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1. 发明申请

US20060024684A1 Prognostic markers for prediction of treatment response and/or survival of breast cell proliferative disorder patients 审中-公开
公开(公告)号：US20060024684A1
公开(公告)日：2006-02-02
申请号：US11011332
申请日：2004-12-13
申请人： John Foekens , Nadia Harbeck , Thomas Koenig , Sabine Maier , John Martens , Fabian Model , Inko Nimmrich , Tamas Rujan , Manfred Schmitt , Ralf Lesche , Dimo Dietrich , Volkmar Mueller , Antje Kluth , Ina Schwope , Oliver Hartmann , Peter Adorjan
发明人： John Foekens , Nadia Harbeck , Thomas Koenig , Sabine Maier , John Martens , Fabian Model , Inko Nimmrich , Tamas Rujan , Manfred Schmitt , Ralf Lesche , Dimo Dietrich , Volkmar Mueller , Antje Kluth , Ina Schwope , Oliver Hartmann , Peter Adorjan
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/118 , C12Q2600/154 , C12Q2600/156 , C12Q2600/158 , C12Q2600/16
摘要： Aspects of the present invention provide compositions and methods for prognosis of, and/or predicting the estrogen treatment outcome of breast cell proliferative disorder patients, and in particular of patients with breast carcinoma. In preferred embodiments, this is achieved, at least in part, by determining the expression level of PITX2, and/or the genetic or the epigenetic modifications of the genomic DNA associated with the gene PITX2. Additional aspects of the invention provide novel sequences, oligomers (e.g., oligonucleotides or peptide nucleic acid (PNA)-oligomers), and antibodies, which have substantial utility in the described inventive methods and compositions.

2. 发明申请

US20050287553A1 Method for the quantification of methylated DNA 审中-公开
标题翻译：甲基化DNA定量的方法
公开(公告)号：US20050287553A1
公开(公告)日：2005-12-29
申请号：US11100779
申请日：2005-04-06
申请人： David Guetig , Dirk Habighorst , Antje Kluth , Armin Schmitt , Matthias Schuster , Ina Schwope
发明人： David Guetig , Dirk Habighorst , Antje Kluth , Armin Schmitt , Matthias Schuster , Ina Schwope
IPC分类号： C12Q1/68 , G06F19/00 , C12P19/34
CPC分类号： C12Q1/6823 , C12Q2565/101 , C12Q2535/131 , C12Q2545/114 , C12Q2523/125
摘要： Particular aspects of the present invention provide a method for quantification of two different variations of a DNA sequence. Particularly, the invention relates to a quantification of methylated DNA, and for this purpose, the test DNA is converted so that cytosine is converted to uracil, while 5-methylcytosine remains unchanged. The converted DNA is amplified by means of a real-time PCR, wherein two labeled real-time probe types are utilized: one specific for methylated DNA; and one for unmethylated DNA. Preferably, the degree of methylation of the test DNA is calculated from the ratio of the signal intensities of the probes or from the Ct values. The inventive methods have substantial utility for diagnosis and prognosis of cancer and other disorders associated with altered or characteristic DNA methylation status, as well as having substantial utility for analysis of SNPs, allelic expression, and prediction of drug response, drug interactions, among other uses.
摘要翻译：本发明的特定方面提供了用于定量DNA序列的两个不同变体的方法。特别地，本发明涉及甲基化DNA的定量，为此目的，转化测试DNA使得胞嘧啶转化为尿嘧啶，而5-甲基胞嘧啶保持不变。通过实时PCR扩增转化的DNA，其中使用两种标记的实时探针类型：一种特异性用于甲基化DNA; 一个用于未甲基化的DNA。优选地，根据探针的信号强度与Ct值的比值来计算测试DNA的甲基化程度。本发明的方法具有用于诊断和预测与改变或特征性DNA甲基化状态相关的癌症和其他病症的实质性用途，并且具有用于分析SNP，等位基因表达和药物反应预测，药物相互作用以及其它用途的实质性用途。

3. 发明授权

US09017944B2 Methods for the prognosis of breast cancer 有权
标题翻译：乳腺癌预后的方法
公开(公告)号：US09017944B2
公开(公告)日：2015-04-28
申请号：US10582705
申请日：2004-12-13
申请人： John Foekens , Nadia Harbeck , Thomas Koenig , Sabine Maier , John W. Martens , Fabian Model , Inko Nimmrich , Manfred Schmitt , Ralf Lesche , Dimo Dietrich , Volkmar Mueller , Antje Kluth Lukas , Ina Schwope , Oliver Hartmann , Peter Adorjan , Almuth Marx , Heinz Hoefler
发明人： John Foekens , Nadia Harbeck , Thomas Koenig , Sabine Maier , John W. Martens , Fabian Model , Inko Nimmrich , Manfred Schmitt , Ralf Lesche , Dimo Dietrich , Volkmar Mueller , Antje Kluth Lukas , Ina Schwope , Oliver Hartmann , Peter Adorjan , Almuth Marx , Heinz Hoefler
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/118 , C12Q2600/154 , C12Q2600/158 , C12Q2600/16
摘要： The present invention relates to modified and genomic sequences, to oligonucleotides and/or PNA-oligomers for detecting the cytosine methylation state of genomic DNA, as well as to a method for predicting the disease free survival and/or response of a subject with a cell proliferative disorder of the breast tissues, to endocrine treatment.
摘要翻译：本发明涉及修饰和基因组序列，用于检测基因组DNA的胞嘧啶甲基化状态的寡核苷酸和/或PNA寡聚体，以及用于预测受试者与细胞的无病存活和/或应答的方法乳腺组织增生性疾病，进行内分泌治疗。

4. 发明申请

US20090269736A1 Prognostic markers for prediction of treatment response and/or survival of breast cell proliferative disorder patients 审中-公开
标题翻译：用于预测乳腺增生性疾病患者的治疗反应和/或存活的预后标志物
公开(公告)号：US20090269736A1
公开(公告)日：2009-10-29
申请号：US11628703
申请日：2005-06-06
申请人： Inko Nimmrich , Ralf Lesche , Ina Schwope , Sabine Maier , Antje Kluth Lukas , Oliver Hartmann , Almuth Marx
发明人： Inko Nimmrich , Ralf Lesche , Ina Schwope , Sabine Maier , Antje Kluth Lukas , Oliver Hartmann , Almuth Marx
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/118 , C12Q2600/154 , C12Q2600/156 , C12Q2600/158 , C12Q2600/16
摘要： Aspects of the present invention provide compositions and methods for prognosis of, and/or predicting the estrogen treatment outcome of breast cell proliferative disorder patients, and in particular of patients with breast carcinoma. In preferred embodiments, this is achieved, at least in part, by determining the expression level of PITX2, and/or the genetic or the epigenetic modifications of the genomic DNA associated with the gene PITX2. Additional aspects of the invention provide novel sequences, oligomers (e.g., oligonucleotides or peptide nucleic acid (PNA)-oligomers), and antibodies, which have substantial utility in the described inventive methods and compositions.
摘要翻译：本发明的方面提供了用于预测和/或预测乳腺增生性疾病患者，特别是乳腺癌患者的雌激素治疗结果的组合物和方法。在优选的实施方案中，这通过确定PITX2的表达水平和/或与基因PITX2相关的基因组DNA的遗传或表观遗传修饰至少部分地实现。本发明的另外的方面提供新的序列，低聚物（例如，寡核苷酸或肽核酸（PNA）寡聚体））和抗体，其在所述的发明方法和组合物中具有实用性。

5. 发明申请

US20080254447A1 Method and Nucleic Acids for the Improved Treatment of Breast Cell Proliferative Disorders 有权
标题翻译：改善乳腺增生性疾病治疗的方法和核酸
公开(公告)号：US20080254447A1
公开(公告)日：2008-10-16
申请号：US10582705
申请日：2004-12-13
申请人： John Foekens , Nadia Harbeck , Thomas Koenig , Sabine Maier , John Martens , Fabian Model , Inko Nimmrich , Manfred Schmitt , Ralf Lesche , Dimo Dietrich , Volkmar Mueller , Antje Kluth , Ina Schwope , Oliver Hartmann , Peter Adorjan , Almuth Marx , Heinz Hoefler
发明人： John Foekens , Nadia Harbeck , Thomas Koenig , Sabine Maier , John Martens , Fabian Model , Inko Nimmrich , Manfred Schmitt , Ralf Lesche , Dimo Dietrich , Volkmar Mueller , Antje Kluth , Ina Schwope , Oliver Hartmann , Peter Adorjan , Almuth Marx , Heinz Hoefler
IPC分类号： C12Q1/68 , C07H21/04
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/118 , C12Q2600/154 , C12Q2600/158 , C12Q2600/16
摘要： The present invention relates to modified and genomic sequences, to oligonucleotides and/or PNA-oligomers for detecting the cytosine methylation state of genomic DNA, as well as to a method for predicting the disease free survival and/or response of a subject with a cell proliferative disorder of the breast tissues, to endocrine treatment.
摘要翻译：本发明涉及修饰和基因组序列，用于检测基因组DNA的胞嘧啶甲基化状态的寡核苷酸和/或PNA寡聚体，以及用于预测受试者与细胞的无病存活和/或应答的方法乳腺组织增生性疾病，进行内分泌治疗。

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