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1. 发明专利

AU2003214612A1 METHOD AND APPARATUS FOR ALTERING ACTIVITY OF TISSUE LAYERS 未知
公开(公告)号：AU2003214612A1
公开(公告)日：2003-09-29
申请号：AU2003214612
申请日：2003-03-17
申请人： IGER YONI
发明人： IGER YONI
IPC分类号： A61B18/00 , A61N7/00
摘要： The present invention concerns ultrasonic methods and devices for altering activity of layers of natural--or of artificial tissues and organs, and for altering activity of particular components within said layers, while minimizing alterations in neighboring layers located deeper to—or outer to—treated layer. It is carried out by focused or non focused irradiation at certain angles and preferably via cooling medium, so to at least partially create surface waves propagating in the appropriate layers, and altering their activity, while leaving the other layers essentially intact. System can allow also monitoring of beam location and of effect. The device can be constructed for either superficial treatment, or minimal invasive treatment, or layered tissues and organs. It can be used as stand alone or add on device in cosmetic and clinical applications.

2. 发明专利

DE60237201D1 APPARAT ZUR ABGABE VON SUBSTANZEN AN BIOLOGISCHE KOMPONENTEN 未知
公开(公告)号：DE60237201D1
公开(公告)日：2010-09-16
申请号：DE60237201
申请日：2002-01-22
申请人： IGER YONI
发明人： IGER YONI
IPC分类号： A61B8/00 , A61B1/313 , A61H5/00 , A61M5/30 , A61M37/00

3. 发明专利

CA2791458A1 SYSTEM, DEVICE AND METHODS OF TISSUE TREATMENT FOR ACHIEVING TISSUE SPECIFIC EFFECTS 未知
公开(公告)号：CA2791458A1
公开(公告)日：2011-09-09
申请号：CA2791458
申请日：2011-03-01
申请人： IGER YONI
发明人： IGER YONI
IPC分类号： A61N1/06 , A61B18/14 , A61N1/32 , A61N7/00 , A61N7/02
摘要： A tissue treatment system and a treatment applicator provide multi-modality treatment of skin, tissue and organ conditions and pathologies using different types of treatment energy, alone or in combination, including radiofrequency (RF) energy and ultrasound energy to achieve multiple and different treatment effects that are tissue-specific and tissue depth- specific. The system and the applicator according to the invention selectively and fractionally and, as an option, nonfractionally, treat one or more tissue zones within a three-dimensional volume of skin or other soft tissue with one or more energy types and precisely target measured treatment energy to specific tissue types, tissue layers and/or specific depths or locations within the volume of skin or tissue. The system and the applicator can also target one or more energy types to treat a specific location or depth within a given tissue layer. The system and the applicator can provide different RF and ultrasound treatment energies that accurately affect the structure or activity of different tissue types, layers and/or depths within a given tissue zone of the skin or tissue volume in accordance with the treatment effects desired in particular tissue layers and/or at particular tissue depths to thereby selectively produce multiple and different treatment impacts.

4. 发明专利

AT476143T 未知
公开(公告)号：AT476143T
公开(公告)日：2010-08-15
申请号：AT02715702
申请日：2002-01-22
申请人： IGER YONI
发明人： IGER YONI
IPC分类号： A61B8/00 , A61B1/313 , A61H5/00 , A61M5/30 , A61M37/00

5. 发明授权

EP1389064B1 APPARATUS FOR THE DELIVERY OF SUBSTANCES TO BIOLOGICAL COMPONENTS 有权
标题翻译：设备对化学物质对生物元件传送
公开(公告)号：EP1389064B1
公开(公告)日：2010-08-04
申请号：EP02715702.3
申请日：2002-01-22
申请人： Iger, Yoni
发明人： Iger, Yoni
IPC分类号： A61B8/00 , A61H5/00 , A61M37/00
CPC分类号： A61M37/0092 , A61B1/313 , A61M5/30

6. 发明公开

EP1539081A2 METHOD AND APPARATUS FOR ALTERING ACTIVITY OF TISSUE LAYERS 审中-公开
标题翻译：方法和装置在组织层的活性的变化
公开(公告)号：EP1539081A2
公开(公告)日：2005-06-15
申请号：EP03710192.0
申请日：2003-03-17
申请人： Iger, Yoni
发明人： Iger, Yoni
IPC分类号： A61H1/00
CPC分类号： A61N7/00 , A61B2018/00023
摘要： The present invention concerns ultrasonic methods and devices for altering activity of layers of natural or of artificial tissues and organs, and for altering activity of particular components within said layers, while maintaining alterations in neighboring layers located deeper to or outer to treated layer. The method is carried out by focused or non focused irradiation at certain angles and preferably via cooling medium (13, 23, 39), so to at least partially create surface waves (34) propagating in the appropriate layers (18), and altering their activity.

7. 发明专利

AU2003214612A8 Method and apparatus for altering activity of tissue layers 未知
公开(公告)号：AU2003214612A8
公开(公告)日：2003-09-29
申请号：AU2003214612
申请日：2003-03-17
申请人： IGER YONI
发明人： IGER YONI
IPC分类号： A61B18/00 , A61N7/00 , A61H1/00
摘要： The present invention concerns ultrasonic methods and devices for altering activity of layers of natural--or of artificial tissues and organs, and for altering activity of particular components within said layers, while minimizing alterations in neighboring layers located deeper to—or outer to—treated layer. It is carried out by focused or non focused irradiation at certain angles and preferably via cooling medium, so to at least partially create surface waves propagating in the appropriate layers, and altering their activity, while leaving the other layers essentially intact. System can allow also monitoring of beam location and of effect. The device can be constructed for either superficial treatment, or minimal invasive treatment, or layered tissues and organs. It can be used as stand alone or add on device in cosmetic and clinical applications.

8. 发明申请

WO2002058530A2 METHOD AND APPARATUS FOR THE DELIVERY OF SUBSTANCES TO BIOLOGICAL COMPONENTS 审中-公开
标题翻译：用于向生物组分提供物质的方法和装置
公开(公告)号：WO2002058530A2
公开(公告)日：2002-08-01
申请号：PCT/IL2002/000056
申请日：2002-01-22
申请人： IGER, Yoni
发明人： IGER, Yoni
IPC分类号： A61B
CPC分类号： A61M37/0092 , A61B1/313 , A61M5/30
摘要： The invention concerns a method and device for needle-less delivery of substances into or through natural or artificial biological components such as membranes, organelles, cells, tissues, organs, or creatures, by exposing the said biological components to accelerated substances wherein high impact mechanical movement over short distance is used to create acceleration of substances so to drive substances into or through said natural or artificial biological components, while isolating the biological component from the driving force. The mechanical movement is preferably created by an ultrasonic member having a high repetition rate, and the space between accelerating element and biological target is preferably composed of low density compound. The delivery device can be provided with a unit for supplying substance to be delivered, to the mechanical accelerating element. The device can be constructed either as delivery device for superficial tissues, or as an endoscopes laparoscope-like or catheter-like device for delivery in minimally invasive procedures.
摘要翻译：本发明涉及一种通过将所述生物成分暴露于加速物质的无针状物质输入或通过天然或人造生物成分例如膜，细胞器，细胞，组织，器官或生物而无针的方法和装置，其中高冲击机械短距离的运动用于产生物质的加速度，以便将物质驱入或通过所述天然或人造生物成分，同时将生物成分与驱动力隔离。机械运动优选由具有高重复率的超声波部件产生，加速元件与生物靶之间的空间优选由低密度化合物构成。输送装置可以设置有用于将待输送物质的单元提供给机械加速元件。该装置可以构建为用于表面组织的递送装置，或者作为用于在微创程序中递送的腹腔镜或类似导管的装置。

9. 发明申请

WO1998032379A1 AN ULTRASOUND SYSTEM AND METHODS UTILIZING SAME 审中-公开
标题翻译：一种超声波系统及其应用方法
公开(公告)号：WO1998032379A1
公开(公告)日：1998-07-30
申请号：PCT/IL1997000406
申请日：1997-12-12
申请人： TECHNION RESEARCH AND DEVELOPMENT FOUNDATION LTD. , IGER, Yoni , KIMMEL, Eitan
发明人： TECHNION RESEARCH AND DEVELOPMENT FOUNDATION LTD.
IPC分类号： A61B08/00
CPC分类号： A61B17/2251 , A45D26/00 , A61B8/4281 , A61B17/22004 , A61B2017/00752 , A61N7/00
摘要： The present invention concerns an ultrasound system (10) for the administration of a focused ultrasound beam, for example, to the body of a patient (15, 25) comprising a container (13, 23) holding a liquid media. The container (13, 23) guides the ultrasound beam from the ultrasound generating element to the desired location of administration.
摘要翻译：本发明涉及一种用于将聚焦超声波束施用于例如包含容纳液体介质的容器（13,23）的患者体（15,25）的超声系统（10）。容器（13,23）将超声波束从超声发生元件引导到期望的给药位置。

10. 发明公开

EP1389064A2 METHOD AND APPARATUS FOR THE DELIVERY OF SUBSTANCES TO BIOLOGICAL COMPONENTS 有权
标题翻译：设备对化学物质对生物元件传送
公开(公告)号：EP1389064A2
公开(公告)日：2004-02-18
申请号：EP02715702.3
申请日：2002-01-22
申请人： Iger, Yoni
发明人： Iger, Yoni
IPC分类号： A61B8/00 , A61H5/00
CPC分类号： A61M37/0092 , A61B1/313 , A61M5/30
摘要： The invention concerns a method and device for needle-less delivery of substances into or through natural or artificial biological components such as membranes, organelles, cells, tissues, organs, or creatures, by exposing the said biological components to accelerated substances wherein high impact mechanical movement over short distance is used to create acceleration of substances so to drive substances into or through said natural or artificial biological components, while isolating the biological component from the driving force. The mechanical movement is preferably created by an ultrasonic member having a high repetition rate, and the space between accelerating element and biological target is preferably composed of low density compound. The delivery device can be provided with a unit for supplying substance to be delivered, to the mechanical accelerating element. The device can be constructed either as delivery device for superficial tissues, or as an endoscopes laparoscope-like or catheter-like device for delivery in minimally invasive procedures.

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