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1. 发明申请

US20120189683A1 COMPOSITE OF AMORPHOUS CALCIUM PHOSPHATE/CALCIUM SULFATE HEMIHYDRATE (CSH/ACP) FOR BONE IMPLANTATION AND PROCESS FOR PRODUCING THE SAME 有权
标题翻译：无机磷酸钙/硫酸钙（CSH / ACP）用于骨植入及其制备方法的复合物
公开(公告)号：US20120189683A1
公开(公告)日：2012-07-26
申请号：US13010473
申请日：2011-01-20
申请人： JEN-CHANG YANG , SHENG-YANG LEE , DUEN-CHENG WANG , HAW-MING HUANG , WEI-JEN CHANG , MALOSI POMA , HONG-DA WU , DIAN-YU JI
发明人： JEN-CHANG YANG , SHENG-YANG LEE , DUEN-CHENG WANG , HAW-MING HUANG , WEI-JEN CHANG , MALOSI POMA , HONG-DA WU , DIAN-YU JI
IPC分类号： A61K9/00 , A61P19/08 , A61K33/42
CPC分类号： A61K33/42 , A61L27/425 , A61L27/427
摘要： The invention provides a composite of α-calcium sulfate (CS) hemihydrate/amorphous calcium phosphate (α-CSH/ACP), comprising α-CSH and ACP at a weight ratio of about 10:90 to about 90:10. Particularly, the composite of the invention has a resorption period of 3-6 months. The invention also provides a one-pot process for producing α-CSH/ACP composite of the invention. The one-pot process of the invention can produce α-CSH and ACP in a single process and easily obtain α-CSH/ACP composite.
摘要翻译：本发明提供了以约10:90至约90:10的重量比包含α-CSH和ACP的α-硫酸钙（CS）半水合物/无定形磷酸钙（α-CSH / ACP）的复合物。特别地，本发明的复合材料的吸收期为3-6个月。本发明还提供了一种用于制备本发明的α-CSH / ACP复合材料的一锅法。本发明的一锅法可以在单一工艺中生产α-CSH和ACP，容易获得α-CSH / ACP复合材料。

2. 发明授权

US08309689B2 High yield dialysis-free process for producing organosoluble regenerated silk fibroin 有权
标题翻译：用于生产有机溶剂的再生丝素蛋白的高产率透析工艺
公开(公告)号：US08309689B2
公开(公告)日：2012-11-13
申请号：US12783818
申请日：2010-05-20
申请人： Jen-Chang Yang , Sheng-Yang Lee , Chien Chung Chen , Yun-Ting Hsu , Hong-Da Wu , Dian-Yu Ji
发明人： Jen-Chang Yang , Sheng-Yang Lee , Chien Chung Chen , Yun-Ting Hsu , Hong-Da Wu , Dian-Yu Ji
IPC分类号： C07K1/30
CPC分类号： C07K14/43586
摘要： The invention relates to a simple and high yield process for producing a regenerated silk fibroin which does not need dialysis. Particularly, a process of the invention is characterized in that the silk fibroin is precipitated by applying a shear stress and/or changing the solvent power of the fibroin solution. The process of the invention simplifies the process of producing silk fibroin and greatly shortens the process time to 1 to 2 hours, whereas the conventional dialysis process is complex and needs around 2 to 3 days. In addition to reducing the time needed, the process of the invention can increase productivity of silk fibroin by at least 8%.
摘要翻译：本发明涉及用于生产不需要透析的再生丝素蛋白的简单且高产率的方法。特别地，本发明的方法的特征在于，通过施加剪切应力和/或改变丝心蛋白溶液的溶剂能力使丝素蛋白沉淀。本发明的方法简化了生产丝素蛋白的过程，大大缩短了1至2小时的处理时间，而常规透析过程复杂，需要2至3天左右。除了减少所需时间之外，本发明的方法可以将丝素蛋白的生产率提高至少8％。

3. 发明授权

US07700066B1 Process for preparing alpha calcium sulfate hemihydrate 有权
标题翻译：制备α硫酸钙半水合物的方法
公开(公告)号：US07700066B1
公开(公告)日：2010-04-20
申请号：US12245644
申请日：2008-10-03
申请人： Jen-Chang Yang , Hong-Da Wu , Nai-Chia Teng , Sheng-Yang Lee
发明人： Jen-Chang Yang , Hong-Da Wu , Nai-Chia Teng , Sheng-Yang Lee
IPC分类号： C01B17/96 , C01F11/46
CPC分类号： C01F11/46
摘要： The invention provides a process for preparing α-calcium sulfate hemihydrate which comprises the following steps: adding aqueous solutions containing sulfate ions and calcium ions to calcium chloride solution with a range of concentration; reacting the mixture of a) at a range of temperature for an appropriate time; filtering and washing the reaction products of b) with a rising solvent to isolate the solid and liquid phases; and d) collecting and drying the solid phase to obtain α-calcium sulfate hemihydrate with high purity; wherein the relationship between the range of the concentration of calcium chloride (y) and the range of the reaction temperature (x) is shown as the following formula: −0.4x5+7.33x4−52.83x3+187.17x2−328.27x+316
摘要翻译：本发明提供了一种制备α-硫酸钙半水合物的方法，包括以下步骤：将含有硫酸根离子和钙离子的水溶液加入到浓度范围的氯化钙溶液中; 使a）的混合物在一定温度范围内反应适当的时间; 过滤和洗涤b）的反应产物与上升溶剂分离固相和液相; 和d）收集和干燥固相以获得高纯度的α-硫酸钙半水合物; 其中氯化钙浓度范围（y）与反应温度（x）的范围之间的关系如下式所示：-0.4x5 + 7.33x4-52.83x3 + 187.17x2-328.27x + 316 < y <1.2x5-22x4 + 158.5x3-561.5x2 + 984.8x-588（2

4. 发明授权

US08465582B2 Process for producing inorganic interconnected 3D open cell bone substitutes 有权
标题翻译：生产无机互连3D开放细胞骨替代物的方法
公开(公告)号：US08465582B2
公开(公告)日：2013-06-18
申请号：US12725163
申请日：2010-03-16
申请人： Jen-Chang Yang , Sheng-Yang Lee , Tsuimin Tsai , Hong-Da Wu , Hsin-Tai Hu , Yan-Cheng Yang , Chen-Feng Ma
发明人： Jen-Chang Yang , Sheng-Yang Lee , Tsuimin Tsai , Hong-Da Wu , Hsin-Tai Hu , Yan-Cheng Yang , Chen-Feng Ma
IPC分类号： A61L27/00
CPC分类号： A61K35/32 , A61K35/28 , A61K38/1875 , A61K38/39 , A61L27/10 , A61L27/12 , A61L27/18 , A61L27/20 , A61L27/56 , A61L2430/02 , C08L79/02
摘要： The present invention relates to a process of using a heat responsive mixture to produce inorganic interconnected 3D open-cell bone substitutes which can be applied in the orthopedic or dental field for treatment of bone damage. The invention provides a simple and easily-controlled process of preparing porous inorganic bone substitute materials.
摘要翻译：本发明涉及使用热响应混合物来生产可应用于整形外科或牙科领域用于治疗骨损伤的无机互连3D开放细胞骨替代物的方法。本发明提供了制备多孔无机骨替代材料的简单且容易控制的方法。

5. 发明申请

US20110288273A1 HIGH YIELD DIALYSIS-FREE PROCESS FOR PRODUCING ORGANOSOLUBLE REGENERATED SILK FIBROIN 有权
标题翻译：用于生产有机溶剂再生丝绸纤维素的高产率无渗透方法
公开(公告)号：US20110288273A1
公开(公告)日：2011-11-24
申请号：US12783818
申请日：2010-05-20
申请人： Jen-Chang YANG , Sheng-Yang LEE , Chien Chung CHEN , Yun-Ting HSU , Hong-Da WU , Dian-Yu JI
发明人： Jen-Chang YANG , Sheng-Yang LEE , Chien Chung CHEN , Yun-Ting HSU , Hong-Da WU , Dian-Yu JI
IPC分类号： C07K1/30
CPC分类号： C07K14/43586
摘要： The invention relates to a simple and high yield process for producing a regenerated silk fibroin which does not need dialysis. Particularly, a process of the invention is characterized in that the silk fibroin is precipitated by applying a shear stress and/or changing the solvent power of the fibroin solution. The process of the invention simplifies the process of producing silk fibroin and greatly shortens the process time to 1 to 2 hours, whereas the conventional dialysis process is complex and needs around 2 to 3 days. In addition to reducing the time needed, the process of the invention can increase productivity of silk fibroin by at least 8%.
摘要翻译：本发明涉及用于生产不需要透析的再生丝素蛋白的简单且高产率的方法。特别地，本发明的方法的特征在于，通过施加剪切应力和/或改变丝心蛋白溶液的溶剂能力使丝素蛋白沉淀。本发明的方法简化了生产丝素蛋白的过程，大大缩短了1至2小时的处理时间，而常规透析过程复杂，需要2至3天左右。除了减少所需时间之外，本发明的方法可以将丝素蛋白的生产率提高至少8％。

6. 发明申请

US20100086474A1 Process for Preparing alpha Calcium Sulfate Hemihydrate 有权
标题翻译：制备α硫酸钙半水合物的方法
公开(公告)号：US20100086474A1
公开(公告)日：2010-04-08
申请号：US12245644
申请日：2008-10-03
申请人： Jen-Chang Yang , Hong-Da Wu , Nai-Chia Teng , Sheng-Yang Lee
发明人： Jen-Chang Yang , Hong-Da Wu , Nai-Chia Teng , Sheng-Yang Lee
IPC分类号： C01F11/46
CPC分类号： C01F11/46
摘要： The invention provides a process for preparing α-calcium sulfate hemihydrate which comprises the following steps: adding aqueous solutions containing sulfate ions and calcium ions to calcium chloride solution with a range of concentration; reacting the mixture of a) at a range of temperature for an appropriate time; filtering and washing the reaction products of b) with a rising solvent to isolate the solid and liquid phases; and d) collecting and drying the solid phase to obtain α-calcium sulfate hemihydrate with high purity; wherein the relationship between the range of the concentration of calcium chloride (y) and the range of the reaction temperature (x) is shown as the following formula: −0.4x5+7.33x4−52.83x3+187.17x2−328.27x+316
摘要翻译：本发明提供了一种制备α-硫酸钙半水合物的方法，包括以下步骤：将含有硫酸根离子和钙离子的水溶液加入到浓度范围的氯化钙溶液中; 使a）的混合物在一定温度范围内反应适当的时间; 过滤和洗涤b）的反应产物与上升溶剂分离固相和液相; 和d）收集和干燥固相以获得高纯度的α-硫酸钙半水合物; 其中氯化钙浓度范围（y）与反应温度（x）的范围之间的关系如下式所示：-0.4x5 + 7.33x4-52.83x3 + 187.17x2-328.27x + 316 < y <1.2x5-22x4 + 158.5x3-561.5x2 + 984.8x-588（2

7. 发明授权

US09056097B2 Composite of amorphous calcium phosphate/calcium sulfate hemihydrate (CSH/ACP) for bone implantation and process for producing the same 有权
标题翻译：用于骨植入的无定形磷酸钙/硫酸钙半水合物复合物（CSH / ACP）及其制备方法
公开(公告)号：US09056097B2
公开(公告)日：2015-06-16
申请号：US13010473
申请日：2011-01-20
申请人： Jen-Chang Yang , Sheng-Yang Lee , Duen-Cheng Wang , Haw-Ming Huang , Wei-Jen Chang , Malosi Poma , Hong-Da Wu , Dian-Yu Ji
发明人： Jen-Chang Yang , Sheng-Yang Lee , Duen-Cheng Wang , Haw-Ming Huang , Wei-Jen Chang , Malosi Poma , Hong-Da Wu , Dian-Yu Ji
IPC分类号： A61K33/42 , A61L27/42
CPC分类号： A61K33/42 , A61L27/425 , A61L27/427
摘要： The invention provides a composite of α-calcium sulfate (CS) hemihydrate/amorphous calcium phosphate (α-CSH/ACP), comprising α-CSH and ACP at a weight ratio of about 10:90 to about 90:10. Particularly, the composite of the invention has a resorption period of 3-6 months. The invention also provides a one-pot process for producing α-CSH/ACP composite of the invention. The one-pot process of the invention can produce α-CSH and ACP in a single process and easily obtain α-CSH/ACP composite.
摘要翻译：本发明提供了以约10:90至约90:10的重量比包含α-CSH和ACP的α-硫酸钙（CS）半水合物/无定形磷酸钙（α-CSH / ACP）的复合物。特别地，本发明的复合材料的吸收期为3-6个月。本发明还提供了一种用于制备本发明的α-CSH / ACP复合材料的一锅法。本发明的一锅法可以在单一工艺中生产α-CSH和ACP，容易获得α-CSH / ACP复合材料。

8. 发明授权

US08263048B2 Calcium phosphate complex for oral care applications, its preparation method, and compositions containing the same 有权
标题翻译：用于口腔护理应用的磷酸钙复合物，其制备方法和含有它们的组合物
公开(公告)号：US08263048B2
公开(公告)日：2012-09-11
申请号：US12975052
申请日：2010-12-21
申请人： Jen-Chang Yang , Sheng-Yang Lee , Der-Zen Liu , Nai-Chia Teng , En-Sheng Ke , Chien Chung Chen , Dian-Yu Ji , Chen-Feng Ma , Hong-Da Wu
发明人： Jen-Chang Yang , Sheng-Yang Lee , Der-Zen Liu , Nai-Chia Teng , En-Sheng Ke , Chien Chung Chen , Dian-Yu Ji , Chen-Feng Ma , Hong-Da Wu
IPC分类号： A61K8/55 , A61Q11/00
CPC分类号： A61Q11/00 , A61K8/24 , A61K8/88 , A61K2800/58
摘要： The invention is directed to a calcium phosphate complex and the composition containing the same for oral care applications, in which the calcium phosphate complex is formed by chelating the γ-polyglutamic acid (γ-PGA) with amorphous calcium phosphate (ACP). This complex can prevent crystallization of ACP and maintain its high solubility. The calcium phosphate complex has superior mucoadhesion properties, allowing it to remain in the mouth longer and offering effective buffering, by which dental caries can be alleviated and prevented.
摘要翻译：本发明涉及一种磷酸钙复合物和含有该磷酸钙络合物的组合物，其中通过用无定形磷酸钙（ACP）螯合γ-聚谷氨酸（γ-PGA）形成磷酸钙复合物。该复合物可以防止ACP的结晶并保持其高溶解度。磷酸钙复合物具有优异的粘膜粘附性质，使其能够更长时间地保留在口腔中，并提供有效的缓冲，可以减轻和预防龋齿。

9. 发明申请

US20110229547A1 PROCESS FOR PRODUCING INORGANIC INTERCONNECTED 3D OPEN CELL BONE SUBSTITUTES 有权
标题翻译：生产无机互连3D开放细胞骨替代物的方法
公开(公告)号：US20110229547A1
公开(公告)日：2011-09-22
申请号：US12725163
申请日：2010-03-16
申请人： Jen-Chang Yang , Sheng-Yang Lee , Tsuimin Tsai , Hong-Da Wu , Hsin-Tai Hu , Yan-Cheng Yang , Chen-Feng Ma
发明人： Jen-Chang Yang , Sheng-Yang Lee , Tsuimin Tsai , Hong-Da Wu , Hsin-Tai Hu , Yan-Cheng Yang , Chen-Feng Ma
IPC分类号： A61K38/18 , A61F2/00 , A61K35/12 , A61K38/39 , A61P19/08
CPC分类号： A61K35/32 , A61K35/28 , A61K38/1875 , A61K38/39 , A61L27/10 , A61L27/12 , A61L27/18 , A61L27/20 , A61L27/56 , A61L2430/02 , C08L79/02
摘要： The present invention relates to a process of using a heat responsive mixture to produce inorganic interconnected 3D open-cell bone substitutes which can be applied in the orthopedic or dental field for treatment of bone damage. The invention provides a simple and easily-controlled process of preparing porous inorganic bone substitute materials.
摘要翻译：本发明涉及使用热响应混合物来生产可应用于整形外科或牙科领域用于治疗骨损伤的无机互连3D开放细胞骨替代物的方法。本发明提供了制备多孔无机骨替代材料的简单且容易控制的方法。

10. 发明申请

US20110150791A1 CALCIUM PHOSPHATE COMPLEX FOR ORAL CARE APPLICATIONS, ITS PREPARATION METHOD, AND COMPOSITIONS CONTAINING THE SAME 有权
标题翻译：用于口腔护理应用的磷酸钙复合物，其制备方法和包含其的组合物
公开(公告)号：US20110150791A1
公开(公告)日：2011-06-23
申请号：US12975052
申请日：2010-12-21
申请人： JEN-CHANG YANG , SHENG-YANG LEE , DER-ZEN LIU , NAI-CHIA TENG , EN-SHENG KE , CHIEN CHUNG CHEN , DIAN-YU JI , CHEN-FENG MA , HONG-DA WU
发明人： JEN-CHANG YANG , SHENG-YANG LEE , DER-ZEN LIU , NAI-CHIA TENG , EN-SHENG KE , CHIEN CHUNG CHEN , DIAN-YU JI , CHEN-FENG MA , HONG-DA WU
IPC分类号： A61K8/55 , A61Q11/00
CPC分类号： A61Q11/00 , A61K8/24 , A61K8/88 , A61K2800/58
摘要： The invention is directed to a calcium phosphate complex and the composition containing the same for oral care applications, in which the calcium phosphate complex is formed by chelating the γ-polyglutamic acid (γ-PGA) with amorphous calcium phosphate (ACP). This complex can prevent crystallization of ACP and maintain its high solubility. The calcium phosphate complex has superior mucoadhesion properties, allowing it to remain in the mouth longer and offering effective buffering, by which dental caries can be alleviated and prevented.
摘要翻译：本发明涉及一种磷酸钙复合物和含有该磷酸钙络合物的组合物，其中通过用无定形磷酸钙（ACP）螯合γ-聚谷氨酸（γ-PGA）形成磷酸钙复合物。该复合物可以防止ACP的结晶并保持其高溶解度。磷酸钙复合物具有优异的粘膜粘附性质，使其能够更长时间地保留在口腔中，并提供有效的缓冲，可以减轻和预防龋齿。

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