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1. 发明申请

US20080118439A1 SYSTEMS AND METHODS FOR HIGH-RESOLUTION IN VIVO IMAGING OF BIOCHEMICAL ACTIVITY IN A LIVING ORGANISM 审中-公开
标题翻译：生活有机体生物活性成像高分辨率的系统与方法
公开(公告)号：US20080118439A1
公开(公告)日：2008-05-22
申请号：US11875245
申请日：2007-10-19
申请人： Ileana Hancu , Mohan Mark Amaratunga , Denyce Kramer Wicht , Paritosh Dhawale , Nadeem Ishaque , Faisal Ahmed Syud , Bruce Fletcher Johnson , Amy Casey Williams
发明人： Ileana Hancu , Mohan Mark Amaratunga , Denyce Kramer Wicht , Paritosh Dhawale , Nadeem Ishaque , Faisal Ahmed Syud , Bruce Fletcher Johnson , Amy Casey Williams
IPC分类号： A61K49/06 , A61K49/04
CPC分类号： A61K49/0056 , A61K49/0002 , A61K49/0032 , A61K49/085 , A61K49/10 , A61K49/14
摘要： This invention relates to multifunctional detection agents useful for providing high-resolution, in vivo imaging of biochemical activity in a living organism. Methods of using these multifunctional detection agents may comprise administering them into a living organism, and then estimating the localization of the detection agent using one modality (i.e., MRI), while concurrently estimating the level of biological activity using a second modality (i.e., optical imaging). One of the multifunctional detection agents comprises a magnetic resonance component and an optical imaging component. The magnetic resonance component comprises a contrast agent that is always activated or “on”. The optical imaging component comprises a plurality of activatable contrast agents or dyes, at least two of which are different from one another, wherein at least one of the activatable contrast agents can be activated or turned “on” only in the presence of a particular event.
摘要翻译：本发明涉及可用于提供活体内生物化学活性的高分辨率，体内成像的多功能检测剂。使用这些多功能检测剂的方法可以包括将其施用于活生物体中，然后使用一种模态（即，MRI）估计检测剂的定位，同时使用第二模态估计生物活性的水平（即，光学成像）。多功能检测剂之一包括磁共振成分和光学成像元件。磁共振成分包括始终被激活或“开启”的造影剂。光学成像组件包括多个可激活的造影剂或染料，其中至少两个不同于其中，其中可激活的造影剂中的至少一个可以在特定事件的存在下被激活或“打开” 。

2. 发明申请

US20070134159A1 Quantitation of sample properties using contrast enhancement from saturation transfer 失效
标题翻译：使用饱和传递的对比度增强对样本特性的定量
公开(公告)号：US20070134159A1
公开(公告)日：2007-06-14
申请号：US11297263
申请日：2005-12-08
申请人： W. Dixon , Ileana Hancu
发明人： W. Dixon , Ileana Hancu
IPC分类号： A61K49/10 , A61B5/055
CPC分类号： G01R33/5601 , G01R33/4804 , G01R33/483 , G01R33/5605
摘要： The manipulation of RF irradiation to a subject in which a CEST agent has been administered is employed to determine a biological parameter in vivo in conjunction with an MRI imaging process. The exchange rate of the CEST agent is determined through RF manipulation which in turn enables the determination of a biological parameter through standard calibration techniques. The exchange rate of CEST agents is modulated as a function of many biological parameters, such as pH. MRI apparatuses and computer program products configured for determining exchanges rates of CEST agents in vivo are also disclosed.
摘要翻译：使用已经给予CEST试剂的受试者的RF照射的操作来与MRI成像过程结合来确定体内的生物学参数。通过RF操作确定CEST试剂的汇率，其进而通过标准校准技术确定生物参数。作为许多生物参数（如pH）的函数调节CEST试剂的交换率。还公开了配置用于确定CEST试剂在体内的交换速率的MRI装置和计算机程序产品。

3. 发明授权

US08981778B2 Method and apparatus for imaging a patient using local shim coils 有权
标题翻译：使用局部垫片对患者成像的方法和装置
公开(公告)号：US08981778B2
公开(公告)日：2015-03-17
申请号：US13094602
申请日：2011-04-26
申请人： Seung-Kyun Lee , Ileana Hancu , Lorne Wyatt Hofstetter
发明人： Seung-Kyun Lee , Ileana Hancu , Lorne Wyatt Hofstetter
IPC分类号： G01R33/48 , G01R33/3415 , G01R33/3875
CPC分类号： G01R33/3415 , G01R33/3875
摘要： A method of generating a magnetic resonance (MR) image includes applying a localized magnetic field to a portion of a patient, determining a difference between a local field strength around a first region of interest and a local field strength around a different second region of interest, adjusting the local field strength around the first region of interest such that the local field strength around the first region of interest is substantially the same as the local field strength around the second region of interest, and generating an image of the first and second regions after adjusting the local field strength around the first second region of interest. A coil apparatus and a system are also described herein.
摘要翻译：产生磁共振（MR）图像的方法包括将局部磁场施加到患者的一部分，确定感兴趣的第一区域周围的局部场强与不同的第二感兴趣区域周围的局部场强之间的差异调整围绕所述第一感兴趣区域的局部场强，使得所述第一感兴趣区周围的局部场强与所述第二感兴趣区周围的局部场强基本相同，并且产生所述第一和第二区的图像在调整感兴趣的第一个第二区域周围的局部场强之后。本文还描述了线圈装置和系统。

4. 发明授权

US08049501B2 Multi-frequency RF coil 有权
标题翻译：多频RF线圈
公开(公告)号：US08049501B2
公开(公告)日：2011-11-01
申请号：US12420098
申请日：2009-04-08
申请人： Ileana Hancu , Joseph Edward Piel , William Thomas Dixon
发明人： Ileana Hancu , Joseph Edward Piel , William Thomas Dixon
IPC分类号： G01V3/00
CPC分类号： G01R33/3635 , G01R33/281 , G01R33/34061 , G01R33/34076 , G01R33/3664 , G01R33/3678 , G01R33/543 , G01R33/5601 , G01R33/5611 , G01R33/58
摘要： A multi-frequency imaging radio frequency (RF) coil operational at three or more different frequencies, with a shifting frequency loop structure proximate the coil and switchably coupled to provide different frequencies when the loop structure is coupled to the coil. In one embodiment one of the frequencies is a proton frequency, one is a sodium frequency, and one of the frequencies is a carbon frequency. One example involves imaging examinations using hyperpolarized compounds.
摘要翻译：一种以三个或更多个不同频率工作的多频成像射频（RF）线圈，其具有靠近线圈的移动频率环结构，并且当环路结构耦合到线圈时可切换地耦合以提供不同的频率。在一个实施例中，频率之一是质子频率，一个是钠频率，其中一个频率是碳频率。一个例子涉及使用超极化化合物的成像检查。

5. 发明授权

US07741844B2 Method and system for magnetic resonance imaging using labeled contrast agents 有权
标题翻译：使用标记的造影剂进行磁共振成像的方法和系统
公开(公告)号：US07741844B2
公开(公告)日：2010-06-22
申请号：US11745043
申请日：2007-05-07
申请人： Ileana Hancu , Richard Philip Mallozzi
发明人： Ileana Hancu , Richard Philip Mallozzi
IPC分类号： G01V3/00 , A61B5/05
CPC分类号： G01R33/5601 , A61B5/0037 , A61B5/055 , G01R33/4633 , G01R33/543 , G01R33/583
摘要： A method and system for imaging using labeled contrast agents and a magnetic resonance imaging (MRI) scanner are provided. The method comprises performing a prescan at a frequency selected to be substantially similar to a frequency of the labeled contrast agent and performing an examination scan at the frequency of the labeled contrast agent substantially immediately after administering the labeled contrast agent to a subject.
摘要翻译：提供了使用标记的造影剂和磁共振成像（MRI）扫描仪进行成像的方法和系统。该方法包括以选定的频率基本上类似于标记的造影剂的频率执行预扫描，并且在对受试者施用标记的造影剂之后基本上立即以标记的造影剂的频率执行检查扫描。

6. 发明授权

US07610077B2 Quantitation of sample properties using contrast enhancement from saturation transfer 失效
标题翻译：使用饱和传递的对比度增强对样本特性的定量
公开(公告)号：US07610077B2
公开(公告)日：2009-10-27
申请号：US11297263
申请日：2005-12-08
申请人： W. Thomas Dixon , Ileana Hancu
发明人： W. Thomas Dixon , Ileana Hancu
IPC分类号： A61B5/055
CPC分类号： G01R33/5601 , G01R33/4804 , G01R33/483 , G01R33/5605
摘要： The manipulation of RF irradiation to a subject in which a CEST agent has been administered is employed to determine a biological parameter in vivo in conjunction with an MRI imaging process. The exchange rate of the CEST agent is determined through RF manipulation which in turn enables the determination of a biological parameter through standard calibration techniques. The exchange rate of CEST agents is modulated as a function of many biological parameters, such as pH. MRI apparatuses and computer program products configured for determining exchanges rates of CEST agents in vivo are also disclosed.
摘要翻译：使用已经给予CEST试剂的受试者的RF照射的操作来与MRI成像过程结合来确定体内的生物学参数。通过RF操作确定CEST试剂的汇率，其进而通过标准校准技术确定生物参数。作为许多生物参数（如pH）的函数调节CEST试剂的交换率。还公开了配置用于确定CEST试剂在体内的交换率的MRI装置和计算机程序产品。

7. 发明申请

US20090256569A1 MULTI-FREQUENCY RF COIL 有权
标题翻译：多频RF线圈
公开(公告)号：US20090256569A1
公开(公告)日：2009-10-15
申请号：US12420098
申请日：2009-04-08
申请人： Ileana Hancu , Joseph Edward Piel , William Thomas Dixon
发明人： Ileana Hancu , Joseph Edward Piel , William Thomas Dixon
IPC分类号： G01R33/32
CPC分类号： G01R33/3635 , G01R33/281 , G01R33/34061 , G01R33/34076 , G01R33/3664 , G01R33/3678 , G01R33/543 , G01R33/5601 , G01R33/5611 , G01R33/58
摘要： A multi-frequency imaging radio frequency (RF) coil operational at three or more different frequencies, with a shifting frequency loop structure proximate the coil and switchably coupled to provide different frequencies when the loop structure is coupled to the coil. In one embodiment one of the frequencies is a proton frequency, one is a sodium frequency, and one of the frequencies is a carbon frequency. One example involves imaging examinations using hyperpolarized compounds.
摘要翻译：一种以三个或更多个不同频率工作的多频成像射频（RF）线圈，其具有靠近线圈的移动频率环结构，并且当环路结构耦合到线圈时可切换地耦合以提供不同的频率。在一个实施例中，频率之一是质子频率，一个是钠频率，其中一个频率是碳频率。一个例子涉及使用超极化化合物的成像检查。

8. 发明授权

US07375523B1 System and method for fast MR coil sensitivity mapping 有权
标题翻译：快速MR线圈灵敏度映射的系统和方法
公开(公告)号：US07375523B1
公开(公告)日：2008-05-20
申请号：US11554516
申请日：2006-10-30
申请人： Ileana Hancu
发明人： Ileana Hancu
IPC分类号： G01V3/00
CPC分类号： G01R33/10 , G01R33/246
摘要： A system and method for mapping the sensitivity of MR coils includes a neural network or other computer intelligence trained from sample MR data to determine coil sensitivity profiles or sensitivity normalizations. Once the network is trained, subsequent coil mapping determinations may include fewer mapping acquisitions per coil. The resulting sensitivity map can be used in compensating for B1 inhomogeneities, parallel imaging reconstruction, generating tailored excitation currents for each individual coil, RF shimming, or other processes.
摘要翻译：用于映射MR线圈的灵敏度的系统和方法包括从采样MR数据训练的神经网络或其他计算机智能，以确定线圈灵敏度分布或灵敏度归一化。一旦网络被训练，随后的线圈映射确定可以包括每线圈更少的映射采集。所得到的灵敏度图可以用于补偿B1不均匀性，并行成像重建，为每个单独的线圈产生定制的激励电流，RF匀场或其他过程。

9. 发明申请

US20080100292A1 SYSTEM AND METHOD FOR FAST MR COIL SENSITIVITY MAPPING 有权
标题翻译：快速MR线灵敏度映射的系统和方法
公开(公告)号：US20080100292A1
公开(公告)日：2008-05-01
申请号：US11554516
申请日：2006-10-30
申请人： Ileana Hancu
发明人： Ileana Hancu
IPC分类号： G01V3/00
CPC分类号： G01R33/10 , G01R33/246
摘要： A system and method for mapping the sensitivity of MR coils includes a neural network or other computer intelligence trained from sample MR data to determine coil sensitivity profiles or sensitivity normalizations. Once the network is trained, subsequent coil mapping determinations may include fewer mapping acquisitions per coil. The resulting sensitivity map can be used in compensating for B1 inhomogeneities, parallel imaging reconstruction, generating tailored excitation currents for each individual coil, RF shimming, or other processes.
摘要翻译：用于映射MR线圈的灵敏度的系统和方法包括从采样MR数据训练的神经网络或其他计算机智能，以确定线圈灵敏度分布或灵敏度归一化。一旦网络被训练，随后的线圈映射确定可以包括每线圈更少的映射采集。所得到的灵敏度图可以用于补偿B1不均匀性，并行成像重建，为每个单独的线圈产生定制的激励电流，RF匀场或其他过程。

10. 发明授权

US07303741B2 Systems and methods for high-resolution in vivo imaging of biochemical activity in a living organism 失效
标题翻译：生物体内生物化学活性高分辨率体内成像的系统和方法
公开(公告)号：US07303741B2
公开(公告)日：2007-12-04
申请号：US10252311
申请日：2002-09-23
申请人： Ileana Hancu , Mohan Mark Amaratunga , Denyce Kramer Wicht , Paritosh Dhawale , Nadeem Ishaque , Faisal Ahmed Syud , Bruce Fletcher Johnson , Amy Casey Williams
发明人： Ileana Hancu , Mohan Mark Amaratunga , Denyce Kramer Wicht , Paritosh Dhawale , Nadeem Ishaque , Faisal Ahmed Syud , Bruce Fletcher Johnson , Amy Casey Williams
IPC分类号： A61B5/055
CPC分类号： A61K49/0056 , A61K49/0002 , A61K49/0032 , A61K49/085 , A61K49/10 , A61K49/14
摘要： This invention relates to bifunctional detection agents useful for providing high-resolution, in vivo imaging of biochemical activity in a living organism. Methods of using these bifunctional detection agents may comprise administering them into a living organism, and then estimating the localization of the detection agent using one modality (i.e., MRI), while concurrently estimating the level of biological activity using a second modality (i.e., optical imaging). One of the bifunctional detection agents comprises a magnetic resonance component and an optical imaging component. The magnetic resonance component comprises a contrast agent that is always activated or “on”. The optical imaging component comprises an activatable contrast agent or dye that is activated or turned “on” only in the presence of a particular event. For example, the optical imaging component may be activated by a certain wavelength of light and (1) by the presence of a particular biochemical marker, (2) by enzyme cleavage, or (3) by a change in the temperature or pH of the surrounding medium. These bifunctional detection agents allow both anatomical and functional/metabolic information to be obtained simultaneously.
摘要翻译：本发明涉及用于提供生物体内生化活性的高分辨率体内成像的双功能检测剂。使用这些双功能检测剂的方法可以包括将它们施用于活生物体中，然后使用一种模态（即，MRI）估计检测剂的定位，同时使用第二模态估计生物活性的水平（即，光学成像）。双功能检测剂之一包括磁共振成分和光学成像成分。磁共振成分包括始终被激活或“开启”的造影剂。光学成像组件包括可激活的造影剂或染料，其仅在特定事件的存在下被激活或变为“开启”。例如，光学成像组件可以被一定波长的光激活，并且（1）存在特定的生物化学标记，（2）通过酶切割，或（3）通过温度或pH的变化周围介质。这些双功能检测剂允许同时获得解剖学和功能性/代谢信息。

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