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1. 发明申请

WO2004026267A2 TRI(ALKYLCARBOXYLATO) GALLIUM (III) PRODUCTS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM 审中-公开
标题翻译：三唑（ALKYLCARBOXYLATO）GALLIUM（III）产品和含有它们的药物组合物
公开(公告)号：WO2004026267A2
公开(公告)日：2004-04-01
申请号：PCT/US2003/030792
申请日：2003-09-22
申请人： GENTA INC. , JIANG, Jack, B. , WARRELL, Raymond, P., Jr. , RAMASWAMY, Kollengoode, K. , KLEM, Robert, E.
发明人： JIANG, Jack, B. , WARRELL, Raymond, P., Jr. , RAMASWAMY, Kollengoode, K. , KLEM, Robert, E.
IPC分类号： A61K
CPC分类号： C07C51/412 , C07C53/126 , C07F5/003
摘要： Provided are novel tri(alkylcarboxylato) gallium (III) compounds, exemplified by tripalmitato gallium (III), methods for making them, pharmaceutical compositions containing them, and methods of using the pharmaceutical compositions.
摘要翻译：提供了新颖的三（烷基羧基）镓（III）化合物，其例子是三异氰酸镓（III），其制备方法，含有它们的药物组合物和使用该药物组合物的方法。

2. 发明申请

WO02057480A3 CELL-PROLIFERATIVE DISORDER TREATMENTS USING CRE DECOY OLIGOMERS, BCL-2 ANTISENSE AND HYBRID OLIGOMERS 审中-公开
标题翻译：细胞增殖性疾病使用CRE DECOY OLIGOMERS，BCL-2抗体和混合寡聚体
公开(公告)号：WO02057480A3
公开(公告)日：2003-07-24
申请号：PCT/US0201967
申请日：2002-01-22
申请人： GENTA INC , KLEM ROBERT E
发明人： KLEM ROBERT E
IPC分类号： A61K38/00 , A61K48/00 , C07H21/02 , C12N15/113 , C12Q1/68 , C07H21/04 , C12N15/63 , C12N15/85 , C12P19/34
CPC分类号： C12N15/113 , A61K38/00 , C07K2319/00 , C12N15/1135 , C12N2310/13 , C12N2310/315 , C12N2310/53
摘要： The present invention is directed to hybrid oligomers comprising a cyclic AMP response element CRE sequence and a sequence that hybridizes to a bcl-2 pre-mRNA or mRNA, and pharmaceutical compositions comprising such hybrids. The present invention is also directed to the use of CRE decoy oligomers, comprising a CRE consensus sequence, and bcl-2 antisense oligomers in combination therapies, and the use of bcl-2/CRE hybrid oligomers, to treat or prevent cell-proliferative related disorders, including hyperplasias, cancers, tumors and carcinomas. In one embodiment, the invention relates to therapeutic protocols comprising the administration of a CRE decoy oligomer and a bcl-2 antisense oligomer for the treatment of cell-proliferative related disorders. In another embodiment, the invention relates to therapeutic protocols comprising the administration of a bcl-2 antisense/CRE decoy bcl-2/CRE hybrid oligomer for the treatment of cell-proliferative related disorders.
摘要翻译：本发明涉及包含环AMP响应元件CRE序列和与bcl-2前mRNA或mRNA杂交的序列的杂交寡聚体，以及包含这种杂交体的药物组合物。本发明还涉及包含CRE共有序列的CRE诱饵低聚物和联合治疗中的bcl-2反义寡聚体的用途，以及使用bcl-2 / CRE杂合寡聚体来治疗或预防细胞增殖相关疾病，包括增生，癌症，肿瘤和癌。在一个实施方案中，本发明涉及包括施用CRE诱饵寡聚体和bcl-2反义寡聚体用于治疗细胞增殖性相关疾病的治疗方案。在另一个实施方案中，本发明涉及治疗方案，其包括施用bcl-2反义/ CRE诱饵bcl-2 / CRE杂合寡聚体用于治疗细胞增殖相关病症。

3. 发明申请

WO2004026267A3 TRI(ALKYLCARBOXYLATO) GALLIUM (III) PRODUCTS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM 审中-公开
标题翻译： TRI（烷基乙氧基）镓（III）产品和含有它们的药物组合物
公开(公告)号：WO2004026267A3
公开(公告)日：2004-06-10
申请号：PCT/US0330792
申请日：2003-09-22
申请人： GENTA INC , JIANG JACK B , WARRELL RAYMOND P JR , RAMASWAMY KOLLENGOODE K , KLEM ROBERT E
发明人： JIANG JACK B , WARRELL RAYMOND P JR , RAMASWAMY KOLLENGOODE K , KLEM ROBERT E
IPC分类号： A61K31/28 , C07C51/41 , C07C53/126 , C07F5/00 , C30B7/10
CPC分类号： C07C51/412 , C07C53/126 , C07F5/003
摘要： Provided are novel tri(alkylcarboxylato) gallium (III) compounds, exemplified by tripalmitato gallium (III), methods for making them, pharmaceutical compositions containing them, and methods of using the pharmaceutical compositions.
摘要翻译：提供了新的三（烷基羧基）镓（III）化合物，例如三棕榈酸镓（III），其制备方法，含有它们的药物组合物，以及使用该药物组合物的方法。

4. 发明申请

WO0217852A3 METHODS OF TREATMENT OF A BCL-2 DISORDER USING BCL-2 ANTISENSE OLIGOMERS 审中-公开
标题翻译：使用BCL-2抗体寡聚体治疗BCL-2病症的方法
公开(公告)号：WO0217852A3
公开(公告)日：2003-04-03
申请号：PCT/US0126414
申请日：2001-08-23
申请人： GENTA INC , WARREL RAYMOND P JR , KLEM ROBERT E , FINGERT HOWARD
发明人： WARREL RAYMOND P JR , KLEM ROBERT E , FINGERT HOWARD
IPC分类号： C12N15/09 , A61K31/337 , A61K31/4164 , A61K31/4745 , A61K31/513 , A61K31/664 , A61K31/704 , A61K31/7048 , A61K31/7072 , A61K31/7076 , A61K31/7088 , A61K31/711 , A61K33/24 , A61K38/00 , A61K48/00 , A61P35/00 , C12N15/113 , C12N15/12 , A61K51/04 , C07H21/04
CPC分类号： C12N15/1135 , A61K38/00 , C12N2310/315
摘要： The present invention is directed to the use of bcl-2 antisense oligomers to treat and prevent bcl-2 related disorders. These disorders include cancers, tumors, carcinomas and cell-proliferative related disorders. In one embodiment of the invention, a bcl-2 antisense oligomer is administered at high doses. The present invention is also directed to a method of preventing or treating a bcl-2 related disorder, in particular cancer, comprising administering a bcl-2 antisense oligomer for short periods of time. The present invention is further drawn to the use of bcl-2 antisense oligomers to increase the sensitivity of a subject to cancer therapeutics. The present invention also relates to pharmaceutical compositions comprising one or more bcl-2 antisense oligomers, which may comprise one or more cancer therapeutic agents.
摘要翻译：本发明涉及bcl-2反义寡聚体用于治疗和预防bcl-2相关疾病的用途。这些疾病包括癌症，肿瘤，癌和细胞增殖相关疾病。在本发明的一个实施方案中，以高剂量施用bcl-2反义寡聚体。本发明还涉及预防或治疗bcl-2相关病症，特别是癌症的方法，包括短时间施用bcl-2反义寡聚体。本发明进一步涉及使用bcl-2反义寡聚物来增加受试者对癌症治疗剂的敏感性。本发明还涉及包含一种或多种bcl-2反义寡聚体的药物组合物，其可以包含一种或多种癌症治疗剂。

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