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1. 发明申请

WO2006134125A9 ANTIGEN CONJUGATES AND USES THEREOF 审中-公开
标题翻译：抗原结合物及其用途
公开(公告)号：WO2006134125A9
公开(公告)日：2007-05-10
申请号：PCT/EP2006063198
申请日：2006-06-14
申请人： CYTOS BIOTECHNOLOGY AG , BACHMANN MARTIN , TISSOT ALAIN , JEGERLEHNER ANDREA , SAUDAN PHILIPPE , ZOU YU , SCHMITZ NICOLE , HUBER ADRIAN , MARTIN STEPHEN , HINTON HEATHER
发明人： BACHMANN MARTIN , TISSOT ALAIN , JEGERLEHNER ANDREA , SAUDAN PHILIPPE , ZOU YU , SCHMITZ NICOLE , HUBER ADRIAN , MARTIN STEPHEN , HINTON HEATHER
IPC分类号： A61K39/12 , C12N15/12 , C12N15/48 , C12N15/52
CPC分类号： A61K39/21 , A61K39/0005 , A61K39/0008 , A61K39/0011 , A61K39/12 , A61K47/646 , A61K2039/5258 , A61K2039/54 , A61K2039/545 , A61K2039/55505 , A61K2039/57 , A61K2039/6075 , A61K2039/622 , A61K2039/627 , A61K2039/64 , C07K2319/70 , C12N2740/16211 , C12N2740/16234 , C12N2795/18123
摘要： The present invention is in the fields of medicine, public health, immunology, molecular biology and virology. The invention provides composition comprising a virus-like particle (VLP) linked to at least one antigen of the invention, wherein said antigen of the invention is CCR5 of the invention, gastrin of the invention, CXCR4 of the invention, CETP of the invention or C5a of the invention. The invention also provides a process for producing the composition. The compositions of this invention are useful in the production of vaccines, in particular, for the treatment of diseases in which the antigen of the invention mediates, or contributes to the condition, particularly for the treatment of AIDS, gastrointestinal cancers, coronary heart diseases or inflammatory diseases. Moreover, the compositions of the invention induce efficient immune responses, in particular antibody responses. Furthermore, the compositions of the invention are particularly useful to efficiently induce self-specific immune responses within the indicated context.
摘要翻译：本发明涉及医药，公共卫生，免疫学，分子生物学和病毒学领域。本发明提供包含连接至本发明的至少一种抗原的病毒样颗粒（VLP）的组合物，其中本发明的所述抗原是本发明的CCR5，本发明的胃泌素，本发明的CXCR4，本发明的CETP或 C5a。本发明还提供了一种制备该组合物的方法。本发明的组合物可用于疫苗的生产，特别是用于治疗其中本发明的抗原介导或有助于该疾病的疾病，特别是用于治疗AIDS，胃肠癌，冠心病或炎性疾病。此外，本发明的组合物诱导有效的免疫应答，特别是抗体应答。此外，本发明的组合物特别有用于在指定的上下文中有效诱导自身特异性免疫应答。

2. 发明申请

WO2010122164A1 VIRUS-LIKE PARTICLES OF BACTERIOPHAGE φCB5 审中-公开
标题翻译：病毒类FBSB5的病毒颗粒
公开(公告)号：WO2010122164A1
公开(公告)日：2010-10-28
申请号：PCT/EP2010/055487
申请日：2010-04-23
申请人： CYTOS BIOTECHNOLOGY AG , BACHMANN, Martin , JEGERLEHNER, Andrea , KAZAKS, Andris , LINK, Alexander , LIPOWSKY, Gerd , TARS, Kaspars
发明人： BACHMANN, Martin , JEGERLEHNER, Andrea , KAZAKS, Andris , LINK, Alexander , LIPOWSKY, Gerd , TARS, Kaspars
IPC分类号： C12N7/04 , A61K38/20 , A61K38/16
CPC分类号： C07K14/005 , A61K38/00 , A61K2039/5256 , A61K2039/5258 , C12N7/00 , C12N2760/16134 , C12N2795/18122 , C12N2795/18123
摘要： The present invention relates to virus-like particles of bacteriophage φCb5 and to recombinant φCb5 proteins which are capable of forming virus-like particles. The virus-like particles according to the invention are useful as immunological carriers which can, for example, be linked to an antigen, e.g. by chemical coupling or by genetic fusion. Virus-like particles according to the invention are also useful for the delivery of immunostimulatory substances, e.g. of immunostimulatory nucleic acids, to the immune system. The invention further relates to compositions, vaccines and pharmaceutical compositions comprising the inventive virus-like particles, wherein said compositions, vaccines and pharmaceutical compositions are capable of inducing or enhancing an immune response. The compositions, vaccines and pharmaceutical compositions described herein can therefore be used as a medicament for the treatment of a disease, disorder or physiological condition.
摘要翻译：本发明涉及噬菌体fCb5的病毒样颗粒和能够形成病毒样颗粒的重组fCb5蛋白。根据本发明的病毒样颗粒可用作免疫载体，其可以例如与抗原连接，例如，通过化学偶联或遗传融合。根据本发明的病毒样颗粒也可用于递送免疫刺激物质，例如，的免疫刺激核酸，免疫系统。本发明还涉及包含本发明的病毒样颗粒的组合物，疫苗和药物组合物，其中所述组合物，疫苗和药物组合物能够诱导或增强免疫应答。因此，本文所述的组合物，疫苗和药物组合物可用作治疗疾病，病症或生理状况的药物。

3. 发明申请

WO2007039458A3 HIV PEPTIDE CONJUGATES AND USES THEREOF 审中-公开
标题翻译：艾滋病毒肽结合物及其用途
公开(公告)号：WO2007039458A3
公开(公告)日：2007-06-07
申请号：PCT/EP2006066526
申请日：2006-09-20
申请人： CYTOS BIOTECHNOLOGY AG , BACHMANN MARTIN , SAUDAN PHILIPPE , JEGERLEHNER ANDREA , ROEHN TILL ALEXANDER , JENNINGS GARY
发明人： BACHMANN MARTIN , SAUDAN PHILIPPE , JEGERLEHNER ANDREA , ROEHN TILL ALEXANDER , JENNINGS GARY
IPC分类号： A61K39/21 , C07K14/16
CPC分类号： C07K14/005 , A61K39/12 , A61K39/21 , A61K2039/5256 , A61K2039/5258 , C12N2740/16122 , C12N2740/16134 , C12N2795/18123
摘要： The present invention is in the fields of medicine, public health, immunology, molecular biology and virology. The invention provides composition comprising a virus-like particle (VLP) linked to at least one antigen, wherein said antigen is HIV gpl60 peptide. The invention also provides a process for producing the composition. The compositions of this invention are useful in the production of vaccines, in particular, for the prevention and treatment of diseases. Moreover, the compositions of the invention induce efficient immune responses, in particular antibody responses.
摘要翻译：本发明涉及医药，公共卫生，免疫学，分子生物学和病毒学领域。本发明提供包含与至少一种抗原连接的病毒样颗粒（VLP）的组合物，其中所述抗原是HIV gpl60肽。本发明还提供了一种制备该组合物的方法。本发明的组合物可用于生产疫苗，特别是用于预防和治疗疾病。此外，本发明的组合物诱导有效的免疫应答，特别是抗体应答。

4. 发明申请

WO2006134125A1 ANTIGEN CONJUGATES AND USES THEREOF 审中-公开
标题翻译：抗原结合及其用途
公开(公告)号：WO2006134125A1
公开(公告)日：2006-12-21
申请号：PCT/EP2006/063198
申请日：2006-06-14
申请人： CYTOS BIOTECHNOLOGY AG , BACHMANN, Martin , TISSOT, Alain , JEGERLEHNER, Andrea , SAUDAN, Philippe , ZOU, Yu , SCHMITZ, Nicole , HUBER, Adrian , MARTIN, Stephen , HINTON, Heather
发明人： BACHMANN, Martin , TISSOT, Alain , JEGERLEHNER, Andrea , SAUDAN, Philippe , ZOU, Yu , SCHMITZ, Nicole , HUBER, Adrian , MARTIN, Stephen , HINTON, Heather
IPC分类号： A61K39/12 , C12N15/12 , C12N15/48 , C12N15/52
CPC分类号： A61K39/21 , A61K39/0005 , A61K39/0008 , A61K39/0011 , A61K39/12 , A61K47/646 , A61K2039/5258 , A61K2039/54 , A61K2039/545 , A61K2039/55505 , A61K2039/57 , A61K2039/6075 , A61K2039/622 , A61K2039/627 , A61K2039/64 , C07K2319/70 , C12N2740/16211 , C12N2740/16234 , C12N2795/18123
摘要： The present invention is in the fields of medicine, public health, immunology, molecular biology and virology. The invention provides composition comprising a virus-like particle (VLP) linked to at least one antigen of the invention, wherein said antigen of the invention is CCR5 of the invention, gastrin of the invention, CXCR4 of the invention, CETP of the invention or C5a of the invention. The invention also provides a process for producing the composition. The compositions of this invention are useful in the production of vaccines, in particular, for the treatment of diseases in which the antigen of the invention mediates, or contributes to the condition, particularly for the treatment of AIDS, gastrointestinal cancers, coronary heart diseases or inflammatory diseases. Moreover, the compositions of the invention induce efficient immune responses, in particular antibody responses. Furthermore, the compositions of the invention are particularly useful to efficiently induce self-specific immune responses within the indicated context.
摘要翻译：本发明涉及医药，公共卫生，免疫学，分子生物学和病毒学领域。本发明提供包含连接至本发明的至少一种抗原的病毒样颗粒（VLP）的组合物，其中本发明的所述抗原是本发明的CCR5，本发明的胃泌素，本发明的CXCR4，本发明的CETP或 C5a。本发明还提供了一种制备该组合物的方法。本发明的组合物可用于疫苗的生产，特别是用于治疗其中本发明的抗原介导或有助于该疾病的疾病，特别是用于治疗AIDS，胃肠癌，冠心病或炎性疾病。此外，本发明的组合物诱导有效的免疫应答，特别是抗体应答。此外，本发明的组合物特别有用于在指定的上下文中有效诱导自身特异性免疫应答。

5. 发明申请

WO2010125202A1 INFLUENZA HEMAGGLUTININ COMPOSITIONS AND USES THEREOF 审中-公开
标题翻译：流感嗜血红蛋白组合物及其用途
公开(公告)号：WO2010125202A1
公开(公告)日：2010-11-04
申请号：PCT/EP2010/055944
申请日：2010-04-30
申请人： CYTOS BIOTECHNOLOGY AG , BACHMANN, Martin , JEGERLEHNER, Andrea , SAUDAN, Philippe
发明人： BACHMANN, Martin , JEGERLEHNER, Andrea , SAUDAN, Philippe
IPC分类号： A61K47/48 , A61P39/00
CPC分类号： A61K47/6901 , A61K47/646
摘要： The present invention is in the fields of medicine, public health, immunology, molecular biology and virology. The invention provides compositions, vaccine compositions and pharmaceutical compositions for the treatment, amelioration and / or prevention of influenza. The compositions, vaccine compositions and pharmaceutical compositions of the invention comprise a virus-like particle of an RNA bacteriophage and at least one antigen, wherein said at least one antigen is an ectodomain of an influenza virus hemagglutinin protein or a fragment of said ectodomain of an influenza virus hemagglutinin protein. When administered to an animal, preferably to a human, said compositions, vaccine compositions and pharmaceutical compositions efficiently induce immune responses, in particular antibody responses, wherein typically and preferably said antibody responses are directed against influenza virus. Thus, the invention further provides methods of treating, ameliorating and / or preventing influenza virus infection.
摘要翻译：本发明涉及医药，公共卫生，免疫学，分子生物学和病毒学领域。本发明提供用于治疗，改善和/或预防流感的组合物，疫苗组合物和药物组合物。本发明的组合物，疫苗组合物和药物组合物包含RNA噬菌体和至少一种抗原的病毒样颗粒，其中所述至少一种抗原是流感病毒血凝素蛋白的胞外域或所述胞外域的片段流感病毒血凝素蛋白。当施用于动物，优选给人时，所述组合物，疫苗组合物和药物组合物有效诱导免疫应答，特别是抗体应答，其中通常且优选地，所述抗体应答针对流感病毒。因此，本发明还提供了治疗，改善和/或预防流感病毒感染的方法。

6. 发明申请

WO2007039458A2 HIV PEPTIDE CONJUGATES AND USES THEREOF 审中-公开
标题翻译： HIV肽缀合物及其用途
公开(公告)号：WO2007039458A2
公开(公告)日：2007-04-12
申请号：PCT/EP2006/066526
申请日：2006-09-20
申请人： CYTOS BIOTECHNOLOGY AG , BACHMANN, Martin , SAUDAN, Philippe , JEGERLEHNER, Andrea , RÖHN, Till Alexander , JENNINGS, Gary
发明人： BACHMANN, Martin , SAUDAN, Philippe , JEGERLEHNER, Andrea , RÖHN, Till Alexander , JENNINGS, Gary
IPC分类号： A61K39/21 , C07K14/16
CPC分类号： C07K14/005 , A61K39/12 , A61K39/21 , A61K2039/5256 , A61K2039/5258 , C12N2740/16122 , C12N2740/16134 , C12N2795/18123
摘要： The present invention is in the fields of medicine, public health, immunology, molecular biology and virology. The invention provides composition comprising a virus-like particle (VLP) linked to at least one antigen, wherein said antigen is HIV gpl60 peptide. The invention also provides a process for producing the composition. The compositions of this invention are useful in the production of vaccines, in particular, for the prevention and treatment of diseases. Moreover, the compositions of the invention induce efficient immune responses, in particular antibody responses.
摘要翻译：本发明属于医学，公共卫生，免疫学，分子生物学和病毒学领域。本发明提供了包含与至少一种抗原连接的病毒样颗粒（VLP）的组合物，其中所述抗原是HIV gp160肽。本发明还提供了一种生产该组合物的方法。本发明的组合物可用于生产疫苗，特别是用于预防和治疗疾病。而且，本发明的组合物诱导有效的免疫应答，特别是抗体应答。

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