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1. 发明申请

US20130005967A1 METHOD FOR PREPARING (R)-3-(3-FLUORO-4-(1-METHYL-5,6-DIHYDRO-1,2,4-TRIAZIN-4(1H)-YL)PHENYL)-5-(SUBSTITUTED METHYL)OXAZOLIDIN-2-ONE DERIVATIVES 有权
标题翻译：制备（R）-3-（3-氟-4-（1-甲基-5,6-二氢-1,2,4-三氮杂-4（1H） - 基）苯基）-5-（取代的甲基））OXAZOLIDIN-2-ONE衍生物
公开(公告)号：US20130005967A1
公开(公告)日：2013-01-03
申请号：US13583492
申请日：2011-03-08
申请人： Young Lag Cho , Sung Yoon Baek , Sang Eun Chae , Hong Bum Lee , Tae Kyo Park , Sung Ho Woo , Yong Zu Kim
发明人： Young Lag Cho , Sung Yoon Baek , Sang Eun Chae , Hong Bum Lee , Tae Kyo Park , Sung Ho Woo , Yong Zu Kim
IPC分类号： C07D413/10 , C07D253/06
CPC分类号： C07D255/02 , C07D253/06 , C07D413/10
摘要： Provided are a method for preparing (R)-3-(3-fluoro-4-(1-methyl-5,6-dihydro-1,2,4-triazin-4(1H)-yl)phenyl)-5-(substituted methyl)oxazolidin-2-one derivatives, which are oxazolidinone antibiotic compounds having a cyclic amidrazone group, represented by Chemical Formula 1, and intermediates thereof, and uses 3,4-difluoro-4-nitrobenzen as a starting material. According to the preparation method of the present invention, (R)-3-(3-fluoro-4-(1-methyl-5,6-dihydro-1,2,4-triazin-4(1H)-yl)phenyl)-5-(substituted methyl)oxazolidin-2-one derivatives, which are useful as oxazolidinone antibiotics, can be prepared in high purity and high yield in a simpler manner than conventional methods.
摘要翻译：提供制备（R）-3-（3-氟-4-（1-甲基-5,6-二氢-1,2,4-三嗪-4（1H） - 基）苯基）-5- （取代甲基）恶唑烷-2-酮衍生物，它们是由化学式1表示的具有环状氨基腙基的恶唑烷酮类抗生素化合物及其中间体，并以3,4-二氟-4-硝基苯为起始原料。根据本发明的制备方法，将（R）-3-（3-氟-4-（1-甲基-5,6-二氢-1,2,4-三嗪-4（1H） - 基）苯基）-5-（取代的甲基）恶唑烷-2-酮衍生物可以以比常规方法更简单的方式以高纯度和高产率制备，其可用作恶唑烷酮抗生素。

2. 发明授权

US08846669B2 Oxazolidinone derivative and medical composition containing same 有权
标题翻译：恶唑烷酮衍生物和含有它们的医药组合物
公开(公告)号：US08846669B2
公开(公告)日：2014-09-30
申请号：US14008702
申请日：2012-03-29
申请人： Young Lag Cho , Sung Yoon Baek , Sang Eun Chae , Sun Young Kim , Hong Bum Lee , Hyang Sook Lee , Kyuman Oh , Hye Jin Heo , Tae Kyo Park , Sung Ho Woo , Yong Zu Kim
发明人： Young Lag Cho , Sung Yoon Baek , Sang Eun Chae , Sun Young Kim , Hong Bum Lee , Hyang Sook Lee , Kyuman Oh , Hye Jin Heo , Tae Kyo Park , Sung Ho Woo , Yong Zu Kim
IPC分类号： C07D413/14 , A61K31/53 , A61K31/5355
CPC分类号： C07D413/14
摘要： Disclosed is a novel oxazolidinone derivative represented by Formula 1 above, in particular, a novel oxazolidinone compound having a cyclic amidoxime or cyclic amidrazone group.In Formula 1, R and Q are the same as defined in the detailed description.In addition, disclosed is a pharmaceutical composition for an antibiotic which includes the novel oxazolidinone derivative of Formula 1, a prodrug thereof, a hydrate thereof, a solvate thereof, an isomer thereof, or a pharmaceutically acceptable salt thereof as an active ingredient.The novel oxazolidinone derivative, the prodrug thereof, the hydrate thereof, the solvate thereof, the isomer thereof, and the pharmaceutically acceptable salt thereof have broad antibacterial spectrum against resistant bacteria, low toxicity and strong antibacterial effects against Gram-positive and Gram-negative bacteria and thus may be effectively used as antibiotics.
摘要翻译：公开了上述通式1所示的新型恶唑烷酮衍生物，特别是具有环状偕胺肟或环状氨基腙基的新型恶唑烷酮化合物。在式1中，R和Q与详细描述中定义相同。此外，公开了一种抗生素的药物组合物，其包含式1的新型恶唑烷酮衍生物，其前药，其水合物，其溶剂合物，其异构体或其药学上可接受的盐作为活性成分。新型恶唑烷酮衍生物，其前体药剂，其水合物，其溶剂合物，其异构体及其药学上可接受的盐具有抗抗性细菌的抗菌谱，对革兰氏阳性和革兰氏阴性菌具有低毒性和强抗菌作用因此可以有效地用作抗生素。

3. 发明申请

US20140179691A1 NOVEL OXAZOLIDINONE DERIVATIVE AND MEDICAL COMPOSITION CONTAINING SAME 有权
标题翻译：新型奥昔洛芬衍生物和含有它们的医药组合物
公开(公告)号：US20140179691A1
公开(公告)日：2014-06-26
申请号：US14008702
申请日：2012-03-29
申请人： Young Lag Cho , Sung Yoon Baek , Sang Eun Chae , Sun Young Kim , Hong Bum Lee , Hyang Sook Lee , Kyuman Oh , Tae Kyo Park , Sung Ho Woo , Yong Zu Kim , Hye Jin Heo
发明人： Young Lag Cho , Sung Yoon Baek , Sang Eun Chae , Sun Young Kim , Hong Bum Lee , Hyang Sook Lee , Kyuman Oh , Tae Kyo Park , Sung Ho Woo , Yong Zu Kim , Hye Jin Heo
IPC分类号： C07D413/14
CPC分类号： C07D413/14
摘要： Disclosed is a novel oxazolidinone derivative represented by Formula 1 above, in particular, a novel oxazolidinone compound having a cyclic amidoxime or cyclic amidrazone group.In Formula 1, R and Q are the same as defined in the detailed description.In addition, disclosed is a pharmaceutical composition for an antibiotic which includes the novel oxazolidinone derivative of Formula 1, a prodrug thereof, a hydrate thereof, a solvate thereof, an isomer thereof, or a pharmaceutically acceptable salt thereof as an active ingredient.The novel oxazolidinone derivative, the prodrug thereof, the hydrate thereof, the solvate thereof, the isomer thereof, and the pharmaceutically acceptable salt thereof have broad antibacterial spectrum against resistant bacteria, low toxicity and strong antibacterial effects against Gram-positive and Gram-negative bacteria and thus may be effectively used as antibiotics.
摘要翻译：公开了上述通式1所示的新型恶唑烷酮衍生物，特别是具有环状偕胺肟或环状氨基腙基的新型恶唑烷酮化合物。在式1中，R和Q与详细描述中定义相同。此外，公开了一种抗生素的药物组合物，其包含式1的新型恶唑烷酮衍生物，其前药，其水合物，其溶剂合物，其异构体或其药学上可接受的盐作为活性成分。新型恶唑烷酮衍生物，其前体药剂，其水合物，其溶剂合物，其异构体及其药学上可接受的盐具有抗抗性细菌的抗菌谱，对革兰氏阳性和革兰氏阴性菌具有低毒性和强抗菌作用因此可以有效地用作抗生素。

4. 发明授权

US08703939B2 Method for preparing (R)-3-(3-fluoro-4-(1-methyl-5,6-dihydro-1,2,4-triazin-4(1H)-yl)phenyl)-5-(substituted methyl)oxazolidin-2-one derivatives 有权
标题翻译：制备（R）-3-（3-氟-4-（1-甲基-5,6-二氢-1,2,4-三嗪-4（1H） - 基）苯基）-5-（取代的甲基）恶唑烷-2-酮衍生物
公开(公告)号：US08703939B2
公开(公告)日：2014-04-22
申请号：US13583492
申请日：2011-03-08
申请人： Young Lag Cho , Sung Yoon Baek , Sang Eun Chae , Hong Bum Lee , Tae Kyo Park , Sung Ho Woo , Yong Zu Kim
发明人： Young Lag Cho , Sung Yoon Baek , Sang Eun Chae , Hong Bum Lee , Tae Kyo Park , Sung Ho Woo , Yong Zu Kim
IPC分类号： C07D253/065 , C07D413/10 , C07D413/14
CPC分类号： C07D255/02 , C07D253/06 , C07D413/10
摘要： Provided are a method for preparing (R)-3-(3-fluoro-4-(1-methyl-5, 6-dihydro-1,2,4-triazin-4(1H)-yl)phenyl)-5-(substituted methyl) oxazolidin-2-one derivatives, which are oxazolidinone antibiotic compounds having a cyclic amidrazone group, represented by Chemical Formula 1, and intermediates thereof, and uses 3,4-difluoro-4-nitrobenzen as a starting material. According to the preparation method of the present invention, (R)-3-(3-fluoro-4-(1-methyl-5, 6-dihydro-1,2,4-triazin-4(1H)-yl)phenyl)-5-(substituted methyl) oxazolidin-2-one derivatives, which are useful as oxazolidinone antibiotics, can be prepared in high purity and high yield in a simpler manner than conventional methods.
摘要翻译：提供制备（R）-3-（3-氟-4-（1-甲基-5,6-二氢-1,2,4-三嗪-4（1H） - 基）苯基）-5- （取代甲基）恶唑烷-2-酮衍生物，它们是由化学式1表示的具有环状氨基腙基的恶唑烷酮类抗生素化合物及其中间体，并以3,4-二氟-4-硝基苯为起始原料。根据本发明的制备方法，使用（R）-3-（3-氟-4-（1-甲基-5,6-二氢-1,2,4-三嗪-4（1H） - 基）苯基）-5-（取代的甲基）恶唑烷-2-酮衍生物可以以比常规方法更简单的方式以高纯度和高产率制备，其可用作恶唑烷酮抗生素。

5. 发明授权

US6093482A Carbon-carbon composite for friction products and method of making same 有权
标题翻译：用于摩擦产品的碳 - 碳复合材料及其制造方法
公开(公告)号：US6093482A
公开(公告)日：2000-07-25
申请号：US210891
申请日：1998-12-16
申请人： Hyun Cheol Park , Hong Bum Lee , Ik Hyun Oh , Hyun Kyu Shin , Kwang Soo Kim , John Hyun Park
发明人： Hyun Cheol Park , Hong Bum Lee , Ik Hyun Oh , Hyun Kyu Shin , Kwang Soo Kim , John Hyun Park
IPC分类号： C04B35/83 , F16D69/02 , B32B18/00 , C01B31/00
CPC分类号： F16D69/023 , C04B35/83 , Y10T428/2918 , Y10T428/292 , Y10T428/30
摘要： A carbon--carbon composite for friction products comprises an outer friction part and a load bearing structure part supporting the friction part. The friction part contains a mixture of carbon fibers, pitch powder and graphite powder, whereas the structure part is comprised of a pack of alternating layers of the mixture and layers of one member selected from the group consisting of carbon fabrics, carbon-based prepregs and carbon-based, segmented prepregs. The carbon--carbon composite is formed by way of aternatingly piling up layers of a mixture of carbon fibers, pitch powder and graphite powder and layers of one member selected from the group consisting of carbon fabrics, carbon-based prepregs and carbon-based, segmented prepregs one above the other to provide a preform, heating and pressing the preform within a mold to obtain a green body, carbonizing the green body to prepare a carbonized body, impregnating the carbonized body with pitch powder and recarbonizing the impregnated body, and subjecting the impregnated and recarbonized body to chemical vapor infiltration with hydrocarbon gas.
摘要翻译：用于摩擦产品的碳 - 碳复合材料包括外摩擦部件和支撑摩擦部件的承载结构部件。摩擦部分包含碳纤维，沥青粉末和石墨粉末的混合物，而结构部分由混合物的一组交替层组成，并且选自碳织物，碳基预浸料和碳基分段预浸料。碳 - 碳复合材料是通过将碳纤维，沥青粉末和石墨粉末的混合物层和由碳纤维，碳基预浸料和碳基组成的组中选择的一个层的层叠在一起而形成的，预成型件之间，预成型件一起预成型件，在模具内加热预压成形体，得到生坯，将生坯碳化，制成碳化体，用沥青粉浸渍碳化体，再重新浸渍浸渍体，浸渍和再碳化身体与碳氢化合物气体进行化学气相渗透。

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