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1. 发明授权

US5238921A Oligopeptide, angiotensin converting enzyme inhibitors, hypotensive agent, and method for treatment of hypertension 失效
标题翻译：寡糖，血管紧张素转化酶抑制剂，高血压药物和治疗高血压的方法
公开(公告)号：US5238921A
公开(公告)日：1993-08-24
申请号：US660878
申请日：1991-02-26
申请人： Susumu Maruyama , Hideoki Tanaka , Hidekatsu Maeda , Shinsuke Miyoshi , Hiromi Ishikawa , Fumio Fukui
发明人： Susumu Maruyama , Hideoki Tanaka , Hidekatsu Maeda , Shinsuke Miyoshi , Hiromi Ishikawa , Fumio Fukui
IPC分类号： A23L1/305 , A61K38/00 , C07K5/083 , C07K5/087 , C07K7/06
CPC分类号： C07K7/06 , A23L33/18 , C07K5/0808 , C07K5/0812 , A61K38/00
摘要： L-Tyr-L-Val, L-Leu-L-Tyr, L-Leu-L-Pro, L-Phe-L-Tyr, L-Tyr-L-Arg and its acid addition salts, L-Leu-L-Ser-L-Pro, L-Leu-L-Gln-L-Pro, L-Phe-L-Leu-L-Pro, L-Leu-L-Leu-L-Pro, L-Leu-L-Asn-L-Pro, L-Phe-L-Pro, L-Leu-L-Ala-L-Ala, L-Val-L-Ala-L-Ala, L-Leu-L-Gln-L-Gln, L-Val-L-Ala-L-Tyr, L-Leu-L-Ala-L-Tyr, L-Leu-L-Ser-L-His and its acid solution salts, L-Ile-L-Arg-L-Ala and its acid addition salts, L-Leu-L-Arg-L-Pro and its acid addition salts, and L-Ile-L-Arg-L-Ala-L-Gln-L-Gln and its acid addition salts, derived from a corn protein .alpha.-zein, and tripeptides represented by the formulaL-(or D-) Leu-L-X.sub.aa -L-Prowherein X.sub.aa is Gly, Ala, Val, Ile, Thr, Asp, Glu, Lys, Orn, Cys, Met, Phe, Tyr, Trp, His or a hydroxyproline residue, pharmacologically acceptable acid addition salts of the above tripeptides wherein X.sub.aa is Lys, Orn, His or Arg, and pharmacologically acceptable alkali or alkaline earth metal salts, ammonium salts or organic base salts of the tripeptides wherein X.sub.aa is Asp or Glu, have an angiotensin converting enzyme-inhibiting activity.

2. 外观设计

USD579758S1 Sash lock 有权
标题翻译：窗框锁
公开(公告)号：USD579758S1
公开(公告)日：2008-11-04
申请号：US29266451
申请日：2006-09-21
申请人： Hideoki Tanaka , Naoki Yasuda , Yutaka Nakamura , Toshio Isono , Michizumi Ito , Yasuhito Hibi , Yoshitada Sakamoto , Masaki Nomura , Akira Ueda
设计人： Hideoki Tanaka , Naoki Yasuda , Yutaka Nakamura , Toshio Isono , Michizumi Ito , Yasuhito Hibi , Yoshitada Sakamoto , Masaki Nomura , Akira Ueda

3. 外观设计

USD539634S1 Lock 有权
公开(公告)号：USD539634S1
公开(公告)日：2007-04-03
申请号：US29238004
申请日：2005-09-09
申请人： Hideoki Tanaka , Naoki Yasuda , Masashi Sugawara , Toru Kanai , Masaki Nomura
设计人： Hideoki Tanaka , Naoki Yasuda , Masashi Sugawara , Toru Kanai , Masaki Nomura

4. 发明授权

US5010004A Method for continuous reaction with fluidized immobilized lipase 失效
标题翻译：与流化固定化脂肪酶连续反应的方法
公开(公告)号：US5010004A
公开(公告)日：1991-04-23
申请号：US255599
申请日：1988-10-11
申请人： Yoshitsugu Kosugi , Hideoki Tanaka , Hideo Suzuki , Masaru Shiraki
发明人： Yoshitsugu Kosugi , Hideoki Tanaka , Hideo Suzuki , Masaru Shiraki
IPC分类号： C12P7/64 , C12M1/40
CPC分类号： C12M23/34 , C12M21/18 , C12M23/02 , C12M25/20 , C12M27/00 , C12M47/10 , Y10S435/813
摘要： A water-soluble substrate and an oily substrate are continuously reacted with immobilized lipase in a reaction vessel having vertically maintained apart upper and lower conically-shaped regions, respectively, for separation of a water-soluble product and an oily product, a plurality of lipase reaction zones each containing immobilized lipase capable of being fluidized and an agitating means, and a plurality of intermediate separation zones for separation of an oily substance and a water-soluble substance. The lipase reaction zones and the intermediate separation zones are disposed alternately between the upper and lower conically-shaped separation regions. Boundaries between the lipase reaction zones and intermediate separation zones are pervious to liquid but impervious to the immobilized lipase. The water-soluble substrate and oily substrate are passed in counterflow contact through the lipase reaction zones and intermediate separation zones and mutually contact the immobilized lipase which has been fluidized. An oily product is recovered from the upper conically-shaped separation region and a water-soluble product is recovered from the lower conically-shaped separation region.
摘要翻译：水溶性底物和油性底物分别在具有垂直保持分开的上下圆锥形区域的反应容器中与固定化脂肪酶连续反应，用于分离水溶性产物和油性产物，多种脂肪酶每个含有能够流化的固定化脂肪酶的反应区和搅拌装置，以及用于分离油性物质和水溶性物质的多个中间分离区。脂肪酶反应区和中间分离区交替设置在上下圆锥形分离区之间。脂肪酶反应区和中间分离区之间的边界可以渗透液体，但对固定的脂肪酶是不透水的。水溶性底物和油性底物通过反向流动接触通过脂肪酶反应区和中间分离区，并与已流化的固定化脂肪酶相互接触。从上部圆锥形分离区域回收油状产物，并从下锥形分离区域回收水溶性产物。

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