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1. 发明申请

US20130005967A1 METHOD FOR PREPARING (R)-3-(3-FLUORO-4-(1-METHYL-5,6-DIHYDRO-1,2,4-TRIAZIN-4(1H)-YL)PHENYL)-5-(SUBSTITUTED METHYL)OXAZOLIDIN-2-ONE DERIVATIVES 有权
标题翻译：制备（R）-3-（3-氟-4-（1-甲基-5,6-二氢-1,2,4-三氮杂-4（1H） - 基）苯基）-5-（取代的甲基））OXAZOLIDIN-2-ONE衍生物
公开(公告)号：US20130005967A1
公开(公告)日：2013-01-03
申请号：US13583492
申请日：2011-03-08
申请人： Young Lag Cho , Sung Yoon Baek , Sang Eun Chae , Hong Bum Lee , Tae Kyo Park , Sung Ho Woo , Yong Zu Kim
发明人： Young Lag Cho , Sung Yoon Baek , Sang Eun Chae , Hong Bum Lee , Tae Kyo Park , Sung Ho Woo , Yong Zu Kim
IPC分类号： C07D413/10 , C07D253/06
CPC分类号： C07D255/02 , C07D253/06 , C07D413/10
摘要： Provided are a method for preparing (R)-3-(3-fluoro-4-(1-methyl-5,6-dihydro-1,2,4-triazin-4(1H)-yl)phenyl)-5-(substituted methyl)oxazolidin-2-one derivatives, which are oxazolidinone antibiotic compounds having a cyclic amidrazone group, represented by Chemical Formula 1, and intermediates thereof, and uses 3,4-difluoro-4-nitrobenzen as a starting material. According to the preparation method of the present invention, (R)-3-(3-fluoro-4-(1-methyl-5,6-dihydro-1,2,4-triazin-4(1H)-yl)phenyl)-5-(substituted methyl)oxazolidin-2-one derivatives, which are useful as oxazolidinone antibiotics, can be prepared in high purity and high yield in a simpler manner than conventional methods.
摘要翻译：提供制备（R）-3-（3-氟-4-（1-甲基-5,6-二氢-1,2,4-三嗪-4（1H） - 基）苯基）-5- （取代甲基）恶唑烷-2-酮衍生物，它们是由化学式1表示的具有环状氨基腙基的恶唑烷酮类抗生素化合物及其中间体，并以3,4-二氟-4-硝基苯为起始原料。根据本发明的制备方法，将（R）-3-（3-氟-4-（1-甲基-5,6-二氢-1,2,4-三嗪-4（1H） - 基）苯基）-5-（取代的甲基）恶唑烷-2-酮衍生物可以以比常规方法更简单的方式以高纯度和高产率制备，其可用作恶唑烷酮抗生素。

2. 发明授权

US08846669B2 Oxazolidinone derivative and medical composition containing same 有权
标题翻译：恶唑烷酮衍生物和含有它们的医药组合物
公开(公告)号：US08846669B2
公开(公告)日：2014-09-30
申请号：US14008702
申请日：2012-03-29
申请人： Young Lag Cho , Sung Yoon Baek , Sang Eun Chae , Sun Young Kim , Hong Bum Lee , Hyang Sook Lee , Kyuman Oh , Hye Jin Heo , Tae Kyo Park , Sung Ho Woo , Yong Zu Kim
发明人： Young Lag Cho , Sung Yoon Baek , Sang Eun Chae , Sun Young Kim , Hong Bum Lee , Hyang Sook Lee , Kyuman Oh , Hye Jin Heo , Tae Kyo Park , Sung Ho Woo , Yong Zu Kim
IPC分类号： C07D413/14 , A61K31/53 , A61K31/5355
CPC分类号： C07D413/14
摘要： Disclosed is a novel oxazolidinone derivative represented by Formula 1 above, in particular, a novel oxazolidinone compound having a cyclic amidoxime or cyclic amidrazone group.In Formula 1, R and Q are the same as defined in the detailed description.In addition, disclosed is a pharmaceutical composition for an antibiotic which includes the novel oxazolidinone derivative of Formula 1, a prodrug thereof, a hydrate thereof, a solvate thereof, an isomer thereof, or a pharmaceutically acceptable salt thereof as an active ingredient.The novel oxazolidinone derivative, the prodrug thereof, the hydrate thereof, the solvate thereof, the isomer thereof, and the pharmaceutically acceptable salt thereof have broad antibacterial spectrum against resistant bacteria, low toxicity and strong antibacterial effects against Gram-positive and Gram-negative bacteria and thus may be effectively used as antibiotics.
摘要翻译：公开了上述通式1所示的新型恶唑烷酮衍生物，特别是具有环状偕胺肟或环状氨基腙基的新型恶唑烷酮化合物。在式1中，R和Q与详细描述中定义相同。此外，公开了一种抗生素的药物组合物，其包含式1的新型恶唑烷酮衍生物，其前药，其水合物，其溶剂合物，其异构体或其药学上可接受的盐作为活性成分。新型恶唑烷酮衍生物，其前体药剂，其水合物，其溶剂合物，其异构体及其药学上可接受的盐具有抗抗性细菌的抗菌谱，对革兰氏阳性和革兰氏阴性菌具有低毒性和强抗菌作用因此可以有效地用作抗生素。

3. 发明授权

US09062066B2 Anti-inflammatory compound having inhibitory activity against multiple tyrosine kinases and pharmaceutical composition containing same 有权
标题翻译：对多种酪氨酸激酶具有抑制活性的抗炎化合物和含有它们的药物组合物
公开(公告)号：US09062066B2
公开(公告)日：2015-06-23
申请号：US13699970
申请日：2011-05-26
申请人： Beom-Seok Yang , Yong-Zu Kim , Tae-Kyo Park , Sung-Ho Woo , Hyang-Sook Lee , Sun-Young Kim , Jong-Un Cho , Hong-Bum Lee
发明人： Beom-Seok Yang , Yong-Zu Kim , Tae-Kyo Park , Sung-Ho Woo , Hyang-Sook Lee , Sun-Young Kim , Jong-Un Cho , Hong-Bum Lee
IPC分类号： C07D495/04
CPC分类号： C07D495/04
摘要： The present invention is for the anti-inflammatory compounds that have an inhibitory activity against protein tyrosine kinases and their pharmaceutical composition(s) containing the compound as the active ingredient. Since the compounds of the present invention can inhibit multiple protein kinases associated with inflammatory diseases and immune disorders, they are useful for their prevention or treatment.
摘要翻译：本发明涉及对蛋白酪氨酸激酶具有抑制活性的抗炎化合物及其含有该化合物作为活性成分的药物组合物。由于本发明的化合物可以抑制与炎性疾病和免疫疾病相关的多种蛋白激酶，因此它们可用于其预防或治疗。

4. 发明授权

US6093482A Carbon-carbon composite for friction products and method of making same 有权
标题翻译：用于摩擦产品的碳 - 碳复合材料及其制造方法
公开(公告)号：US6093482A
公开(公告)日：2000-07-25
申请号：US210891
申请日：1998-12-16
申请人： Hyun Cheol Park , Hong Bum Lee , Ik Hyun Oh , Hyun Kyu Shin , Kwang Soo Kim , John Hyun Park
发明人： Hyun Cheol Park , Hong Bum Lee , Ik Hyun Oh , Hyun Kyu Shin , Kwang Soo Kim , John Hyun Park
IPC分类号： C04B35/83 , F16D69/02 , B32B18/00 , C01B31/00
CPC分类号： F16D69/023 , C04B35/83 , Y10T428/2918 , Y10T428/292 , Y10T428/30
摘要： A carbon--carbon composite for friction products comprises an outer friction part and a load bearing structure part supporting the friction part. The friction part contains a mixture of carbon fibers, pitch powder and graphite powder, whereas the structure part is comprised of a pack of alternating layers of the mixture and layers of one member selected from the group consisting of carbon fabrics, carbon-based prepregs and carbon-based, segmented prepregs. The carbon--carbon composite is formed by way of aternatingly piling up layers of a mixture of carbon fibers, pitch powder and graphite powder and layers of one member selected from the group consisting of carbon fabrics, carbon-based prepregs and carbon-based, segmented prepregs one above the other to provide a preform, heating and pressing the preform within a mold to obtain a green body, carbonizing the green body to prepare a carbonized body, impregnating the carbonized body with pitch powder and recarbonizing the impregnated body, and subjecting the impregnated and recarbonized body to chemical vapor infiltration with hydrocarbon gas.
摘要翻译：用于摩擦产品的碳 - 碳复合材料包括外摩擦部件和支撑摩擦部件的承载结构部件。摩擦部分包含碳纤维，沥青粉末和石墨粉末的混合物，而结构部分由混合物的一组交替层组成，并且选自碳织物，碳基预浸料和碳基分段预浸料。碳 - 碳复合材料是通过将碳纤维，沥青粉末和石墨粉末的混合物层和由碳纤维，碳基预浸料和碳基组成的组中选择的一个层的层叠在一起而形成的，预成型件之间，预成型件一起预成型件，在模具内加热预压成形体，得到生坯，将生坯碳化，制成碳化体，用沥青粉浸渍碳化体，再重新浸渍浸渍体，浸渍和再碳化身体与碳氢化合物气体进行化学气相渗透。

5. 发明申请

US20140179691A1 NOVEL OXAZOLIDINONE DERIVATIVE AND MEDICAL COMPOSITION CONTAINING SAME 有权
标题翻译：新型奥昔洛芬衍生物和含有它们的医药组合物
公开(公告)号：US20140179691A1
公开(公告)日：2014-06-26
申请号：US14008702
申请日：2012-03-29
申请人： Young Lag Cho , Sung Yoon Baek , Sang Eun Chae , Sun Young Kim , Hong Bum Lee , Hyang Sook Lee , Kyuman Oh , Tae Kyo Park , Sung Ho Woo , Yong Zu Kim , Hye Jin Heo
发明人： Young Lag Cho , Sung Yoon Baek , Sang Eun Chae , Sun Young Kim , Hong Bum Lee , Hyang Sook Lee , Kyuman Oh , Tae Kyo Park , Sung Ho Woo , Yong Zu Kim , Hye Jin Heo
IPC分类号： C07D413/14
CPC分类号： C07D413/14
摘要： Disclosed is a novel oxazolidinone derivative represented by Formula 1 above, in particular, a novel oxazolidinone compound having a cyclic amidoxime or cyclic amidrazone group.In Formula 1, R and Q are the same as defined in the detailed description.In addition, disclosed is a pharmaceutical composition for an antibiotic which includes the novel oxazolidinone derivative of Formula 1, a prodrug thereof, a hydrate thereof, a solvate thereof, an isomer thereof, or a pharmaceutically acceptable salt thereof as an active ingredient.The novel oxazolidinone derivative, the prodrug thereof, the hydrate thereof, the solvate thereof, the isomer thereof, and the pharmaceutically acceptable salt thereof have broad antibacterial spectrum against resistant bacteria, low toxicity and strong antibacterial effects against Gram-positive and Gram-negative bacteria and thus may be effectively used as antibiotics.
摘要翻译：公开了上述通式1所示的新型恶唑烷酮衍生物，特别是具有环状偕胺肟或环状氨基腙基的新型恶唑烷酮化合物。在式1中，R和Q与详细描述中定义相同。此外，公开了一种抗生素的药物组合物，其包含式1的新型恶唑烷酮衍生物，其前药，其水合物，其溶剂合物，其异构体或其药学上可接受的盐作为活性成分。新型恶唑烷酮衍生物，其前体药剂，其水合物，其溶剂合物，其异构体及其药学上可接受的盐具有抗抗性细菌的抗菌谱，对革兰氏阳性和革兰氏阴性菌具有低毒性和强抗菌作用因此可以有效地用作抗生素。

6. 发明授权

US08703939B2 Method for preparing (R)-3-(3-fluoro-4-(1-methyl-5,6-dihydro-1,2,4-triazin-4(1H)-yl)phenyl)-5-(substituted methyl)oxazolidin-2-one derivatives 有权
标题翻译：制备（R）-3-（3-氟-4-（1-甲基-5,6-二氢-1,2,4-三嗪-4（1H） - 基）苯基）-5-（取代的甲基）恶唑烷-2-酮衍生物
公开(公告)号：US08703939B2
公开(公告)日：2014-04-22
申请号：US13583492
申请日：2011-03-08
申请人： Young Lag Cho , Sung Yoon Baek , Sang Eun Chae , Hong Bum Lee , Tae Kyo Park , Sung Ho Woo , Yong Zu Kim
发明人： Young Lag Cho , Sung Yoon Baek , Sang Eun Chae , Hong Bum Lee , Tae Kyo Park , Sung Ho Woo , Yong Zu Kim
IPC分类号： C07D253/065 , C07D413/10 , C07D413/14
CPC分类号： C07D255/02 , C07D253/06 , C07D413/10
摘要： Provided are a method for preparing (R)-3-(3-fluoro-4-(1-methyl-5, 6-dihydro-1,2,4-triazin-4(1H)-yl)phenyl)-5-(substituted methyl) oxazolidin-2-one derivatives, which are oxazolidinone antibiotic compounds having a cyclic amidrazone group, represented by Chemical Formula 1, and intermediates thereof, and uses 3,4-difluoro-4-nitrobenzen as a starting material. According to the preparation method of the present invention, (R)-3-(3-fluoro-4-(1-methyl-5, 6-dihydro-1,2,4-triazin-4(1H)-yl)phenyl)-5-(substituted methyl) oxazolidin-2-one derivatives, which are useful as oxazolidinone antibiotics, can be prepared in high purity and high yield in a simpler manner than conventional methods.
摘要翻译：提供制备（R）-3-（3-氟-4-（1-甲基-5,6-二氢-1,2,4-三嗪-4（1H） - 基）苯基）-5- （取代甲基）恶唑烷-2-酮衍生物，它们是由化学式1表示的具有环状氨基腙基的恶唑烷酮类抗生素化合物及其中间体，并以3,4-二氟-4-硝基苯为起始原料。根据本发明的制备方法，使用（R）-3-（3-氟-4-（1-甲基-5,6-二氢-1,2,4-三嗪-4（1H） - 基）苯基）-5-（取代的甲基）恶唑烷-2-酮衍生物可以以比常规方法更简单的方式以高纯度和高产率制备，其可用作恶唑烷酮抗生素。

7. 发明申请

US20090155094A1 COOLING FAN CLUTCH 审中-公开
标题翻译：冷却风扇离合器
公开(公告)号：US20090155094A1
公开(公告)日：2009-06-18
申请号：US12238084
申请日：2008-09-25
申请人： Hong Bum LEE
发明人： Hong Bum LEE
IPC分类号： F04D27/00 , F01D15/12
CPC分类号： F16D35/024 , F01P7/085 , F16D48/066 , F16D2500/10468 , F16D2500/3064 , F16D2500/504 , F16D2500/70424
摘要： A disk-shaped cover has a first toothed portion at one surface thereof. A housing is coupled with the cover such that a space is defined therebetween. The housing has a second toothed portion at one surface thereof, facing the first toothed portion. A shaft is rotatably disposed through a middle portion of the housing. A fan is fixedly connected to the housing and rotatable with the housing. A rotor is mounted in the space between the cover and the housing, engaged with and rotatable with the shaft, with third and fourth toothed portions at both surfaces thereof, engaged with the first and second toothed portions, respectively. An operation unit controls an amount of fluid supplied to the space between the cover and the housing to control a frictional force generated between the rotor, the housing, and the cover. A control unit controls the operation unit based on a coolant temperature.
摘要翻译：盘形盖在其一个表面上具有第一齿形部分。壳体与盖体联接，从而在其间限定一个空间。壳体在其一个表面上具有面向第一齿形部分的第二齿形部分。轴可旋转地设置穿过壳体的中间部分。风扇固定地连接到壳体并且可以与壳体一起旋转。转子安装在盖和壳体之间的空间中，与轴接合并且可与轴一起旋转，其两个表面上的第三和第四齿部分别与第一和第二齿形部分接合。操作单元控制供给到盖和壳体之间的空间的流体的量，以控制在转子，壳体和盖之间产生的摩擦力。控制单元基于冷却剂温度控制操作单元。

8. 发明申请

US20130072482A1 ANTI-INFLAMMATORY COMPOUND HAVING INHIBITORY ACTIVITY AGAINST MULTIPLE TYROSINE KINASES AND PHARMACEUTICAL COMPOSITION CONTAINING SAME 有权
标题翻译：具有抗多种类型蛇毒的抑制活性的抗炎化合物和含有其的药物组合物
公开(公告)号：US20130072482A1
公开(公告)日：2013-03-21
申请号：US13699970
申请日：2011-05-26
申请人： Beom-Seok Yang , Yong-Zu Kim , Tae-Kyo Park , Sung-Ho Woo , Hyang-Sook Lee , Sun-Young Kim , Jong-Un Cho , Hong-Bum Lee
发明人： Beom-Seok Yang , Yong-Zu Kim , Tae-Kyo Park , Sung-Ho Woo , Hyang-Sook Lee , Sun-Young Kim , Jong-Un Cho , Hong-Bum Lee
IPC分类号： A61K31/519 , A61K31/5377 , A61K31/4545 , A61P17/02 , A61K31/4365 , A61P29/00 , A61P37/00 , C07D495/04 , A61K31/496
CPC分类号： C07D495/04
摘要： The present invention is for the anti-inflammatory compounds that have an inhibitory activity against protein tyrosine kinases and their pharmaceutical composition(s) containing the compound as the active ingredient. Since the compounds of the present invention can inhibit multiple protein kinases associated with inflammatory diseases and immune disorders, they are useful for their prevention or treatment.
摘要翻译：本发明涉及对蛋白酪氨酸激酶具有抑制活性的抗炎化合物及其含有该化合物作为活性成分的药物组合物。由于本发明的化合物可以抑制与炎性疾病和免疫疾病相关的多种蛋白激酶，因此它们可用于其预防或治疗。

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