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    • 6. 发明申请
    • LEAD COMPOUND OF ANTI-HYPERTENSIVE DRUG AND METHOD FOR SCREENING THE SAME
    • 抗高血压药物的铅化合物及其筛选方法
    • US20110257379A1
    • 2011-10-20
    • US13170107
    • 2011-06-27
    • Hsin-Hsien Wu
    • Hsin-Hsien Wu
    • C07D285/135C07D405/06C07D417/06C07C229/64C07C235/84C07C245/08C07D403/06
    • A61K31/135A61K31/40A61K31/41A61K31/415A61K31/495A61K31/505G16B35/00G16C20/60
    • A system for screening a small molecule library with 250,000 molecules to find out a compound of an anti-hypertensive drug aiming at human Angiotensin II type IA receptor is provided. The system includes a first database having a three-dimensional structure datum of a human Angiotensin II type IA receptor, a second database having molecular data of a plurality of small molecules, and a computer acquiring the three-dimensional structure datum and the molecular data from the first database and the second database respectively, wherein the computer has a molecular docking software for calculating a free energy of the human Angiotensin II type IA receptor bound to each of the plurality of small molecules, ranks the plurality of small molecules according to the respective free energy so as to select a top small molecule in the ranking as the compound of the drug.
    • 提供用于筛选具有25万分子的小分子文库的系统,以找出靶向人类血管紧张素II型IA受体的抗高血压药物的化合物。 该系统包括具有人类血管紧张素II型IA受体的三维结构基准的第一数据库,具有多个小分子的分子数据的第二数据库,以及从三维结构数据获取三维结构数据和分子数据的计算机 第一数据库和第二数据库,其中计算机具有用于计算结合多个小分子中的每一个的人类血管紧张素II型IA受体的自由能的分子对接软件,根据相应的方法对多个小分子进行排列 自由能,以便选择排名中的顶级小分子作为药物的化合物。
    • 7. 发明申请
    • Fan Device
    • 风扇装置
    • US20110150639A1
    • 2011-06-23
    • US12778477
    • 2010-05-12
    • Chien-Jung ChenChih-Tsung HsuHsin-Hsien Wu
    • Chien-Jung ChenChih-Tsung HsuHsin-Hsien Wu
    • F04D11/00
    • F04D29/328F04D25/0613F04D25/08F04D29/544F04D29/666F04D29/667
    • A fan device includes: a fan housing configured with a receiving space defined among opposite top and bottom walls, and a surrounding side wall; and a fan impeller mounted in the receiving space, disposed adjacent to an air outlet in the top wall and operable to rotate about a central axis transverse to the top and bottom walls of the fan housing. The fan impeller includes a hub body disposed coaxially with the central axis, and a plurality of angularly spaced apart fan blades extending outwardly and radially from the hub body. An angular distance between each adjacent pair of the fan blades is different from that of any other adjacent pair of the fan blades.
    • 风扇装置包括:风扇壳体,其被构造成具有限定在相对的顶壁和底壁之间的容纳空间和周围侧壁; 以及安装在所述容纳空间中的风扇叶轮,所述风扇叶轮邻近所述顶壁中的空气出口设置并且可操作以围绕横向于所述风扇壳体的顶壁和底壁的中心轴线旋转。 风扇叶轮包括与中心轴线同轴设置的毂体,以及从轮毂体向外并径向延伸的多个角度间隔开的风扇叶片。 每个相邻的一对风扇叶片之间的角距离与任何其它相邻的一对风扇叶片的角度距离不同。
    • 8. 发明申请
    • Fan Device
    • 风扇装置
    • US20110150638A1
    • 2011-06-23
    • US12778429
    • 2010-05-12
    • Chien-Jung ChenChih-Tsung HsuHsin-Hsien Wu
    • Chien-Jung ChenChih-Tsung HsuHsin-Hsien Wu
    • F01D1/00
    • F04D25/0613F04D25/08F04D29/328F04D29/544F04D29/666F04D29/667
    • A fan device includes: a fan housing configured with a receiving space defined among opposite top and bottom walls, and a surrounding side wall; a fan impeller mounted in the receiving space, disposed adjacent to an air outlet in the top wall and operable to rotate about a central axis transverse to the top and bottom walls of the fan housing; and an air-guiding unit mounted fixedly in the receiving space and disposed adjacent to an air inlet in the bottom wall. The air-guiding unit includes a central connecting member disposed axially with the central axis, and a plurality of angularly spaced apart air-guiding blades interconnecting the central connecting member and the surrounding sidewall. An angular distance between each adjacent pair of the air-guiding blades is different from that of any other adjacent pair of the air-guiding blades.
    • 风扇装置包括:风扇壳体,其被构造成具有限定在相对的顶壁和底壁之间的容纳空间和周围侧壁; 安装在所述容纳空间中的风扇叶轮,邻近所述顶壁中的空气出口设置并且可操作以围绕横向于所述风扇壳体的顶壁和底壁的中心轴线旋转; 以及空气引导单元,其固定地安装在所述容纳空间中并且邻近所述底壁中的空气入口设置。 空气引导单元包括与中心轴线轴向配置的中心连接构件,以及将中心连接构件和周围侧壁互连的多个角度间隔开的空气导向叶片。 每个相邻的一对空气引导叶片之间的角距离与任何其它相邻的一对导风叶片的距离不同。