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1. 发明申请

WO2006134125A9 ANTIGEN CONJUGATES AND USES THEREOF 审中-公开
标题翻译：抗原结合物及其用途
公开(公告)号：WO2006134125A9
公开(公告)日：2007-05-10
申请号：PCT/EP2006063198
申请日：2006-06-14
申请人： CYTOS BIOTECHNOLOGY AG , BACHMANN MARTIN , TISSOT ALAIN , JEGERLEHNER ANDREA , SAUDAN PHILIPPE , ZOU YU , SCHMITZ NICOLE , HUBER ADRIAN , MARTIN STEPHEN , HINTON HEATHER
发明人： BACHMANN MARTIN , TISSOT ALAIN , JEGERLEHNER ANDREA , SAUDAN PHILIPPE , ZOU YU , SCHMITZ NICOLE , HUBER ADRIAN , MARTIN STEPHEN , HINTON HEATHER
IPC分类号： A61K39/12 , C12N15/12 , C12N15/48 , C12N15/52
CPC分类号： A61K39/21 , A61K39/0005 , A61K39/0008 , A61K39/0011 , A61K39/12 , A61K47/646 , A61K2039/5258 , A61K2039/54 , A61K2039/545 , A61K2039/55505 , A61K2039/57 , A61K2039/6075 , A61K2039/622 , A61K2039/627 , A61K2039/64 , C07K2319/70 , C12N2740/16211 , C12N2740/16234 , C12N2795/18123
摘要： The present invention is in the fields of medicine, public health, immunology, molecular biology and virology. The invention provides composition comprising a virus-like particle (VLP) linked to at least one antigen of the invention, wherein said antigen of the invention is CCR5 of the invention, gastrin of the invention, CXCR4 of the invention, CETP of the invention or C5a of the invention. The invention also provides a process for producing the composition. The compositions of this invention are useful in the production of vaccines, in particular, for the treatment of diseases in which the antigen of the invention mediates, or contributes to the condition, particularly for the treatment of AIDS, gastrointestinal cancers, coronary heart diseases or inflammatory diseases. Moreover, the compositions of the invention induce efficient immune responses, in particular antibody responses. Furthermore, the compositions of the invention are particularly useful to efficiently induce self-specific immune responses within the indicated context.
摘要翻译：本发明涉及医药，公共卫生，免疫学，分子生物学和病毒学领域。本发明提供包含连接至本发明的至少一种抗原的病毒样颗粒（VLP）的组合物，其中本发明的所述抗原是本发明的CCR5，本发明的胃泌素，本发明的CXCR4，本发明的CETP或 C5a。本发明还提供了一种制备该组合物的方法。本发明的组合物可用于疫苗的生产，特别是用于治疗其中本发明的抗原介导或有助于该疾病的疾病，特别是用于治疗AIDS，胃肠癌，冠心病或炎性疾病。此外，本发明的组合物诱导有效的免疫应答，特别是抗体应答。此外，本发明的组合物特别有用于在指定的上下文中有效诱导自身特异性免疫应答。

2. 发明申请

WO2007039458A3 HIV PEPTIDE CONJUGATES AND USES THEREOF 审中-公开
标题翻译：艾滋病毒肽结合物及其用途
公开(公告)号：WO2007039458A3
公开(公告)日：2007-06-07
申请号：PCT/EP2006066526
申请日：2006-09-20
申请人： CYTOS BIOTECHNOLOGY AG , BACHMANN MARTIN , SAUDAN PHILIPPE , JEGERLEHNER ANDREA , ROEHN TILL ALEXANDER , JENNINGS GARY
发明人： BACHMANN MARTIN , SAUDAN PHILIPPE , JEGERLEHNER ANDREA , ROEHN TILL ALEXANDER , JENNINGS GARY
IPC分类号： A61K39/21 , C07K14/16
CPC分类号： C07K14/005 , A61K39/12 , A61K39/21 , A61K2039/5256 , A61K2039/5258 , C12N2740/16122 , C12N2740/16134 , C12N2795/18123
摘要： The present invention is in the fields of medicine, public health, immunology, molecular biology and virology. The invention provides composition comprising a virus-like particle (VLP) linked to at least one antigen, wherein said antigen is HIV gpl60 peptide. The invention also provides a process for producing the composition. The compositions of this invention are useful in the production of vaccines, in particular, for the prevention and treatment of diseases. Moreover, the compositions of the invention induce efficient immune responses, in particular antibody responses.
摘要翻译：本发明涉及医药，公共卫生，免疫学，分子生物学和病毒学领域。本发明提供包含与至少一种抗原连接的病毒样颗粒（VLP）的组合物，其中所述抗原是HIV gpl60肽。本发明还提供了一种制备该组合物的方法。本发明的组合物可用于生产疫苗，特别是用于预防和治疗疾病。此外，本发明的组合物诱导有效的免疫应答，特别是抗体应答。

3. 发明申请

WO2006063974A2 IL-15 ANTIGEN ARRAYS AND USES THEREOF 审中-公开
标题翻译： IL-15抗原阵列及其用途
公开(公告)号：WO2006063974A2
公开(公告)日：2006-06-22
申请号：PCT/EP2005056680
申请日：2005-12-12
申请人： CYTOS BIOTECHNOLOGY AG , BACHMANN MARTIN , ZOU YU , TISSOT ALAIN , MAURER PATRIK
发明人： BACHMANN MARTIN , ZOU YU , TISSOT ALAIN , MAURER PATRIK
IPC分类号： A61K39/00 , A61K39/385 , A61P9/10 , A61P11/06 , A61P19/02
CPC分类号： A61K39/0008 , A61K39/0005 , A61K2039/5258
摘要： The present invention is related to the fields of molecular biology, virology, immunology and medicine. The invention provides a composition comprising an ordered and repetitive antigen array, wherein the antigen is an IL-15 protein, an IL-15 mutein or an IL-15 fragment. More specifically, the invention provides a composition comprising a virus-like particle, and at least one IL-15 protein, IL-15 mutein or at least one IL-15 fragment linked thereto. The invention also provides a process for producing the composition. The compositions of the invention are useful in the production of vaccines for the treatment of inflammatory and chronic autoimmune diseases. The composition of the invention efficiently induces immune responses, in particular antibody responses. Furthermore, the compositions of the invention are particularly useful to efficiently induce self-specific immune responses within the indicated context.
摘要翻译：本发明涉及分子生物学，病毒学，免疫学和医学领域。本发明提供了包含有序和重复抗原阵列的组合物，其中抗原是IL-15蛋白，IL-15突变蛋白或IL-15片段。更具体地，本发明提供了包含病毒样颗粒和至少一种IL-15蛋白，IL-15突变蛋白或与其连接的至少一种IL-15片段的组合物。本发明还提供了一种生产该组合物的方法。本发明的组合物可用于生产用于治疗炎性和慢性自身免疫性疾病的疫苗。本发明的组合物有效诱导免疫应答，特别是抗体应答。此外，本发明的组合物对于有效诱导指定背景内的自身特异性免疫应答特别有用。

4. 发明申请

WO2004096272A2 METHODS AND COMPOSITIONS FOR MODULATING THE INTERACTION BETWEEN ADIPONECTIN AND ITS RECEPTOR 审中-公开
标题翻译：调节ADIPONECTIN与其受体之间相互作用的方法和组合物
公开(公告)号：WO2004096272A2
公开(公告)日：2004-11-11
申请号：PCT/EP2004004473
申请日：2004-04-28
申请人： CYTOS BIOTECHNOLOGY AG , SAUDAN PHILIPPE , BACHMANN MARTIN
发明人： SAUDAN PHILIPPE , BACHMANN MARTIN
IPC分类号： C07K14/47 , C07K14/705 , G01N33/566 , A61K39/395
CPC分类号： G01N33/566 , A61K38/00 , A61K38/2264 , A61K49/0004 , C07K14/47 , C07K14/705 , C07K16/28 , C07K2319/43 , G01N2333/705 , A61K2300/00
摘要： The invention is directed to methods for identifying agents that mimic or modulate the interaction between adiponectin and its receptor. In particular, the invention is directed to methods for mimicking or modulating the adiponectin-T-cadherin interaction in order to treat diseases and disorders associated with a deficiency or overabundance of adiponectin. Such diseases include, e.g., obesity, anorexia nervosa, type I and type II diabetes, coronary artery disease and atherosclerosis. The invention also provides isolated adiponectin-T-cadherin complexes and methods for identifying polypeptides that interact with adiponectin.
摘要翻译：本发明涉及用于鉴定模拟或调节脂联素及其受体之间的相互作用的试剂的方法。具体地，本发明涉及用于模拟或调节脂连蛋白-T-钙粘蛋白相互作用以便治疗与脂联素缺乏或过量相关的疾病和病症的方法。这些疾病包括例如肥胖症，神经性厌食症，I型和II型糖尿病，冠状动脉疾病和动脉粥样硬化。本发明还提供了分离的脂联素-T-钙粘蛋白复合物和用于鉴定与脂连蛋白相互作用的多肽的方法。

5. 发明申请

WO02056905A3 MOLECULAR ANTIGEN ARRAY 审中-公开
标题翻译：分子抗体阵列
公开(公告)号：WO02056905A3
公开(公告)日：2003-10-09
申请号：PCT/IB0200166
申请日：2002-01-21
申请人： CYTOS BIOTECHNOLOGY AG , RENNER WOLFGANG A , BACHMANN MARTIN , TISSOT ALAIN , MAURER PATRICK , LECHNER FRANZISKA , SEBBEL PETER , PIOSSEK CHRISTINE
发明人： RENNER WOLFGANG A , BACHMANN MARTIN , TISSOT ALAIN , MAURER PATRICK , LECHNER FRANZISKA , SEBBEL PETER , PIOSSEK CHRISTINE
IPC分类号： A61K39/00 , A61K35/76 , A61K38/00 , A61K38/11 , A61K39/02 , A61K39/12 , A61K39/29 , A61K39/35 , A61K39/385 , A61K39/39 , A61K47/48 , A61P25/28 , A61P29/00 , A61P31/00 , A61P35/00 , A61P37/02 , A61P37/08 , A61P39/00 , C07K14/005 , C07K14/02 , C07K14/08 , C07K14/245 , C07K14/52 , C07K14/54 , C07K16/00 , C07K16/08 , C07K16/22 , C07K16/28 , C07K16/40 , C07K16/42 , C12N15/40 , A61K39/44
CPC分类号： A61K39/12 , A61K38/00 , A61K39/0005 , A61K39/0007 , A61K39/0008 , A61K39/001 , A61K39/35 , A61K39/385 , A61K39/39 , A61K47/6901 , A61K2039/5256 , A61K2039/5258 , A61K2039/6075 , A61K2039/627 , C07K14/005 , C07K14/523 , C07K14/5409 , C07K14/5437 , C07K16/00 , C07K16/082 , C07K16/22 , C07K16/2863 , C07K16/2875 , C07K16/40 , C07K16/4291 , C07K2317/34 , C07K2317/52 , C07K2317/55 , C07K2319/00 , C07K2319/30 , C12N7/00 , C12N2730/10122 , C12N2730/10123 , C12N2795/18122 , C12N2795/18134
摘要： The present invention is related to the fields of molecular biology, virology, immunology and medicine. The invention provides a composition comprising an ordered and repetitive antigen or antigenic determinant array. The invention also provides a process for producing an antigen or antigenic determinant in an ordered and repetitive array. The ordered and repetitive antigen or antigenic determinant is useful in the production of vaccines for the treatment of infectious diseases, the treatment of allergies and as a pharmaccine to prevent or cure cancer and to efficiently induce self-specific immune responses, in particular antibody responses.
摘要翻译：本发明涉及分子生物学，病毒学，免疫学和医学领域。本发明提供包含有序重复抗原或抗原决定簇的组合物。本发明还提供了以有序和重复阵列产生抗原或抗原决定簇的方法。有序的和重复的抗原或抗原决定簇可用于生产用于治疗感染性疾病的疫苗，用于预防或治愈癌症以及有效地诱导自身特异性免疫应答（特别是抗体应答）的过敏症药物和药物。

6. 发明申请

WO2006045796A9 GASTRIC INHIBITORY POLYPEPTIDE (GIP) ANTIGEN ARRAYS AND USES THEREOF 审中-公开
标题翻译：胃肠道抑制性多肽（GIP）抗原阵列及其应用
公开(公告)号：WO2006045796A9
公开(公告)日：2007-05-24
申请号：PCT/EP2005055529
申请日：2005-10-25
申请人： CYTOS BIOTECHNOLOGY AG , BACHMANN MARTIN , FULURIJA ALMA , SAUDAN PHILIPPE
发明人： BACHMANN MARTIN , FULURIJA ALMA , SAUDAN PHILIPPE
IPC分类号： A61K47/48 , A61K38/26 , A61P3/10
CPC分类号： C07K16/26 , A61K39/00 , A61K47/646 , A61K47/6901 , A61K2039/5258 , A61K2039/6075 , A61K2039/64 , C07K14/005 , C07K2317/34 , C12N7/00 , C12N2730/10122 , C12N2730/10123
摘要： The present invention is in the fields of medicine, public health, immunology, molecular biology and virology. The present invention provides, inter alia, a composition comprising a virus-like particle (VLP) and at least one antigen, wherein said antigen is a GIP protein or a GIP fragment linked to the VLP respectively. The invention also provides a method for producing the aforesaid composition. The compositions of this invention are useful in the production of vaccines, in particular, for the prevention and/or treatment of obesity and hereby, in particular, by inducing efficient immune responses, in particular antibody responses. Furthermore, the compositions of the invention are particularly useful to efficiently induce self-specific immune responses within the indicated context.
摘要翻译：本发明属于医学，公共卫生，免疫学，分子生物学和病毒学领域。本发明尤其提供了包含病毒样颗粒（VLP）和至少一种抗原的组合物，其中所述抗原分别是与VLP连接的GIP蛋白或GIP片段。本发明还提供了生产上述组合物的方法。本发明的组合物可用于生产疫苗，特别是用于预防和/或治疗肥胖症，并且特别是通过诱导有效的免疫应答，特别是抗体应答。此外，本发明的组合物对于有效诱导指定背景内的自身特异性免疫应答特别有用。

7. 发明申请

WO02056907A3 MOLECULAR ANTIGEN ARRAY PRESENTING AMYLOID BETA 审中-公开
标题翻译：分子抗原阵列呈现AMYLOID BETA
公开(公告)号：WO02056907A3
公开(公告)日：2002-12-27
申请号：PCT/IB0200168
申请日：2002-01-21
申请人： CYTOS BIOTECHNOLOGY AG , NOVARTIS PHARMA AG , RENNER WOLFGANG A , BACHMANN MARTIN , TISSOT ALAIN , MAURER PATRICK , LECHNER FRANZISKA , SEBBEL PETER , PIOSSEK CHRISTINE , ORTMANN RAINER , LUEOEND RAINER , STAUFENBIEL MATTHIAS , FREY PETER
发明人： RENNER WOLFGANG A , BACHMANN MARTIN , TISSOT ALAIN , MAURER PATRICK , LECHNER FRANZISKA , SEBBEL PETER , PIOSSEK CHRISTINE , ORTMANN RAINER , LUEOEND RAINER , STAUFENBIEL MATTHIAS , FREY PETER
IPC分类号： A61K39/00 , A61K35/76 , A61K38/00 , A61K38/11 , A61K39/02 , A61K39/12 , A61K39/29 , A61K39/35 , A61K39/385 , A61K39/39 , A61K47/48 , A61P25/28 , A61P29/00 , A61P31/00 , A61P35/00 , A61P37/02 , A61P37/08 , A61P39/00 , C07K14/005 , C07K14/02 , C07K14/08 , C07K14/245 , C07K14/52 , C07K14/54 , C07K16/00 , C07K16/08 , C07K16/22 , C07K16/28 , C07K16/40 , C07K16/42 , C12N15/40
CPC分类号： A61K39/12 , A61K38/00 , A61K39/0005 , A61K39/0007 , A61K39/0008 , A61K39/001 , A61K39/35 , A61K39/385 , A61K39/39 , A61K47/6901 , A61K2039/5256 , A61K2039/5258 , A61K2039/6075 , A61K2039/627 , C07K14/005 , C07K14/523 , C07K14/5409 , C07K14/5437 , C07K16/00 , C07K16/082 , C07K16/22 , C07K16/2863 , C07K16/2875 , C07K16/40 , C07K16/4291 , C07K2317/34 , C07K2317/52 , C07K2317/55 , C07K2319/00 , C07K2319/30 , C12N7/00 , C12N2730/10122 , C12N2730/10123 , C12N2795/18122 , C12N2795/18134
摘要： The present invention is related to the fields of molecular biology, virology, immunology and medicine. The invention provides a composition comprising an ordered and repetitive antigen or antigenic determinant array. The invention also provides a process for producing an antigen or antigenic determinant in an ordered and repetitive array. The ordered and repetitive antigen or antigenic determinant is useful in the production of vaccines for the treatment of infectious diseases, the treatment of allergies and as a pharmaccine to prevent or cure cancer and to efficiently induce self-specific immune responses, in particular antibody responses.
摘要翻译：本发明涉及分子生物学，病毒学，免疫学和医学领域。本发明提供包含有序重复抗原或抗原决定簇的组合物。本发明还提供了以有序和重复阵列产生抗原或抗原决定簇的方法。有序的和重复的抗原或抗原决定簇可用于生产用于治疗感染性疾病的疫苗，用于预防或治愈癌症以及有效地诱导自身特异性免疫应答（特别是抗体应答）的过敏症药物和药物。

8. 发明申请

WO0185208A8 MOLECULAR ANTIGEN ARRAYS AND VACCINES 审中-公开
标题翻译：分子抗原阵列和疫苗
公开(公告)号：WO0185208A8
公开(公告)日：2002-09-19
申请号：PCT/IB0100741
申请日：2001-05-02
申请人： CYTOS BIOTECHNOLOGY AG , SEBBEL PETER , DUNANT NICOLAS , BACHMANN MARTIN , TISSOT ALAIN , LECHENER FRANZISKA
发明人： SEBBEL PETER , DUNANT NICOLAS , BACHMANN MARTIN , TISSOT ALAIN , LECHENER FRANZISKA
IPC分类号： A61K38/00 , A61K39/385 , A61P31/00 , A61P35/00 , A61P37/00 , A61P37/08 , C07K14/245 , C12N15/30 , C12N15/31 , C12N15/33 , C12N15/51
CPC分类号： A61K39/385 , A61K38/00 , A61K2039/57 , A61K2039/6068 , A61K2039/625 , C07K14/245 , C07K2319/00 , Y10S530/807
摘要： The invention provides compositions and processes for the production of ordered and repetitive antigen or antigenic determinant arrays. The compositions of the invention are useful for the production of vaccines for the prevention of infectious diseases, the treatment of allergies and the treatment of cancers. Various embodiments of the invention provide for a core particle that is coated with any desired antigen in a highly ordered and repetitive fashion as the result of specific interactions.
摘要翻译：本发明提供用于产生有序和重复抗原或抗原决定簇的组合物和方法。本发明的组合物可用于生产用于预防感染性疾病，过敏症的治疗和癌症治疗的疫苗。作为特定相互作用的结果，本发明的各种实施方案提供以高度有序和重复的方式涂覆任何所需抗原的核心颗粒。

9. 发明申请

WO0185208A3 MOLECULAR ANTIGEN ARRAYS AND VACCINES 审中-公开
标题翻译：分子抗原阵列和疫苗
公开(公告)号：WO0185208A3
公开(公告)日：2002-05-23
申请号：PCT/IB0100741
申请日：2001-05-02
申请人： CYTOS BIOTECHNOLOGY AG , SEBBEL PETER , DUNANT NICOLAS , BACHMANN MARTIN , TISSOT ALAIN , LECHENER FRANZISKA
发明人： SEBBEL PETER , DUNANT NICOLAS , BACHMANN MARTIN , TISSOT ALAIN , LECHENER FRANZISKA
IPC分类号： A61K38/00 , A61K39/385 , A61P31/00 , A61P35/00 , A61P37/00 , A61P37/08 , C07K14/245 , C12N15/30 , C12N15/31 , C12N15/33 , C12N15/51
CPC分类号： A61K39/385 , A61K38/00 , A61K2039/57 , A61K2039/6068 , A61K2039/625 , C07K14/245 , C07K2319/00 , Y10S530/807
摘要： The invention provides compositions and processes for the production of ordered and repetitive antigen or antigenic determinant arrays. The compositions of the invention are useful for the production of vaccines for the prevention of infectious diseases, the treatment of allergies and the treatment of cancers. Various embodiments of the invention provide for a core particle that is coated with any desired antigen in a highly ordered and repetitive fashion as the result of specific interactions.
摘要翻译：本发明提供了用于生产有序和重复的抗原或抗原决定簇阵列的组合物和方法。本发明的组合物可用于生产用于预防感染性疾病，治疗变态反应和治疗癌症的疫苗。本发明的各种实施方式提供了作为特异性相互作用的结果以高度有序且重复的方式涂覆有任何期望的抗原的核心颗粒。

10. 发明申请

WO2006097530A2 CAT ALLERGEN CONJUGATES AND USES THEREOF 审中-公开
标题翻译： CAT过敏反应及其用途
公开(公告)号：WO2006097530A2
公开(公告)日：2006-09-21
申请号：PCT/EP2006060845
申请日：2006-03-17
申请人： CYTOS BIOTECHNOLOGY AG , BACHMANN MARTIN , BAUER MONIKA , DIETMEIER KLAUS , SCHMITZ NICOLE , UTZINGER STEPHAN
发明人： BACHMANN MARTIN , BAUER MONIKA , DIETMEIER KLAUS , SCHMITZ NICOLE , UTZINGER STEPHAN
IPC分类号： A61K39/00
CPC分类号： A61K47/48776 , A61K39/35 , A61K47/6901 , A61K2039/5258 , A61K2039/55505 , C07K14/005 , C07K2319/00
摘要： The present invention is in the fields of medicine, public health, immunology, molecular biology and virology. The invention provides compositions comprising a virus-like particle (VLP) or a virus particle and at least one antigen, particularly at least one feline antigen, and more particularly at least one feline antigen that is a human allergen. In certain embodiments, the antigen is a Fel d1 antigen or a fragment thereof, covalently linked to the VLP. The invention also provides methods for producing the compositions. The compositions of the invention induce efficient immune responses, in particular antibody responses, in mammals, particularly humans. The compositions and methods of the invention are useful in the production of vaccines, in particular for the treatment and/or prevention of allergies to cat dander and other cat antigens and allergens.
摘要翻译：本发明涉及医药，公共卫生，免疫学，分子生物学和病毒学领域。本发明提供包含病毒样颗粒（VLP）或病毒颗粒和至少一种抗原，特别是至少一种猫科动物抗原的组合物，更特别是至少一种作为人类变应原的猫科动物抗原。在某些实施方案中，抗原是与VLP共价连接的Fel d1抗原或其片段。本发明还提供了用于制备组合物的方法。本发明的组合物在哺乳动物，特别是人类中诱导有效的免疫应答，特别是抗体应答。本发明的组合物和方法可用于疫苗的制备，特别是用于治疗和/或预防猫皮屑和其它猫抗原和变应原的过敏。

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