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1. 发明申请

WO2008008709A2 METHOD OF SELECTIVE PROTEIN ENRICHMENT AND ASSOCIATED APPLICATIONS 审中-公开
标题翻译：选择性蛋白质丰富和相关应用的方法
公开(公告)号：WO2008008709A2
公开(公告)日：2008-01-17
申请号：PCT/US2007072947
申请日：2007-07-06
申请人： LEAP BIOSCIENCE CORP , HUI CEN
发明人： HUI CEN
IPC分类号： G01N33/53
CPC分类号： G01N33/554 , G01N33/6803
摘要： Provided herein are methods of selective enrichment of ligands present in a suitable biological sample. According to the invention, one or a plurality of receptor carriers may be used to capture ligands which are capable of binding to receptors immobilized on the surface of the receptor carriers. The receptor carriers bound with the ligands are separated from the remaining sample and the ligands are then eluted with a ligand elution solution to result in a ligand-containing solution, which is further concentrated to give a ligand sample. In one embodiment, the receptor carriers are living cells comprising a plurality of receptors on the outer leaflet of cytoplasmic membranes. Ligand samples obtained by the present invention may be useful for ligand profiling, for example, via any known methods including 2-D gel electrophoresis coupled with mass spectrometry, for example.
摘要翻译：本文提供选择性富集存在于合适的生物样品中的配体的方法。根据本发明，可以使用一种或多种受体载体捕获能够结合固定在受体载体表面上的受体的配体。与配体结合的受体载体与剩余的样品分离，然后用配体洗脱溶液洗脱配体，得到含配体的溶液，其进一步浓缩得到配体样品。在一个实施方案中，受体载体是在细胞质膜外叶上包含多个受体的活细胞。通过本发明获得的配体样品可用于配体分析，例如通过任何已知的方法，包括与质谱联用的2-D凝胶电泳。

2. 发明授权

US07705117B2 EGFH2 genes and gene products 失效
标题翻译： EGFH2基因和基因产物
公开(公告)号：US07705117B2
公开(公告)日：2010-04-27
申请号：US11656882
申请日：2007-01-22
申请人： W. Michael Kavanaugh , Hui Cen , Pauline Lee
发明人： W. Michael Kavanaugh , Hui Cen , Pauline Lee
IPC分类号： A61K38/00 , C07K14/00
CPC分类号： C07K14/4756 , A61K38/00
摘要： This invention relates to mouse and human EGFH2, and to variants thereof and to polynucleotides encoding EGFH2. This invention also relates to therapeutic agents related to the polynucleotides and proteins.
摘要翻译：本发明涉及小鼠和人EGFH2及其变体，以及编码EGFH2的多核苷酸。本发明还涉及与多核苷酸和蛋白质相关的治疗剂。

3. 发明申请

US20070161063A1 Identifying, monitoring, and treating women for breast precancer or cancer 审中-公开
标题翻译：识别，监测和治疗乳腺癌前期癌症或癌症的妇女
公开(公告)号：US20070161063A1
公开(公告)日：2007-07-12
申请号：US11713495
申请日：2007-03-02
申请人： Susan Love , David Hung , Hui Cen
发明人： Susan Love , David Hung , Hui Cen
IPC分类号： G01N33/574
CPC分类号： A61K31/4535 , A61K31/00 , A61K31/138 , A61K31/352 , A61K31/4196 , A61K31/437 , A61K31/566 , C12Q1/6886 , G01N33/5091 , G01N33/57415 , G01N2333/723 , A61K2300/00
摘要： The invention is to methods for screening women for breast cancer and precancer by determining a level of an estrogen-related marker. The invention further provides methods of treating such patients identified as having one or more abnormal ductal epithelial cells and an estrogen-related marker. The invention provides methods for screening patient for hormone replacement therapy (HRT), and of monitoring such patients once they begin HRT. The invention provides methods of treating peri-, menopausal or postmenopausal women for both cancer risk reduction and menopausal symptoms (or other conditions related to lowered systemic estrogen levels). The invention also provides kits for the screening, monitoring, and treating methods described.
摘要翻译：本发明是通过测定雌激素相关标志物的水平来筛选乳腺癌和癌前期妇女的方法。本发明还提供了治疗被鉴定为具有一种或多种异常导管上皮细胞和雌激素相关标志物的患者的方法。本发明提供了用于筛选患者激素替代疗法（HRT）的方法，以及一旦开始HRT就监测这些患者。本发明提供治疗绝经期或绝经后妇女的方法，用于癌症风险降低和绝经症状（或与降低的系统性雌激素水平相关的其它病症）。本发明还提供了用于所述的筛选，监测和处理方法的试剂盒。

4. 发明申请

US20050095600A1 Methods of generating gene-specific probes for nucleic acid array detection 审中-公开
标题翻译：生成用于核酸阵列检测的基因特异性探针的方法
公开(公告)号：US20050095600A1
公开(公告)日：2005-05-05
申请号：US10700304
申请日：2003-10-31
申请人： Xiang Yu , Li Shen , Xiao Zeng , Ying Han , Kun Lu , Hui Cen
发明人： Xiang Yu , Li Shen , Xiao Zeng , Ying Han , Kun Lu , Hui Cen
IPC分类号： C12P19/34 , C12Q1/68
CPC分类号： C12Q1/6837 , C12Q2565/513 , C12Q2531/113 , C12Q2531/107
摘要： This invention provides gene-specific probe labeling methods for nucleic acid array detection. In the subject invention, a set of a representational number of distinct gene specific primers is used to generate a sub-population of labeled nucleic acids from each of the different physiological samples. The labeled nucleic acids are then compared to each other by hybridizing to a specially designed nucleic acid array that contains the representational number of distinct genes. The subject methods find use in identifying the expression pattern of the genes of special interest in the physiological samples.
摘要翻译：本发明提供用于核酸阵列检测的基因特异性探针标记方法。在本发明中，使用一组不同的基因特异性引物的代表数量来产生来自不同生理样品中每一种的标记核酸的亚群。然后通过与包含不同基因的代表性数量的特别设计的核酸阵列杂交，将标记的核酸彼此进行比较。主题方法用于鉴定生理样品中特别感兴趣的基因的表达模式。

5. 发明授权

US06825333B1 EGFH2 genes and gene products 失效
标题翻译： EGFH2基因和基因产物
公开(公告)号：US06825333B1
公开(公告)日：2004-11-30
申请号：US09640041
申请日：2000-08-15
申请人： W. Michael Kavanaugh , Hui Cen , Pauline Lee
发明人： W. Michael Kavanaugh , Hui Cen , Pauline Lee
IPC分类号： C07H2104
CPC分类号： C07K14/4756 , A61K38/00
摘要： This invention relates to mouse and human EGFH2, and to variants thereof and to polynucleotides encoding EGFH2. This invention also relates to therapeutic agents related to the polynucleotides and proteins.
摘要翻译：本发明涉及小鼠和人EGFH2及其变体，以及编码EGFH2的多核苷酸。本发明还涉及与多核苷酸和蛋白质相关的治疗剂。

6. 发明授权

US6165733A .gamma. II adaptin 失效
标题翻译： γII适应症
公开(公告)号：US6165733A
公开(公告)日：2000-12-26
申请号：US861745
申请日：1997-05-22
申请人： Hui Cen , Lewis T. Williams
发明人： Hui Cen , Lewis T. Williams
IPC分类号： C07K14/47 , C12N9/12 , C12N15/12 , C12Q1/00 , C07K14/46 , C12N15/62
CPC分类号： C12N9/1205 , C07K14/47 , C07K2319/00
摘要： A mammalian protein involved in receptor-mediated endocytosis specifically binds to phosphatidylinositol 3-kinase. More specifically it binds to the Bcr homology domain of the p85 subunit of phosphatidylinositol 3-kinase. Phathoidylinositol 3-kinase also binds to platelet derived growth factor receptor. Other receptors may also bind, including those for insulin, insulin-like growth factor-1, colony stimulating factor 1, nerve growth factor, hepatocyte growth factor, stem cell growth factor, and epidermal growth factor. Mitogenesis is the consequence of the binding and internalization of these growth factors. Inhibition of the process of receptor-mediated internalization inhibits mitogenesis.
摘要翻译：参与受体介导的内吞作用的哺乳动物蛋白质特异性结合磷脂酰肌醇3-激酶。更具体地说，它结合磷脂酰肌醇3-激酶的p85亚基的Bcr同源结构域。 Phathoidylinositol 3-kinase也与血小板衍生生长因子受体结合。其他受体也可能结合，包括胰岛素，胰岛素样生长因子-1，集落刺激因子1，神经生长因子，肝细胞生长因子，干细胞生长因子和表皮生长因子。有丝分裂是这些生长因子的结合和内化的结果。受体介导的内化过程的抑制抑制有丝分裂。

7. 发明授权

US08586325B2 Enzyme substrate comprising a functional dye and associated technology and methods 有权
标题翻译：酶底物包含功能染料及相关技术和方法
公开(公告)号：US08586325B2
公开(公告)日：2013-11-19
申请号：US13891406
申请日：2013-05-10
申请人： Fei Mao , Hui Cen
发明人： Fei Mao , Hui Cen
IPC分类号： C12Q1/37 , A61K38/14 , C07D279/08
CPC分类号： C12N9/96 , C07D263/60 , C07D417/06 , C07D501/00 , C07K7/06 , C12Q1/37 , C12Q1/48 , C12Q1/485 , G01N21/6486 , G01N33/582
摘要： Enzyme substrates and associated technology of the present invention are provided. An enzyme substrate of the invention may comprise a biologically functional fluorescent dye and an enzyme-specific substrate moiety attached in such a way that the functionality of the functional dye is diminished. An enzymatic reaction may cleave at least a portion of the substrate moiety from the enzyme substrate to provide a more functional product dye. This product dye may be nonfluorescent or weakly fluorescent, in general, and relatively fluorescent, in a particular condition, such as when bound to a partner biological molecule or an assembly of partner biological molecules. An enzyme substrate of the present invention may thus be useful in fluorescence detection, and/or in any of a variety of useful applications, such as the detection of enzymatic activity in a cell-free system or in a living cell, the screening of drugs, or the diagnosis of disease.
摘要翻译：提供了本发明的酶底物和相关技术。本发明的酶底物可以包含生物功能性荧光染料和酶特异性底物部分，其功能性染料的官能度减弱。酶反应可以从酶底物切割底物部分的至少一部分以提供更多功能的产物染料。通常，在特定条件下，例如当结合到伴侣生物分子或伴侣生物分子的组合时，该产物染料通常可以是非荧光的或弱荧光的，并且是相对荧光的。因此，本发明的酶底物可用于荧光检测和/或各种有用应用中的任何一种，例如在无细胞系统或活细胞中检测酶活性，筛选药物，或疾病的诊断。

8. 发明授权

US08092784B2 Enzyme substrate comprising a functional dye and associated technology and methods 有权
标题翻译：酶底物包含功能染料及相关技术和方法
公开(公告)号：US08092784B2
公开(公告)日：2012-01-10
申请号：US12095322
申请日：2006-11-21
申请人： Fei Mao , Hui Cen , Wai-yee Leung
发明人： Fei Mao , Hui Cen , Wai-yee Leung
IPC分类号： A61B10/00 , C12Q1/68
CPC分类号： C12N9/96 , C07D263/60 , C07D417/06 , C07D501/00 , C07K7/06 , C12Q1/37 , C12Q1/48 , C12Q1/485 , G01N21/6486 , G01N33/582
摘要： Enzyme substrates and associated technology of the present invention are provided. An enzyme substrate of the invention may comprise a biologically functional fluorescent dye and an enzyme-specific substrate moiety attached in such a way that the functionality of the functional dye is diminished. An enzymatic reaction may cleave at least a portion of the substrate moiety from the enzyme substrate to provide a more functional product dye. This product dye may be nonfluorescent or weakly fluorescent, in general, and relatively fluorescent, in a particular condition, such as when bound to a partner biological molecule or an assembly of partner biological molecules. An enzyme substrate of the present invention may thus be useful in fluorescence detection, and/or in any of a variety of useful applications, such as the detection of enzymatic activity in a cell-free system or in a living cell, the screening of drugs, or the diagnosis of disease.
摘要翻译：提供了本发明的酶底物和相关技术。本发明的酶底物可以包含生物功能性荧光染料和酶特异性底物部分，其功能性染料的官能度减弱。酶反应可以从酶底物切割底物部分的至少一部分以提供更多功能的产物染料。通常，在特定条件下，例如当结合到伴侣生物分子或伴侣生物分子的组合时，该产物染料通常可以是非荧光的或弱荧光的，并且是相对荧光的。因此，本发明的酶底物可用于荧光检测和/或各种有用应用中的任何一种，例如在无细胞系统或活细胞中检测酶活性，筛选药物，或疾病的诊断。

9. 发明申请

US20050202006A1 EGFH2 genes and gene products 失效
标题翻译： EGFH2基因和基因产物
公开(公告)号：US20050202006A1
公开(公告)日：2005-09-15
申请号：US10931285
申请日：2004-08-31
申请人： W. Kavanaugh , Hui Cen , Pauline Lee
发明人： W. Kavanaugh , Hui Cen , Pauline Lee
IPC分类号： A61K38/00 , C07K14/475 , C07H21/02 , A61K39/395 , C07K14/485 , C07K16/22 , C12P21/06
CPC分类号： C07K14/4756 , A61K38/00
摘要： This invention relates to mouse and human EGFH2, and to variants thereof and to polynucleotides encoding EGFH2. This invention also relates to therapeutic agents related to the polynucleotides and proteins.
摘要翻译：本发明涉及小鼠和人EGFH2及其变体，以及编码EGFH2的多核苷酸。本发明还涉及与多核苷酸和蛋白质相关的治疗剂。

10. 发明申请

US20130236888A1 ENZYME SUBSTRATE COMPRISING A FUNCTIONAL DYE AND ASSOCIATED TECHNOLOGY AND METHODS 有权
公开(公告)号：US20130236888A1
公开(公告)日：2013-09-12
申请号：US13891406
申请日：2013-05-10
申请人： Fei Mao , Hui Cen
发明人： Fei Mao , Hui Cen
IPC分类号： G01N21/64 , C07K7/06 , C07D501/00 , C07D417/06
CPC分类号： C12N9/96 , C07D263/60 , C07D417/06 , C07D501/00 , C07K7/06 , C12Q1/37 , C12Q1/48 , C12Q1/485 , G01N21/6486 , G01N33/582
摘要： Enzyme substrates and associated technology of the present invention are provided. An enzyme substrate of the invention may comprise a biologically functional fluorescent dye and an enzyme-specific substrate moiety attached in such a way that the functionality of the functional dye is diminished. An enzymatic reaction may cleave at least a portion of the substrate moiety from the enzyme substrate to provide a more functional product dye. This product dye may be nonfluorescent or weakly fluorescent, in general, and relatively fluorescent, in a particular condition, such as when bound to a partner biological molecule or an assembly of partner biological molecules. An enzyme substrate of the present invention may thus be useful in fluorescence detection, and/or in any of a variety of useful applications, such as the detection of enzymatic activity in a cell-free system or in a living cell, the screening of drugs, or the diagnosis of disease.

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