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    • 2. 发明授权
    • Method and agents for permanently styling hair, with a base consisting of N,N-disubstituted mercaptoacetamides
    • 用于永久定型毛发的方法和试剂,其中由N,N-二取代的巯基乙酰胺组成的底物
    • US06399051B2
    • 2002-06-04
    • US09269901
    • 1999-06-08
    • Beate DanneckerGuenther LangWolfgang HanefeldHeiko Walther
    • Beate DanneckerGuenther LangWolfgang HanefeldHeiko Walther
    • A61K709
    • A61Q5/04A61K8/46C07C323/60
    • The present invention relates to a composition and method for permanently shaping hair, in which an N,N-disubstituted mercaptoacetamide of the formula I: or a salt thereof, wherein R1 and R2 are each independently selected from the group consisting of straight-chain alkyl groups having 1 to 6 carbon atoms, branched-chain alkyl groups having 1 to 6 carbon atoms, monohydroxyalkyl groups having 1 to 6 carbon atoms, polyhydroxyalkyl groups having 1 to 6 carbon atoms and carboxyalkyl groups having 1 to 6 carbon atoms, is employed as keratin reducing agent. A process for making these mercaptoacetamides is also described as well as a novel mercaptoacetamide, N-ethyl-2′-hydroxyethyl-mercaptoacetamide. The mercaptoacetamides provide gentle and uniform shaping of hair in a pH range of 4.5 to 9.5 and do not cause allergic or sensitizing reactions.
    • 本发明涉及用于永久形成头发的组合物和方法,其中式I的N,N-二取代的巯基乙酰胺或其盐,其中R 1和R 2各自独立地选自直链烷基 使用具有1至6个碳原子的基团,具有1至6个碳原子的支链烷基,具有1至6个碳原子的单羟基烷基,具有1至6个碳原子的多羟基烷基和具有1至6个碳原子的羧基烷基作为 角蛋白还原剂。 还描述了制备这些巯基乙酰胺的方法以及新的巯基乙酰胺,N-乙基-2'-羟乙基 - 巯基乙酰胺。 巯基乙酰胺在4.5至9.5的pH范围内提供温和均匀的头发成型,并且不引起过敏或致敏反应。
    • 3. 发明授权
    • Agent and method for permanently shaping the hair, based on
n-branched-chain alkyl-substituted mercapto acetamides and process for
their preparation
    • 基于正链支链烷基取代的巯基乙酰胺永久定型毛发的剂和方法及其制备方法
    • US6153180A
    • 2000-11-28
    • US142576
    • 1998-09-10
    • Guenther LangBeate DanneckerWolfgang HanefeldHeiko Walther
    • Guenther LangBeate DanneckerWolfgang HanefeldHeiko Walther
    • A61K8/00A61K8/44A61K8/46A61K31/16A61Q5/04A61Q5/10A61K7/09
    • A61Q5/04A61K8/447A61K8/46A61Q5/10
    • The subject of the invention is an agent for the permanent shaping of hair, characterized in that it contains as active keratin-reducing substance a compound in accordance with the general formula ##STR1## in which R.sub.1, R.sub.2 and R.sub.3 stand for H, carboxy or a straight- or branched-chain alkyl radical, monohydroxyalkyl radical or polyhydroxyalkyl radical with 1 to 6 carbon atoms respectively, on the condition thatnot all radicals R.sub.1 to R.sub.3 stand for H at the same time;if R.sub.1 and R.sub.2 stand for H, then R.sub.3 is carboxy or a branched alkyl, branched monohydroxyalkyl or branched polyhydroxyalkyl radical with 1 to 6 carbon atoms;if none of the radicals R.sub.1 to R.sub.2 stand for carboxy or have a branched alkyl, branched monohydroxyalkyl or branched polyhydroxyalkyl radical with 1 to 6 carbon atoms, then at least two of the radicals R.sub.1, R.sub.2 or R.sub.3 stand for a straight-chain alkyl, monohydroxyalkyl or polyhydroxyalkyl radical with 1 to 6 carbon atoms andif one of the radicals is carboxy, then the other two radicals are not carboxy at the same time.The agent allows for gentle, even shaping of the hair in a way that protects the skin and the hair, at a pH range of 6.5 to 9.5, without causing allergic and sensitizing reactions.
    • PCT No.PCT / EP97 / 06860 Sec。 371日期:1998年9月10日 102(e)1998年9月10日PCT 1997年12月9日PCT PCT。 第WO98 / 30197号公报 日本1998年7月16日本发明的主题是头发永久成形剂,其特征在于,其含有作为活性角蛋白还原剂的化合物,其中R1,R2和R3代表H, 羧基或直链或支链烷基,单羟基烷基基团或具有1至6个碳原子的多羟基烷基基团,条件是不是所有基团R 1至R 3同时代表H; 如果R1和R2代表H,则R3是羧基或具有1-6个碳原子的支链烷基,支链一羟基烷基或支链多羟基烷基; 如果基团R 1至R 2不能代表羧基或具有1至6个碳原子的支链烷基,支化单羟基烷基或支链多羟基烷基,则基团R 1,R 2或R 3中的至少两个表示直链烷基, 具有1至6个碳原子的单羟基烷基或多羟基烷基,如果其中一个基团是羧基,则其它两个基团不是同时为羧基。 该试剂允许以6.5至9.5的pH范围以保护皮肤和毛发的方式温和,均匀地成形,而不引起过敏和敏化反应。
    • 4. 发明授权
    • Hair shaping compositions containing mercaptoethylamines and methods for
the permanent shaping of hair using same
    • 包含巯基乙胺的毛发成型组合物和使用其使头发永久成形的方法
    • US5985253A
    • 1999-11-16
    • US36849
    • 1998-03-09
    • Guenther LangHeiko WaltherBeate DanneckerWolfgang Hanefeld
    • Guenther LangHeiko WaltherBeate DanneckerWolfgang Hanefeld
    • A61K8/46A61Q5/04A61K7/06A61K7/09
    • A61Q5/04A61K8/46
    • The aqueous permanent shaping composition has a pH of 6.5 to 9.5 and contains water, from 3 to 28 percent by weight of one or more mercaptoethylamines of the formula IHS--CH.sub.2 --CH.sub.2 --NR.sub.1 R.sub.2 (I),wherein R.sub.1 represents hydrogen, a straight or branched chain alkyl, hydroxyalkyl or polyhydroxyalkyl group having 1 to 6 carbon atoms; R.sub.2 represents a cyclohexyl group, a furfuryl group, a straight or branched chain hydroxyalkyl group having 1 to 6 carbon atoms or a polyhydroxyalkyl group having 1 to 6 carbon atoms; or wherein R.sub.1 and R.sub.2 together with the nitrogen atom form a five or six membered ring containing, or not containing, another heteroatom and the five or six membered ring is substituted with a hydroxyl group, a carboxyl group or with one or two alkyl, hydroxyalkyl, polyhydroxyalkyl or alkoxycarboxyl groups having from 1 to 4 carbon atoms; or at least one physiologically compatible salt thereof; and one or more additive ingredients, which can be a surfactant or emulsifier, alcohol, sugar, solvating agent, stabilizer, buffer substance, perfume oil, dyestuff, hair conditioning or care ingredient.
    • 水性永久性成形组合物的pH为6.5至9.5并含有水,3至28重量%的一种或多种式IHS-CH 2 -CH 2 -NR 1 R 2(I)的巯基乙胺,其中R 1表示氢,直链或 具有1-6个碳原子的支链烷基,羟烷基或多羟基烷基; R2表示环己基,糠基,碳原子数1〜6的直链或支链羟烷基或碳原子数1〜6的多羟基烷基。 或其中R 1和R 2与氮原子一起形成含有或不含有另一个杂原子的五元或六元环,并且五元或六元环被羟基,羧基或与一个或两个烷基,羟烷基 ,具有1至4个碳原子的多羟基烷基或烷氧基羧基; 或其至少一种生理上相容的盐; 以及一种或多种添加剂成分,其可以是表面活性剂或乳化剂,醇,糖,溶剂化剂,稳定剂,缓冲物质,香料油,染料,头发调理剂或护理成分。
    • 7. 发明授权
    • Agent and method for permanent shaping of hair and method for the production of N-alkylmercaptoacetamides
    • 用于头发永久成型的剂和方法以及用于生产N-烷基巯基乙酰胺的方法
    • US06264932B1
    • 2001-07-24
    • US09269471
    • 1999-03-27
    • Beate DanneckerGünther LangWolfgang HanefeldHeiko Walther
    • Beate DanneckerGünther LangWolfgang HanefeldHeiko Walther
    • A61K709
    • A61Q5/04A61K8/447A61K8/46C07C319/12
    • The aqueous ready-to-apply composition for permanent waving of hair has a pH of 4 to 8.5 and from 3 to 28% by weight of at least one N-alkylmercaptoacetamide of formula (I): wherein R represents a straight-chain alkyl group having from 3 to 6 carbon atoms or a straight-chain hydroxyalkyl group having from 3 to 6 carbon atoms; or a salt thereof; and at least one standard cosmetic additive ingredient, such as thickeners, wetting agents and emulsifiers, perfume oils, conditioners and buffer substances. The ready-to-apply composition can be made by mixing two or more components, one of which contains the N-alkylmercaptoacetamide. A method for permanent waving of hair using the ready-to-apply composition is also described. A process for making the N-alkylmercapto-acetamides includes reacting a suitable amine with methylthioglycolate under a protective gas atmosphere at temperatures that are not greater than 30° C.
    • 用于永久挥发头发的水性即用涂料组合物的pH为4至8.5和3至28重量%的至少一种式(I)的N-烷基巯基乙酰胺:其中R表示直链烷基 具有3至6个碳原子的直链羟烷基或具有3至6个碳原子的直链羟烷基; 或其盐; 和至少一种标准化妆品添加剂成分,例如增稠剂,润湿剂和乳化剂,香料油,调理剂和缓冲物质。 可应用的组合物可以通过混合两种或多种组分来制备,其中一种组分含有N-烷基巯基乙酰胺。 还描述了使用即用涂抹组合物永久挥发毛发的方法。 制备N-烷基巯基乙酰胺的方法包括在不高于30℃的温度下,在保护气体气氛下使合适的胺与巯基乙酸甲酯反应。