIS-(羟基喹啉)) - 氨基丁酸酯抑制剂
    • WO1992007557A1
    • 1992-05-14
    • PCT/US1991008026
    • 1991-10-30
    • SPINX PHARMACEUTICALS CORPORATIONJIANG, Jack, B.JOHNSON, Mary, George
    • SPINX PHARMACEUTICALS CORPORATION
    • A61K31/045
    • C07D303/36C07C225/34C07C225/36C07C229/74C07C271/12C07C335/32C07C2603/24
    • The present invention provides novel substituted anthraquinones having formula ( alpha ), wherein R1 and R2 are independently H, C1-C10 alkyl, aryl, arylalkyl, alkylaryl, or R1 and R2 taken together with the adjacent nitrogen atom N form a substituted or unsubstituted cyclic ring which may contain additional heteroatoms; n and m are independently 1, 2, or 3; A is halogen, OH, alkoxy, OCO(NR3R4), S-C(NH2)=NR5, or when m = 1, comprises an oxirane ring with the adjacent oxygen atom; R3, R4, and R5 are independently H, alkyl, or aryl; X is H, OH, NR6R7, Cl, Br, I, F, alkyl, aryl, alkoxy, aryloxy, COOR8, or CONR9R10; and R6, R7, R8, R9, and R10 are independently H, lower alkyl, or aryl useful for inhibiting protein kinase C and treating conditions related to, or affected by inhibition of protein kinase C, particularly cancer tumors, inflammatory disease, reperfusion injury, and cardiac dysfunctions related to reperfusion injury.
    • 本发明提供具有式(α)的新的取代的蒽醌,其中R 1和R 2独立地为H,C 1 -C 10烷基,芳基,芳基烷基,烷基芳基或R 1和R 2与相邻的氮原子N一起形成取代或未取代的环状 可能含有其他杂原子的环; n和m独立地为1,2或3; A是卤素,OH,烷氧基,OCO(NR 3 R 4),S-C(NH 2)= NR 5,或当m = 1时,包含具有相邻氧原子的环氧乙烷环; R3,R4和R5独立地是H,烷基或芳基; X是H,OH,NR 6 R 7,Cl,Br,I,F,烷基,芳基,烷氧基,芳氧基,COOR 8或CONR 9 R 10; R 6,R 7,R 8,R 9和R 10独立地为可用于抑制蛋白激酶C的H,低级烷基或芳基,并且与抑制蛋白激酶C,特别是癌症肿瘤,炎性疾病,再灌注损伤有关或受其影响 ,以及与再灌注损伤相关的心脏功能障碍。