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1. 发明专利

JP2004269520A PEPTIDE DEACTIVATING ANAPHYLATOXIN C5a 有权
公开(公告)号：JP2004269520A
公开(公告)日：2004-09-30
申请号：JP2004044012
申请日：2004-02-20
申请人： Hidechika Okada , Noriko Okada , 則子岡田 , 秀親岡田
发明人： OKADA HIDECHIKA , OKADA NORIKO , FUJITA EMIKO
IPC分类号： A61K38/00 , A61P9/00 , A61P29/00 , A61P37/00 , A61P37/08 , A61P43/00 , C07K7/08
摘要： PROBLEM TO BE SOLVED: To provide a treating and prophylactic agent for an inflammatory disease, which contains a peptide deactivating an anaphylatoxin C5a as an active ingredient.
SOLUTION: A peptide complementary to the peptide part consisting of the amino-terminal number 37-53 amino acids of a complement fragment C5a is structurally designed and synthesized to give a peptide deactivating an anaphylatoxin activity of C5a by binding with C5a.
COPYRIGHT: (C)2004,JPO&NCIPI

2. 发明专利

JP2004262910A Thrombomodulin-inactivating peptide 审中-公开
公开(公告)号：JP2004262910A
公开(公告)日：2004-09-24
申请号：JP2003102267
申请日：2003-02-28
申请人： Hidechika Okada , Noriko Okada , 則子岡田 , 秀親岡田
发明人： OKADA HIDECHIKA , OKADA NORIKO , SHIMOMURA YASUYO
IPC分类号： A61K38/00 , A61P9/00 , A61P29/00 , A61P37/08 , C07K7/08
摘要： PROBLEM TO BE SOLVED: To provide a preventing and treating agent of inflammatory morbid state, thrombosis, etc., by using a peptide inactivating thrombomodulin as an active ingredient.
SOLUTION: This peptide inhibiting the activity of the trombomodulin for reinforcing the activity of thrombin is created by designing/synthesizing a complemental peptide against a part of thrombobodulin from 408th glutamine to 426th glutamic acid of the thrombomodulin and performing the reaction with thrombomodulin.
COPYRIGHT: (C)2004,JPO&NCIPI

3. 发明专利

JP2003313200A Evaluation system for active peptide and new active peptide 有权
标题翻译：活性肽和新活性肽的评估系统
公开(公告)号：JP2003313200A
公开(公告)日：2003-11-06
申请号：JP2003042731
申请日：2003-02-20
申请人： Hidechika Okada , Okada Yuubu , 岡田有武 , 秀親岡田
发明人： OKADA HIDECHIKA , WILLIAM CAMPBELL , LAJOS BARANNI , OKADA NORIKO , LAWRENCE KLEIMAN
IPC分类号： C07K14/00 , C07K7/08
摘要： PROBLEM TO BE SOLVED: To provide a new active peptide exerting control action on a target peptide by effectively designing a peptide having reactivity to the target peptide and synthesizing the designed peptide.
SOLUTION: The evaluation system for peptide comprises a calculation means, wherein a hydrophobicity mean value is calculated from front and rear five or few amino acids of the peptide at each position except terminal amino acids and the value is evaluated as an opposite signed value, a calculation means, wherein demerit mark is evaluated based on a degree of inhibition by evaluating a side chain volume uninhibiting approach of α-carbons of the mutually corresponding amino acids within 5 angstroms to each other, and a calculation means, wherein a configuration of merit is evaluated based on accordance of backbone parallelism of peptide skeletons.
COPYRIGHT: (C)2004,JPO
摘要翻译：要解决的问题：通过有效设计对靶肽具有反应性并合成设计的肽的肽来提供新的活性肽对靶肽施加控制作用。肽解决方案：肽的评估系统包括计算装置，其中除了末端氨基酸之外的每个位置，肽的前后五个或几个氨基酸计算疏水性平均值，并且该值被评估为相反的符号值，计算装置，其中基于抑制程度通过评价彼此相互相对应的氨基酸的α-碳的侧链体积不受抑制的方法来评估不同标记，以及计算装置，其中配置基于肽骨架的骨架平行度来评价优点。版权所有（C）2004，JPO

4. 发明授权

US07595050B2 Human IGM monoclonal antibody capable of inducing apoptosis in HIV-infected cells 失效
标题翻译：能够诱导HIV感染细胞凋亡的人IGM单克隆抗体
公开(公告)号：US07595050B2
公开(公告)日：2009-09-29
申请号：US10519855
申请日：2003-06-30
申请人： Hidechika Okada , Noriko Okada
发明人： Hidechika Okada , Noriko Okada
IPC分类号： A61K39/42
CPC分类号： C07K16/28 , A61K2039/505 , C07K2317/21 , C07K2317/52 , C07K2317/73
摘要： A monoclonal antibody falling within the category of human IgM which specifically recognizes HIV-infected cells and induces apoptosis is obtained. Using the obtained antibody, it is intended to provide a remedy for patients suffering from HIV-infection, which contains as the active ingredient a human IgM antibody capable of specifically reacting with HIV-infected cells, inducing apoptosis in the infected cells and thus disrupting the cells, etc.
摘要翻译：属于特异性识别HIV感染细胞并诱导凋亡的人IgM类别的单克隆抗体。使用获得的抗体旨在为患有HIV感染的患者提供补救措施，其包含作为活性成分的能够与HIV感染的细胞特异性反应的人IgM抗体，诱导感染的细胞中的细胞凋亡，从而破坏细胞等

5. 发明申请

US20060292160A1 Human igm antibody inducing apotosis in hiv-infected cells and remedy for hiv-infection 失效
标题翻译：人igm抗体在HIV感染细胞中诱导凋亡，并用于HIV感染治疗
公开(公告)号：US20060292160A1
公开(公告)日：2006-12-28
申请号：US10519855
申请日：2003-06-30
申请人： Hidechika Okada , Noriko Okada
发明人： Hidechika Okada , Noriko Okada
IPC分类号： A61K39/42 , C07K16/10
CPC分类号： C07K16/28 , A61K2039/505 , C07K2317/21 , C07K2317/52 , C07K2317/73
摘要： A monoclonal antibody falling within the category of human IgM which specifically recognizes HIV-infected cells and induces apoptosis is obtained. Using the obtained antibody, it is intended to provide a remedy for patients suffering from HIV-infection, which contains as the active ingredient a human IgM antibody capable of specifically reacting with HIV-infected cells, inducing apoptosis in the infected cells and thus disrupting the cells, etc.
摘要翻译：属于特异性识别HIV感染细胞并诱导凋亡的人IgM类别的单克隆抗体。使用获得的抗体旨在为患有HIV感染的患者提供补救措施，其包含作为活性成分的能够与HIV感染的细胞特异性反应的人IgM抗体，诱导感染的细胞中的细胞凋亡，从而破坏细胞等

6. 发明申请

US20060275826A1 Artificial antibody comprising complementary peptide 审中-公开
标题翻译：包含互补肽的人工抗体
公开(公告)号：US20060275826A1
公开(公告)日：2006-12-07
申请号：US11414713
申请日：2006-04-28
申请人： Hidechika Okada , Noriko Okada
发明人： Hidechika Okada , Noriko Okada
IPC分类号： G01N33/53
CPC分类号： G01N33/6854 , C07K14/001 , C07K2318/20
摘要： A method for detecting an antigen using a complementary peptide reactive to a target protein as an artificial antibody.
摘要翻译：使用与靶蛋白反应的互补肽作为人造抗体来检测抗原的方法。

7. 发明授权

US06190863B1 Sugar chain-recognizing antibodies and remedies for HIV infectious diseases 失效
标题翻译：糖链识别抗体和HIV传染病的补救措施
公开(公告)号：US06190863B1
公开(公告)日：2001-02-20
申请号：US09077091
申请日：1998-05-19
申请人： Hidechika Okada , Noriko Okada
发明人： Hidechika Okada , Noriko Okada
IPC分类号： C12Q170
CPC分类号： C07K16/18 , A61K38/00 , A61K2039/505 , C07K16/28
摘要： The present invention is directed to a sugar-chain-recognizing antibody which belongs to the IgM isotype and which recognizes Gg4Cer(Gal&bgr;1-3GalNAc&bgr;1-4Gal&bgr;1-4Glc&bgr;Cer) or GM2 which appears on HIV infected cells, as well as to a therapeutics for HIV diseases containing those IgMs.
摘要翻译：本发明涉及属于IgM同种型并识别出现在HIV感染细胞上的Gg4Cer（Galbeta1-3GalNAcbeta1-4Galbeta1-4GlcbetaCer）或GM2的糖链识别抗体，以及用于HIV疾病的治疗剂含有这些IgM。

8. 发明授权

US5179198A Glycoprotein and gene coding therefor 失效
标题翻译： GLYCOPROTEIN及其基因编码
公开(公告)号：US5179198A
公开(公告)日：1993-01-12
申请号：US376828
申请日：1989-07-07
申请人： Hidechika Okada , Noriko Okada , Yoichi Nagami , Kazuhiro Takahashi , Hisao Takizawa , Jun Kondo
发明人： Hidechika Okada , Noriko Okada , Yoichi Nagami , Kazuhiro Takahashi , Hisao Takizawa , Jun Kondo
IPC分类号： A61K38/00 , C07K14/47 , C07K14/81 , C12N15/12
CPC分类号： C07K14/4703 , C07K14/8107 , A61K38/00 , Y10S530/827
摘要： The present invention provides a glycoprotein derived from human cell membrane, which has a molecular weight of 20 to 25 Kd as estimated by SDS polyacrylamide gel electrophoresis, and contains N-glycoside type carbohydrate chain and phosphatidylinositol, and possesses an inhibitory activity to complement-mediated cell membrane damage. The present invention further provides a gene coding for the glycoprotein, and a method for the production of the glycoprotein and the gene therefor.

9. 发明授权

US07914790B2 Human IgM antibody lysing activated lymphocytes under mediation by homologous complement 失效
标题翻译：人IgM抗体通过同源补体在调解下溶解活化的淋巴细胞
公开(公告)号：US07914790B2
公开(公告)日：2011-03-29
申请号：US10520016
申请日：2003-06-30
申请人： Hidechika Okada , Noriko Okada
发明人： Hidechika Okada , Noriko Okada
IPC分类号： A61K39/395 , C12N5/07
CPC分类号： C07K16/28 , A61K2039/505 , C07K2317/21 , C07K2317/56 , Y10S530/809
摘要： A human IgM monoclonal antibody responding to HIV-infected cells too, which is characterized by lysing activated human lymphocytes, etc. under the mediation by a homologous human complement, is obtained. Using the thus obtained monoclonal antibody, it is intended to provide an immune reaction controlling remedy, etc. containing the human IgM monoclonal antibody which responds specifically to activated lymphocytes and induces cell lysis under the mediation by a homologous complement. Using the human IgM monoclonal antibody responding to activated human lymphocytes, it is also intended to provide an HIV remedy, etc. characterized by lysing and eliminating activated lymphocytes to thereby treat transplantation rejection and autoimmune diseases caused by an over-response of T lymphocytes as well as HIV infection.
摘要翻译：获得了响应于HIV感染细胞的人IgM单克隆抗体，其特征在于通过同源人补体在介导下裂解活化的人淋巴细胞等。使用如此获得的单克隆抗体，旨在提供含有人IgM单克隆抗体的免疫反应控制药物，其特异性响应于活化的淋巴细胞，并在同源补体的介导下诱导细胞裂解。使用对活化的人淋巴细胞作出反应的人IgM单克隆抗体，还旨在提供HIV疗法等，其特征在于裂解和消除活化的淋巴细胞，从而治疗由T淋巴细胞过度反应引起的移植排斥反应和自身免疫性疾病作为艾滋病毒感染。

10. 发明授权

US07144864B2 Carboxypeptidase R inhibiting peptide 有权
标题翻译：羧肽酶R抑制肽
公开(公告)号：US07144864B2
公开(公告)日：2006-12-05
申请号：US10254610
申请日：2002-09-25
申请人： Hidechika Okada , Eliada Lazoura , William Campbell , Noriko Okada
发明人： Hidechika Okada , Eliada Lazoura , William Campbell , Noriko Okada
IPC分类号： A61K38/08 , A61K38/00 , A61K38/02 , C07K2/00 , C07K7/04
CPC分类号： C07K7/06 , A61K38/00
摘要： A novel carboxypeptidase R (CPR) inhibiting peptide is prepared using rational structure-based strategies, incorporating two principle facts: (a) CPR has a strong affinity for basic amino acids and; and (b) the two lysines and arginine residues of PCI are orientated in the same direction and held in close spatial proximity by three disulfide bonds.
摘要翻译：使用合理的基于结构的策略制备新的羧肽酶R（CPR）抑制肽，并结合两个主要事实：（a）CPR对碱性氨基酸具有很强的亲和力; 和（b）PCI的两个赖氨酸和精氨酸残基以相同方向取向，并通过三个二硫键保持紧密的空间接近。

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