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1. 发明授权

US5244677A Application system for drug containing microemulsions 失效
标题翻译：含微量药物的药物应用系统
公开(公告)号：US5244677A
公开(公告)日：1993-09-14
申请号：US979446
申请日：1992-11-20
申请人： Karl W. Kreckel , Horst-Georg Zerbe
发明人： Karl W. Kreckel , Horst-Georg Zerbe
IPC分类号： A61K9/70 , A61L15/00
CPC分类号： A61K9/703 , A61K9/7084 , Y10T428/14 , Y10T428/1476 , Y10T428/249953 , Y10T428/249982 , Y10T428/28
摘要： The invention deals with devices, in particular with bandage strips, for a transdermal delivery of drugs to patients, whereby the drug formulations include highly viscous preparations, topical solutions of a low viscosity and micro-emulsions of a low viscosity containing the drugs. Depending on the consistency of the medium containing the drug, the drug formulation is stored in a reservoir, consisting, e.g., of a punched out cavity or of an absorbent piece of material, which is encased or supported by a carrier element (a foamed material piece or a non-woven fleece tape) adhering to the skin by means of a skin-compatible adhesive, whereby specially formed protective films are applied at the filling and delivery side during the storage of the device to prevent a lateral migration, and whereby during its use, the device can be refilled with dosed amounts by the patient without requiring a removal of the device from the skin surface to be treated (FIG. 2).
摘要翻译：本发明涉及用于药物经皮递送给患者的装置，特别是用于绷带的装置，其中药物制剂包括高粘度制剂，低粘度的局部溶液和含有药物的低粘度微乳液。取决于含有药物的培养基的一致性，药物制剂储存在由例如冲压出的空腔或吸收材料片组成的容器中，该容器被载体元件（泡沫材料）包裹或支撑片或非织造羊毛带）通过皮肤相容的粘合剂粘附到皮肤上，由此在装置的储存期间在填充和输送侧施加特殊形成的保护膜以防止横向移动，并且由此在在使用时，可以不需要从待治疗的皮肤表面去除装置，患者可以以患者的剂量重新装满装置（图2）。

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