专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20070011755A1 Diabetes type 2 animal model 审中-公开
标题翻译：糖尿病2型动物模型
公开(公告)号：US20070011755A1
公开(公告)日：2007-01-11
申请号：US10568271
申请日：2004-08-18
申请人： Helena Edlund , Michael Walker , Nir Rubins , Par Steneberge
发明人： Helena Edlund , Michael Walker , Nir Rubins , Par Steneberge
IPC分类号： A01K67/027
CPC分类号： A01K67/0275 , A01K2217/05 , A01K2227/105 , A01K2267/0362 , C07K14/723 , C12N15/8509 , C12N2830/008
摘要： A diabetes type 2 model laboratory animal is disclosed which comprises cells over-expressing GPR40 under the control of the Ipfl/Pdx 1 promoter. Also disclosed is the use of the model animal for the identification of agonists or antagonists towards GPR40, useful for the development of pharmaceuticals towards treatment of the disease.
摘要翻译：公开了一种糖尿病2型模型实验室动物，其包含在Ipfl / Pdx1启动子控制下过度表达GPR40的细胞。还公开了使用模型动物来鉴定针对GPR40的激动剂或拮抗剂，其用于开发用于治疗该疾病的药物。

2. 发明授权

US07098375B2 Animal and cell models for type II diabetes and their use 失效
标题翻译： II型糖尿病的动物和细胞模型及其用途
公开(公告)号：US07098375B2
公开(公告)日：2006-08-29
申请号：US10257155
申请日：2001-04-06
申请人： Helena Edlund , Alan Hart , Nathalie Baeza , Åsa Apelqvist
发明人： Helena Edlund , Alan Hart , Nathalie Baeza , Åsa Apelqvist
IPC分类号： A01K27/027 , A01K67/033
CPC分类号： A01K67/0276 , A01K2217/075 , A01K2227/105 , A01K2267/0306 , A01K2267/0362 , A61K38/00 , A61K48/00 , C07K14/71 , C12N15/8509 , C12N2517/02
摘要： A transgenic diabetes type II model laboratory animal is disclosed which comprises β-cells expressing a dominant negative form (dnFGFR1c) of FGFR1c. Also disclosed is the use of the Ipf1/pdx1 promoter for controlling expression of FGFR1c; β-cells in which the expression of PC1/3 is down-regulated or absent or which are competent to express a dominant negative form (dnFGFR1c) of FGFR1c; mature β-cells incompetent to express Glut2 or in which the processing of proinsulin is substantially impaired; a method of preventing or treating type II diabetes.
摘要翻译：公开了一种转基因糖尿病II型模型实验室动物，其包含表达FGFR1c的显性阴性形式（dnFGFR1c）的β细胞。还公开了Ipf1 / pdx1启动子用于控制FGFR1c表达的用途; 其中PC1 / 3的表达下调或不存在或能够表达FGFR1c的显性负性形式（dnFGFR1c）的β细胞; 成熟的β细胞不能表达Glut2或其中胰岛素原的加工显着受损; 预防或治疗II型糖尿病的方法。

3. 发明申请

US20090269309A1 Retinoic acid stimulates differentiation of pancreatic progenitor cells into insulin producing cells 审中-公开
标题翻译：视黄酸刺激胰腺祖细胞分化成胰岛素生成细胞
公开(公告)号：US20090269309A1
公开(公告)日：2009-10-29
申请号：US11666257
申请日：2005-10-28
申请人： Helena Edlund , Maria Öström
发明人： Helena Edlund , Maria Öström
IPC分类号： A61K35/12 , C12N5/06 , C12N5/08
CPC分类号： A61K35/39 , A61K35/12 , C12N5/0676 , C12N2501/385
摘要： The invention relates to a method of forming pancreatic hormone-producing endocrine cells in vitro, wherein pancreatic stem cells are treated with one or more retinoids and/or retinoic acid in vitro and cultured. Especially the dorsal pancreatic bud is used and to the cells obtained by the method. Further, it relates to the use of the pancreatic hormone-producing endocrine cells, for the production of a pharmaceutical composition for transplantation and/or treatment of type 1 and type 2 diabetes. It also relates to a method for treatment of type 1 and type 2 diabetes by administrating the hormone-producing endocrine cells to individuals in need thereof. The invention also regards the use of one or more retinoids and/or retinoic acid for the differentiation, in vitro of pancreatic stem cells into pancreatic hormone-producing endocrine cells, such as glucagon producing cells, and in particular, insulin producing β-cells.
摘要翻译：本发明涉及在体外产生产生胰激素的内分泌细胞的方法，其中胰体干细胞在体外用一种或多种类视色素和/或视黄酸处理并培养。特别是使用背部胰芽和通过该方法得到的细胞。此外，本发明涉及产生胰腺激素的内分泌细胞用于生产用于移植和/或治疗1型和2型糖尿病的药物组合物。本发明还涉及通过将产生激素的内分泌细胞施用于有需要的个体来治疗1型和2型糖尿病的方法。本发明还涉及一种或多种类维生素A和/或视黄酸用于将胰干细胞体外分化成产胰多孕激素的内分泌细胞，例如胰高血糖素产生细胞，特别是产生胰岛素的β细胞。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式