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1. 发明专利

JP2005241439A Immobilization carrier for biomolecule-containing particle, and method of immobilizing biomolecule-containing particle 有权
标题翻译：用于生物分子颗粒的固定载体和使含有生物分子的颗粒物的方法
公开(公告)号：JP2005241439A
公开(公告)日：2005-09-08
申请号：JP2004051708
申请日：2004-02-26
申请人： Yoichiro Hosokawa , Kyoritsu Kagaku Sangyo Kk , Hiroshi Masuhara , Isamu O , 協立化学産業株式会社 , 宏増原 , 勇王 , 陽一郎細川
发明人： MASUHARA HIROSHI , O ISAMU , HOSOKAWA YOICHIRO , MATSUBARA CHIE
IPC分类号： G01N33/53 , G01N33/543 , G01N33/544 , G01N33/553 , G01N37/00
摘要： PROBLEM TO BE SOLVED: To provide a biomolecule-containing particle immobilizing carrier immobilized strongly under the condition where a particle containing a biomolecule keeps its activity, and a biomolecule-containing particle immobilizing method capable of immobilizing strongly the particle containing the biomolecule under the condition where the particle containing the biomolecule keeps its activity, without modifying the particle containing the biomolecule.
SOLUTION: This biomolecule-containing particle immobilizing carrier comprises a substrate, and the particle containing the biomolecule immobilized on a surface of the substrate, and the particle is immobilized on the substrate by a photocuring resin. In this biomolecule-containing particle immobilizing method, a dispersion dispersed with the particle containing the biomolecule is dropped on the substrate layered with a thin layer comprising a photocuring resin composition on its surface, and then light having a wavelength capable of curing the thin layer is emitted thereto to cure the thin layer, and the bimolecule-containing particle is immobilized on the surface of the substrate.
COPYRIGHT: (C)2005,JPO&NCIPI
摘要翻译：待解决的问题：提供一种在含有生物分子保持其活性的颗粒状态下固定化载体的固体化载体，以及能够将含有生物分子的粒子牢固固定的生物分子的粒子固定化方法含有生物分子的颗粒保持其活性，而不改变含有生物分子的颗粒的条件。解决方案：该含有生物分子的颗粒固定载体包含底物，含有固定在基材表面上的生物分子的颗粒，并通过光固化树脂将颗粒固定在基材上。在该含有生物分子的粒子固定化方法中，将分散有含有生物分子的粒子的分散液滴在由表面含有光固化性树脂组合物的薄层层叠的基材上，然后将具有固化该薄层的波长的光发射到其上以固化薄层，并且将含双分子的颗粒固定在基材的表面上。版权所有（C）2005，JPO＆NCIPI

2. 发明专利

JP2003047841A Surface stripping and cleaning method using ultra short pulse laser and device therefor 有权
标题翻译：使用超短脉冲激光的表面剥离和清洁方法及其设备
公开(公告)号：JP2003047841A
公开(公告)日：2003-02-18
申请号：JP2001235422
申请日：2001-08-02
申请人： Electron Kiki Kk , Japan Science & Technology Corp , Hiroshi Masuhara , エレクトロン機器株式会社 , 宏増原 , 科学技術振興事業団
发明人： HOSOKAWA YOICHIRO , MATSUMOTO YUTAKA , MASUHARA HIROSHI , SATO SETSUYA
IPC分类号： B08B7/00 , B01J19/12
摘要： PROBLEM TO BE SOLVED: To provide a surface stripping and cleaning method, by which surface stripping and cleaning requiring fine and careful work is performed precisely for a short time. SOLUTION: The surface stripping and cleaning method is used for stripping and cleaning a unnecessary material stuck on the surface of a material to be cleaned. The unnecessary material is irradiated with ultra short pulse laser to excite the unnecessary material and to cause the drastic increase in shear between the material to be cleaned and the unnecessary material and as a result, the unnecessary material is fragmented and stripped from the surface of the material to be cleaned.
摘要翻译：要解决的问题：提供表面剥离和清洁方法，通过该表面剥离和清洁方法，在短时间内精确地执行需要精细和细致工作的表面剥离和清洁。解决方案：表面剥离和清洁方法用于剥离和清洁粘附在待清洁材料表面上的不必要的材料。用超短脉冲激光照射不需要的材料以激发不需要的材料并引起要清洗的材料和不需要的材料之间的剪切力的急剧增加，结果，不需要的材料被碎片化并从要清洗的材料

3. 发明专利

JP2003015054A Microcell plate and method for manufacturing the same 审中-公开
标题翻译： MICROCELL板及其制造方法
公开(公告)号：JP2003015054A
公开(公告)日：2003-01-15
申请号：JP2001201128
申请日：2001-07-02
申请人： Electron Kiki Kk , Japan Science & Technology Corp , Hiroshi Masuhara , エレクトロン機器株式会社 , 宏増原 , 科学技術振興事業団
发明人： HOSOKAWA YOICHIRO , MATSUMOTO YUTAKA , MASUHARA HIROSHI , SATO SETSUYA
IPC分类号： G01N1/28 , G02B21/34
摘要： PROBLEM TO BE SOLVED: To improve operation and observation by enabling operation and observation of a cell, etc. in a solution dispersed state even under a transmission type optical microscope.
SOLUTION: In a microcell plate, a thin film (2) having either groove parts formed on at least either a upper or lower face, or penetrating parts (A, B, C, D and E) on the upper and lower faces is held between and unified with upper and lower transparent substrates (1) and (3).
COPYRIGHT: (C)2003,JPO
摘要翻译：要解决的问题：即使在透射型光学显微镜下，通过使溶液分散状态下的电池等能够操作和观察来改善操作和观察。解决方案：在微电池板中，保持在上表面和下表面上的至少一个上表面或下表面上形成有凹槽部分或穿透部分（A，B，C，D和E）的薄膜（2）在上下透明基板（1）和（3）之间并且统一。

4. 发明专利

JP2004341463A Optical stage 审中-公开
公开(公告)号：JP2004341463A
公开(公告)日：2004-12-02
申请号：JP2003175553
申请日：2003-05-16
申请人： Yoichiro Hosokawa , Hiroshi Masuhara , Yoji Yoshikawa , 洋史吉川 , 宏増原 , 陽一郎細川
发明人： HOSOKAWA YOICHIRO , YOSHIKAWA YOJI , MASUHARA HIROSHI
IPC分类号： G02B7/00
摘要： PROBLEM TO BE SOLVED: To provide an optical stage having easily produceable mechanism and easy to adjust since the conventional optical stage has complicated mechanism and requires time and labor of production and, moreover, its adjustment is difficult in an optical system.
SOLUTION: A hollow curved pipe is arranged in the component of an optical stage. It is made possible to adjust the position of the optical stage from a position where adjustment is easy by making force which screws an adjusting screw to be propagated to the optical stage while arranging a plurality of spherical and cylindrical components in the curved pipe. It is mentioned as a reason which makes this invention possible that the hollow curved pipe whose production is difficult conventionally can be produced easily by an optical forming method.
COPYRIGHT: (C)2005,JPO&NCIPI

5. 发明专利

JP2005144538A Laser beam machining apparatus 审中-公开
标题翻译：激光加工设备
公开(公告)号：JP2005144538A
公开(公告)日：2005-06-09
申请号：JP2003389882
申请日：2003-11-19
申请人： Cybox Co Ltd , Yoichiro Hosokawa , Hiroshi Masuhara , Isamu O , サイボックス株式会社 , 宏増原 , 勇王 , 陽一郎細川
发明人： HOSOKAWA YOICHIRO , O ISAMU , MASUHARA HIROSHI , YAMATO TOSHIYUKI , MATSUMOTO YUTAKA , SATO SETSUYA
IPC分类号： C12M1/00 , B23K26/02 , B23K26/03
摘要： PROBLEM TO BE SOLVED: To realize a simplified construction and space saving in a laser beam machining apparatus capable of performing microfabrication while observing a workpiece, and to provide a laser beam machining apparatus that can be designed and manufactured flexibly and quickly in accordance with an intended purpose. SOLUTION: The laser beam machining apparatus is equipped with a microscope section for observing a workpiece and a laser introducing section for guiding a laser beam into the inside of the supporting member 1 of the microscope section. The apparatus is intended for machining a workpiece by converging laser beams thereon or its proximity while the workpiece is being observed. The microscope section is nearly integrated with the supporting member 1 which is composed of two to four pieces of components molded of a polymer material. COPYRIGHT: (C)2005,JPO&NCIPI
摘要翻译：要解决的问题：为了实现能够在观察工件的同时进行微细加工的激光束加工装置中的简化的结构和空间节省，并且提供可以按照以下方式灵活和快速地设计和制造的激光束加工装置有预期的目的。解决方案：激光束加工装置配备有用于观察工件的显微镜部分和用于将激光束引导到显微镜部分的支撑部件1的内部的激光引入部。该装置旨在通过在其上观察工件的同时会聚激光束或其邻近来加工工件。显微镜部分与由聚合物材料模制的两到四个部件组成的支撑构件1几乎一体化。版权所有（C）2005，JPO＆NCIPI

6. 发明授权

US07900855B2 Method for producing fullerene suspension 有权
标题翻译：富勒烯悬浮液的制备方法
公开(公告)号：US07900855B2
公开(公告)日：2011-03-08
申请号：US12069172
申请日：2008-02-07
申请人： Tsuyoshi Asahi , Hiroshi Masuhara , Teruki Sugiyama , Isamu Oh , Sen-ichi Ryo
发明人： Tsuyoshi Asahi , Hiroshi Masuhara , Teruki Sugiyama , Isamu Oh , Sen-ichi Ryo
IPC分类号： B02C1/00 , B02C11/08 , B02C21/00 , B02C23/00
CPC分类号： B82Y40/00 , B01J19/121 , B82Y30/00 , C01B32/15 , C01B32/152
摘要： The present invention provides a fullerene suspension and a method for producing a fullerene suspension having high dispersion stability without any chemical compound. Also, the fullerene suspension and its producing method makes it possible to be applied in various fields including the field of medical and pharmaceutical science and the field of foods and environment, in which the fullerene suspension obtained by the prior methods had not been applied. The fullerene is ground to form nanoparticles by irradiating a fullerene in a poor solvent with a laser. The pulse laser having a width of several-ten femtoseconds to several-hundred nanoseconds is appropriately applied.
摘要翻译：本发明提供一种富勒烯悬浮液和一种具有高分散稳定性的富勒烯悬浮液的方法，而没有任何化合物。此外，富勒烯悬浮液及其制造方法可以应用于医疗和制药科学以及食品和环境领域的各个领域，其中通过现有方法获得的富勒烯悬浮液未被应用。通过用激光在不良溶剂中照射富勒烯来研磨富勒烯以形成纳米颗粒。适当地施加宽度为几十飞秒至数百纳秒的脉冲激光器。

7. 发明申请

US20070284769A1 APPARATUS FOR FORMING ULTRAFINE PARTICLES 失效
标题翻译：用于形成超细颗粒的装置
公开(公告)号：US20070284769A1
公开(公告)日：2007-12-13
申请号：US11748842
申请日：2007-05-15
申请人： Hiroyuki Kato , Isao Umeda , Tsuyoshi Asahi , Hiroshi Masuhara , Teruki Sugiyama , Isamu Oh , Sen-ichi Ryo , Kazuya Hirata , Motohiko Nohmi
发明人： Hiroyuki Kato , Isao Umeda , Tsuyoshi Asahi , Hiroshi Masuhara , Teruki Sugiyama , Isamu Oh , Sen-ichi Ryo , Kazuya Hirata , Motohiko Nohmi
IPC分类号： B82B3/00 , B02C19/18
CPC分类号： B02C19/18 , B01J19/0093 , B01J2219/0086 , B01J2219/00862 , B01J2219/00873 , B01J2219/00934 , B01J2219/00984 , Y10S977/901
摘要： An apparatus for forming ultrafine particles, including: a light source generating a laser beam to be irradiated at an organic substance; at least one microflow channel capable of passing therethrough a suspension containing the organic substance; and a flow device for allowing the suspension containing the organic substance to continuously or intermittently pass through the microflow channel, the organic substance present in the microflow channel being irradiated with the laser beam at least once within a predetermined period, thereby forming ultrafine particles of the organic substance.
摘要翻译：一种用于形成超微粒子的装置，包括：产生要在有机物质上照射的激光束的光源; 至少一个能够通过其中含有有机物的悬浮液的微流道; 以及用于允许包含有机物质的悬浮液连续或间歇地通过微流道的流动装置，存在于微流道中的有机物质在预定时间内至少一次被激光束照射，由此形成超细颗粒有机物质。

8. 发明授权

US07247203B2 Process for producing crystalline nucleus and method of screening crystallization conditions 失效
标题翻译：生产晶核的方法和筛选结晶条件的方法
公开(公告)号：US07247203B2
公开(公告)日：2007-07-24
申请号：US10525809
申请日：2003-08-25
申请人： Takatomo Sasaki , Yusuke Mori , Masashi Yoshimura , Hiroaki Adachi , Hiroshi Masuhara , Youichiroh Hosokawa , Kazufumi Takano
发明人： Takatomo Sasaki , Yusuke Mori , Masashi Yoshimura , Hiroaki Adachi , Hiroshi Masuhara , Youichiroh Hosokawa , Kazufumi Takano
IPC分类号： C30B29/54
CPC分类号： C30B7/00 , C30B29/58 , Y10S117/904
摘要： The present invention relates to a process for producing high-quality crystals of protein or organic substances easily and efficiently. A solution of protein or an organic substance is prepared and then is cooled slowly to be supersaturated to a low degree. This supersaturated solution is irradiated with a femtosecond laser 10. A local explosion phenomenon occurs at the focal point of the laser and thereby a crystalline nucleus is generated. A high-quality crystal is obtained when a crystal is grown on the crystalline nucleus over a long period of time. The femtosecond laser to be used herein can be a titanium:sapphire laser having a wavelength of 800 nm, a duration of 120 fs, a frequency of 1 kHz, and an output of 400 mW.
摘要翻译：本发明涉及容易高效地生产蛋白质或有机物质的优质晶体的方法。制备蛋白质或有机物质的溶液，然后缓慢冷却至低饱和度。用飞秒激光10照射该过饱和溶液。在激光的焦点发生局部爆炸现象，从而产生晶核。当晶体长时间在晶核上生长时，获得高质量的晶体。本文使用的飞秒激光可以是波长为800nm，持续时间为120fs，频率为1kHz，输出为400mW的钛：蓝宝石激光。

9. 发明申请

US20100068794A1 Cell Fusion Chip 审中-公开
标题翻译：细胞融合芯片
公开(公告)号：US20100068794A1
公开(公告)日：2010-03-18
申请号：US12225977
申请日：2007-03-27
申请人： Isamu Oh , Hiroshi Masuhara , Toshiyuki t Yamato , Katsuaki Hayashi , Yasuji Adachi , Sato Setsuya
发明人： Isamu Oh , Hiroshi Masuhara , Toshiyuki t Yamato , Katsuaki Hayashi , Yasuji Adachi , Sato Setsuya
IPC分类号： C12M3/00
CPC分类号： C12M35/02
摘要： (Problems) To provide a cell fusion chip, which allows to perform a cell fusion on a single chip, excels in the operating efficiency, does not require experience so much in cell feed or recovery, and has no risk of the contamination to the cells during the operation.(Means for Solving Problems) The present invention provides a cell fusion chip comprising: an isolation chamber for receiving isolated cells to be subjected to an fusion operation; a fusion chamber for fusing the cells together supplied from the isolation chamber; a culture chamber for culturing the cells fused in the fusion chamber; a first channel for connecting the isolation chamber and the fusion chamber; and a second channel for connecting the fusion chamber and the culture chamber, wherein the isolation chamber, the fusion chamber, the culture chamber, the first channel and the second channel are formed on a single chip.
摘要翻译：（问题）为了提供能够在单个芯片上进行细胞融合的细胞融合芯片，其操作效率优异，在细胞进料或回收中不需要经验，并且没有细胞污染的风险在操作期间。（解决问题的手段）本发明提供一种细胞融合芯片，包括：隔离室，用于接收待进行融合操作的分离细胞; 用于将从隔离室供应的单元熔合的熔化室; 用于培养在所述融合室中熔融的细胞的培养室; 用于连接隔离室和熔化室的第一通道; 以及用于连接熔融室和培养室的第二通道，其中隔离室，熔化室，培养室，第一通道和第二通道形成在单个芯片上。

10. 发明申请

US20080237376A1 Method of producing medicinal nanoparticle suspension 失效
标题翻译：生产药用纳米颗粒悬浮液的方法
公开(公告)号：US20080237376A1
公开(公告)日：2008-10-02
申请号：US11798621
申请日：2007-05-15
申请人： Tsuyoshi Asahi , Hiroshi Masuhara , Teruki Sugiyama , Isamu Oh , Sen-ichi Ryo , Hiroyuki Kato , Isao Umeda
发明人： Tsuyoshi Asahi , Hiroshi Masuhara , Teruki Sugiyama , Isamu Oh , Sen-ichi Ryo , Hiroyuki Kato , Isao Umeda
IPC分类号： B02C19/18
CPC分类号： A61K9/10 , A61K9/14 , A61K31/475 , B01J19/10 , B01J19/121 , B01J2219/089
摘要： A method of producing a medicinal nanoparticle suspension is provided, wherein a medicinal ingredient added in a suspending solution is ground to form nanoparticles of the medicinal ingredient by irradiating the suspending solution with a laser. The process is implemented after adding a poorly water-soluble or water-insoluble medicinal ingredient of a drug in a poor solvent to form the suspending solution.
摘要翻译：提供一种生产药用纳米颗粒悬浮液的方法，其中通过用激光照射悬浮溶液将加入悬浮液中的药物成分研磨成药物成分的纳米颗粒。在不良溶剂中加入难溶于水或不溶于水的药物成分的药物后，进行上述处理，形成悬浮液。

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